CY1113824T1 - Ενδορινικες συνθεσεις - Google Patents

Ενδορινικες συνθεσεις

Info

Publication number
CY1113824T1
CY1113824T1 CY20131100059T CY131100059T CY1113824T1 CY 1113824 T1 CY1113824 T1 CY 1113824T1 CY 20131100059 T CY20131100059 T CY 20131100059T CY 131100059 T CY131100059 T CY 131100059T CY 1113824 T1 CY1113824 T1 CY 1113824T1
Authority
CY
Cyprus
Prior art keywords
apomorphine
cyclodextrin
intensive
compositions
intensive compositions
Prior art date
Application number
CY20131100059T
Other languages
English (en)
Inventor
Peter Watts
Yu-Hui Cheng
Original Assignee
Archimedes Development Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archimedes Development Limited filed Critical Archimedes Development Limited
Publication of CY1113824T1 publication Critical patent/CY1113824T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ένα υγρό υδατικό σκεύασμα για την ενδορινική χορήγηση απομορφίνης, το οποίο περιλαμβάνει: (α) τουλάχιστον περίπου 15 mg/ml απομορφίνη˙ και (β) ένα διαλυτοποιητικό παράγοντα που επιλέγεται από (i) τουλάχιστον ένα συμπολυμερές πολυοξυαιθυλενίου-πολυοξυπροπυλενίου (πολοξαμερές)˙ (ii) τουλάχιστον μία κυκλοδεξτρίνη˙ και (iii) τουλάχιστον μία κυκλοδεξτρίνη μαζί με χιτοζάνη. Τα σκευάσματα της εφεύρεσης μπορούν να χρησιμοποιηθούν στη θεραπευτική αντιμετώπιση/διαχείριση της νόσου του Πάρκινσον.
CY20131100059T 2007-11-09 2013-01-23 Ενδορινικες συνθεσεις CY1113824T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07254426A EP2057982A1 (en) 2007-11-09 2007-11-09 Intranasal compositions
EP08847366A EP2214640B1 (en) 2007-11-09 2008-11-10 Intranasal compositions

Publications (1)

Publication Number Publication Date
CY1113824T1 true CY1113824T1 (el) 2016-07-27

Family

ID=39052379

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100059T CY1113824T1 (el) 2007-11-09 2013-01-23 Ενδορινικες συνθεσεις

Country Status (21)

Country Link
US (1) US8309108B2 (el)
EP (2) EP2057982A1 (el)
JP (1) JP5530931B2 (el)
KR (1) KR101522529B1 (el)
CN (1) CN101883555B (el)
AU (1) AU2008326220B2 (el)
BR (1) BRPI0819115A2 (el)
CA (1) CA2705153C (el)
CY (1) CY1113824T1 (el)
DK (1) DK2214640T3 (el)
ES (1) ES2398267T3 (el)
HK (1) HK1146711A1 (el)
HR (1) HRP20121036T1 (el)
MX (1) MX2010005013A (el)
NZ (1) NZ585107A (el)
PL (1) PL2214640T3 (el)
PT (1) PT2214640E (el)
SI (1) SI2214640T1 (el)
TW (1) TWI426928B (el)
WO (1) WO2009060226A1 (el)
ZA (1) ZA201003172B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
EP2545905A1 (en) * 2011-07-11 2013-01-16 Britannia Pharmaceuticals Limited A new therapeutical composition containing apomorphine as active ingredient
EP3167876B1 (en) 2012-03-15 2021-09-08 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
CN104349768B (zh) * 2012-06-05 2017-11-07 纽罗德姆有限公司 包含阿朴吗啡和有机酸的组合物及其用途
CN104602675B (zh) 2012-06-21 2019-06-28 法斯瑞斯公司 靛玉红的奈米粒子、其衍生物以及制造和使用所述奈米粒子的方法
GB201217419D0 (en) 2012-09-28 2012-11-14 Innotesto Bvba Improvements in or relating to oromucosal apomorphine compositions
CN113181110A (zh) 2013-07-19 2021-07-30 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
GB201912686D0 (en) * 2019-09-04 2019-10-16 Reown Pharma Inc Pharmaceutical composition
CN115804754A (zh) * 2022-12-16 2023-03-17 广州新济药业科技有限公司 吗啡鼻喷剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9103824D0 (en) * 1991-02-23 1991-04-10 Fisons Ag Formulation
WO1994022445A2 (en) * 1993-03-26 1994-10-13 Merkus Franciscus W H M Pharmaceutical compositions for intranasal administration of dihydroergotamine, apomorphine and morphine
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
EP0834308A1 (en) * 1996-09-30 1998-04-08 LG Chemical Limited Ophthalmic formulation for treating myopia comprising dopamine agonist and cyclodextrin
GB9713980D0 (en) 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
EP1035833B1 (en) * 1997-12-02 2005-08-31 Archimedes Development Limited Compositions for nasal administration
US6436950B1 (en) 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution

Also Published As

Publication number Publication date
SI2214640T1 (sl) 2013-02-28
TW200936179A (en) 2009-09-01
DK2214640T3 (da) 2013-02-04
CN101883555A (zh) 2010-11-10
BRPI0819115A2 (pt) 2015-07-07
NZ585107A (en) 2012-05-25
ZA201003172B (en) 2012-10-31
ES2398267T3 (es) 2013-03-15
MX2010005013A (es) 2010-05-27
US8309108B2 (en) 2012-11-13
PT2214640E (pt) 2013-01-16
CA2705153A1 (en) 2009-05-14
KR101522529B1 (ko) 2015-05-26
CA2705153C (en) 2016-05-24
JP2011503044A (ja) 2011-01-27
US20100249170A1 (en) 2010-09-30
AU2008326220B2 (en) 2013-05-23
KR20100094980A (ko) 2010-08-27
EP2214640B1 (en) 2012-10-24
HRP20121036T1 (hr) 2013-01-31
EP2057982A1 (en) 2009-05-13
AU2008326220A1 (en) 2009-05-14
HK1146711A1 (en) 2011-07-08
AU2008326220A2 (en) 2010-11-04
CN101883555B (zh) 2012-07-11
TWI426928B (zh) 2014-02-21
PL2214640T3 (pl) 2013-03-29
WO2009060226A1 (en) 2009-05-14
EP2214640A1 (en) 2010-08-11
JP5530931B2 (ja) 2014-06-25

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