CY1121384T1 - Συνδυαστικη θεραπεια για την αγωγη ανθεκτικων βακτηριακων λοιμωξεων - Google Patents
Συνδυαστικη θεραπεια για την αγωγη ανθεκτικων βακτηριακων λοιμωξεωνInfo
- Publication number
- CY1121384T1 CY1121384T1 CY20191100315T CY191100315T CY1121384T1 CY 1121384 T1 CY1121384 T1 CY 1121384T1 CY 20191100315 T CY20191100315 T CY 20191100315T CY 191100315 T CY191100315 T CY 191100315T CY 1121384 T1 CY1121384 T1 CY 1121384T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- bacterial infections
- pharmaceutically acceptable
- acceptable salt
- combination
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 238000011284 combination treatment Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 2
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 2
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 abstract 2
- 229960002182 imipenem Drugs 0.000 abstract 2
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 abstract 2
- 229940125904 compound 1 Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 abstract 1
- 229960005256 sulbactam Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση αφορά συνδυασμούς αναστολέα β-λακταμάσης με σουλβακτάμη και ενδεχομένως ιμιπενέμη/σιλαστατίνη. Οι συνδυασμοί είναι χρήσιμοι για την αγωγή βακτηριακών λοιμώξεων, όπου συμπεριλαμβάνονται λοιμώξεις οι οποίες οφείλονται σε οργανισμούς που είναι ανθεκτικοί σε δραστική ουσία, όπου συμπεριλαμβάνονται παθογόνα ανθεκτικά σε πολλές δραστικές ουσίες. Πλέον συγκεκριμένα, η εφεύρεση αφορά έναν συνδυασμό ένωσης 1 αναστολέα β-λακταμάσης: ή ενός φαρμακευτικά αποδεκτού άλατος αυτής, με σουλβακτάμη, ή ένα φαρμακευτικά αποδεκτό άλας αυτής, και, ενδεχομένως ιμιπενέμη/σιλαστατίνη, ή ένα φαρμακευτικά αποδεκτό άλας αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080667P | 2014-11-17 | 2014-11-17 | |
| PCT/US2015/061076 WO2016081452A1 (en) | 2014-11-17 | 2015-11-17 | Combination therapy for treatment of resistant bacterial infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121384T1 true CY1121384T1 (el) | 2020-05-29 |
Family
ID=54704148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100315T CY1121384T1 (el) | 2014-11-17 | 2019-03-18 | Συνδυαστικη θεραπεια για την αγωγη ανθεκτικων βακτηριακων λοιμωξεων |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US9968593B2 (el) |
| EP (1) | EP3221313B1 (el) |
| JP (1) | JP6764862B2 (el) |
| KR (1) | KR102542392B1 (el) |
| CN (1) | CN107108624B (el) |
| AU (1) | AU2015350128B2 (el) |
| BR (1) | BR112017010132B1 (el) |
| CA (1) | CA2966632C (el) |
| CY (1) | CY1121384T1 (el) |
| DK (1) | DK3221313T3 (el) |
| EA (1) | EA033829B1 (el) |
| ES (1) | ES2717776T3 (el) |
| HK (1) | HK1244798B (el) |
| HR (1) | HRP20190580T1 (el) |
| HU (1) | HUE044061T2 (el) |
| IL (1) | IL251979B (el) |
| LT (1) | LT3221313T (el) |
| ME (1) | ME03357B (el) |
| MX (1) | MX2017006383A (el) |
| MY (1) | MY196240A (el) |
| NZ (1) | NZ731601A (el) |
| PH (1) | PH12017500852A1 (el) |
| PL (1) | PL3221313T3 (el) |
| PT (1) | PT3221313T (el) |
| RS (1) | RS58429B1 (el) |
| SG (1) | SG11201703633TA (el) |
| SI (1) | SI3221313T1 (el) |
| TR (1) | TR201905233T4 (el) |
| TW (1) | TWI690317B (el) |
| WO (1) | WO2016081452A1 (el) |
| ZA (1) | ZA201703245B (el) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015350128B2 (en) | 2014-11-17 | 2019-05-16 | Entasis Therapeutics Limited | Combination therapy for treatment of resistant bacterial infections |
| WO2017203266A1 (en) * | 2016-05-25 | 2017-11-30 | Entasis Therapeutics Limited | Combination therapy for treatment of resistant bacterial infections |
