CZ301695B6 - Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptoru, jejich výroba a léciva - Google Patents

Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptoru, jejich výroba a léciva Download PDF

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Publication number
CZ301695B6
CZ301695B6 CZ20011813A CZ20011813A CZ301695B6 CZ 301695 B6 CZ301695 B6 CZ 301695B6 CZ 20011813 A CZ20011813 A CZ 20011813A CZ 20011813 A CZ20011813 A CZ 20011813A CZ 301695 B6 CZ301695 B6 CZ 301695B6
Authority
CZ
Czechia
Prior art keywords
alkyl
substituted
phenyl
triazolylmethylpiperazine
formula
Prior art date
Application number
CZ20011813A
Other languages
Czech (cs)
English (en)
Other versions
CZ20011813A3 (cs
Inventor
Jasserand@Daniel
Schön@Uwe
Sann@Holger
Brückner@Reinhard
Eeckhout@Christian
Original Assignee
Solvay Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals Gmbh filed Critical Solvay Pharmaceuticals Gmbh
Publication of CZ20011813A3 publication Critical patent/CZ20011813A3/cs
Publication of CZ301695B6 publication Critical patent/CZ301695B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CZ20011813A 2000-07-28 2001-05-23 Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptoru, jejich výroba a léciva CZ301695B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10036818A DE10036818A1 (de) 2000-07-28 2000-07-28 Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (2)

Publication Number Publication Date
CZ20011813A3 CZ20011813A3 (cs) 2002-03-13
CZ301695B6 true CZ301695B6 (cs) 2010-05-26

Family

ID=7650544

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20011813A CZ301695B6 (cs) 2000-07-28 2001-05-23 Deriváty N-triazolylmethylpiperazinu jako antagonistické látky neurokininových receptoru, jejich výroba a léciva

Country Status (27)

Country Link
US (1) US6407106B1 (en:Method)
EP (1) EP1176144B1 (en:Method)
JP (1) JP2002053577A (en:Method)
KR (1) KR100924405B1 (en:Method)
CN (1) CN1167698C (en:Method)
AR (1) AR028743A1 (en:Method)
AT (1) ATE244716T1 (en:Method)
AU (1) AU779318B2 (en:Method)
BR (1) BR0103048A (en:Method)
CA (1) CA2354213C (en:Method)
CZ (1) CZ301695B6 (en:Method)
DE (2) DE10036818A1 (en:Method)
DK (1) DK1176144T3 (en:Method)
DZ (1) DZ3119A1 (en:Method)
ES (1) ES2201007T3 (en:Method)
HU (1) HU226687B1 (en:Method)
IL (1) IL144299A (en:Method)
IN (1) IN191021B (en:Method)
NO (1) NO323233B1 (en:Method)
NZ (1) NZ513041A (en:Method)
PL (1) PL210436B1 (en:Method)
PT (1) PT1176144E (en:Method)
RU (1) RU2288918C2 (en:Method)
SK (1) SK284802B6 (en:Method)
TW (1) TWI304403B (en:Method)
UA (1) UA73728C2 (en:Method)
ZA (1) ZA200105737B (en:Method)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77515C2 (en) 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
CN1313450C (zh) * 2002-04-26 2007-05-02 伊莱利利公司 速激肽受体拮抗剂
DE60318697T2 (de) * 2002-04-26 2009-01-08 Eli Lilly And Co., Indianapolis Triazolderivate als tachykininrezeptor-antagonisten
WO2005000821A1 (en) * 2003-06-12 2005-01-06 Eli Lilly And Company Tachykinin receptor antagonists
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
BRPI0613881A2 (pt) * 2005-07-25 2011-02-15 Hoffmann La Roche derivados de triazol substituìdo e seu uso como antagonistas de receptor de neuroquinina 3
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
US9782397B2 (en) 2011-07-04 2017-10-10 Irbm Science Park S.P.A. Treatment of corneal neovascularization
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency
CN115184498B (zh) * 2022-07-15 2023-02-21 山东京卫制药有限公司 N-Boc-哌嗪中有关物质哌嗪的检测方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0655442A1 (en) * 1993-11-29 1995-05-31 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives as Tachykinin antagonists
WO1998057954A1 (en) * 1997-06-17 1998-12-23 Fujisawa Pharmaceutical Co., Ltd. Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists
EP0899270A1 (de) * 1997-08-27 1999-03-03 Solvay Pharmaceuticals GmbH Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten
US6087357A (en) * 1995-12-18 2000-07-11 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives as tachykinin antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883098A (en) 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
KR19990021857A (ko) * 1995-05-25 1999-03-25 후지야마 아키라 뉴로키닌 수용체 길항물질로서 1-벤조일-2-(인돌일-3-알킬)-피페라진 유도체
GB9513118D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
KR100458346B1 (ko) * 1996-03-29 2005-06-21 듀파 인터내셔날 리서치 베 파우 피페라진및피페리딘화합물
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0655442A1 (en) * 1993-11-29 1995-05-31 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives as Tachykinin antagonists
US6087357A (en) * 1995-12-18 2000-07-11 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives as tachykinin antagonists
WO1998057954A1 (en) * 1997-06-17 1998-12-23 Fujisawa Pharmaceutical Co., Ltd. Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists
EP0899270A1 (de) * 1997-08-27 1999-03-03 Solvay Pharmaceuticals GmbH Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten

Also Published As

Publication number Publication date
SK7572001A3 (en) 2002-02-05
AU5767501A (en) 2002-01-31
HUP0102931A3 (en) 2003-07-28
US6407106B1 (en) 2002-06-18
TWI304403B (en) 2008-12-21
NO20013709L (no) 2002-01-29
CZ20011813A3 (cs) 2002-03-13
NZ513041A (en) 2002-12-20
IL144299A0 (en) 2002-05-23
DE10036818A1 (de) 2002-02-07
JP2002053577A (ja) 2002-02-19
BR0103048A (pt) 2002-04-02
DZ3119A1 (fr) 2004-09-19
IN191021B (en:Method) 2003-09-13
SK284802B6 (sk) 2005-11-03
PL348946A1 (en) 2002-02-11
HU226687B1 (en) 2009-06-29
DE50100358D1 (de) 2003-08-14
NO20013709D0 (no) 2001-07-27
DK1176144T3 (da) 2003-10-27
PL210436B1 (pl) 2012-01-31
KR100924405B1 (ko) 2009-10-29
ES2201007T3 (es) 2004-03-16
ZA200105737B (en) 2002-01-22
HK1042699A1 (en) 2002-08-23
AR028743A1 (es) 2003-05-21
KR20020010482A (ko) 2002-02-04
US20020065276A1 (en) 2002-05-30
RU2288918C2 (ru) 2006-12-10
ATE244716T1 (de) 2003-07-15
HU0102931D0 (en) 2001-09-28
AU779318B2 (en) 2005-01-13
NO323233B1 (no) 2007-02-05
IL144299A (en) 2004-08-31
CA2354213A1 (en) 2002-01-28
PT1176144E (pt) 2003-11-28
CN1167698C (zh) 2004-09-22
HUP0102931A2 (hu) 2002-11-28
EP1176144B1 (de) 2003-07-09
CN1335316A (zh) 2002-02-13
EP1176144A1 (de) 2002-01-30
UA73728C2 (en) 2005-09-15
CA2354213C (en) 2010-04-27

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Legal Events

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MM4A Patent lapsed due to non-payment of fee

Effective date: 20120523