CY1124368T1 - Μεθοδοι αυξησης της τονικης αναστολης και θεραπειας του συνδρομου angelman - Google Patents

Μεθοδοι αυξησης της τονικης αναστολης και θεραπειας του συνδρομου angelman

Info

Publication number
CY1124368T1
CY1124368T1 CY20211100510T CY211100510T CY1124368T1 CY 1124368 T1 CY1124368 T1 CY 1124368T1 CY 20211100510 T CY20211100510 T CY 20211100510T CY 211100510 T CY211100510 T CY 211100510T CY 1124368 T1 CY1124368 T1 CY 1124368T1
Authority
CY
Cyprus
Prior art keywords
treatment
methods
angelman syndrome
tonic inhibition
increasing tonic
Prior art date
Application number
CY20211100510T
Other languages
English (en)
Inventor
Matthew During
Original Assignee
Ovid Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ovid Therapeutics, Inc. filed Critical Ovid Therapeutics, Inc.
Publication of CY1124368T1 publication Critical patent/CY1124368T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

Η εφεύρεση αναφέρεται σε μια φαρμακευτική σύνθεση που περιλαμβάνει μια αποτελεσματική ποσότητα 4,5,6,7-τετραϋδροϊσοξαζολο(5,4-c)πυριδιν-3-όλης (ΤΗ IP) ή ένα φαρμακευτικώς αποτελεσματικό άλας αυτής και έναν φαρμακευτικά αποδεκτό φορέα ή έκδοχο για χρήση σε μια μέθοδο θεραπείας ενός ανθρώπινου υποκειμένου με σύνδρομο Angelman.
CY20211100510T 2014-06-06 2021-06-10 Μεθοδοι αυξησης της τονικης αναστολης και θεραπειας του συνδρομου angelman CY1124368T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462008939P 2014-06-06 2014-06-06
EP15803364.7A EP3151832B1 (en) 2014-06-06 2015-06-03 Methods of increasing tonic inhibition and treating secondary insomnia
PCT/US2015/034018 WO2015187851A1 (en) 2014-06-06 2015-06-03 Methods of increasing tonic inhibition and treating secondary insomnia

Publications (1)

Publication Number Publication Date
CY1124368T1 true CY1124368T1 (el) 2022-07-22

Family

ID=54767324

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20211100509T CY1124366T1 (el) 2014-06-06 2021-06-10 Μεθοδοι αυξησης τονικης αναστολης και θεραπειας της δευτερογενους αϋπνιας
CY20211100510T CY1124368T1 (el) 2014-06-06 2021-06-10 Μεθοδοι αυξησης της τονικης αναστολης και θεραπειας του συνδρομου angelman

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20211100509T CY1124366T1 (el) 2014-06-06 2021-06-10 Μεθοδοι αυξησης τονικης αναστολης και θεραπειας της δευτερογενους αϋπνιας

Country Status (19)

Country Link
US (10) US20150352085A1 (el)
EP (3) EP3151832B1 (el)
JP (4) JP2017516868A (el)
AR (1) AR100772A1 (el)
AU (4) AU2015269667B2 (el)
CA (1) CA2950845C (el)
CY (2) CY1124366T1 (el)
DK (2) DK3372229T3 (el)
ES (2) ES2875742T3 (el)
HR (2) HRP20210901T1 (el)
HU (2) HUE055155T2 (el)
IL (2) IL249287B (el)
LT (2) LT3372229T (el)
MX (2) MX2020012404A (el)
PL (2) PL3151832T3 (el)
PT (2) PT3372229T (el)
RS (2) RS62007B1 (el)
SI (2) SI3151832T1 (el)
WO (1) WO2015187851A1 (el)

