BR112019002538A2 - uso de uma composição farmacêutica compreendendo um modulador alostérico, uso de uma composição farmacêutica compreendendo garboxadol ou um sal farmaceuticamente aceitável do mesmo, e composição farmacêutica para a administração parenteral - Google Patents
uso de uma composição farmacêutica compreendendo um modulador alostérico, uso de uma composição farmacêutica compreendendo garboxadol ou um sal farmaceuticamente aceitável do mesmo, e composição farmacêutica para a administração parenteralInfo
- Publication number
- BR112019002538A2 BR112019002538A2 BR112019002538-3A BR112019002538A BR112019002538A2 BR 112019002538 A2 BR112019002538 A2 BR 112019002538A2 BR 112019002538 A BR112019002538 A BR 112019002538A BR 112019002538 A2 BR112019002538 A2 BR 112019002538A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- garboxadol
- pharmaceutically acceptable
- acceptable salt
- parenteral administration
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 3
- 229940125516 allosteric modulator Drugs 0.000 title 1
- 238000007911 parenteral administration Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 abstract 1
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 230000001037 epileptic effect Effects 0.000 abstract 1
- 229950004346 gaboxadol Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
a presente invenção refere-se ao uso de moduladores alostéricos e/ou gaboxadol para o tratamento de distúrbios epiléticos em um indivíduo em necessidade dos mesmos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662373589P | 2016-08-11 | 2016-08-11 | |
US62/373,589 | 2016-08-11 | ||
US201762490293P | 2017-04-26 | 2017-04-26 | |
US62/490,293 | 2017-04-26 | ||
PCT/US2017/046256 WO2018031748A1 (en) | 2016-08-11 | 2017-08-10 | Methods and compositions for treatment of epileptic disorders |
Publications (1)
Publication Number | Publication Date |
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BR112019002538A2 true BR112019002538A2 (pt) | 2019-05-21 |
Family
ID=61159951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019002538-3A BR112019002538A2 (pt) | 2016-08-11 | 2017-08-10 | uso de uma composição farmacêutica compreendendo um modulador alostérico, uso de uma composição farmacêutica compreendendo garboxadol ou um sal farmaceuticamente aceitável do mesmo, e composição farmacêutica para a administração parenteral |
Country Status (12)
Country | Link |
---|---|
US (13) | US20180042903A1 (pt) |
EP (3) | EP4233861A3 (pt) |
JP (3) | JP2019524816A (pt) |
KR (2) | KR102518846B1 (pt) |
CN (1) | CN109715151A (pt) |
AU (2) | AU2017311412B2 (pt) |
BR (1) | BR112019002538A2 (pt) |
CA (1) | CA3032686A1 (pt) |
CO (1) | CO2019001193A2 (pt) |
IL (2) | IL264510A (pt) |
MX (2) | MX2019001669A (pt) |
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