MX2016016136A - Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. - Google Patents
Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario.Info
- Publication number
- MX2016016136A MX2016016136A MX2016016136A MX2016016136A MX2016016136A MX 2016016136 A MX2016016136 A MX 2016016136A MX 2016016136 A MX2016016136 A MX 2016016136A MX 2016016136 A MX2016016136 A MX 2016016136A MX 2016016136 A MX2016016136 A MX 2016016136A
- Authority
- MX
- Mexico
- Prior art keywords
- sleep
- subject
- increase
- methods
- reduce
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
Se describen métodos para incrementar la inhibición tónica en un sujeto en necesidad del mismo, por ejemplo, un sujeto con el síndrome Fragile X o el síndrome de Angelman. Los métodos para tratar insomnio secundario en un sujeto con un trastorno o desorden neurodegenerativo, también se describen. Los métodos pueden incluir administrar al sujeto una cantidad efectiva de 4,5,6,7-tetrahidroisoxazolo(5,4-c)piridina-3-ol (THIP) o un derivado de la misma, una sal farmacéuticamente aceptable de la misma, incrementar la inhibición tónica en neuronas del sujeto, para incrementar el sueño de onda lenta (SWS), y/o la actividad de onda lenta (SWA), normalizar la arquitectura del sueño, reducir el insomnio secundario, incrementar el sueño paradójico (NREM), incrementar la continuidad del sueño, mejorar la actividad delta dentro de NREM, incrementar o mejorar el tiempo total del sueño (TST), incrementar o mejorar la eficiencia del sueño, reducir el tiempo total despierto (TAA), reducir el número de despertamientos (NWA), reducir la latencia del sueño persistente (LPS) o reducir los despertamiento después de conciliar el sueño (WASO) en el sujeto, o cualquier combinación de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462008939P | 2014-06-06 | 2014-06-06 | |
PCT/US2015/034018 WO2015187851A1 (en) | 2014-06-06 | 2015-06-03 | Methods of increasing tonic inhibition and treating secondary insomnia |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016016136A true MX2016016136A (es) | 2017-07-05 |
Family
ID=54767324
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020012404A MX2020012404A (es) | 2014-06-06 | 2015-06-03 | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. |
MX2016016136A MX2016016136A (es) | 2014-06-06 | 2015-06-03 | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020012404A MX2020012404A (es) | 2014-06-06 | 2015-06-03 | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. |
Country Status (19)
Country | Link |
---|---|
US (10) | US20150352085A1 (es) |
EP (3) | EP3151832B1 (es) |
JP (4) | JP2017516868A (es) |
AR (1) | AR100772A1 (es) |
AU (4) | AU2015269667B2 (es) |
CA (1) | CA2950845C (es) |
CY (2) | CY1124368T1 (es) |
DK (2) | DK3151832T3 (es) |
ES (2) | ES2876350T3 (es) |
HR (2) | HRP20210902T1 (es) |
HU (2) | HUE055400T2 (es) |
IL (2) | IL249287B (es) |
LT (2) | LT3151832T (es) |
MX (2) | MX2020012404A (es) |
PL (2) | PL3372229T3 (es) |
PT (2) | PT3372229T (es) |
RS (2) | RS62007B1 (es) |
SI (2) | SI3372229T1 (es) |
WO (1) | WO2015187851A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2020012404A (es) * | 2014-06-06 | 2022-04-11 | Ovid Therapeutics Inc | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. |
US10080898B2 (en) * | 2015-05-29 | 2018-09-25 | Medtronic, Inc. | Simultaneous physiological sensing and stimulation with saturation detection |
US10434308B2 (en) | 2015-05-29 | 2019-10-08 | Medtronic, Inc. | Impedance matching and electrode conditioning in patient interface systems |
CN116531370A (zh) * | 2015-07-17 | 2023-08-04 | 奥维德医疗公司 | 用加波沙朵治疗发育障碍的方法 |
