IL111184A - Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin - Google Patents

Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin

Info

Publication number
IL111184A
IL111184A IL11118494A IL11118494A IL111184A IL 111184 A IL111184 A IL 111184A IL 11118494 A IL11118494 A IL 11118494A IL 11118494 A IL11118494 A IL 11118494A IL 111184 A IL111184 A IL 111184A
Authority
IL
Israel
Prior art keywords
diclofenac
cyclodextrin
inclusion complex
unsubstituted beta
crystalline inclusion
Prior art date
Application number
IL11118494A
Other versions
IL111184A0 (en
Original Assignee
Farmarc Nederland B V Of Cito
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmarc Nederland B V Of Cito filed Critical Farmarc Nederland B V Of Cito
Publication of IL111184A0 publication Critical patent/IL111184A0/en
Publication of IL111184A publication Critical patent/IL111184A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

An inclusion complex of diclofenac, preferably as diclofenac sodium, and an unsubstituted beta-cyclodextrin has the formula 1 molecule of diclofenac to 1 molecule of the unsubstituted beta-cyclodextrin and preferably from 5 to 11 water molecules. The inclusion complex may be formulated as a pharmaceutical composition. <CHEM> <IMAGE>
IL11118494A 1993-10-08 1994-10-06 Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin IL111184A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ZA937480 1993-10-08

Publications (2)

Publication Number Publication Date
IL111184A0 IL111184A0 (en) 1994-12-29
IL111184A true IL111184A (en) 2000-08-13

Family

ID=66767030

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11118494A IL111184A (en) 1993-10-08 1994-10-06 Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin

Country Status (12)

Country Link
US (1) US5674854A (en)
EP (1) EP0647451B1 (en)
JP (1) JPH07196484A (en)
KR (1) KR950010910A (en)
CN (1) CN1161115C (en)
AT (1) ATE294593T1 (en)
AU (1) AU682887B2 (en)
CA (1) CA2133885C (en)
DE (1) DE69434356T2 (en)
ES (1) ES2240960T3 (en)
IL (1) IL111184A (en)
ZA (1) ZA948078B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2735136B1 (en) * 1995-06-08 1997-08-14 Roquette Freres PULVERULENT COMPOSITION OF HYDROXYPROPYL-BETACYCLODEXTRIN AND ITS PREPARATION PROCESS.
HUP9600758A2 (en) * 1996-03-27 1998-03-02 Cyclolab Ciklodextrin Kutato F Diclofenac composition of diminished gastrointestinal irritation and enhanced biological resorption
BR0006838A (en) * 1999-07-01 2001-08-07 Italfarmaco Spa Paroxetine complexes, with cyclodextrins or cyclodextrin derivatives
US7122376B2 (en) * 2001-11-01 2006-10-17 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US7049146B2 (en) 2000-11-14 2006-05-23 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
JP2005298338A (en) * 2002-02-27 2005-10-27 Eisai Co Ltd Quickly disintegrating compression-molded preparation
KR100473716B1 (en) * 2002-03-27 2005-03-08 주식회사 참 존 Inclusion complex of 7-dehydrocholesterol and cyclodextrin, cosmetic compositions containing the same and method of stabilizing 7-dehydrocholeserol
WO2004027361A1 (en) * 2002-09-17 2004-04-01 University Of Virginia Patent Foundation Remote temperature sensing of small volume and related apparatus thereof
FR2850040B1 (en) * 2003-01-20 2005-03-11 Centre Nat Rech Scient SYSTEMS FOR MICROENCAPSULATION AND THEIR APPLICATIONS
JP2007528384A (en) * 2004-03-10 2007-10-11 シモダ、バイオテック（プロプライエタリー）リミテッド Stable injectable diclofenac composition
JP2007534693A (en) 2004-04-23 2007-11-29 サイデックス・インコーポレイテッド DPI formulation containing sulfoalkyl ether cyclodextrin
EP1945228B9 (en) 2005-10-26 2015-03-11 CyDex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US20070267033A1 (en) * 2006-02-09 2007-11-22 Philip Morris Usa Inc. Gamma cyclodextrin flavoring-release additives
JP2009531451A (en) * 2006-03-28 2009-09-03 ジャヴェリン ファーマシューティカルズ インコーポレイテッド Low dose non-steroidal anti-inflammatory drug and β-cyclodextrin combination
EP2522344A1 (en) 2006-03-28 2012-11-14 Javelin Pharmaceuticals, Inc. Formulations of Low Dose Diclofenac and Beta-Cyclodextrin
FR2912061A1 (en) * 2007-02-01 2008-08-08 Aliscience Soc Par Actions Sim Cyclodextrin inclusion complexes of amino acids useful in pharmaceutical, veterinary, nutraceutical, food or cosmetic compositions
MY166036A (en) * 2011-07-20 2018-05-21 Hospira Inc Methods of treating pain
CN115335040B (en) 2020-03-23 2025-01-21 西泽普研究与发展有限责任公司 Oral terpene cyclodextrin inclusion complex vehicle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5984821A (en) * 1982-11-04 1984-05-16 Teikoku Chem Ind Corp Ltd Gradual solubility composition
IT1196033B (en) * 1984-02-22 1988-11-10 Chiesi Farma Spa COMPOUND WITH ANTI-INFLAMMATORY ACTIVITY OBTAINED BY COMPLEXATION WITH BETA-CYCLODEXTRINE AND RELATED PHARMACEUTICAL FORMULATIONS
US4845188A (en) * 1988-08-19 1989-07-04 Eastman Kodak Company Condensation polymers containing methine ultraviolet radiation-absorbing residues and shaped articles produced therefrom
MY106598A (en) * 1988-08-31 1995-06-30 Australian Commercial Res & Development Ltd Compositions and methods for drug delivery and chromatography.
IT1241088B (en) * 1990-03-27 1993-12-29 Chiesi Farma Spa PROCEDURE FOR THE PREPARATION OF PIROXICAM / CYCLODESTRINE COMPLEXES, PRODUCTS OBTAINED AND THEIR PHARMACEUTICAL COMPOSITIONS
IT1243342B (en) * 1990-07-13 1994-06-10 Farcon Ag ORAL PHARMACEUTICAL COMPOSITIONS FOR LIQUID ANTI-INFLAMMATORY ACTIVITIES
ATE196426T1 (en) * 1991-06-21 2000-10-15 Takeda Chemical Industries Ltd CYCLODEXTRIN COMPOSITION CONTAINING FUMAGILLOL DERIVATIVES
DE4200792A1 (en) * 1992-01-15 1993-07-22 Solvay Fluor & Derivate PROCESSING OF THE HYDROFLUORINE PHASE FROM REACTION MIXTURES
JPH0616547A (en) * 1992-07-01 1994-01-25 Wakamoto Pharmaceut Co Ltd Anti-inflammatory eye drops

Also Published As

Publication number Publication date
KR950010910A (en) 1995-05-15
ATE294593T1 (en) 2005-05-15
IL111184A0 (en) 1994-12-29
DE69434356D1 (en) 2005-06-09
EP0647451B1 (en) 2005-05-04
CA2133885A1 (en) 1995-04-09
CA2133885C (en) 2008-12-16
JPH07196484A (en) 1995-08-01
EP0647451A1 (en) 1995-04-12
CN1161115C (en) 2004-08-11
ZA948078B (en) 1995-06-05
ES2240960T3 (en) 2005-10-16
CN1107042A (en) 1995-08-23
DE69434356T2 (en) 2006-05-04
US5674854A (en) 1997-10-07
AU7448694A (en) 1995-04-27
AU682887B2 (en) 1997-10-23

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees