CY1121564T1 - Σπειρο-ινδολινες για τη θεραπεια και την προφυλαξη απο τη λοιμωξη απο τον αναπνευστικο συγκυτιακο ιο (rsv) - Google Patents
Σπειρο-ινδολινες για τη θεραπεια και την προφυλαξη απο τη λοιμωξη απο τον αναπνευστικο συγκυτιακο ιο (rsv)Info
- Publication number
- CY1121564T1 CY1121564T1 CY20191100403T CY191100403T CY1121564T1 CY 1121564 T1 CY1121564 T1 CY 1121564T1 CY 20191100403 T CY20191100403 T CY 20191100403T CY 191100403 T CY191100403 T CY 191100403T CY 1121564 T1 CY1121564 T1 CY 1121564T1
- Authority
- CY
- Cyprus
- Prior art keywords
- rsv
- infection
- syntical
- indolines
- spiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Βενζιμιδαζόλες του τύπου (I): όπου : το ένα εκ των Χ και Υ είναι άτομο Ν ή υποκατεστημένο άτομο C και το άλλο είναι CH· το L είναι απλός δεσμός, C1-3 αλκυλένιο, C2-3 αλκενυλένιο ή C2-3 αλκυνυλένιο· το R1 είναι C1-6 αλκύλιο, C2-6 αλκενύλιο, C2-6 αλκυνύλιο, κυκλοαλκύλιο 3 έως 10 μελών, ετεροκυκλική ένωση 5 έως 10 μελών ή ετεροαρύλιο 5 έως 12 μελών, καθένα εκ των οποίων είναι μη υποκατεστημένο ή υποκατεστημένο· το Ζ είναι αλογόνο, C1-6 αλοαλκύλιο, άζωτο, -CN, -N(R2)2, -OR2, -SR2, -S(=0)R2 ή -S(=0)2R2· κάθε R2 είναι ανεξαρτήτως υδρογόνο, C1-6 αλκύλιο, C2-6 αλκενύλιο ή C2-6 αλκυνύλιο, όπου οι εν λόγω αλκυλομάδες, αλκενυλομάδες και αλκυνυλομάδες είναι μη υποκατεστημένες ή υποκατεστημένες· και το m είναι 0 ή 1· και τα φαρμακευτικώς αποδεκτά άλατα τους είναι αναστολείς του RSV και μπορούν, επομένως, να χρησιμοποιηθούν για τη θεραπεία ή την πρόληψη της λοίμωξης από RSV.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1417707.5A GB201417707D0 (en) | 2014-10-07 | 2014-10-07 | Pharmaceutical compounds |
| PCT/GB2015/052920 WO2016055780A1 (en) | 2014-10-07 | 2015-10-06 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (rsv) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121564T1 true CY1121564T1 (el) | 2020-05-29 |
Family
ID=51946966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100403T CY1121564T1 (el) | 2014-10-07 | 2019-04-11 | Σπειρο-ινδολινες για τη θεραπεια και την προφυλαξη απο τη λοιμωξη απο τον αναπνευστικο συγκυτιακο ιο (rsv) |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US10106539B2 (el) |
| EP (1) | EP3204375B1 (el) |
| JP (1) | JP6695334B2 (el) |
| KR (2) | KR102561796B1 (el) |
| CN (1) | CN107108557B (el) |
| AR (1) | AR102181A1 (el) |
| AU (1) | AU2015329778B2 (el) |
| BR (1) | BR112017007311B1 (el) |
| CA (1) | CA2963740C (el) |
| CL (1) | CL2017000839A1 (el) |
| CO (1) | CO2017004603A2 (el) |
| CY (1) | CY1121564T1 (el) |
| DK (1) | DK3204375T3 (el) |
| ES (1) | ES2718976T3 (el) |
| GB (1) | GB201417707D0 (el) |
| HR (1) | HRP20190808T1 (el) |
| HU (1) | HUE043553T2 (el) |
| LT (1) | LT3204375T (el) |
| MX (1) | MX2017004425A (el) |
| NZ (1) | NZ731323A (el) |
| PE (1) | PE20170949A1 (el) |
| PL (1) | PL3204375T3 (el) |
| PT (1) | PT3204375T (el) |
| RS (1) | RS58706B1 (el) |
| RU (1) | RU2734248C2 (el) |
| SG (1) | SG11201702766YA (el) |
| SI (1) | SI3204375T1 (el) |
| TR (1) | TR201903362T4 (el) |
| TW (1) | TWI718107B (el) |
| WO (1) | WO2016055780A1 (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3305790B1 (en) | 2015-06-08 | 2020-08-05 | Shangdong Danhong Pharmaceutical Co., Ltd. | Method for preparing imidazole derivative and intermediate thereof and crystal form |
| JP6944514B2 (ja) | 2016-08-04 | 2021-10-06 | アールイーヴァイラル リミテッド | ピリミジン誘導体および呼吸器合胞体ウイルス感染の治療または予防におけるそれらの使用 |
| GB201711704D0 (en) * | 2017-07-20 | 2017-09-06 | Reviral Ltd | Pharmaceutical compounds |
| GB201721812D0 (en) * | 2017-12-22 | 2018-02-07 | Reviral Ltd | Pharmaceutical compounds |
| CN116077494A (zh) * | 2023-01-11 | 2023-05-09 | 黑龙江中医药大学 | 一种治疗呼吸道合胞病毒的药物组合物及其制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57102863A (en) * | 1980-12-16 | 1982-06-26 | Takeda Chem Ind Ltd | Spiroindolinone and its preparation |
| PL194216B1 (pl) * | 1998-01-23 | 2007-05-31 | Sankyo Co | Pochodne spiropiperydyny, lekarstwo oraz środek zapobiegawczy lub terapeutyczny zawierające jako składnik czynny te pochodne i zastosowanie pochodnych spiropiperydyny |
