MD4201C1 - Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] - Google Patents
Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]Info
- Publication number
- MD4201C1 MD4201C1 MDA20120030A MD20120030A MD4201C1 MD 4201 C1 MD4201 C1 MD 4201C1 MD A20120030 A MDA20120030 A MD A20120030A MD 20120030 A MD20120030 A MD 20120030A MD 4201 C1 MD4201 C1 MD 4201C1
- Authority
- MD
- Moldova
- Prior art keywords
- oxindoles
- cyclopropane
- spiro
- production
- carbonitrile derivatives
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Indole Compounds (AREA)
Abstract
The invention relates to the synthesis of carbonitrile derivatives of spiro[cyclopropane-oxindoles], which can serve as precursors in the synthesis of substances with anti-HIV activity.The process involves the reaction of cyclopropanation of diazoisatins with acrylonitrile, used both as reagent and solvent at its boiling point.The proposed process allows of carrying out the reaction in a shorter time with high yields, without the use of catalysts and inert atmosphere.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120030A MD4201C1 (en) | 2012-03-21 | 2012-03-21 | Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120030A MD4201C1 (en) | 2012-03-21 | 2012-03-21 | Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4201B1 MD4201B1 (en) | 2013-02-28 |
MD4201C1 true MD4201C1 (en) | 2013-09-30 |
Family
ID=47831222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20120030A MD4201C1 (en) | 2012-03-21 | 2012-03-21 | Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4201C1 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57102863A (en) * | 1980-12-16 | 1982-06-26 | Takeda Chem Ind Ltd | Spiroindolinone and its preparation |
US6046341A (en) * | 1995-10-24 | 2000-04-04 | Sanofi-Synthelabo | 3-spiro-indolin-2-one derivatives |
WO2004037247A1 (en) * | 2002-10-21 | 2004-05-06 | Irm Llc | Oxindoles with anti-hiv activity |
US20050015776A1 (en) * | 2003-06-02 | 2005-01-20 | Bimal Mehta | Processing convoy workflow scenarios |
WO2007008664A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | 3-spir0cycl0pr0pyl2-0xind0le kinase inhibitors |
-
2012
- 2012-03-21 MD MDA20120030A patent/MD4201C1/en not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57102863A (en) * | 1980-12-16 | 1982-06-26 | Takeda Chem Ind Ltd | Spiroindolinone and its preparation |
US6046341A (en) * | 1995-10-24 | 2000-04-04 | Sanofi-Synthelabo | 3-spiro-indolin-2-one derivatives |
WO2004037247A1 (en) * | 2002-10-21 | 2004-05-06 | Irm Llc | Oxindoles with anti-hiv activity |
US20050015776A1 (en) * | 2003-06-02 | 2005-01-20 | Bimal Mehta | Processing convoy workflow scenarios |
WO2007008664A1 (en) * | 2005-07-13 | 2007-01-18 | Allergan, Inc. | 3-spir0cycl0pr0pyl2-0xind0le kinase inhibitors |
Non-Patent Citations (6)
Title |
---|
Cava M.P., Litle R.L., Napier D.R. J. Amer. Chem. Soc., 1958, 80, 2257-2262 * |
Chen S., Ma J., Wang J. Tetrahedron Lett., 2008, 49, 6781-6783 * |
Jiang T., Kuhen K. L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Tuntland T., Zhang K., Karanewsky D., He Y. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 2109-2112 * |
Jiang T., Kuhen K. L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Wu T. Y. H., He Y. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 2105-2108 * |
Kumari G., Nutan I., Modi M., Gupta S. K., Singh R. K. Eur. J. Med. Chem., 2011, 46, 1181-1188 * |
Marti C., Carreira E.M. J. Am. Chem. Soc., 2005, 127, 11505-11515 * |
Also Published As
Publication number | Publication date |
---|---|
MD4201B1 (en) | 2013-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY164869A (en) | Catalysts for the production of acrylic acid or its derivatives | |
MY168081A (en) | Ethyl acetate production | |
EA201790916A1 (en) | NEW RIG-I LIGANDS AND METHODS OF THEIR RECEPTION | |
WO2013108045A3 (en) | Process intensification in the catalytic synthesis of supported catalysts with hierarchic pore structure | |
WO2012030065A3 (en) | Catalyst composition for hydroformylation reaction and a hydroformylation process using the same | |
SG11201406833PA (en) | Catalyst for production of butadiene, process for producing the catalyst, and process for producing butadiene using the catalyst | |
MY164527A (en) | Process for production of acrylic acid or its derivatives | |
WO2014057498A3 (en) | Process for the preparation of cobicistat intermediates | |
IN2014DN09600A (en) | ||
MY180633A (en) | Solid particles, containing lactam, activator, and catalyst, method for producing said solid particles, and use of said solid particles | |
WO2012137152A3 (en) | Method for preparing formamide compounds | |
MX351657B (en) | Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts. | |
MY194991A (en) | Method for producing pyrrole compound | |
WO2014141092A3 (en) | Improved process for the preparation of tenofovir | |
MX2015001492A (en) | Supported noble metal-comprising catalyst for oxidative dehydrogenation or epoxidation. | |
IN2014DN09934A (en) | ||
MY160047A (en) | Process for the preparation and work-up of a reaction mixture containing triacetone amine | |
CA2897927C (en) | Process for the conversion of saccharide-containing feedstock | |
MD4201C1 (en) | Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] | |
MX349985B (en) | Process for preparing cis-alkoxy-substituted spirocyclic phenylacetylamino acid esters and cis-alkoxy-substituted spirocyclic 1-h-pyrrolidine-2,4-dione derivatives. | |
MD4202B1 (en) | Process for production of carbomethoxy derivatives of spiro[cyclopropane-oxindoles] | |
IN2014DN09850A (en) | ||
WO2012143771A8 (en) | Improved catalytic process for production of pyridine carboxylic acid amides | |
SA515360071B1 (en) | Dihydroxyethyl piperazine and processes for the synthesis of the same | |
UA78739U (en) | Process for the preparation of 2,5-diformylfuran |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |