CY2366B1 - Process for the production of powdered pulmonary surfactant preparations. - Google Patents

Process for the production of powdered pulmonary surfactant preparations.

Info

Publication number
CY2366B1
CY2366B1 CY0300048A CY0300048A CY2366B1 CY 2366 B1 CY2366 B1 CY 2366B1 CY 0300048 A CY0300048 A CY 0300048A CY 0300048 A CY0300048 A CY 0300048A CY 2366 B1 CY2366 B1 CY 2366B1
Authority
CY
Cyprus
Prior art keywords
pulmonary surfactant
production
powdered
surfactant preparations
powdered pulmonary
Prior art date
Application number
CY0300048A
Other languages
English (en)
Inventor
Klaus Eistetter
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of CY2366B1 publication Critical patent/CY2366B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CY0300048A 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations. CY2366B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06

Publications (1)

Publication Number Publication Date
CY2366B1 true CY2366B1 (en) 2004-06-04

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300048A CY2366B1 (en) 1996-01-24 2003-06-24 Process for the production of powdered pulmonary surfactant preparations.

Country Status (15)

Country Link
US (1) US6315983B1 (ko)
EP (1) EP0877602B1 (ko)
JP (1) JP3725166B2 (ko)
KR (1) KR100449789B1 (ko)
AT (1) ATE212220T1 (ko)
CA (1) CA2244767C (ko)
CY (1) CY2366B1 (ko)
CZ (1) CZ292186B6 (ko)
DE (1) DE59706180D1 (ko)
DK (1) DK0877602T3 (ko)
ES (1) ES2171883T3 (ko)
PT (1) PT877602E (ko)
TR (1) TR199801408T2 (ko)
UA (1) UA59358C2 (ko)
WO (1) WO1997026863A1 (ko)

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EP0971698A4 (en) * 1996-12-31 2006-07-26 Nektar Therapeutics HYDROPHOBIC DRUG PROJECTED BY AEROSOL
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
EP1767195A3 (en) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
ATE365547T1 (de) * 1998-08-25 2007-07-15 Advanced Inhalation Res Inc Sprühgetrocknete proteinformulierungen
ES2253003T3 (es) * 1998-11-10 2006-05-16 Altana Pharma Ag Equipo de tratamiento que contiene composiciones a base de agentes tensioactivos pulmonares.
AU5400000A (en) * 1999-06-11 2001-01-02 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
US6749835B1 (en) * 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
ATE285755T1 (de) * 1999-08-25 2005-01-15 Advanced Inhalation Res Inc Grosse poröse partikel erhältlich durch sprühtrocknung und geeignet zur pulmonalen anwendung
WO2001019392A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
EP1280520B2 (en) 2000-05-10 2018-03-21 Novartis AG Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
EP1435994B1 (de) 2001-10-11 2010-05-19 Nycomed GmbH Neue verwendung von lungensurfactant
AU2002346472A1 (en) * 2001-11-20 2003-06-10 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
EP1458360B1 (en) 2001-12-19 2011-05-11 Novartis AG Pulmonary delivery of aminoglycosides
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
CA2477592A1 (en) * 2002-03-18 2003-09-25 Yamanouchi Pharmaceutical Co., Ltd. Powdery medicinal compositions for inhalation and process for producing the same
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
AU2005247410A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
JP5108515B2 (ja) * 2004-08-06 2012-12-26 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタント及びｔｎｆ由来ペプチドを含有する組成物
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
CN101094651B (zh) * 2004-12-30 2011-03-09 多贝尔有限公司 含有胶原凝集素家族蛋白质或者其变体的喷雾干燥的组合物和其制备方法
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
MX2010010139A (es) * 2008-03-17 2011-02-21 Discovery Lab Inc Adaptador de circuito de ventilacion y sistema proximo de suministro en aerosol.
ES2402241T3 (es) 2008-10-22 2013-04-30 Trudell Medical International Sistema de suministro de aerosol modular
US9289388B2 (en) 2008-12-10 2016-03-22 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
EP3184099A1 (en) * 2009-03-26 2017-06-28 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
EP2711004A1 (en) * 2009-10-05 2014-03-26 Nutri-Fit GmbH & Co. KG Methods for increasing physical capacity of mammalian livestock
CA2805602A1 (en) 2010-08-23 2012-03-01 Takeda Gmbh Humidified particles comprising a therapeutically active substance
PE20142302A1 (es) 2012-03-28 2015-01-21 Discovery Lab Inc Liofilizacion de tensoactivo sintetico liposomal pulmonar
ES2674797T3 (es) 2014-03-05 2018-07-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidificador para humedecer un aerosol
BR112016020519B1 (pt) 2014-03-05 2021-11-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Dispositivo para fornecer um aerossol a partir de um material aerossolizável e sistema de controle
CA2940351A1 (en) * 2014-03-18 2015-09-24 Apeptico Forschung Und Entwicklung Gmbh Dry-powder peptide medicament
MA45451A (fr) * 2016-06-24 2019-05-01 Civitas Therapeutics Inc Formulations tensioactives destinées à l'inhalation
JP7335263B2 (ja) * 2017-12-21 2023-08-29 キウィタス セラピューティクス，インコーポレイテッド 吸入のための界面活性剤製剤
MX2020006633A (es) * 2017-12-21 2021-01-15 Civitas Therapeutics Inc Formulaciones de surfactantes para inhalacion.

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) * 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
JPH04506809A (ja) 1989-07-11 1992-11-26 ジェネンテク，インコーポレイテッド 界面活性剤組成物および方法
IN172208B (ko) * 1990-04-02 1993-05-01 Sint Sa
CA2093133C (en) 1990-10-17 1999-03-30 Andrew S. Janoff Synthetic lung surfactant
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
CZ295827B6 (cs) 1994-03-07 2005-11-16 Nektar Therapeutics Způsob aerosolizace dávky inzulinu, inzulinový přípravek a jeho použití
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
AU706195B2 (en) * 1995-04-14 1999-06-10 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
EP0971698A4 (en) * 1996-12-31 2006-07-26 Nektar Therapeutics HYDROPHOBIC DRUG PROJECTED BY AEROSOL
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
ATE365547T1 (de) 1998-08-25 2007-07-15 Advanced Inhalation Res Inc Sprühgetrocknete proteinformulierungen

Also Published As

Publication number Publication date
DE59706180D1 (de) 2002-03-14
CZ233898A3 (cs) 1999-02-17
DK0877602T3 (da) 2002-05-06
KR100449789B1 (ko) 2005-02-03
ATE212220T1 (de) 2002-02-15
EP0877602B1 (de) 2002-01-23
EP0877602A1 (de) 1998-11-18
ES2171883T3 (es) 2002-09-16
CA2244767C (en) 2005-11-22
KR19990081886A (ko) 1999-11-15
US6315983B1 (en) 2001-11-13
WO1997026863A1 (de) 1997-07-31
UA59358C2 (uk) 2003-09-15
JP3725166B2 (ja) 2005-12-07
TR199801408T2 (xx) 1998-10-21
JP2000503976A (ja) 2000-04-04
PT877602E (pt) 2002-07-31
CA2244767A1 (en) 1997-07-31
CZ292186B6 (cs) 2003-08-13

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