CY1106824T1 - Σταθερες ενεσιμες συνθεσεις δικλοφενακ - Google Patents

Σταθερες ενεσιμες συνθεσεις δικλοφενακ

Info

Publication number
CY1106824T1
CY1106824T1 CY20071101108T CY071101108T CY1106824T1 CY 1106824 T1 CY1106824 T1 CY 1106824T1 CY 20071101108 T CY20071101108 T CY 20071101108T CY 071101108 T CY071101108 T CY 071101108T CY 1106824 T1 CY1106824 T1 CY 1106824T1
Authority
CY
Cyprus
Prior art keywords
diclofenac
cyclodextrin
injectable compositions
stable injectable
pharmaceutically acceptable
Prior art date
Application number
CY20071101108T
Other languages
English (en)
Inventor
Lawrence John Penkler
Original Assignee
Shimoda Biotech (Pty) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34826259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1106824(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shimoda Biotech (Pty) Ltd filed Critical Shimoda Biotech (Pty) Ltd
Publication of CY1106824T1 publication Critical patent/CY1106824T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Η παρούσα ευρεσιτεχνία αναφέρεται σε σταθερά παρεντερικά υδατικά διαλύματα περιλαμβάνοντα είτε α) δικλοφενάκ ((diclofenac) ή φαρμακευτικώς παραδεκτό άλας δικλοφενάκ και κυκλοδεξτρίνη, είτε β) σύμπλοκο εγκλεισμού δικλοφενάκ ή φαρμακευτικώς παραδεκτό άλας δικλοφενάκ και κυκλοδεξτρίνη, ή μείγμα των (α) και (β), και τα οποία είναι κατάλληλα για ενδομυϊκή και ενδοφλέβια χορήγηση. Τα διαλύματα περιέχουν δικλοφενάκ ή άλας δικλοφενάκ, κυκλοδεξτρίνη, και αντι-οξειδωτικό εκλεγόμενο από μονοθειογλυκερόλη ή συνδυασμό αιθυλενο-διαμινο-τετραοξικού οξέος και Ν-ακετυλο-κυστεΐνης.
CY20071101108T 2004-03-10 2007-08-23 Σταθερες ενεσιμες συνθεσεις δικλοφενακ CY1106824T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55135104P 2004-03-10 2004-03-10

Publications (1)

Publication Number Publication Date
CY1106824T1 true CY1106824T1 (el) 2012-05-23

Family

ID=34826259

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101108T CY1106824T1 (el) 2004-03-10 2007-08-23 Σταθερες ενεσιμες συνθεσεις δικλοφενακ

Country Status (20)

Country Link
US (2) US20050238674A1 (el)
EP (2) EP1574221B1 (el)
JP (1) JP2007528384A (el)
KR (1) KR20070028331A (el)
AT (2) ATE364402T1 (el)
AU (1) AU2004317520B2 (el)
BR (1) BRPI0418474A (el)
CA (1) CA2555429C (el)
CY (1) CY1106824T1 (el)
DE (2) DE602004025151D1 (el)
DK (2) DK1767219T3 (el)
ES (2) ES2336034T3 (el)
HK (1) HK1079118A1 (el)
IL (1) IL177529A (el)
MX (1) MXPA06010336A (el)
PL (2) PL1574221T3 (el)
PT (2) PT1767219E (el)
SI (2) SI1574221T1 (el)
WO (2) WO2005092387A1 (el)
ZA (2) ZA200607631B (el)

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* Cited by examiner, † Cited by third party
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NZ554779A (en) 2005-02-01 2011-02-25 Troikaa Pharmaceuticals Ltd Injectable preparations of diclofenac ((2,6-dichloranilino)phenylacetic acid) and its pharmaceutically acceptable salts
US20060205080A1 (en) * 2005-03-01 2006-09-14 David Frey Formulations for therapeutic viruses having enhanced storage stability
AU2012209035B9 (en) * 2006-03-28 2014-05-22 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
CN101410012A (zh) * 2006-03-28 2009-04-15 杰佛林制药公司 低剂量的非甾体抗炎药和β-环糊精的制剂
KR20080112285A (ko) 2006-03-28 2008-12-24 자블린 파머슈티칼스 인코포레이티드 저 복용량의 디클로페낙 및 베타-사이클로덱스트린 제형
CL2007003877A1 (es) 2007-12-28 2008-06-27 Univ De Concepcion Lab Androma Composicion farmaceutica que comprende un complejo de inclusion formado por disulfiram y una ciclodextrina; y su uso para el tratamiento de la dependencia de alcohol y cocaina.
US20100022652A1 (en) * 2008-07-28 2010-01-28 Tyco Healthcare Group Lp Antimicrobial and Anticoagulant Compositions and Methods
JP2012520342A (ja) 2009-03-16 2012-09-06 ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ 代謝障害を処置するのに有用な抗炎症剤および抗酸化剤のコンジュゲート
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
GB201021267D0 (en) * 2010-12-15 2011-01-26 Reckitt Benckiser Healthcare Int Ltd Novel pharmaceutical formulation
CN103781484A (zh) * 2011-07-20 2014-05-07 赫思公司 治疗疼痛的方法
MX2014001679A (es) * 2011-08-11 2014-10-15 Cross Sa Composicion farmaceutica que comprende un farmaco que contiene por lo menos una funcion de toxicoforo y n-acetil-l-cisteina.
KR101260636B1 (ko) 2012-11-29 2013-05-13 씨제이제일제당 (주) 안정화된 페메트렉시드 제제
US20140187635A1 (en) 2012-12-28 2014-07-03 Themis Medicare Limited Diclofenac compositions
US20140275261A1 (en) 2013-03-15 2014-09-18 Dr. Reddy's Laboratories, Inc. Diclofenac parenteral compositions
KR101485243B1 (ko) 2013-05-08 2015-01-21 씨제이헬스케어 주식회사 안정화된 페메트렉시드 제제
US11110073B2 (en) 2017-03-24 2021-09-07 Cadila Healthcare Limited Storage stable aqueous injectable solution comprising diclofenac
WO2019032910A1 (en) * 2017-08-09 2019-02-14 Piedmont Animal Health Llc THERAPEUTIC FORMULATIONS AND USES THEREOF
US20220280463A1 (en) 2019-09-09 2022-09-08 Ftf Pharma Private Limited Pharmaceutical formulations comprising diclofenac
US11707443B2 (en) 2019-09-26 2023-07-25 Rk Pharma Inc. Storage stable aqueous parenteral solutions comprising diclofenac
CN110872942B (zh) * 2019-10-24 2021-09-28 中国石油化工股份有限公司 油藏注采耦合方式下不同作用力对采收率贡献的研究方法

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DE3446873A1 (de) * 1984-12-21 1986-07-10 Merckle Gmbh Fluessige diclofenac-zubereitungen
US5690954A (en) * 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US5389681A (en) * 1992-10-22 1995-02-14 Ciba-Geigy Corporation Parenteral solutions for diclofenac salts
IL111184A (en) * 1993-10-08 2000-08-13 Farmarc Nederland B V Of Cito Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin
ZA949182B (en) * 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
WO1996011003A1 (en) * 1994-10-10 1996-04-18 Novartis Ag Ophthalmic and aural compositions containing diclofenac potassium
US5821237A (en) * 1995-06-07 1998-10-13 The Procter & Gamble Company Compositions for visually improving skin
AU5774796A (en) * 1995-06-13 1997-01-09 Dyer, Alison Margaret Pharmaceutical compositions containing lornoxicam and cyclod extrin
TW434023B (en) * 1995-09-18 2001-05-16 Novartis Ag Preserved ophthalmic composition
FR2751875B1 (fr) * 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
DE60013425T2 (de) * 1999-05-03 2005-09-08 Battelle Memorial Institute, Columbus Arzneizusammensetzungen zur aerosolbildung und zu inhalationszwecken
ATE279920T1 (de) * 2000-12-28 2004-11-15 Fresenius Kabi Austria Gmbh Stabile infusionslösung von diclofenac-salzen, deren herstellung und verwendung
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Also Published As

Publication number Publication date
US20120142779A1 (en) 2012-06-07
PL1767219T3 (pl) 2010-06-30
DK1767219T3 (da) 2010-05-10
ATE364402T1 (de) 2007-07-15
KR20070028331A (ko) 2007-03-12
EP1574221A1 (en) 2005-09-14
US20050238674A1 (en) 2005-10-27
PL1574221T3 (pl) 2007-10-31
MXPA06010336A (es) 2007-02-16
SI1767219T1 (sl) 2010-03-31
DE602004006952D1 (de) 2007-07-26
CA2555429C (en) 2010-05-18
WO2005086763A2 (en) 2005-09-22
PT1574221E (pt) 2007-07-09
EP1767219A3 (en) 2007-04-25
JP2007528384A (ja) 2007-10-11
EP1767219A2 (en) 2007-03-28
ES2287658T3 (es) 2007-12-16
SI1574221T1 (sl) 2007-10-31
DE602004006952T2 (de) 2008-02-14
HK1079118A1 (en) 2006-03-31
ATE454905T1 (de) 2010-01-15
ZA200805860B (en) 2009-05-27
EP1574221B1 (en) 2007-06-13
ES2336034T3 (es) 2010-04-07
DK1574221T3 (da) 2007-07-16
AU2004317520B2 (en) 2011-06-09
BRPI0418474A (pt) 2007-06-19
EP1767219B1 (en) 2010-01-13
CA2555429A1 (en) 2005-10-06
WO2005092387A1 (en) 2005-10-06
ZA200607631B (en) 2008-10-29
DE602004025151D1 (de) 2010-03-04
AU2004317520A1 (en) 2005-10-06
IL177529A0 (en) 2006-12-10
PT1767219E (pt) 2010-02-15
IL177529A (en) 2013-08-29
WO2005086763A3 (en) 2006-03-02

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