US9682069B2 (en) | 2015-07-17 | 2017-06-20 | Ovid Therapeutics Inc | Methods of treating Dravet syndrome |
WO2018017639A1 (en) * | 2016-07-19 | 2018-01-25 | Georgia State University Research Foundation | Methods for treating rett syndrome |
WO2018031748A1 (en) | 2016-08-11 | 2018-02-15 | Ovid Therapeutics Inc. | Methods and compositions for treatment of epileptic disorders |
JP2019535760A (ja) * | 2016-11-22 | 2019-12-12 | オービッド・セラピューティクス・インコーポレイテッドOvid Therapeutics Inc. | フルピルチンを用いた発達障害および/または発作性障害の処置方法 |
US10071083B2 (en) * | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
CA3071939A1 (en) | 2017-08-04 | 2019-02-07 | Ovid Therapeutics Inc. | Use of gaboxadol in the treatment of diabetes and related conditions |
US11181384B2 (en) * | 2018-07-23 | 2021-11-23 | Waymo Llc | Verifying map data using challenge questions |
JP2022501384A (ja) | 2018-09-20 | 2022-01-06 | オービッド・セラピューティクス・インコーポレイテッドOvid Therapeutics Inc. | トゥレット症候群、チックおよび吃音の処置のためのガボキサドールの使用 |
GB2594616A (en) | 2018-11-21 | 2021-11-03 | Certego Therapeutics Inc | Gaboxadol for reducing risk of suicide and rapid relief of depression |
US11690829B2 (en) | 2018-12-17 | 2023-07-04 | Ovid Therapeutics Inc. | Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder |
US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
CA3146737A1 (en) * | 2019-07-15 | 2021-01-21 | Ovid Therapeutics Inc. | Pharmaceutical formulations containing gaboxadol for therapeutic treatment |
CN114786669A (zh) * | 2019-12-18 | 2022-07-22 | 奥维德医疗公司 | 用于1p36缺失综合征的治疗性治疗的加波沙朵 |
CN116267014A (zh) | 2020-05-20 | 2023-06-20 | Certego治疗公司 | 环状氘化加波沙朵及其用于治疗精神障碍的用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
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DK270378A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Isoxazolderivater |
US4362731A (en) | 1980-09-01 | 1982-12-07 | Sandoz Ltd. | Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof |
US4353910A (en) | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
DE19526864A1 (de) | 1995-07-22 | 1997-01-23 | Labtec Gmbh | Hormonpflaster |
US6461644B1 (en) | 1996-03-25 | 2002-10-08 | Richard R. Jackson | Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods |
US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
US6676961B1 (en) | 2002-03-06 | 2004-01-13 | Automated Carrier Technologies, Inc. | Transdermal patch assembly |
US20050137222A1 (en) * | 2003-12-18 | 2005-06-23 | H. Lundbeck A/S | Treatment of insomnia in human patients |
JP2007530604A (ja) | 2004-04-02 | 2007-11-01 | ハー・ルンドベック・アクチエゼルスカベット | 呼吸機能障害の治療 |
DE102005020882A1 (de) * | 2005-05-04 | 2006-11-09 | Dömling, Alexander, Dr. | Verwendung von Gaboxadol und Derivaten zur Behandlung von Kinase-induzierten Krankheiten |
US20110046090A1 (en) * | 2005-10-31 | 2011-02-24 | Braincells Inc. | Modulation of neurogenesis with gaba agents and gaba analogs |
US20090143335A1 (en) | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
CA2705733C (en) | 2007-11-13 | 2015-02-03 | Cadence Pharmaceuticals | Reduced dose intravenous acetaminophen |
EP2334299A1 (en) * | 2008-09-01 | 2011-06-22 | H. Lundbeck A/S | Pharmaceutical composition comprising gaboxadol and an inhibitor of patl or oat |
MX2020012404A (es) | 2014-06-06 | 2022-04-11 | Ovid Therapeutics Inc | Metodos para incrementar la inhibicion tonica y para tratar insomnio secundario. |
CN116531370A (zh) * | 2015-07-17 | 2023-08-04 | 奥维德医疗公司 | 用加波沙朵治疗发育障碍的方法 |
US9399034B1 (en) | 2015-08-11 | 2016-07-26 | Ovid Therapeutics Inc | Methods of sedation during critical care treatment |
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2015
- 2015-06-03 MX MX2020012404A patent/MX2020012404A/es unknown
