MD4201C1 - Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] - Google Patents

Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

Info

Publication number
MD4201C1
MD4201C1 MDA20120030A MD20120030A MD4201C1 MD 4201 C1 MD4201 C1 MD 4201C1 MD A20120030 A MDA20120030 A MD A20120030A MD 20120030 A MD20120030 A MD 20120030A MD 4201 C1 MD4201 C1 MD 4201C1
Authority
MD
Moldova
Prior art keywords
oxindoles
cyclopropane
spiro
production
carbonitrile derivatives
Prior art date
Application number
MDA20120030A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4201B1 (en
Inventor
Наталия СУКМАН
Флюр МАКАЕВ
Original Assignee
Институт Химии Академии Наук Молдовы
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Химии Академии Наук Молдовы filed Critical Институт Химии Академии Наук Молдовы
Priority to MDA20120030A priority Critical patent/MD4201C1/en
Publication of MD4201B1 publication Critical patent/MD4201B1/en
Publication of MD4201C1 publication Critical patent/MD4201C1/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

The invention relates to the synthesis of carbonitrile derivatives of spiro[cyclopropane-oxindoles], which can serve as precursors in the synthesis of substances with anti-HIV activity.The process involves the reaction of cyclopropanation of diazoisatins with acrylonitrile, used both as reagent and solvent at its boiling point.The proposed process allows of carrying out the reaction in a shorter time with high yields, without the use of catalysts and inert atmosphere.
MDA20120030A 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] MD4201C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120030A MD4201C1 (en) 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120030A MD4201C1 (en) 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

Publications (2)

Publication Number Publication Date
MD4201B1 MD4201B1 (en) 2013-02-28
MD4201C1 true MD4201C1 (en) 2013-09-30

Family

ID=47831222

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20120030A MD4201C1 (en) 2012-03-21 2012-03-21 Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]

Country Status (1)

Country Link
MD (1) MD4201C1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102863A (en) * 1980-12-16 1982-06-26 Takeda Chem Ind Ltd Spiroindolinone and its preparation
US6046341A (en) * 1995-10-24 2000-04-04 Sanofi-Synthelabo 3-spiro-indolin-2-one derivatives
WO2004037247A1 (en) * 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
US20050015776A1 (en) * 2003-06-02 2005-01-20 Bimal Mehta Processing convoy workflow scenarios
WO2007008664A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. 3-spir0cycl0pr0pyl2-0xind0le kinase inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102863A (en) * 1980-12-16 1982-06-26 Takeda Chem Ind Ltd Spiroindolinone and its preparation
US6046341A (en) * 1995-10-24 2000-04-04 Sanofi-Synthelabo 3-spiro-indolin-2-one derivatives
WO2004037247A1 (en) * 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
US20050015776A1 (en) * 2003-06-02 2005-01-20 Bimal Mehta Processing convoy workflow scenarios
WO2007008664A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. 3-spir0cycl0pr0pyl2-0xind0le kinase inhibitors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Cava M.P., Litle R.L., Napier D.R. J. Amer. Chem. Soc., 1958, 80, 2257-2262 *
Chen S., Ma J., Wang J. Tetrahedron Lett., 2008, 49, 6781-6783 *
Jiang T., Kuhen K. L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Tuntland T., Zhang K., Karanewsky D., He Y. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 2109-2112 *
Jiang T., Kuhen K. L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Wu T. Y. H., He Y. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 2105-2108 *
Kumari G., Nutan I., Modi M., Gupta S. K., Singh R. K. Eur. J. Med. Chem., 2011, 46, 1181-1188 *
Marti C., Carreira E.M. J. Am. Chem. Soc., 2005, 127, 11505-11515 *

Also Published As

Publication number Publication date
MD4201B1 (en) 2013-02-28

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees