DD208989A5 - Verfahren zur synthetisierung von menschlichem insulin - Google Patents

Verfahren zur synthetisierung von menschlichem insulin Download PDF

Info

Publication number
DD208989A5
DD208989A5 DD80238563A DD23856380A DD208989A5 DD 208989 A5 DD208989 A5 DD 208989A5 DD 80238563 A DD80238563 A DD 80238563A DD 23856380 A DD23856380 A DD 23856380A DD 208989 A5 DD208989 A5 DD 208989A5
Authority
DD
German Democratic Republic
Prior art keywords
sequence
proinsulin
human
insulin
encoding
Prior art date
Application number
DD80238563A
Other languages
German (de)
English (en)
Inventor
Graeme Bell
Raymond L Pictet
Howard M Goodmann
William J Rutter
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of DD208989A5 publication Critical patent/DD208989A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DD80238563A 1979-09-12 1980-09-12 Verfahren zur synthetisierung von menschlichem insulin DD208989A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7519279A 1979-09-12 1979-09-12

Publications (1)

Publication Number Publication Date
DD208989A5 true DD208989A5 (de) 1984-04-18

Family

ID=22124154

Family Applications (3)

Application Number Title Priority Date Filing Date
DD80223873A DD155004A5 (de) 1979-09-12 1980-09-12 Verfahren zur herstellung eines dns-transfervektors
DD80238563A DD208989A5 (de) 1979-09-12 1980-09-12 Verfahren zur synthetisierung von menschlichem insulin
DD80238569A DD201693A5 (de) 1979-09-12 1980-09-12 Verfahren zur synthetisierung von menschlichem proinsulin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DD80223873A DD155004A5 (de) 1979-09-12 1980-09-12 Verfahren zur herstellung eines dns-transfervektors

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD80238569A DD201693A5 (de) 1979-09-12 1980-09-12 Verfahren zur synthetisierung von menschlichem proinsulin

Country Status (28)

Country Link
EP (1) EP0026598A1 (fi)
JP (1) JP2637393B2 (fi)
KR (1) KR870000501B1 (fi)
AT (1) AT377003B (fi)
AU (1) AU538154B2 (fi)
BE (1) BE885196A (fi)
BG (2) BG41137A3 (fi)
CA (1) CA1180289A (fi)
CZ (2) CZ278883B6 (fi)
DD (3) DD155004A5 (fi)
DK (1) DK385980A (fi)
ES (3) ES495030A0 (fi)
FI (1) FI802837A (fi)
FR (1) FR2464997B1 (fi)
GR (1) GR70279B (fi)
IE (1) IE52781B1 (fi)
IL (1) IL61041A (fi)
IT (1) IT1129250B (fi)
LU (1) LU82757A1 (fi)
NZ (1) NZ194786A (fi)
PH (1) PH26475A (fi)
PL (1) PL226725A1 (fi)
PT (1) PT71790B (fi)
RO (1) RO80005A (fi)
SK (1) SK278191B6 (fi)
SU (1) SU1491345A3 (fi)
YU (1) YU233480A (fi)
ZA (1) ZA805341B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3001928A1 (de) * 1980-01-19 1981-08-06 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
US4249952A (en) * 1980-03-03 1981-02-10 Pennsylvania Engineering Corporation Method for producing cement clinker from cement kiln waste dust
AU545912B2 (en) * 1980-03-10 1985-08-08 Cetus Corporation Cloned heterologous jive products in bacillies
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
ZA824218B (en) * 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
WO1983003413A1 (en) * 1982-03-31 1983-10-13 Genetics Inst Creation of dna sequences encoding modified proinsulin precursors
NZ206534A (en) * 1982-12-13 1988-05-30 Florey Howard Inst Molecular cloning and characterisation of gene sequence coding for human relaxin
US5023321A (en) * 1982-12-13 1991-06-11 Howard Florey Institute Of Experimental Physiology & Medicine Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL71991A (en) 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
DE3751863T2 (de) * 1986-05-20 1996-12-12 Gen Hospital Corp Bestimmung der Insulin Expression
ATE386811T1 (de) 1996-04-05 2008-03-15 Novartis Vaccines & Diagnostic Alphaviren-vektors mit eine reduzierte inhibierung der synthese von zellmakromolekülen
AUPP655698A0 (en) * 1998-10-16 1998-11-05 Commonwealth Scientific And Industrial Research Organisation Delivery system for porcine somatotropin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
GR71687B (fi) * 1977-11-08 1983-06-21 Genentech Inc
DE2862495D1 (en) * 1977-11-08 1989-05-24 Genentech Inc Plasmid for transforming bacterial host to render it capable of polypeptide expression
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
IE48385B1 (en) * 1978-08-11 1984-12-26 Univ California Synthesis of a eucaryotic protein by a microorganism

Also Published As

Publication number Publication date
LU82757A1 (fr) 1981-02-02
SU1491345A3 (ru) 1989-06-30
RO80005B (ro) 1983-06-30
SK621580A3 (en) 1996-03-06
PH26475A (en) 1992-07-27
BE885196A (fr) 1980-12-31
KR870000501B1 (ko) 1987-03-12
JP2637393B2 (ja) 1997-08-06
BG41136A3 (en) 1987-04-15
PT71790A (en) 1980-10-01
ES8300857A1 (es) 1982-11-16
DD155004A5 (de) 1982-05-05
RO80005A (ro) 1983-07-07
ES503567A0 (es) 1983-04-01
NZ194786A (en) 1984-02-03
ATA458580A (de) 1984-06-15
ES503568A0 (es) 1982-11-16
DK385980A (da) 1981-03-13
GR70279B (fi) 1982-09-03
AU538154B2 (en) 1984-08-02
FI802837A (fi) 1981-03-13
PL226725A1 (en) 1983-07-18
CZ621580A3 (en) 1994-03-16
IE801912L (en) 1981-03-12
IT8068405A0 (it) 1980-09-11
ES8107307A1 (es) 1981-10-01
ZA805341B (en) 1982-01-27
IE52781B1 (en) 1988-03-02
FR2464997B1 (fr) 1985-05-24
FR2464997A1 (fr) 1981-03-20
AT377003B (de) 1985-01-25
IT1129250B (it) 1986-06-04
AU6232480A (en) 1981-03-19
KR830003576A (ko) 1983-06-21
IL61041A (en) 1984-02-29
YU233480A (en) 1984-02-29
PT71790B (en) 1981-07-07
CZ278883B6 (en) 1994-08-17
ES495030A0 (es) 1981-10-01
CZ548884A3 (en) 1996-08-14
JPS5695199A (en) 1981-08-01
CA1180289A (en) 1985-01-02
IL61041A0 (en) 1980-11-30
DD201693A5 (de) 1983-08-03
SK278191B6 (en) 1996-03-06
BG41137A3 (en) 1987-04-15
EP0026598A1 (en) 1981-04-08
ES8305420A1 (es) 1983-04-01

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