CL2017000839A1 - Espiroindolinas para el tratamiento y profilaxis de infección por virus respiratorio sincitial (rsv) - Google Patents

Espiroindolinas para el tratamiento y profilaxis de infección por virus respiratorio sincitial (rsv)

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Publication number
CL2017000839A1
CL2017000839A1 CL2017000839A CL2017000839A CL2017000839A1 CL 2017000839 A1 CL2017000839 A1 CL 2017000839A1 CL 2017000839 A CL2017000839 A CL 2017000839A CL 2017000839 A CL2017000839 A CL 2017000839A CL 2017000839 A1 CL2017000839 A1 CL 2017000839A1
Authority
CL
Chile
Prior art keywords
rsv
spiroindolins
prophylaxis
treatment
alkenyl
Prior art date
Application number
CL2017000839A
Other languages
English (en)
Inventor
Stuart Cockerill
Neil Mathews
Simon Ward
Graham Lunn
Michael Paradowski
Simorte Jose Miguel Gascon
Original Assignee
Reviral Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51946966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000839(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Reviral Ltd filed Critical Reviral Ltd
Publication of CL2017000839A1 publication Critical patent/CL2017000839A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>Fórmula de Benzimidazoles (I):</p> <p>* incluir figura de estructura pagina 274,escrito 13-04-2017</p> <p>Fórmula (I):Donde: - uno de X e Y es un átomo de N o un átomo de C sustituido, y el otro es CH; - L es un enlace sencillo, alquileno C2-3, alquenileno C2-3 o alquinileno C2-3; - R 1 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo de 3 a 10 miembros, heterocíclico de 5 a 10 miembros o heteroarilo de 5 a 12 miembros, cada uno de los cuales está no sustituido o sustituido; - Z es halo, haloalquilo C1-6, nitro, -CN, -N(R2 )2, -OR2 , -SR2 , -S(=O)R2 o -S(=O)2R 2 - cada R2 es independientemente hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2- 6, en el que dichos grupos alquilo, alquenilo y alquinilo están no sustituido o sustituidos; y - m es 0 o 1; Y la sal farmacéuticamente aceptable de los mismos son inhibidores de RSV y por tanto pueden usarse para tratar o prevenir una infección por RSV.</p>
CL2017000839A 2014-10-07 2017-04-06 Espiroindolinas para el tratamiento y profilaxis de infección por virus respiratorio sincitial (rsv) CL2017000839A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1417707.5A GB201417707D0 (en) 2014-10-07 2014-10-07 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
CL2017000839A1 true CL2017000839A1 (es) 2017-10-13

Family

ID=51946966

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000839A CL2017000839A1 (es) 2014-10-07 2017-04-06 Espiroindolinas para el tratamiento y profilaxis de infección por virus respiratorio sincitial (rsv)

Country Status (30)

Country Link
US (1) US10106539B2 (es)
EP (1) EP3204375B1 (es)
JP (1) JP6695334B2 (es)
KR (2) KR102561796B1 (es)
CN (1) CN107108557B (es)
AR (1) AR102181A1 (es)
AU (1) AU2015329778B2 (es)
BR (1) BR112017007311B1 (es)
CA (1) CA2963740C (es)
CL (1) CL2017000839A1 (es)
CO (1) CO2017004603A2 (es)
CY (1) CY1121564T1 (es)
DK (1) DK3204375T3 (es)
ES (1) ES2718976T3 (es)
GB (1) GB201417707D0 (es)
HR (1) HRP20190808T1 (es)
HU (1) HUE043553T2 (es)
LT (1) LT3204375T (es)
MX (1) MX2017004425A (es)
NZ (1) NZ731323A (es)
PE (1) PE20170949A1 (es)
PL (1) PL3204375T3 (es)
PT (1) PT3204375T (es)
RS (1) RS58706B1 (es)
RU (1) RU2734248C2 (es)
SG (1) SG11201702766YA (es)
SI (1) SI3204375T1 (es)
TR (1) TR201903362T4 (es)
TW (1) TWI718107B (es)
WO (1) WO2016055780A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2821649T3 (es) * 2015-06-08 2021-04-27 Shangdong Danhong Pharmaceutical Co Ltd Método para preparar derivados de imidazol e intermedios de los mismos y formas cristalinas
PT3494110T (pt) 2016-08-04 2021-06-03 Reviral Ltd Derivados de pirimidina e sua utilização no tratamento ou prevenção de uma infeção pelo vírus sincicial respiratório
GB201711704D0 (en) 2017-07-20 2017-09-06 Reviral Ltd Pharmaceutical compounds
GB201721812D0 (en) * 2017-12-22 2018-02-07 Reviral Ltd Pharmaceutical compounds
CN116077494A (zh) * 2023-01-11 2023-05-09 黑龙江中医药大学 一种治疗呼吸道合胞病毒的药物组合物及其制备方法
WO2024174953A1 (zh) * 2023-02-21 2024-08-29 苏州隆博泰药业有限公司 苯并咪唑类衍生物及其医药用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102863A (en) * 1980-12-16 1982-06-26 Takeda Chem Ind Ltd Spiroindolinone and its preparation
RU2184735C2 (ru) * 1998-01-23 2002-07-10 Санкио Компани, Лимитед Производные спиропиперидина, лекарственное средство, способ профилактики или лечения
PT1196408E (pt) * 1999-06-28 2005-01-31 Janssen Pharmaceutica Nv Inibidores da replicacao do virus sincicial respiratorio
US6774134B2 (en) * 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
US7205328B2 (en) * 2002-10-21 2007-04-17 Irm Llc Oxindoles with anti-HIV activity
JO2355B1 (en) 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
EP1802637B1 (en) 2004-10-13 2008-10-15 Merck & Co., Inc. Cgrp receptor antagonists
WO2010103306A1 (en) 2009-03-10 2010-09-16 Astrazeneca Uk Limited Benzimidazole derivatives and their use as antivaral agents
GB201119538D0 (en) * 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
TWI598351B (zh) 2012-10-16 2017-09-11 健生科學愛爾蘭無限公司 Ｒｓｖ抗病毒化合物
CN105392787B (zh) * 2013-05-14 2017-11-24 豪夫迈·罗氏有限公司 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚
EP2997028A1 (en) * 2013-05-14 2016-03-23 F.Hoffmann-La Roche Ag Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
KR20160007629A (ko) * 2013-05-14 2016-01-20 에프. 호프만-라 로슈 아게 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌
CN105408330A (zh) * 2013-08-12 2016-03-16 豪夫迈·罗氏有限公司 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚
RU2016105970A (ru) * 2013-08-12 2017-09-19 Ф. Хоффманн-Ля Рош Аг Новые азаоксоиндолы для лечения и профилактики инфекции респираторного синцитиального вируса
KR20160030271A (ko) * 2013-08-12 2016-03-16 에프. 호프만-라 로슈 아게 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌
WO2015022301A1 (en) * 2013-08-15 2015-02-19 F. Hoffmann-La Roche Ag Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
KR20160030569A (ko) * 2013-08-15 2016-03-18 에프. 호프만-라 로슈 아게 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 신규한 아자-옥소-인돌
CN105431419A (zh) * 2013-08-15 2016-03-23 豪夫迈·罗氏有限公司 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚

Also Published As

Publication number Publication date
WO2016055780A1 (en) 2016-04-14
HUE043553T2 (hu) 2019-09-30
CA2963740A1 (en) 2016-04-14
PE20170949A1 (es) 2017-07-13
BR112017007311B1 (pt) 2022-11-22
KR102561796B1 (ko) 2023-07-31
CN107108557A (zh) 2017-08-29
GB201417707D0 (en) 2014-11-19
AU2015329778B2 (en) 2020-04-23
RS58706B1 (sr) 2019-06-28
HRP20190808T1 (hr) 2019-08-23
PT3204375T (pt) 2019-04-01
TWI718107B (zh) 2021-02-11
SI3204375T1 (sl) 2019-05-31
BR112017007311A2 (pt) 2017-12-19
CA2963740C (en) 2022-11-29
RU2017113026A3 (es) 2019-03-22
CO2017004603A2 (es) 2017-10-31
SG11201702766YA (en) 2017-05-30
KR20170066577A (ko) 2017-06-14
TW201625583A (zh) 2016-07-16
US20170305908A1 (en) 2017-10-26
US10106539B2 (en) 2018-10-23
LT3204375T (lt) 2019-05-10
CN107108557B (zh) 2020-11-10
ES2718976T3 (es) 2019-07-05
PL3204375T3 (pl) 2019-06-28
AU2015329778A1 (en) 2017-05-04
RU2017113026A (ru) 2018-11-13
TR201903362T4 (tr) 2019-04-22
EP3204375A1 (en) 2017-08-16
AR102181A1 (es) 2017-02-08
JP2017530992A (ja) 2017-10-19
KR20230116097A (ko) 2023-08-03
AU2015329778A8 (en) 2017-05-18
JP6695334B2 (ja) 2020-05-20
DK3204375T3 (en) 2019-04-01
MX2017004425A (es) 2017-10-11
RU2734248C2 (ru) 2020-10-13
NZ731323A (en) 2022-09-30
CY1121564T1 (el) 2020-05-29
EP3204375B1 (en) 2019-02-13

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