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EP3151832B1 (en) 2014-06-06 2021-03-24 Ovid Therapeutics, Inc. Methods of increasing tonic inhibition and treating secondary insomnia
US10434308B2 (en) 2015-05-29 2019-10-08 Medtronic, Inc. Impedance matching and electrode conditioning in patient interface systems
US10080898B2 (en) 2015-05-29 2018-09-25 Medtronic, Inc. Simultaneous physiological sensing and stimulation with saturation detection
CA2992734A1 (en) * 2015-07-17 2017-01-26 Ovid Therapeutics, Inc. Methods of treating developmental disorders with gaboxadol
US9682069B2 (en) 2015-07-17 2017-06-20 Ovid Therapeutics Inc Methods of treating Dravet syndrome
WO2018017639A1 (en) * 2016-07-19 2018-01-25 Georgia State University Research Foundation Methods for treating rett syndrome
BR112019002538A2 (pt) 2016-08-11 2019-05-21 Ovid Therapeutics Inc. uso de uma composição farmacêutica compreendendo um modulador alostérico, uso de uma composição farmacêutica compreendendo garboxadol ou um sal farmaceuticamente aceitável do mesmo, e composição farmacêutica para a administração parenteral
AU2017363598A1 (en) * 2016-11-22 2019-05-23 Ovid Therapeutics Inc. Methods of treating developmental disorders and/or seizure disorders with flupirtine
US10071083B2 (en) * 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
US20180338959A1 (en) * 2017-05-24 2018-11-29 Ovid Therapeutics Inc. Treatment of depressive disorders
WO2019028234A1 (en) 2017-08-04 2019-02-07 Ovid Therapeutics Inc. USE OF GABOXADOL IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS
US11181384B2 (en) * 2018-07-23 2021-11-23 Waymo Llc Verifying map data using challenge questions
EP3833351A4 (en) 2018-09-20 2021-10-13 Ovid Therapeutics Inc. USE OF GABOXADOL TO TREAT TOURETTE SYNDROME, TICKS, AND STUTTERS
CA3120856A1 (en) * 2018-11-21 2020-05-28 Certego Therapeutics, Inc. Gaboxadol for reducing risk of suicide and rapid relief of depression
CA3123876A1 (en) 2018-12-17 2020-06-25 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
US20210015760A1 (en) * 2019-07-15 2021-01-21 Ovid Therapeutics Inc. Pharmaceutical formulations containing gaboxadol for therapeutic treatment
EP4051272A4 (en) 2019-12-18 2023-01-04 Ovid Therapeutics Inc. GABOXADOL FOR THE THERAPEUTIC TREATMENT OF 1p36 DELETION SYNDROME
JP2023526439A (ja) 2020-05-20 2023-06-21 セルテゴ セラピューティクス インコーポレイテッド 精神障害の処置のための環重水素化ガボキサドールおよびその使用

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Also Published As

Publication number Publication date
LT3151832T (lt) 2021-07-12
EP3151832A4 (en) 2018-01-17
AU2024202604A1 (en) 2024-05-09
IL249287B (en) 2021-03-25
ES2875742T3 (es) 2021-11-11
HUE055155T2 (hu) 2021-11-29
US20170071917A1 (en) 2017-03-16
US20150352085A1 (en) 2015-12-10
US9339495B2 (en) 2016-05-17
SI3151832T1 (sl) 2021-08-31
AR100772A1 (es) 2016-11-02
PT3372229T (pt) 2021-06-17
HRP20210902T1 (hr) 2021-09-17
US20220016091A1 (en) 2022-01-20
WO2015187851A1 (en) 2015-12-10
ES2876350T3 (es) 2021-11-12
EP3151832B1 (en) 2021-03-24
US20230051859A1 (en) 2023-02-16
DK3372229T3 (da) 2021-06-14
MX2016016136A (es) 2017-07-05
JP2017516868A (ja) 2017-06-22
EP3372229A1 (en) 2018-09-12
US20170273956A1 (en) 2017-09-28
US20180303805A1 (en) 2018-10-25
JP2021178836A (ja) 2021-11-18
EP3151832A1 (en) 2017-04-12
US20160038469A1 (en) 2016-02-11
US9446028B2 (en) 2016-09-20
US9801864B2 (en) 2017-10-31
LT3372229T (lt) 2021-07-12
DK3151832T3 (da) 2021-06-14
US20160228418A1 (en) 2016-08-11
MX2020012404A (es) 2022-04-11
RS62007B1 (sr) 2021-07-30
EP3372229B1 (en) 2021-03-24
US20170087133A1 (en) 2017-03-30
EP3795156A1 (en) 2021-03-24
US9744159B2 (en) 2017-08-29
PL3151832T3 (pl) 2021-10-25
US20180015076A1 (en) 2018-01-18
PT3151832T (pt) 2021-06-15
IL268960B (en) 2021-05-31
HUE055400T2 (hu) 2021-11-29
CA2950845A1 (en) 2015-12-10
US11278529B2 (en) 2022-03-22
RS62006B1 (sr) 2021-07-30
JP2020063264A (ja) 2020-04-23
CY1124366T1 (el) 2022-07-22
PL3372229T3 (pl) 2021-10-04
CA2950845C (en) 2023-04-25
AU2022200085A1 (en) 2022-02-03
IL249287A0 (en) 2017-02-28
AU2015269667B2 (en) 2020-07-30
AU2020217342A1 (en) 2020-08-27
HRP20210901T1 (hr) 2021-09-17
SI3372229T1 (sl) 2021-09-30
JP2023123442A (ja) 2023-09-05
AU2015269667A1 (en) 2016-12-22
AU2020217342B2 (en) 2021-10-07
IL268960A (en) 2019-10-31

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