CY1124690T1 - Σκευασματα ενδοφλεβιου διαλυματος ποσακοναζολης σταθεροποιημενα με υποκατεστημενη βητα-κυκλοδεξτρινη - Google Patents
Σκευασματα ενδοφλεβιου διαλυματος ποσακοναζολης σταθεροποιημενα με υποκατεστημενη βητα-κυκλοδεξτρινηInfo
- Publication number
- CY1124690T1 CY1124690T1 CY20211100950T CY211100950T CY1124690T1 CY 1124690 T1 CY1124690 T1 CY 1124690T1 CY 20211100950 T CY20211100950 T CY 20211100950T CY 211100950 T CY211100950 T CY 211100950T CY 1124690 T1 CY1124690 T1 CY 1124690T1
- Authority
- CY
- Cyprus
- Prior art keywords
- beta
- posaconazole
- intravenous solution
- substituted cyclodextrin
- solution preparations
- Prior art date
Links
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 title abstract 3
- 229960001589 posaconazole Drugs 0.000 title abstract 3
- 238000001990 intravenous administration Methods 0.000 title abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229940009662 edetate Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/4965—Non-condensed pyrazines
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- A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35970110P | 2010-06-29 | 2010-06-29 | |
| PCT/US2011/041715 WO2012005973A1 (en) | 2010-06-29 | 2011-06-24 | Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin |
| EP11804061.7A EP2588116A4 (en) | 2010-06-29 | 2011-06-24 | BY SUBSTITUTED BETA-CYCLODEXTRIN STABILIZED INTRAVENOUS POSACONAZOLE SOLUTION FORMULATIONS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124690T1 true CY1124690T1 (el) | 2022-07-22 |
Family
ID=45441500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100950T CY1124690T1 (el) | 2010-06-29 | 2021-11-03 | Σκευασματα ενδοφλεβιου διαλυματος ποσακοναζολης σταθεροποιημενα με υποκατεστημενη βητα-κυκλοδεξτρινη |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9023790B2 (enExample) |
| EP (3) | EP2588116A4 (enExample) |
| JP (1) | JP6008849B2 (enExample) |
| KR (1) | KR101834024B1 (enExample) |
| CN (2) | CN102958528A (enExample) |
| AU (1) | AU2011276680B2 (enExample) |
| BR (1) | BR112012033077B8 (enExample) |
| CA (1) | CA2802929C (enExample) |
| CY (1) | CY1124690T1 (enExample) |
| DK (1) | DK3391890T3 (enExample) |
| ES (1) | ES2893444T3 (enExample) |
| HR (1) | HRP20211686T1 (enExample) |
| HU (1) | HUE056581T2 (enExample) |
| LT (1) | LT3391890T (enExample) |
| MX (2) | MX338685B (enExample) |
| PL (1) | PL3391890T3 (enExample) |
| PT (1) | PT3391890T (enExample) |
| RS (1) | RS62583B1 (enExample) |
| SI (1) | SI3391890T1 (enExample) |
| WO (1) | WO2012005973A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| PL3391890T3 (pl) | 2010-06-29 | 2021-12-20 | Merck Sharp & Dohme Corp. | Preparaty dożylnego roztworu pozakonazolu stabilizowane podstawioną beta-cyklodekstryną |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| HUE058834T2 (hu) | 2012-02-15 | 2022-09-28 | Cydex Pharmaceuticals Inc | Elõállítási eljárás ciklodextrin-származékokhoz |
| MX363386B (es) | 2013-10-03 | 2019-03-20 | Dow Pharmaceutical Sciences | Formulaciones de efinaconazol estabilizadas. |
| CN104546724A (zh) * | 2013-10-12 | 2015-04-29 | 博瑞生物医药技术(苏州)有限公司 | 一种抗真菌药的固体分散体 |
| KR102612453B1 (ko) | 2013-11-22 | 2023-12-08 | 다우 파마슈티컬 사이언시즈, 인코포레이티드 | 항감염 방법，조성물，및 장치 |
| CN105879041A (zh) * | 2014-11-14 | 2016-08-24 | 北京赛林泰医药技术有限公司 | 一种泊沙康唑口服液及其制备方法 |
| EA201791100A1 (ru) * | 2014-11-19 | 2017-11-30 | Гуфик Байосайенсиз Лимитед | Способ получения парентерального состава на основе анидулафунгина |
| CN104473871B (zh) * | 2014-11-28 | 2017-03-08 | 济南康和医药科技有限公司 | 一种泊沙康唑脂肪乳注射液及其制备方法 |
| CN106265534A (zh) * | 2015-05-25 | 2017-01-04 | 江苏正大丰海制药有限公司 | 一种泊沙康唑冻干粉针剂的制备方法 |
| CN106511262A (zh) * | 2015-09-11 | 2017-03-22 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑口服溶液剂及其制备方法 |
| US10517867B2 (en) | 2016-02-04 | 2019-12-31 | Wuhan Ll Science And Technology Development Co., Ltd. | Posaconazole derivative, pharmaceutical composition and use thereof |
| CN110022857A (zh) | 2016-11-18 | 2019-07-16 | 艾库里斯抗感染治疗有限公司 | 基于改性环糊精和酸化剂的脒取代β-内酰胺化合物的新制剂、其制备及作为抗微生物药物组合物的用途 |
| AU2019254483B2 (en) | 2018-04-16 | 2025-02-27 | Merck Patent Gmbh | Viscosity reduction of highly concentrated protein formulations |
| CN110711174A (zh) * | 2018-07-11 | 2020-01-21 | 郑州泰丰制药有限公司 | 一种泊沙康唑注射液中间体溶液配制方法 |
| WO2020139209A1 (en) * | 2018-12-28 | 2020-07-02 | Polifarma Ilac Sanayi Ve Ticaret Anonim Srketi | Stable injectable posaconazole formulations comprising cyclodextrin and sugar |
| CN115038723A (zh) | 2019-11-18 | 2022-09-09 | 锡德克斯药物公司 | 烷基化环糊精组合物及其制备和使用方法 |
| WO2021245703A2 (en) * | 2020-06-06 | 2021-12-09 | Inventia Healthcare Limited | Stable liquid compositions of posaconazole |
| US12698348B2 (en) | 2020-09-24 | 2026-08-04 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| CN115429748A (zh) * | 2021-06-02 | 2022-12-06 | 江苏奥赛康药业有限公司 | 一种泊沙康唑注射液的制备方法 |
| WO2023148763A1 (en) * | 2022-02-01 | 2023-08-10 | Cipla Limited | Injectable pharmaceutical compositions of azole antifungal agents |
| CN117783387A (zh) * | 2023-12-28 | 2024-03-29 | 郑州泰丰制药有限公司 | 一种测定泊沙康唑注射液包合常数的方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5257985A (en) | 1989-12-04 | 1993-11-02 | Richard Puhl | Multi-chamber intravenous bag apparatus |
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