CY1118468T1 - Ενωσεις δικυκλικης ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης χρησιμες για την αγωγη του πονου - Google Patents
Ενωσεις δικυκλικης ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης χρησιμες για την αγωγη του πονουInfo
- Publication number
- CY1118468T1 CY1118468T1 CY20171100065T CY171100065T CY1118468T1 CY 1118468 T1 CY1118468 T1 CY 1118468T1 CY 20171100065 T CY20171100065 T CY 20171100065T CY 171100065 T CY171100065 T CY 171100065T CY 1118468 T1 CY1118468 T1 CY 1118468T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pain
- thiouria
- kianogovanidine
- cyclotic
- guanidine
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 210000002700 urine Anatomy 0.000 title 1
- 101150111783 NTRK1 gene Proteins 0.000 abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000021386 Sjogren Syndrome Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 201000007094 prostatitis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Ενώσεις του Τύπου I: ή στερεοϊσομερή, ταυτομερή ή φαρμακευτικά αποδεκτά άλατα, προϊόντα επιδιαλύτωσης ή προφάρμακα αυτών, όπου ο Δακτύλιος Α, Δακτύλιος C και Χ είναι όπως ορίζεται εδώ, είναι αναστολείς της κινάσης TrkA και είναι χρήσιμες εις την αγωγή νοσημάτων τα οποία μπορούν να υποβληθούν σε αγωγή με έναν αναστολέα κινάσης TrkA όπως πόνος, καρκίνος, φλεγμονή/φλεγμονώδη νοσήματα, νευροεκφυλιστικά νοσήματα, συγκεκριμένα μολυσματικά νοσήματα, σύνδρομο Sjogren, ενδομητρίωση, διαβητική περιφερική νευροπάθεια, προστατίτιδα και σύνδρομο πυελικού πόνου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201261725925P | 2012-11-13 | 2012-11-13 | |
PCT/US2013/069951 WO2014078454A1 (en) | 2012-11-13 | 2013-11-13 | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain |
Publications (1)
Publication Number | Publication Date |
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CY1118468T1 true CY1118468T1 (el) | 2017-07-12 |
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CY20171100065T CY1118468T1 (el) | 2012-11-13 | 2017-01-18 | Ενωσεις δικυκλικης ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης χρησιμες για την αγωγη του πονου |
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US (2) | US10351575B2 (el) |
EP (1) | EP2920166B1 (el) |
JP (2) | JP6345684B2 (el) |
KR (1) | KR102181913B1 (el) |
CN (1) | CN104903310B (el) |
AU (3) | AU2013344886B2 (el) |
BR (1) | BR112015011010B1 (el) |
CA (1) | CA2891334C (el) |
CL (1) | CL2015001282A1 (el) |
CR (1) | CR20150264A (el) |
CY (1) | CY1118468T1 (el) |
DK (1) | DK2920166T3 (el) |
ES (1) | ES2610975T3 (el) |
HK (1) | HK1215431A1 (el) |
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WO2014078417A1 (en) | 2012-11-13 | 2014-05-22 | Array Biopharma Inc. | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors |
HUE031557T2 (en) | 2012-11-13 | 2017-07-28 | Array Biopharma Inc | Bicyclic urea, thiourea, guanidine, and cyanoguadinine compounds used to treat pain |
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