| DE60013836T2 (de) * | 1999-06-28 | 2006-01-19 | Janssen Pharmaceutica N.V. | Replikationsinhibitoren des respiratorischen synzytialvirus |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| WO2004037247A1 (en) * | 2002-10-21 | 2004-05-06 | Irm Llc | Oxindoles with anti-hiv activity |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| US7390798B2 (en) | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| JP4913061B2 (ja) | 2004-10-13 | 2012-04-11 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｇｒｐ受容体拮抗薬 |
| WO2010103306A1 (en) | 2009-03-10 | 2010-09-16 | Astrazeneca Uk Limited | Benzimidazole derivatives and their use as antivaral agents |
| GB201119538D0 (en) * | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
| CN104903313B (zh) | 2012-10-16 | 2017-12-29 | 爱尔兰詹森科学公司 | Rsv抗病毒化合物 |
| CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
| KR20160007629A (ko) * | 2013-05-14 | 2016-01-20 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| JP2016518421A (ja) * | 2013-05-14 | 2016-06-23 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 呼吸器合胞体ウイルス感染症の処置および予防のためのアザ−オキソ−インドール |
| KR20160030271A (ko) * | 2013-08-12 | 2016-03-16 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| CN105408330A (zh) * | 2013-08-12 | 2016-03-16 | 豪夫迈·罗氏有限公司 | 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
| BR112016002638A2 (pt) * | 2013-08-12 | 2017-08-01 | Hoffmann La Roche | novos aza-oxo-indóis para o tratamento e profilaxia de infecção pelo virus sincicial respiratório |
| EP3033333A1 (en) * | 2013-08-15 | 2016-06-22 | F. Hoffmann-La Roche AG | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| CN105431419A (zh) * | 2013-08-15 | 2016-03-23 | 豪夫迈·罗氏有限公司 | 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
| KR20160030569A (ko) * | 2013-08-15 | 2016-03-18 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 신규한 아자-옥소-인돌 |
-
2014
- 2014-10-07 GB GBGB1417707.5A patent/GB201417707D0/en not_active Ceased
-
2015
- 2015-10-06 SI SI201530634T patent/SI3204375T1/sl unknown
- 2015-10-06 SG SG11201702766YA patent/SG11201702766YA/en unknown
- 2015-10-06 ES ES15782033T patent/ES2718976T3/es active Active
- 2015-10-06 PE PE2017000576A patent/PE20170949A1/es unknown
- 2015-10-06 KR KR1020177012311A patent/KR102561796B1/ko active IP Right Grant
- 2015-10-06 TR TR2019/03362T patent/TR201903362T4/tr unknown
- 2015-10-06 BR BR112017007311-0A patent/BR112017007311B1/pt active IP Right Grant
- 2015-10-06 RS RS20190515A patent/RS58706B1/sr unknown
- 2015-10-06 WO PCT/GB2015/052920 patent/WO2016055780A1/en active Application Filing
- 2015-10-06 PT PT15782033T patent/PT3204375T/pt unknown
- 2015-10-06 DK DK15782033.3T patent/DK3204375T3/en active
- 2015-10-06 RU RU2017113026A patent/RU2734248C2/ru active
- 2015-10-06 EP EP15782033.3A patent/EP3204375B1/en active Active
- 2015-10-06 AU AU2015329778A patent/AU2015329778B2/en active Active
- 2015-10-06 NZ NZ731323A patent/NZ731323A/en unknown
- 2015-10-06 JP JP2017519320A patent/JP6695334B2/ja active Active
- 2015-10-06 CA CA2963740A patent/CA2963740C/en active Active
- 2015-10-06 LT LTEP15782033.3T patent/LT3204375T/lt unknown
- 2015-10-06 MX MX2017004425A patent/MX2017004425A/es active IP Right Grant
- 2015-10-06 CN CN201580066385.4A patent/CN107108557B/zh active Active
- 2015-10-06 HU HUE15782033A patent/HUE043553T2/hu unknown
- 2015-10-06 KR KR1020237025697A patent/KR20230116097A/ko not_active Application Discontinuation
- 2015-10-06 AR ARP150103215A patent/AR102181A1/es unknown
- 2015-10-06 PL PL15782033T patent/PL3204375T3/pl unknown
- 2015-10-06 US US15/517,290 patent/US10106539B2/en active Active
- 2015-10-07 TW TW104133092A patent/TWI718107B/zh active
-
2017
- 2017-04-06 CL CL2017000839A patent/CL2017000839A1/es unknown
- 2017-05-05 CO CONC2017/0004603A patent/CO2017004603A2/es unknown
-
2019
- 2019-04-11 CY CY20191100403T patent/CY1121564T1/el unknown
- 2019-04-30 HR HRP20190808TT patent/HRP20190808T1/hr unknown
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