CZ284395B6 - Prostředek pro snižování očního tlaku - Google Patents

Prostředek pro snižování očního tlaku Download PDF

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Publication number
CZ284395B6
CZ284395B6 CZ962694A CZ269496A CZ284395B6 CZ 284395 B6 CZ284395 B6 CZ 284395B6 CZ 962694 A CZ962694 A CZ 962694A CZ 269496 A CZ269496 A CZ 269496A CZ 284395 B6 CZ284395 B6 CZ 284395B6
Authority
CZ
Czechia
Prior art keywords
group
carbon atoms
alkyl
groups
formula
Prior art date
Application number
CZ962694A
Other languages
Czech (cs)
English (en)
Other versions
CZ269496A3 (en
Inventor
Tomihisa Yokoyama
Tsunemichi Hosokawa
Hiroaki Yanagisawa
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of CZ269496A3 publication Critical patent/CZ269496A3/cs
Publication of CZ284395B6 publication Critical patent/CZ284395B6/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
CZ962694A 1994-03-16 1995-03-16 Prostředek pro snižování očního tlaku CZ284395B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4540494 1994-03-16

Publications (2)

Publication Number Publication Date
CZ269496A3 CZ269496A3 (en) 1996-12-11
CZ284395B6 true CZ284395B6 (cs) 1998-11-11

Family

ID=12718322

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ962694A CZ284395B6 (cs) 1994-03-16 1995-03-16 Prostředek pro snižování očního tlaku

Country Status (20)

Country Link
US (1) US5925664A (enExample)
EP (2) EP0795326B1 (enExample)
KR (1) KR100211446B1 (enExample)
CN (2) CN1104898C (enExample)
AT (2) ATE206050T1 (enExample)
AU (1) AU684916B2 (enExample)
CZ (1) CZ284395B6 (enExample)
DE (2) DE69533045T2 (enExample)
DK (2) DK0795326T3 (enExample)
ES (2) ES2163501T3 (enExample)
FI (2) FI114897B (enExample)
GR (1) GR3036989T3 (enExample)
HK (1) HK1000551A1 (enExample)
HU (1) HUT74734A (enExample)
MX (1) MX9604109A (enExample)
NO (1) NO311068B1 (enExample)
NZ (1) NZ282485A (enExample)
PT (2) PT795326E (enExample)
RU (1) RU2123847C1 (enExample)
WO (1) WO1995024902A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1186302E (pt) * 1999-06-11 2005-07-29 Sankyo Co Composicao para fazer descer a tensao ocular para administracao topica
JP4000505B2 (ja) * 1999-12-01 2007-10-31 第一三共株式会社 緑内障を治療するための併用剤
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
AU2002218527A1 (en) * 2000-12-05 2002-06-18 Sankyo Company Limited Ocular tension-lowering compositions for topical administration
JP4489020B2 (ja) * 2003-04-15 2010-06-23 第一三共株式会社 眼内血管新生性疾患の予防又は治療のための医薬

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
JPS6323868A (ja) * 1986-07-11 1988-02-01 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー アンギオテンシン２受容体遮断性イミダゾ−ル
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
KR0163595B1 (ko) * 1989-06-30 1998-12-01 미리암디, 메코너헤이 치환된 이미다졸
WO1991015206A1 (en) * 1990-04-05 1991-10-17 E.I. Du Pont De Nemours And Company Treatment of glaucoma and ocular hypertension with imidazole angiotensin-ii receptor antagonists
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
IE920540A1 (en) * 1991-02-21 1992-08-26 Sankyo Co 1-biphenylmethylimidazole derivatives, their preparation and¹their therapetuic use
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
DE69329982T2 (de) * 1992-06-02 2001-09-27 Sankyo Co., Ltd. 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
CA2111662C (en) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
US5889020A (en) * 1994-02-08 1999-03-30 Ciba Vision Corporation Treatment of normotensive glaucoma with angiotensin II antagonists

Also Published As

Publication number Publication date
FI963645A0 (fi) 1996-09-16
FI963645A7 (fi) 1996-11-14
MX9604109A (es) 1997-09-30
CN1387846A (zh) 2003-01-01
HK1000551A1 (en) 2002-04-12
EP1110551A3 (en) 2001-08-16
CZ269496A3 (en) 1996-12-11
CN1202819C (zh) 2005-05-25
EP0795326A1 (en) 1997-09-17
ES2163501T3 (es) 2002-02-01
ATE206050T1 (de) 2001-10-15
NO963854L (no) 1996-11-14
WO1995024902A1 (en) 1995-09-21
KR970701542A (ko) 1997-04-12
DE69533045T2 (de) 2005-01-27
PT1110551E (pt) 2004-07-30
US5925664A (en) 1999-07-20
CN1148809A (zh) 1997-04-30
DK1110551T3 (da) 2004-06-07
EP1110551B1 (en) 2004-05-12
RU2123847C1 (ru) 1998-12-27
NZ282485A (en) 1997-06-24
NO311068B1 (no) 2001-10-08
EP1110551A2 (en) 2001-06-27
EP0795326A4 (enExample) 1997-09-17
GR3036989T3 (en) 2002-01-31
FI114897B (fi) 2005-01-31
FI115197B (fi) 2005-03-31
HU9602534D0 (en) 1996-11-28
PT795326E (pt) 2002-01-30
HUT74734A (en) 1997-02-28
NO963854D0 (no) 1996-09-13
ATE266402T1 (de) 2004-05-15
DE69522955D1 (de) 2001-10-31
DE69522955T2 (de) 2002-05-29
DK0795326T3 (da) 2001-11-26
KR100211446B1 (ko) 1999-08-02
FI20041236L (fi) 2004-09-24
ES2221872T3 (es) 2005-01-16
AU1960295A (en) 1995-10-03
AU684916B2 (en) 1998-01-08
DE69533045D1 (de) 2004-06-17
CN1104898C (zh) 2003-04-09
EP0795326B1 (en) 2001-09-26

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20100316