| KR102537340B1 (ko) * | 2016-09-16 | 2023-05-26 | 엔타시스 테라퓨틱스 리미티드 | 베타-락타마제 억제제 화합물 |
| EP3301094A1 (en) * | 2016-09-30 | 2018-04-04 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EA202190617A3 (ru) * | 2017-02-08 | 2021-10-29 | Энтасис Терапеутикс Лимитед | Соединения-ингибиторы бета-лактамаз |
| PE20200333A1 (es) | 2017-05-08 | 2020-02-14 | Entasis Therapeutics Inc | Compuestos y metodos para tratar infecciones bacterianas |
| CN109422765B (zh) * | 2017-09-05 | 2020-08-28 | 香港理工大学深圳研究院 | C类β-内酰胺酶抑制剂及其制备方法和应用 |
| AU2019233613A1 (en) * | 2018-03-13 | 2020-10-29 | Sepsia Therapeutics, S.L. | Bacterial-binding peptides for treatment of infectious diseases and related inflammatory processes |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| CN111658642A (zh) * | 2019-03-05 | 2020-09-15 | 广州新创忆药物临床研究有限公司 | 一种治疗耐碳青霉烯类抗生素鲍曼不动杆菌感染的组合物 |
| TWI715397B (zh) * | 2019-12-31 | 2021-01-01 | 高雄榮民總醫院 | 根據領先標準將同儕數據繪製為圖表的方法、電腦程式產品及電腦可讀取媒體 |
| WO2021198715A1 (en) * | 2020-04-02 | 2021-10-07 | Glaxosmithkline Intellectual Property Development Limited | Regimen for treating a neisseria gonorrhoeae infection with gepotidacin |
| WO2022157259A1 (en) * | 2021-01-20 | 2022-07-28 | Entasis Therapeutics Limited | Fixed dosage antibiotic compositions |
| WO2023206580A1 (en) * | 2022-04-29 | 2023-11-02 | Entasis Therapeutics Limited | Durlobactam crystalline forms |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9408450A (pt) | 1993-12-29 | 1997-08-05 | Pfizer | Antagonistas da neuroquinina diazabiciclicos |
| FR2812635B1 (fr) | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| US7439253B2 (en) | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
| FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
| FR2914923B1 (fr) | 2007-04-12 | 2013-06-14 | Novexel | Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens. |
| MY162532A (en) * | 2008-01-18 | 2017-06-15 | Merck Sharp & Dohme | Beta-lactamase inhibitors |
| FR2930553B1 (fr) | 2008-04-29 | 2010-05-21 | Novexel | Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases |
| EP2921559A1 (en) | 2008-06-19 | 2015-09-23 | Astra Zeneca Holding France | Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1]octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases |
| FR2936798B1 (fr) | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| FR2937034B1 (fr) | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
| FR2936951B1 (fr) * | 2008-10-10 | 2010-12-03 | Novexel | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| EP2768503A1 (en) * | 2011-07-26 | 2014-08-27 | Wockhardt Limited | Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor |
| CA2842777C (en) | 2011-07-26 | 2015-12-29 | Wockhardt Limited | Pharmaceutical compositions comprising sulbactam and beta-lactamase inhibitor |
| BR112013028813B1 (pt) | 2011-08-27 | 2020-10-20 | Wockhardt Limited | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e composições farmacêuticas que os compreendem |
| CN103649088B (zh) | 2011-08-30 | 2016-05-11 | 沃克哈特有限公司 | 1, 6- 二氮杂双环[3, 2, 1]辛- 7- 酮衍生物及其在治疗细菌感染中的用途 |
| ES2640520T3 (es) | 2011-09-13 | 2017-11-03 | Wockhardt Limited | Compuestos que contienen nitrógeno y su uso |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| WO2013122888A2 (en) * | 2012-02-15 | 2013-08-22 | Rempex Pharmaceuticals, Inc. | Methods of treating bacterial infections |
| US8969570B2 (en) | 2012-03-30 | 2015-03-03 | Cubist Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| US8933233B2 (en) | 2012-03-30 | 2015-01-13 | Cubist Pharmaceuticals, Inc. | 1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors |
