MD4201B1 - Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] - Google Patents
Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles]Info
- Publication number
- MD4201B1 MD4201B1 MDA20120030A MD20120030A MD4201B1 MD 4201 B1 MD4201 B1 MD 4201B1 MD A20120030 A MDA20120030 A MD A20120030A MD 20120030 A MD20120030 A MD 20120030A MD 4201 B1 MD4201 B1 MD 4201B1
- Authority
- MD
- Moldova
- Prior art keywords
- oxindoles
- cyclopropane
- spiro
- production
- carbonitrile derivatives
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Abstract
The invention relates to the synthesis of carbonitrile derivatives of spiro[cyclopropane-oxindoles], which can serve as precursors in the synthesis of substances with anti-HIV activity.The process involves the reaction of cyclopropanation of diazoisatins with acrylonitrile, used both as reagent and solvent at its boiling point.The proposed process allows of carrying out the reaction in a shorter time with high yields, without the use of catalysts and inert atmosphere.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120030A MD4201C1 (en) | 2012-03-21 | 2012-03-21 | Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120030A MD4201C1 (en) | 2012-03-21 | 2012-03-21 | Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4201B1 true MD4201B1 (en) | 2013-02-28 |
MD4201C1 MD4201C1 (en) | 2013-09-30 |
Family
ID=47831222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20120030A MD4201C1 (en) | 2012-03-21 | 2012-03-21 | Process for production of carbonitrile derivatives of spiro[cyclopropane-oxindoles] |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4201C1 (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57102863A (en) * | 1980-12-16 | 1982-06-26 | Takeda Chem Ind Ltd | Spiroindolinone and its preparation |
FR2740136B1 (en) * | 1995-10-24 | 1998-01-09 | Sanofi Sa | INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
AU2003286604A1 (en) * | 2002-10-21 | 2004-05-13 | Irm Llc | Oxindoles with anti-hiv activity |
US7370333B2 (en) * | 2003-06-02 | 2008-05-06 | Microsoft Corporation | Efficient processing of a convoy workflow scenario in a message driven process |
US7309787B2 (en) * | 2005-07-13 | 2007-12-18 | Allergan, Inc. | Kinase inhibitors |
-
2012
- 2012-03-21 MD MDA20120030A patent/MD4201C1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MD4201C1 (en) | 2013-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |