CY1120099T1 - Ενωσεις ν-πυρρολιδινυλ-, ν'-πυραζολυλ- ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης ως αναστολεις trka κινασης - Google Patents

Ενωσεις ν-πυρρολιδινυλ-, ν'-πυραζολυλ- ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης ως αναστολεις trka κινασης

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Publication number
CY1120099T1
CY1120099T1 CY20181100348T CY181100348T CY1120099T1 CY 1120099 T1 CY1120099 T1 CY 1120099T1 CY 20181100348 T CY20181100348 T CY 20181100348T CY 181100348 T CY181100348 T CY 181100348T CY 1120099 T1 CY1120099 T1 CY 1120099T1
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CY
Cyprus
Prior art keywords
compounds
thiuuria
pyrazylyl
kianogovanidine
uria
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CY20181100348T
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English (en)
Inventor
Shelley Allen
Barbara J. BRANDHUBER
Timothy Kercher
Gabrielle R. Kolakowski
Shannon L. WINSKI
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Array Biopharma, Inc.
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Publication of CY1120099T1 publication Critical patent/CY1120099T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Ενώσεις του Τύπου (I) ή στερεοϊσομερή, ταυτομερή ή φαρμακευτικά αποδεκτά άλατα ή προϊόντα επιδιαλύτωσης ή προφάρμακα αυτών, όπου τα R1, R2, Ra, Rb, Rc, Rd, Χ, ο Δακτύλιος Β και ο Δακτύλιος C είναι όπως ορίζεται εδώ και όπου ο Δακτύλιος Β και το τμήμα NH-C(=X)-NH βρίσκονται σε trans στερεοχημική διαμόρφωση, είναι αναστολείς της TrkA κινάσης και είναι χρήσιμες στην αγωγή νοσημάτων που μπορούν να υποβληθούν σε αγωγή με έναν αναστολέα TrkA κινάσης όπως πόνος, καρκίνος, φλεγμονή/φλεγμονώδη νοσήματα, νευροεκφυλιστικά νοσήματα, συγκεκριμένα μολυσματικά νοσήματα, σύνδρομο Sjogren, ενδομητρίωση, διαβητική περιφερική νευροπάθεια, προστατίτιδα ή σύνδρομο πυελικού πόνου.
CY20181100348T 2012-11-13 2018-03-27 Ενωσεις ν-πυρρολιδινυλ-, ν'-πυραζολυλ- ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης ως αναστολεις trka κινασης CY1120099T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261725913P 2012-11-13 2012-11-13
PCT/US2013/069729 WO2014078323A1 (en) 2012-11-13 2013-11-12 N-pyrrolidinyl, n'-pyrazolyl- urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors

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CY1120099T1 true CY1120099T1 (el) 2018-12-12

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US (2) US9896435B2 (el)
EP (2) EP3409670B1 (el)
JP (3) JP6316834B2 (el)
KR (1) KR102181915B1 (el)
CN (2) CN107857755B (el)
AU (2) AU2013344943B2 (el)
BR (1) BR112015010875B1 (el)
CA (1) CA2890876C (el)
CL (1) CL2015001261A1 (el)
CY (1) CY1120099T1 (el)
DK (1) DK2922844T3 (el)
ES (2) ES2834027T3 (el)
HK (1) HK1215438A1 (el)
HR (1) HRP20180331T1 (el)
HU (1) HUE038512T2 (el)
IL (1) IL238496B (el)
LT (1) LT2922844T (el)
ME (1) ME02990B (el)
MX (2) MX365733B (el)
MY (1) MY178262A (el)
NO (1) NO2876058T3 (el)
NZ (1) NZ708028A (el)
PH (1) PH12015500939A1 (el)
PL (1) PL2922844T3 (el)
PT (1) PT2922844T (el)
RS (1) RS57001B1 (el)
RU (1) RU2677667C2 (el)
SG (1) SG11201503728XA (el)
SI (1) SI2922844T1 (el)
UA (1) UA116455C2 (el)
WO (1) WO2014078323A1 (el)
ZA (1) ZA201503587B (el)

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