IL111184A0 - Inclusion complex - Google Patents

Inclusion complex

Info

Publication number
IL111184A0
IL111184A0 IL11118494A IL11118494A IL111184A0 IL 111184 A0 IL111184 A0 IL 111184A0 IL 11118494 A IL11118494 A IL 11118494A IL 11118494 A IL11118494 A IL 11118494A IL 111184 A0 IL111184 A0 IL 111184A0
Authority
IL
Israel
Prior art keywords
inclusion complex
diclofenac
cyclodextrin
molecule
unsubstituted beta
Prior art date
Application number
IL11118494A
Other versions
IL111184A (en
Original Assignee
South African Druggists Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by South African Druggists Ltd filed Critical South African Druggists Ltd
Publication of IL111184A0 publication Critical patent/IL111184A0/en
Publication of IL111184A publication Critical patent/IL111184A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

An inclusion complex of diclofenac, preferably as diclofenac sodium, and an unsubstituted beta-cyclodextrin has the formula 1 molecule of diclofenac to 1 molecule of the unsubstituted beta-cyclodextrin and preferably from 5 to 11 water molecules. The inclusion complex may be formulated as a pharmaceutical composition. <CHEM> <IMAGE>
IL11118494A 1993-10-08 1994-10-06 Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin IL111184A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ZA937480 1993-10-08

Publications (2)

Publication Number Publication Date
IL111184A0 true IL111184A0 (en) 1994-12-29
IL111184A IL111184A (en) 2000-08-13

Family

ID=66767030

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11118494A IL111184A (en) 1993-10-08 1994-10-06 Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin

Country Status (12)

Country Link
US (1) US5674854A (en)
EP (1) EP0647451B1 (en)
JP (1) JPH07196484A (en)
KR (1) KR950010910A (en)
CN (1) CN1161115C (en)
AT (1) ATE294593T1 (en)
AU (1) AU682887B2 (en)
CA (1) CA2133885C (en)
DE (1) DE69434356T2 (en)
ES (1) ES2240960T3 (en)
IL (1) IL111184A (en)
ZA (1) ZA948078B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2735136B1 (en) * 1995-06-08 1997-08-14 Roquette Freres PULVERULENT COMPOSITION OF HYDROXYPROPYL-BETACYCLODEXTRIN AND ITS PREPARATION PROCESS.
HUP9600758A2 (en) * 1996-03-27 1998-03-02 Cyclolab Ciklodextrin Kutato F Diclofenac composition of diminished gastrointestinal irritation and enhanced biological resorption
ATE248165T1 (en) * 1999-07-01 2003-09-15 Italfarmaco Spa COMPLEXES OF PAROXETINE WITH CYCLODEXTRIN OR CYCLODEXTRIN DERIVATIVES
US7122376B2 (en) * 2001-11-01 2006-10-17 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US7049146B2 (en) 2000-11-14 2006-05-23 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
JP2005298338A (en) * 2002-02-27 2005-10-27 Eisai Co Ltd Quickly disintegrating compression-molded preparation
KR100473716B1 (en) * 2002-03-27 2005-03-08 주식회사 참 존 Inclusion complex of 7-dehydrocholesterol and cyclodextrin, cosmetic compositions containing the same and method of stabilizing 7-dehydrocholeserol
US20040131504A1 (en) * 2002-09-17 2004-07-08 Landers James P. Remote temperature sensing of small volume and related apparatus thereof
FR2850040B1 (en) * 2003-01-20 2005-03-11 Centre Nat Rech Scient SYSTEMS FOR MICROENCAPSULATION AND THEIR APPLICATIONS
ATE454905T1 (en) * 2004-03-10 2010-01-15 Shimoda Biotech Pty Ltd STABLE INJECTABLE DICLOFENAC PREPARATIONS
RU2006141358A (en) 2004-04-23 2008-05-27 Сайдекс, Инк. (Us) DRUG POWDER INGREDIENT FORM CONTAINING SIMPLE SULFALKYL ETHER CYCLODEXTRIN
US7629331B2 (en) * 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
DK2581078T3 (en) 2005-10-26 2015-03-02 Cydex Pharmaceuticals Inc Sulfoalkylætercyclodekstrinsammensætninger and processes for the preparation thereof
US20070267033A1 (en) 2006-02-09 2007-11-22 Philip Morris Usa Inc. Gamma cyclodextrin flavoring-release additives
JP5823093B2 (en) 2006-03-28 2015-11-25 ジャヴェリン ファーマシューティカルズ インコーポレイテッド Low dose diclofenac and β-cyclodextrin formulation
US20070232567A1 (en) * 2006-03-28 2007-10-04 Curtis Wright Formulations Of Low Dose Non-Steroidal Anti-Inflammatory Drugs And Beta-Cyclodextrin
FR2912061A1 (en) * 2007-02-01 2008-08-08 Aliscience Soc Par Actions Sim Cyclodextrin inclusion complexes of amino acids useful in pharmaceutical, veterinary, nutraceutical, food or cosmetic compositions
DK2734212T3 (en) * 2011-07-20 2017-11-06 Hospira Inc Compositions comprising diclofenac for the treatment of postoperative pain

