CY1118468T1 - Ενωσεις δικυκλικης ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης χρησιμες για την αγωγη του πονου - Google Patents

Ενωσεις δικυκλικης ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης χρησιμες για την αγωγη του πονου

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Publication number
CY1118468T1
CY1118468T1 CY20171100065T CY171100065T CY1118468T1 CY 1118468 T1 CY1118468 T1 CY 1118468T1 CY 20171100065 T CY20171100065 T CY 20171100065T CY 171100065 T CY171100065 T CY 171100065T CY 1118468 T1 CY1118468 T1 CY 1118468T1
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CY
Cyprus
Prior art keywords
pain
thiouria
kianogovanidine
cyclotic
guanidine
Prior art date
Application number
CY20171100065T
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English (en)
Inventor
Shelley Allen
Steven Wade Andrews
James F Blake
Barbara J Brandhuber
Julia Haas
Yutong Jiang
Timothy Kercher
Gabrielle R Kolakowski
Allen A Thomas
Shannon L Winski
Original Assignee
Array Biopharma, Inc.
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Publication date
Application filed by Array Biopharma, Inc. filed Critical Array Biopharma, Inc.
Publication of CY1118468T1 publication Critical patent/CY1118468T1/el

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Abstract

Ενώσεις του Τύπου I: ή στερεοϊσομερή, ταυτομερή ή φαρμακευτικά αποδεκτά άλατα, προϊόντα επιδιαλύτωσης ή προφάρμακα αυτών, όπου ο Δακτύλιος Α, Δακτύλιος C και Χ είναι όπως ορίζεται εδώ, είναι αναστολείς της κινάσης TrkA και είναι χρήσιμες εις την αγωγή νοσημάτων τα οποία μπορούν να υποβληθούν σε αγωγή με έναν αναστολέα κινάσης TrkA όπως πόνος, καρκίνος, φλεγμονή/φλεγμονώδη νοσήματα, νευροεκφυλιστικά νοσήματα, συγκεκριμένα μολυσματικά νοσήματα, σύνδρομο Sjogren, ενδομητρίωση, διαβητική περιφερική νευροπάθεια, προστατίτιδα και σύνδρομο πυελικού πόνου.
CY20171100065T 2012-11-13 2017-01-18 Ενωσεις δικυκλικης ουριας, θειοουριας, γουανιδινης και κυανογουανιδινης χρησιμες για την αγωγη του πονου CY1118468T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261725925P 2012-11-13 2012-11-13
PCT/US2013/069951 WO2014078454A1 (en) 2012-11-13 2013-11-13 Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain

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CY1118468T1 true CY1118468T1 (el) 2017-07-12

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