- 2015-06-03 LT LTEP15803364.7T patent/LT3151832T/lt unknown
- 2015-06-03 SI SI201531620T patent/SI3372229T1/sl unknown
- 2015-06-03 ES ES15803364T patent/ES2876350T3/es active Active
- 2015-06-03 HU HUE18169211A patent/HUE055400T2/hu unknown
- 2015-06-03 RS RS20210718A patent/RS62007B1/sr unknown
- 2015-06-03 SI SI201531616T patent/SI3151832T1/sl unknown
- 2015-06-03 AU AU2015269667A patent/AU2015269667B2/en active Active
- 2015-06-03 EP EP15803364.7A patent/EP3151832B1/en active Active
- 2015-06-03 LT LTEP18169211.2T patent/LT3372229T/lt unknown
- 2015-06-03 JP JP2017516256A patent/JP2017516868A/ja not_active Withdrawn
- 2015-06-03 MX MX2016016136A patent/MX2016016136A/es unknown
- 2015-06-03 PL PL18169211T patent/PL3372229T3/pl unknown
- 2015-06-03 PT PT181692112T patent/PT3372229T/pt unknown
- 2015-06-03 PL PL15803364T patent/PL3151832T3/pl unknown
- 2015-06-03 HU HUE15803364A patent/HUE055155T2/hu unknown
- 2015-06-03 PT PT158033647T patent/PT3151832T/pt unknown
- 2015-06-03 RS RS20210711A patent/RS62006B1/sr unknown
- 2015-06-03 CA CA2950845A patent/CA2950845C/en active Active
- 2015-06-03 EP EP18169211.2A patent/EP3372229B1/en active Active
- 2015-06-03 ES ES18169211T patent/ES2875742T3/es active Active
- 2015-06-03 WO PCT/US2015/034018 patent/WO2015187851A1/en active Application Filing
- 2015-06-03 DK DK15803364.7T patent/DK3151832T3/da active
- 2015-06-03 EP EP20204995.3A patent/EP3795156A1/en active Pending
- 2015-06-03 US US14/729,910 patent/US20150352085A1/en not_active Abandoned
- 2015-06-03 DK DK18169211.2T patent/DK3372229T3/da active
- 2015-06-05 AR ARP150101808A patent/AR100772A1/es not_active Application Discontinuation
- 2015-10-19 US US14/886,764 patent/US9339495B2/en active Active
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2016
- 2016-04-19 US US15/132,641 patent/US9446028B2/en active Active
- 2016-11-04 US US15/343,690 patent/US9744159B2/en active Active
- 2016-11-29 IL IL249287A patent/IL249287B/en active IP Right Grant
- 2016-12-12 US US15/375,735 patent/US9801864B2/en active Active
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2017
- 2017-06-09 US US15/618,736 patent/US20170273956A1/en not_active Abandoned
- 2017-09-27 US US15/716,726 patent/US20180015076A1/en not_active Abandoned
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2018
- 2018-06-29 US US16/023,282 patent/US11278529B2/en active Active
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2019
- 2019-08-27 IL IL268960A patent/IL268960B/en active IP Right Grant
- 2019-11-29 JP JP2019217208A patent/JP2020063264A/ja not_active Withdrawn
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2020
- 2020-08-11 AU AU2020217342A patent/AU2020217342B2/en active Active
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2021
- 2021-06-07 HR HRP20210902TT patent/HRP20210902T1/hr unknown
- 2021-06-07 HR HRP20210901TT patent/HRP20210901T1/hr unknown
- 2021-06-10 CY CY20211100510T patent/CY1124368T1/el unknown
- 2021-06-10 CY CY20211100509T patent/CY1124366T1/el unknown
- 2021-07-15 JP JP2021116935A patent/JP2021178836A/ja active Pending
- 2021-09-30 US US17/490,650 patent/US20220016091A1/en not_active Abandoned
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2022
- 2022-01-07 AU AU2022200085A patent/AU2022200085A1/en not_active Abandoned
- 2022-08-08 US US17/882,939 patent/US20230051859A1/en active Pending
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2023
- 2023-05-30 JP JP2023088456A patent/JP2023123442A/ja active Pending
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2024
- 2024-04-22 AU AU2024202604A patent/AU2024202604A1/en active Pending
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