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5984821A (en) * 1982-11-04 1984-05-16 Teikoku Chem Ind Corp Ltd Slowly solubilized composition
IT1196033B (en) * 1984-02-22 1988-11-10 Chiesi Farma Spa COMPOUND WITH ANTI-INFLAMMATORY ACTIVITY OBTAINED BY COMPLEXATION WITH BETA-CYCLODEXTRINE AND RELATED PHARMACEUTICAL FORMULATIONS
US4845188A (en) * 1988-08-19 1989-07-04 Eastman Kodak Company Condensation polymers containing methine ultraviolet radiation-absorbing residues and shaped articles produced therefrom
MY106598A (en) * 1988-08-31 1995-06-30 Australian Commercial Res & Development Ltd Compositions and methods for drug delivery and chromatography.
IT1241088B (en) * 1990-03-27 1993-12-29 Chiesi Farma Spa PROCEDURE FOR THE PREPARATION OF PIROXICAM / CYCLODESTRINE COMPLEXES, PRODUCTS OBTAINED AND THEIR PHARMACEUTICAL COMPOSITIONS
IT1243342B (en) * 1990-07-13 1994-06-10 Farcon Ag ORAL PHARMACEUTICAL COMPOSITIONS FOR LIQUID ANTI-INFLAMMATORY ACTIVITIES
EP0519428B1 (en) * 1991-06-21 2000-09-20 Takeda Chemical Industries, Ltd. Cyclodextrin compositions with fumagillol derivates
DE4200792A1 (en) * 1992-01-15 1993-07-22 Solvay Fluor & Derivate PROCESSING OF THE HYDROFLUORINE PHASE FROM REACTION MIXTURES
JPH0616547A (en) * 1992-07-01 1994-01-25 Wakamoto Pharmaceut Co Ltd Antiphlogistic ophthalmic solution

Also Published As

Publication number Publication date
CA2133885C (en) 2008-12-16
DE69434356T2 (en) 2006-05-04
KR950010910A (en) 1995-05-15
IL111184A (en) 2000-08-13
CN1107042A (en) 1995-08-23
ZA948078B (en) 1995-06-05
CN1161115C (en) 2004-08-11
ES2240960T3 (en) 2005-10-16
AU7448694A (en) 1995-04-27
JPH07196484A (en) 1995-08-01
CA2133885A1 (en) 1995-04-09
EP0647451B1 (en) 2005-05-04
US5674854A (en) 1997-10-07
AU682887B2 (en) 1997-10-23
ATE294593T1 (en) 2005-05-15
DE69434356D1 (en) 2005-06-09
EP0647451A1 (en) 1995-04-12

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees