CY1124690T1 - Σκευασματα ενδοφλεβιου διαλυματος ποσακοναζολης σταθεροποιημενα με υποκατεστημενη βητα-κυκλοδεξτρινη - Google Patents
Σκευασματα ενδοφλεβιου διαλυματος ποσακοναζολης σταθεροποιημενα με υποκατεστημενη βητα-κυκλοδεξτρινηInfo
- Publication number
- CY1124690T1 CY1124690T1 CY20211100950T CY211100950T CY1124690T1 CY 1124690 T1 CY1124690 T1 CY 1124690T1 CY 20211100950 T CY20211100950 T CY 20211100950T CY 211100950 T CY211100950 T CY 211100950T CY 1124690 T1 CY1124690 T1 CY 1124690T1
- Authority
- CY
- Cyprus
- Prior art keywords
- beta
- posaconazole
- intravenous solution
- substituted cyclodextrin
- solution preparations
- Prior art date
Links
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 title abstract 3
- 229960001589 posaconazole Drugs 0.000 title abstract 3
- 238000001990 intravenous administration Methods 0.000 title abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229940009662 edetate Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- Animal Behavior & Ethology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε υδατικά διαλύματα χρήσιμα ως φαρμακευτικές συνθέσεις ποσακοναζόλης για ενδοφλέβια χορήγηση. Αυτές οι συνθέσεις περιλαμβάνουν παράγοντα διαλυτοποίησης, όπως τροποποιημένη β-κυκλοδεξτρίνη σε οξινισμένο διάλυμα, που μπορεί επίσης να περιλαμβάνουν παράγοντα χηλικής σύμπλεξης, όπως εδετικό δινάτριο (EDTA). Σε κλινικές δοκιμές, δόση ποζακοναζόλης 200 χλστγρ. της επιλεγμένης σύνθεσης, βρέθηκε ότι επιτυγχάνει αποδεκτές φαρμακοκινητικές ιδιότητες.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35970110P | 2010-06-29 | 2010-06-29 | |
PCT/US2011/041715 WO2012005973A1 (en) | 2010-06-29 | 2011-06-24 | Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin |
EP11804061.7A EP2588116A4 (en) | 2010-06-29 | 2011-06-24 | FORMULATIONS OF AN INTRAVENOUS SOLUTION OF POSACONAZOLE STABILIZED BY SUBSTITUTED BETA CYCLODEXTRIN |
Publications (1)
Publication Number | Publication Date |
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CY1124690T1 true CY1124690T1 (el) | 2022-07-22 |
Family
ID=45441500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100950T CY1124690T1 (el) | 2010-06-29 | 2021-11-03 | Σκευασματα ενδοφλεβιου διαλυματος ποσακοναζολης σταθεροποιημενα με υποκατεστημενη βητα-κυκλοδεξτρινη |
Country Status (20)
Country | Link |
---|---|
US (2) | US9023790B2 (el) |
EP (3) | EP2588116A4 (el) |
JP (1) | JP6008849B2 (el) |
KR (1) | KR101834024B1 (el) |
CN (2) | CN102958528A (el) |
AU (1) | AU2011276680B2 (el) |
BR (1) | BR112012033077B8 (el) |
CA (1) | CA2802929C (el) |
CY (1) | CY1124690T1 (el) |
DK (1) | DK3391890T3 (el) |
ES (1) | ES2893444T3 (el) |
HR (1) | HRP20211686T1 (el) |
HU (1) | HUE056581T2 (el) |
LT (1) | LT3391890T (el) |
MX (2) | MX338685B (el) |
PL (1) | PL3391890T3 (el) |
PT (1) | PT3391890T (el) |
RS (1) | RS62583B1 (el) |
SI (1) | SI3391890T1 (el) |
WO (1) | WO2012005973A1 (el) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
HUE056581T2 (hu) | 2010-06-29 | 2022-02-28 | Merck Sharp & Dohme | Szubsztituált béta-ciklodextrinnel stabilizált pozakonazol intravénás oldat formulációk |
US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
HUE058834T2 (hu) | 2012-02-15 | 2022-09-28 | Cydex Pharmaceuticals Inc | Elõállítási eljárás ciklodextrin-származékokhoz |
CN105683184B (zh) | 2013-10-03 | 2019-05-10 | 道尔医药科学公司 | 稳定的艾菲康唑组合物 |
CN104546724A (zh) * | 2013-10-12 | 2015-04-29 | 博瑞生物医药技术(苏州)有限公司 | 一种抗真菌药的固体分散体 |
US10245257B2 (en) | 2013-11-22 | 2019-04-02 | Dow Pharmaceutical Sciences, Inc. | Anti-infective methods, compositions, and devices |
CN105879041A (zh) * | 2014-11-14 | 2016-08-24 | 北京赛林泰医药技术有限公司 | 一种泊沙康唑口服液及其制备方法 |
EP3220954A4 (en) * | 2014-11-19 | 2018-06-27 | Gufic Biosciences Limited | Process for preparation of parenteral formulation of anidulafungin |
CN104473871B (zh) * | 2014-11-28 | 2017-03-08 | 济南康和医药科技有限公司 | 一种泊沙康唑脂肪乳注射液及其制备方法 |
CN106265534A (zh) * | 2015-05-25 | 2017-01-04 | 江苏正大丰海制药有限公司 | 一种泊沙康唑冻干粉针剂的制备方法 |
CN106511262A (zh) * | 2015-09-11 | 2017-03-22 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑口服溶液剂及其制备方法 |
CN107033186B (zh) | 2016-02-04 | 2020-06-09 | 武汉朗来科技发展有限公司 | 泊沙康唑衍生物、其药物组合物和用途 |
WO2018091668A1 (en) | 2016-11-18 | 2018-05-24 | Aicuris Anti-Infective Cures Gmbh | Novel formulations of amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and acidifying agents, their preparation and use as antimicrobial pharmaceutical compositions |
CN110711174A (zh) * | 2018-07-11 | 2020-01-21 | 郑州泰丰制药有限公司 | 一种泊沙康唑注射液中间体溶液配制方法 |
WO2020139209A1 (en) * | 2018-12-28 | 2020-07-02 | Polifarma Ilac Sanayi Ve Ticaret Anonim Srketi | Stable injectable posaconazole formulations comprising cyclodextrin and sugar |
US20230285391A1 (en) * | 2020-06-06 | 2023-09-14 | Inventia Healthcare Limited | Stable liquid compositions of posaconazole |
WO2023148763A1 (en) * | 2022-02-01 | 2023-08-10 | Cipla Limited | Injectable pharmaceutical compositions of azole antifungal agents |
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KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5703079A (en) | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
CA2179396C (en) | 1993-12-21 | 2001-04-17 | Anil K. Saksena | Tetrahydrofuran antifungals |
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