CY1907A - Improved process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof - Google Patents

Improved process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Info

Publication number
CY1907A
CY1907A CY190791A CY190791A CY1907A CY 1907 A CY1907 A CY 1907A CY 190791 A CY190791 A CY 190791A CY 190791 A CY190791 A CY 190791A CY 1907 A CY1907 A CY 1907A
Authority
CY
Cyprus
Prior art keywords
hydroxybutylidene
salts
amino
abp
improved process
Prior art date
Application number
CY190791A
Other languages
English (en)
Inventor
Gerard R Kieczykowski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24157769&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1907(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CY1907A publication Critical patent/CY1907A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CY190791A 1990-06-20 1991-06-14 Improved process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof CY1907A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/540,997 US5019651A (en) 1990-06-20 1990-06-20 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Publications (1)

Publication Number Publication Date
CY1907A true CY1907A (en) 1991-06-14

Family

ID=24157769

Family Applications (1)

Application Number Title Priority Date Filing Date
CY190791A CY1907A (en) 1990-06-20 1991-06-14 Improved process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Country Status (21)

Country Link
US (1) US5019651A (ja)
EP (1) EP0462663B1 (ja)
JP (1) JPH07119229B2 (ja)
KR (1) KR0173467B1 (ja)
AT (1) ATE128470T1 (ja)
AU (1) AU642264B2 (ja)
CA (1) CA2044923C (ja)
CY (1) CY1907A (ja)
DE (1) DE69113325T2 (ja)
DK (1) DK0462663T3 (ja)
ES (1) ES2079026T3 (ja)
FI (1) FI94347C (ja)
GR (1) GR3017544T3 (ja)
HK (1) HK64496A (ja)
IE (1) IE69171B1 (ja)
IL (1) IL98462A (ja)
LV (1) LV11471B (ja)
NO (1) NO180050C (ja)
NZ (1) NZ238493A (ja)
PT (1) PT97963B (ja)
ZA (1) ZA914708B (ja)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (ja) * 1993-08-25 1995-09-21 Merck & Co Inc
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
NZ303022A (en) * 1995-02-17 2000-07-28 Merck & Co Inc Treatment of osteoporotic diseases with alendronate
TW393488B (en) * 1995-04-20 2000-06-11 Merck & Co Inc Process for making 1-hydrox-ybisphosphonates
AU713824B2 (en) * 1995-05-12 1999-12-09 Merck Sharp & Dohme Corp. Prevention of tooth loss by the administration of alendronate or its salts
JP3344726B2 (ja) * 1995-06-06 2002-11-18 メルク エンド カンパニー インコーポレーテッド 無水アレンドロネート一ナトリウム塩製剤
AU5973496A (en) 1995-06-06 1996-12-24 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
KR100192215B1 (ko) * 1996-09-03 1999-06-15 강재헌 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
BR9712197A (pt) * 1996-10-04 1999-08-31 Merck & Co Inc Formulação farmacêutica líquida aquosa e processos de preparação da mesma, e, de inibição de reabsorção de osso.
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
BR9910074A (pt) 1998-04-29 2000-12-26 Procter & Gamble Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas
PL198951B1 (pl) 1998-04-29 2008-08-29 Procter & Gamble Sposób wytwarzania 1,3-dipodstawionych-4-oksocyklicznych moczników
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
WO1999067809A1 (en) 1998-06-24 1999-12-29 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6008207A (en) * 1998-08-13 1999-12-28 Merck & Co., Inc. Anhydrous alendronate monosodium salt formulations
DE69932620T2 (de) * 1998-08-27 2006-12-14 Teva Pharmaceutical Industries Ltd. Hydratformen des natriumsalzes von alendronat, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die diese enthalten
EP1702924A3 (en) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
KR100327786B1 (ko) * 1999-03-25 2002-03-14 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
KR100327787B1 (ko) * 2001-02-27 2002-03-15 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
MXPA04006027A (es) * 2001-12-21 2004-09-27 Procter & Gamble Metodo para el tratamiento de trastornos de los huesos.
CA2472578A1 (en) * 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
JP2005522526A (ja) 2002-05-10 2005-07-28 エフ．ホフマン−ラ　ロシュ　アーゲー 骨粗鬆症の治療および予防用のビスホスホン酸
CN1665825A (zh) * 2002-05-17 2005-09-07 特瓦制药工业有限公司 用一定的稀释剂制备双膦酸
CA2487977A1 (en) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co./Merck Frosst Canada & Cie 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
AU2003258433A1 (en) * 2002-08-28 2004-03-19 Merck Frosst Canada Ltd Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
EP1790347B1 (en) * 2002-12-20 2014-12-24 F. Hoffmann-La Roche AG High dose ibandronate formulation
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
EP2279722B1 (en) * 2003-08-12 2013-05-01 3M Innovative Properties Company Self-etching dental compositions and its use
CA2535359A1 (en) 2003-08-21 2005-03-03 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
DK1656386T3 (da) * 2003-08-21 2010-04-19 Sun Pharmaceuticals Ind Ltd Fremgangsmåde til fremstilling af bisphosphonsyreforbindelser
EP1667691A1 (en) * 2003-09-19 2006-06-14 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
US20050113343A1 (en) * 2003-10-14 2005-05-26 Pliva - Research And Development Ltd. Solid-state form of alendronate sodium and preparation thereof
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
JP4605221B2 (ja) 2004-05-24 2011-01-05 味の素株式会社 キレート剤を含有するビスホスホネートの腸溶性で固形の経口剤形
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2005269869B2 (en) * 2004-07-08 2011-12-01 3M Innovative Properties Company Dental methods, compositions, and kits including acid-sensitive dyes
JP5037342B2 (ja) * 2004-08-11 2012-09-26 スリーエム イノベイティブ プロパティズ カンパニー 複数の酸性化合物を含む粘着性組成物
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
EP2783687A1 (en) 2005-03-02 2014-10-01 Merck Sharp & Dohme Corp. Composition for inhibition of cathepsin K
US8158153B2 (en) * 2005-03-17 2012-04-17 Alkermes Pharma Ireland Limited Nanoparticulate bisphosphonate compositions
EP1891081B1 (en) * 2005-06-13 2014-08-20 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
AR054673A1 (es) 2005-07-28 2007-07-11 Gador Sa Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
EP1803727B1 (en) 2005-12-27 2009-03-11 IPCA Laboratories Limited Improved process for manufacture of 4-amino-hydroxybutylidene-1,1-bisphosphonic acid and its salts
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
EP1987046A1 (en) * 2006-02-20 2008-11-05 Alembic Limited An improved process for the preparation of biphosphonic derivatives
WO2007132478A2 (en) * 2006-05-11 2007-11-22 Ind-Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
WO2008076739A2 (en) * 2006-12-13 2008-06-26 3M Innovative Properties Company Methods of using a dental composition having an acidic component and a photobleachable dye
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
EP2310398A2 (en) * 2008-07-11 2011-04-20 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
US20120100206A1 (en) 2009-06-11 2012-04-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
EP2470549B1 (en) 2009-08-28 2014-07-16 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
AU2010302597B2 (en) 2009-10-02 2016-06-09 Monsanto Technology Llc Method for the manufacture of aminohydroxy diphosphonic acids
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
KR102011505B1 (ko) 2010-12-06 2019-08-16 에프락스 파머슈티컬즈 소시에떼 아노님 신속한 용해 특성을 구비한 안정한 발포성 비스포스포네이트 제형
US8791162B2 (en) 2011-02-14 2014-07-29 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
RS61235B1 (sr) 2011-07-13 2021-01-29 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Lipozomi koji ko-inkapsuliraju bisfosfonat i amfipatički agens
EP3055314B1 (en) 2013-10-08 2018-09-12 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
EP3307747A4 (en) 2015-06-12 2019-02-27 Simon Fraser University AMIDE-LINKED EP4-BISPHOSPHONATE AGONIST COMPOUNDS AND USES THEREOF
EP3827010A4 (en) 2018-07-23 2022-03-16 Brise Pharmaceuticals Co., Ltd. BISPHOSPHONATE-DRUG CONJUGATES
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1387311A (en) * 1972-03-24 1975-03-12 Gullick Dobson Ltd Mine roof supports
DE2534390C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1,3-Di-aminoalkan-1,1-diphosphonsäuren
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
US4163733A (en) * 1977-10-25 1979-08-07 Buckman Laboratories, Inc. Synergistic compositions for corrosion and scale control
US4100167A (en) * 1977-05-09 1978-07-11 Nalco Chemical Company Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3047107A1 (de) * 1980-12-13 1982-07-29 Hoechst Ag, 6000 Frankfurt Verfahren zur hertellung von 1-amino-alkan-1,1-diphosphonsaeuren
IT1194748B (it) * 1981-02-12 1988-09-28 Gentili Ist Spa Composizioni farmaceutiche per il trattamento di osteopatie
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Also Published As

