CY1118954T1 - Βιοσυμβατο και βιοδιασπωμενο συστημα στιβαδων βαθμιδωσης για την αναγεννητικη ιατρικη και την υποστηριξη των ιστων - Google Patents

Βιοσυμβατο και βιοδιασπωμενο συστημα στιβαδων βαθμιδωσης για την αναγεννητικη ιατρικη και την υποστηριξη των ιστων

Info

Publication number
CY1118954T1
CY1118954T1 CY20171100401T CY171100401T CY1118954T1 CY 1118954 T1 CY1118954 T1 CY 1118954T1 CY 20171100401 T CY20171100401 T CY 20171100401T CY 171100401 T CY171100401 T CY 171100401T CY 1118954 T1 CY1118954 T1 CY 1118954T1
Authority
CY
Cyprus
Prior art keywords
biocompatible
layers
biodegradable
preferably biodegradable
medicine
Prior art date
Application number
CY20171100401T
Other languages
English (en)
Inventor
Thorsten Steinberg
Pascal Tomakidi
Simon Schulz
Marco Angarano
ROLF MüLHAUPT
Martin Fabritius
Original Assignee
Universitätsklinikum Freiburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitätsklinikum Freiburg filed Critical Universitätsklinikum Freiburg
Publication of CY1118954T1 publication Critical patent/CY1118954T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0095—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Abstract

Η παρούσα εφεύρεση κατευθύνεται προς ένα βιοσυμβατό και κατά προτίμηση βιοδιασπώμενο σύστημα στιβάδων βαθμίδωσης που αποτελείται τουλάχιστον από ένα σύνολο στιβάδων, που αποτελούνται από ένα βιοσυμβατό και κατά προτίμηση βιοδιασπώμενο διασταυρωμένο πολυμερές και από τουλάχιστον μία βιοσυμβατή και κατά προτίμηση βιοδιασπώμενη στιβάδα υποστήριξης, όπου μία βαθμίδωση σχηματίζεται κατά προτίμηση αντίστοιχα με τις μηχανικές και/ή φυσικές ιδιότητες μίας ή περισσοτέρων στιβάδων από τουλάχιστον ένα σύνολο στιβάδων που αποτελούνται από ένα βιοσυμβατό και βιοδιασπώμενο διασταυρωμένο πολυμερές και/ή τουλάχιστον από μία βιοσυμβατή και κατά προτίμηση βιοδιασπώμενη στιβάδα υποστήριξης. Η τουλάχιστον μία στιβάδα υποστήριξης αποτελείται κατά προτίμηση από ένα βιοσυμβατό και κατά προτίμηση βιοδιασπόμενο εύτηκτο πολυμερές και/ή ένα βιοσυμβατό και ενσωματώσιμο υλικό. Αυτό το βιοσυμβατό και κατά προτίμηση βιοδιασπώμενο σύστημα στιβάδων βαθμίδωσης μπορεί να χρησιμοποιηθεί ως βιοϋλικό για την αναγεννητική ιατρική, ιδιαίτερα ως επίδεσμος τραύματος ή για την υποστήριξη ιστών. Η παρούσα εφεύρεση παρέχει επίσης μέσα που χρησιμοποιούν το εν λόγω πρωτότυπο σύστημα στιβάδων βαθμίδωσης και μεθόδους για την παραγωγή αυτών.
CY20171100401T 2011-04-05 2017-04-04 Βιοσυμβατο και βιοδιασπωμενο συστημα στιβαδων βαθμιδωσης για την αναγεννητικη ιατρικη και την υποστηριξη των ιστων CY1118954T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11002836A EP2508212A1 (en) 2011-04-05 2011-04-05 Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support
PCT/EP2012/056155 WO2012136701A1 (en) 2011-04-05 2012-04-04 Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support
EP12715344.3A EP2694124B1 (en) 2011-04-05 2012-04-04 Biocompatible and biodegradable gradient layer system for regenerative medicine and for tissue support

Publications (1)

Publication Number Publication Date
CY1118954T1 true CY1118954T1 (el) 2018-01-10

Family

ID=44343096

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100401T CY1118954T1 (el) 2011-04-05 2017-04-04 Βιοσυμβατο και βιοδιασπωμενο συστημα στιβαδων βαθμιδωσης για την αναγεννητικη ιατρικη και την υποστηριξη των ιστων

