JPS57102863A - Spiroindolinone and its preparation - Google Patents

Spiroindolinone and its preparation

Info

Publication number
JPS57102863A
JPS57102863A JP17828280A JP17828280A JPS57102863A JP S57102863 A JPS57102863 A JP S57102863A JP 17828280 A JP17828280 A JP 17828280A JP 17828280 A JP17828280 A JP 17828280A JP S57102863 A JPS57102863 A JP S57102863A
Authority
JP
Japan
Prior art keywords
substituents
formulai
compound
spiroindolinone
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17828280A
Other languages
Japanese (ja)
Other versions
JPS6341388B2 (en
Inventor
Hirosada Sugihara
Kiyohisa Kawai
Kohei Nishikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP17828280A priority Critical patent/JPS57102863A/en
Publication of JPS57102863A publication Critical patent/JPS57102863A/en
Publication of JPS6341388B2 publication Critical patent/JPS6341388B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:A spiroindolinone of formulaI(R1WR3 are H, halogen nitro, mercapto, carboxyl, lower alkyl which may bear substituents, lower alkoxy, lower alkyltio, amino or acyl, where at least on these groups is other than H; R4 is H, lower alkyl which may have substituents).
EXAMPLE: 6'-Methylspiro(cyclopropane-1,3'-[3H]indole)-2'-[1'H]-one.
USE: A medicine having a combination of high hypotensive and platelet inhibition activities. Further, it shows anti-inflammatory and analgesic activities and is used as a prophylatic or remedy for hypertention, thrombosis, cerebral apoplexy, low back pain or arthritis.
PREPARATION: The compound of formula II (R1'WR3' are the same as R1W R3) is subjected to decarboxylation and, when necessary, introduction of substituents to produce the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP17828280A 1980-12-16 1980-12-16 Spiroindolinone and its preparation Granted JPS57102863A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17828280A JPS57102863A (en) 1980-12-16 1980-12-16 Spiroindolinone and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17828280A JPS57102863A (en) 1980-12-16 1980-12-16 Spiroindolinone and its preparation

Publications (2)

Publication Number Publication Date
JPS57102863A true JPS57102863A (en) 1982-06-26
JPS6341388B2 JPS6341388B2 (en) 1988-08-17

Family

ID=16045737

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17828280A Granted JPS57102863A (en) 1980-12-16 1980-12-16 Spiroindolinone and its preparation

Country Status (1)

Country Link
JP (1) JPS57102863A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327986A2 (en) * 1988-02-09 1989-08-16 Roche Diagnostics GmbH Medicaments containing lactams, substituted lactams and process for their preparation
WO2004037247A1 (en) * 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
WO2011069298A1 (en) * 2009-12-11 2011-06-16 F. Hoffmann-La Roche Ag Novel cyclopropane indolinone derivatives
MD4201C1 (en) * 2012-03-21 2013-09-30 Институт Химии Академии Наук Молдовы Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]
MD4202C1 (en) * 2012-03-21 2013-09-30 Институт Химии Академии Наук Молдовы Process for production of carbomethoxy derivatives of spiro[cyclopropane-oxindoles]
JP2017530992A (en) * 2014-10-07 2017-10-19 アールイーヴァイラル リミテッド Spiroindoline for the treatment or prevention of respiratory syncytial virus infection (RSV)
WO2018229079A1 (en) * 2017-06-14 2018-12-20 Ucb Biopharma Sprl Spirocyclic indolines as il-17 modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123543A (en) * 1971-09-16 1978-10-31 Ab Kabi Derivatives of substituted indoline lactans with effect on the central nervous system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123543A (en) * 1971-09-16 1978-10-31 Ab Kabi Derivatives of substituted indoline lactans with effect on the central nervous system

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0327986A2 (en) * 1988-02-09 1989-08-16 Roche Diagnostics GmbH Medicaments containing lactams, substituted lactams and process for their preparation
US4985448A (en) * 1988-02-09 1991-01-15 Boehringer Mannheim Gmbh Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition
WO2004037247A1 (en) * 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
US7205328B2 (en) 2002-10-21 2007-04-17 Irm Llc Oxindoles with anti-HIV activity
WO2011069298A1 (en) * 2009-12-11 2011-06-16 F. Hoffmann-La Roche Ag Novel cyclopropane indolinone derivatives
US8354443B2 (en) 2009-12-11 2013-01-15 Hoffmann-La Roche Inc. Cyclopropane indolinone derivatives
MD4201C1 (en) * 2012-03-21 2013-09-30 Институт Химии Академии Наук Молдовы Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]
MD4202C1 (en) * 2012-03-21 2013-09-30 Институт Химии Академии Наук Молдовы Process for production of carbomethoxy derivatives of spiro[cyclopropane-oxindoles]
JP2017530992A (en) * 2014-10-07 2017-10-19 アールイーヴァイラル リミテッド Spiroindoline for the treatment or prevention of respiratory syncytial virus infection (RSV)
WO2018229079A1 (en) * 2017-06-14 2018-12-20 Ucb Biopharma Sprl Spirocyclic indolines as il-17 modulators
CN110769821A (en) * 2017-06-14 2020-02-07 Ucb生物制药私人有限公司 Spirocyclic indolines as IL-17 modulators
JP2020523418A (en) * 2017-06-14 2020-08-06 ユーシービー バイオファルマ エスアールエル Spirocyclic indolines as IL-17 modulators
US11052076B2 (en) 2017-06-14 2021-07-06 UCB Biopharma SRL Spirocyclic indolines as IL-17 modulators
CN110769821B (en) * 2017-06-14 2023-07-07 Ucb生物制药有限责任公司 Spiro indolines as IL-17 modulators

Also Published As

Publication number Publication date
JPS6341388B2 (en) 1988-08-17

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