Publication number Publication date
AU7849891A (en) 1992-01-02
JPH07119229B2 (ja) 1995-12-20
FI94347C (fi) 1995-08-25
NO912395L (no) 1991-12-23
IE912112A1 (en) 1992-01-01
FI94347B (fi) 1995-05-15
EP0462663B1 (en) 1995-09-27
NO180050B (no) 1996-10-28
KR0173467B1 (en) 1999-04-01
DK0462663T3 (da) 1996-01-29
US5019651A (en) 1991-05-28
GR3017544T3 (en) 1995-12-31
HK64496A (en) 1996-04-19
IL98462A0 (en) 1992-07-15
CA2044923C (en) 1996-06-18
CA2044923A1 (en) 1991-12-21
AU642264B2 (en) 1993-10-14
IL98462A (en) 1995-12-08
JPH05132492A (ja) 1993-05-28
EP0462663A1 (en) 1991-12-27
NZ238493A (en) 1992-09-25
NO912395D0 (no) 1991-06-19
IE69171B1 (en) 1996-08-07
ZA914708B (en) 1992-03-25
DE69113325D1 (de) 1995-11-02
DE69113325T2 (de) 1996-05-02
LV11471A (lv) 1996-08-20
FI913008A (fi) 1991-12-21
LV11471B (en) 1996-12-20
PT97963A (pt) 1992-03-31
ES2079026T3 (es) 1996-01-01
PT97963B (pt) 1998-11-30
ATE128470T1 (de) 1995-10-15
FI913008A0 (fi) 1991-06-19
NO180050C (no) 1997-02-05

Similar Documents

Publication Publication Date Title
KR0173467B1 (en) Improved process for preparing 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid(abp)or salts thereof
CY1894A (en) Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
ATE1242T1 (de) Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure.
DE69806470D1 (de) Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure
DE69331314D1 (de) Verfahren zur Herstellung von N-Phosphonomethyliminodiessigsäure
ATE121410T1 (de) Verfahren zur herstellung von diphosphonsäuren und salzen davon.
AU1876688A (en) Process for synthesis of aminomethylene phosphonoalkylphosphinates