| US8916709B2 (en) | 2012-03-30 | 2014-12-23 | Cubist Pharmaceuticals, Inc. | 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors |
| KR20150003777A (ko) | 2012-03-30 | 2015-01-09 | 큐비스트 파마슈티컬즈 인코포레이티드 | 이속사졸 β-락타마제 억제제 |
| AR090539A1 (es) * | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| MX366948B (es) | 2012-05-30 | 2019-07-30 | Meiji Seika Pharma Co Ltd | Nuevo inhibidor de beta-lactamasa y proceso para prepararlo. |
| WO2014033560A1 (en) | 2012-08-25 | 2014-03-06 | Wockhardt Limited | 1,6- diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections |
| US20150258072A1 (en) * | 2012-09-03 | 2015-09-17 | Wockhardt Limited | Antibacterial compositions |
| MX2015010077A (es) | 2013-02-06 | 2016-01-25 | Astrazeneca Ab | Terapia de combinacion para el tratamiento de neumonia nosocomial. |
| WO2014141132A1 (en) * | 2013-03-14 | 2014-09-18 | Naeja Pharmaceutical Inc. | NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS |
| AU2015350128B2 (en) | 2014-11-17 | 2019-05-16 | Entasis Therapeutics Limited | Combination therapy for treatment of resistant bacterial infections |
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2015
- 2015-11-17 AU AU2015350128A patent/AU2015350128B2/en active Active
- 2015-11-17 PL PL15801091T patent/PL3221313T3/pl unknown
- 2015-11-17 US US15/527,091 patent/US9968593B2/en active Active
- 2015-11-17 DK DK15801091.8T patent/DK3221313T3/en active
- 2015-11-17 KR KR1020177016295A patent/KR102542392B1/ko active IP Right Grant
- 2015-11-17 EP EP15801091.8A patent/EP3221313B1/en active Active
- 2015-11-17 HU HUE15801091A patent/HUE044061T2/hu unknown
- 2015-11-17 RS RS20190328A patent/RS58429B1/sr unknown
- 2015-11-17 MY MYPI2017000670A patent/MY196240A/en unknown
- 2015-11-17 NZ NZ731601A patent/NZ731601A/en unknown
- 2015-11-17 LT LTEP15801091.8T patent/LT3221313T/lt unknown
- 2015-11-17 EA EA201791069A patent/EA033829B1/ru unknown
- 2015-11-17 TR TR2019/05233T patent/TR201905233T4/tr unknown
- 2015-11-17 SG SG11201703633TA patent/SG11201703633TA/en unknown
- 2015-11-17 CA CA2966632A patent/CA2966632C/en active Active
- 2015-11-17 ES ES15801091T patent/ES2717776T3/es active Active
- 2015-11-17 TW TW104137939A patent/TWI690317B/zh active
- 2015-11-17 MX MX2017006383A patent/MX2017006383A/es active IP Right Grant
- 2015-11-17 CN CN201580062519.5A patent/CN107108624B/zh active Active
- 2015-11-17 JP JP2017526516A patent/JP6764862B2/ja active Active
- 2015-11-17 PT PT15801091T patent/PT3221313T/pt unknown
- 2015-11-17 SI SI201530648T patent/SI3221313T1/sl unknown
- 2015-11-17 ME MEP-2019-80A patent/ME03357B/me unknown
- 2015-11-17 BR BR112017010132-7A patent/BR112017010132B1/pt active IP Right Grant
- 2015-11-17 WO PCT/US2015/061076 patent/WO2016081452A1/en active Application Filing
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2017
- 2017-04-27 IL IL251979A patent/IL251979B/en active IP Right Grant
- 2017-05-08 PH PH12017500852A patent/PH12017500852A1/en unknown
- 2017-05-10 ZA ZA2017/03245A patent/ZA201703245B/en unknown
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2018
- 2018-03-26 HK HK18104155.3A patent/HK1244798B/zh unknown
- 2018-04-09 US US15/947,959 patent/US10376499B2/en active Active
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2019
- 2019-03-18 CY CY20191100315T patent/CY1121384T1/el unknown
- 2019-03-25 HR HRP20190580TT patent/HRP20190580T1/hr unknown
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