BR112018076558A2 - ácidos cicloexil carbamoiloximetil triazol como an-tagonistas de lpa - Google Patents

ácidos cicloexil carbamoiloximetil triazol como an-tagonistas de lpa

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Publication number
BR112018076558A2
BR112018076558A2 BR112018076558-9A BR112018076558A BR112018076558A2 BR 112018076558 A2 BR112018076558 A2 BR 112018076558A2 BR 112018076558 A BR112018076558 A BR 112018076558A BR 112018076558 A2 BR112018076558 A2 BR 112018076558A2
Authority
BR
Brazil
Prior art keywords
cyclohexyl
lpa antagonists
carbamoyloxymethyl
acids
triazole acids
Prior art date
Application number
BR112018076558-9A
Other languages
English (en)
Inventor
Tai Wah Cheng Peter
Robert F. Kaltenbach, Iii
Li Jun
Shi Jun
Shi Yan
Tao Shiwei
Zhang Hao
Dhanusu Suresh
Selvakumar Kumaravel
Babu Reddigunta Ramesh
J Walker Steven
J. Kennedy Lawrence
R. Corte James
Fang Tianan
Jusuf Sutjano
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of BR112018076558A2 publication Critical patent/BR112018076558A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C07C62/10—Saturated compounds containing ether groups, groups, groups, or groups with a six-membered ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

a presente invenção refere-se a compostos de fórmula (i), ou estereoisômeros, tautômeros, sais farmaceuticamente aceitáveis, solvatos ou profármacos dos mesmos, onde todas as variáveis são como aqui definido. esses compostos são inibidores de receptor de lpa seletivos.
BR112018076558-9A 2016-06-21 2017-06-20 ácidos cicloexil carbamoiloximetil triazol como an-tagonistas de lpa BR112018076558A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662352792P 2016-06-21 2016-06-21
US62/352,792 2016-06-21
PCT/US2017/038216 WO2017223016A1 (en) 2016-06-21 2017-06-20 Carbamoyloxymethyl triazole cyclohexyl acids as lpa antagonists

Publications (1)

Publication Number Publication Date
BR112018076558A2 true BR112018076558A2 (pt) 2019-04-02

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BR112018076558-9A BR112018076558A2 (pt) 2016-06-21 2017-06-20 ácidos cicloexil carbamoiloximetil triazol como an-tagonistas de lpa

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US (7) US10071078B2 (pt)
EP (2) EP3472148B1 (pt)
JP (2) JP7073281B2 (pt)
KR (2) KR102463621B1 (pt)
CN (2) CN109963843B (pt)
AR (1) AR108838A1 (pt)
AU (2) AU2017281439B2 (pt)
BR (1) BR112018076558A2 (pt)
CA (1) CA3029202C (pt)
CL (1) CL2018003708A1 (pt)
CO (1) CO2019000471A2 (pt)
CY (2) CY1123443T1 (pt)
DK (2) DK3666771T3 (pt)
EA (1) EA037585B1 (pt)
ES (2) ES2895385T3 (pt)
HR (2) HRP20211708T8 (pt)
HU (2) HUE057211T2 (pt)
IL (1) IL263767B (pt)
LT (2) LT3666771T (pt)
ME (1) ME03804B (pt)
MX (1) MX2018015563A (pt)
MY (1) MY195782A (pt)
PE (1) PE20190211A1 (pt)
PL (2) PL3472148T3 (pt)
PT (2) PT3666771T (pt)
RS (2) RS62524B1 (pt)
SG (1) SG11201811321TA (pt)
SI (2) SI3472148T1 (pt)
TW (2) TWI725200B (pt)
UY (1) UY37302A (pt)
WO (1) WO2017223016A1 (pt)
ZA (1) ZA201808580B (pt)

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