Country Status (13)

Country Link
US (1) US9937278B2 (el)
EP (2) EP2508212A1 (el)
JP (1) JP2014514942A (el)
CN (1) CN103648536B9 (el)
CY (1) CY1118954T1 (el)
DK (1) DK2694124T3 (el)
ES (1) ES2621414T3 (el)
HR (1) HRP20170550T1 (el)
LT (1) LT2694124T (el)
PL (1) PL2694124T3 (el)
PT (1) PT2694124T (el)
SI (1) SI2694124T1 (el)
WO (1) WO2012136701A1 (el)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9358320B2 (en) 2008-04-25 2016-06-07 Allosource Multi-layer tissue patches
US8933145B2 (en) 2009-02-20 2015-01-13 The General Hospital Corporation High temperature melting
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
DE102012002209A1 (de) * 2012-02-07 2013-08-08 Carl Freudenberg Kg Biodegradierbares Vlies für medizinische Zwecke
PT2911676T (pt) 2012-10-29 2020-08-05 Univ Arkansas Adjuvantes das mucosas e sistemas de administração inovadores
JP6502857B2 (ja) 2013-01-14 2019-04-17 スクリップス ヘルス 組織アレイプリンティング
AU2014248873B2 (en) 2013-03-13 2017-03-23 Allosource Fascia fibrous compositions and methods for their use and manufacture
EP2970882B1 (en) 2013-03-15 2018-11-28 AlloSource Cell repopulated collagen matrix for soft tissue repair and regeneration
EP2999491B1 (en) 2013-05-22 2020-03-18 The Penn State Research Foundation Wound dressings and applications thereof
CN103285429A (zh) * 2013-05-28 2013-09-11 上海交通大学医学院附属第九人民医院 一种组织工程关节双相支架及其制备方法和应用
CN103342014B (zh) * 2013-07-12 2015-08-05 华东理工大学 可控生物降解的plga内孔梯度膜及其制备工艺
US10092679B2 (en) 2013-10-18 2018-10-09 Wake Forest University Health Sciences Laminous vascular constructs combining cell sheet engineering and electrospinning technologies
CN103600521B (zh) * 2013-11-15 2015-07-15 无锡中科光远生物材料有限公司 一种性能可控的胶原纳米纤维无纺布制备方法
KR101832203B1 (ko) 2013-12-06 2018-02-27 알로소스 조직의 시트를 건조하는 방법
US11497830B2 (en) 2014-03-14 2022-11-15 Scripps Health Electrospinning of cartilage and meniscus matrix polymers
CN103861147B (zh) * 2014-03-27 2015-10-28 杭州市第三人民医院 一种基于纳米纤维支架的人体黑素细胞的培养方法
CN104258372B (zh) * 2014-09-25 2017-01-25 中山大学 Rgd三肽在制备治疗阿尔茨海默症药物中的用途
CN104524640B (zh) * 2014-12-15 2016-06-29 四川大学 一种用于人工皮肤的梯度孔结构多孔聚氨酯薄膜及其制备方法
US20170360988A1 (en) * 2014-12-19 2017-12-21 Angiocrine Bioscience, Inc. Biocompatible implants comprising engineered endothelial cells
EP3244831B1 (en) 2015-01-12 2024-03-06 Wake Forest University Health Sciences Multi-layer skin substitute products and methods of making and using the same
CN104548201B (zh) * 2015-01-22 2016-10-05 华南理工大学 一种角膜组织修复材料及其制备方法
KR102331359B1 (ko) * 2015-01-26 2021-11-26 주식회사 메타바이오메드 폴리락트산계 봉합사 앵커 및 이의 제조방법
EP3250678A4 (en) 2015-01-30 2018-08-01 The University of North Carolina at Chapel Hill Methods to generate gastrointestinal epithelial tissue constructs
US20180147318A1 (en) * 2015-05-18 2018-05-31 Juana Mendenhall Injectable Therapeutic Biocompatible Co-Polymers and Methods of Making and Using Same
CN106244548B (zh) * 2015-06-09 2019-07-05 成都中医药大学 木犀草素在诱导间充质干细胞向神经细胞定向分化中的用途
EP3319779A4 (en) * 2015-07-07 2019-02-27 Singapore Health Services Pte Ltd POLYMER PRODUCT AND ITS MANUFACTURE
US20180228599A1 (en) * 2015-08-06 2018-08-16 The Johns Hopkins University Tissue-derived scaffolds for corneal reconstruction
WO2017059866A2 (en) * 2015-10-09 2017-04-13 Syddansk Universitet Feedstock for 3d printing and uses thereof
RU2603717C1 (ru) * 2015-10-13 2016-11-27 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") СПОСОБ ОЦЕНКИ БИОИНЕРТНОСТИ МЕДИЦИНСКИХ ИМПЛАНТОВ in vivo
EP3175869A1 (en) * 2015-12-04 2017-06-07 Geistlich Pharma AG Resorbable crosslinked formstable membrane
US11583613B2 (en) * 2016-03-03 2023-02-21 University of Pittsburgh—of the Commonwealth System of Higher Education Hydrogel systems for skeletal interfacial tissue regeneration applied to epiphyseal growth plate repair
CN107224613A (zh) * 2016-03-23 2017-10-03 北京泰盛生物科技有限公司 牙源性间充质干细胞实现软骨再生的方法
EP3438264A1 (en) * 2016-03-31 2019-02-06 Ajinomoto Co., Inc. Fibroin-like protein variant and cell culture method
CN105696195A (zh) * 2016-04-05 2016-06-22 东华大学 一种鼠尾草酚和壳聚糖复合纳米纤维毡的制备方法
CN105696194A (zh) * 2016-04-05 2016-06-22 东华大学 一种鼠尾草酚和壳聚糖自组装芯鞘纳米纤维毡的制备方法
KR101710639B1 (ko) * 2016-06-07 2017-03-08 주식회사 파마리서치프로덕트 핵산, 키토산 및 히알루론산을 포함하는 조직 증강용 충전 조성물 및 이의 제조방법
WO2018006037A1 (en) * 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
US10537417B2 (en) * 2016-07-07 2020-01-21 Collagen Matrix, Inc. Density gradient biopolymeric matrix implants
EP3491122A4 (en) * 2016-07-27 2020-04-08 The University of North Carolina at Chapel Hill METHODS FOR GENERATING POLYMERIC SCAFFOLDS HAVING A GRADIENT OF CROSSLINKING DENSITY
AU2017396754B2 (en) 2016-11-03 2021-08-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
CA3042866A1 (en) 2016-11-03 2018-05-11 Klearchos K. Papas Encapsulation device systems with oxygen sensors with or without exogenous oxygen delivery
CN106620860A (zh) * 2016-11-24 2017-05-10 河北医科大学第三医院 制备plga‑镁混合物的方法及制作骨科内植物的方法
CN106540330A (zh) * 2016-11-24 2017-03-29 河北医科大学第三医院 Plga‑镁混合物的制备方法及制作骨科内植物的方法
WO2018107243A1 (en) * 2016-12-16 2018-06-21 Field Orthopaedics Pty Ltd A medical implant and a method of coating a medical implant
CN106823006A (zh) * 2017-01-09 2017-06-13 中关村竞成细胞及组织工程研究院 用于髌骨修复的组织工程骨支架及其制备方法
GB201700368D0 (en) * 2017-01-10 2017-02-22 ECOLE POLYTECHNIQUE FéDéRALE DE LAUSANNE Cryogel 3D scaffolds and methods for producing thereof
US10772986B2 (en) 2017-01-26 2020-09-15 Allosource Fascia fibrous compositions and methods for their use and manufacture
CA3053898A1 (en) 2017-02-17 2018-08-23 The Research Foundation For The State University Of New York High-flux thin-film nanocomposite reverse osmosis membrane for desalination
CN107007879A (zh) * 2017-03-14 2017-08-04 暨南大学 一种活性人工角膜及其制备方法
CA3063847A1 (en) 2017-05-16 2018-11-22 Embody Inc. Biopolymer compositions, scaffolds and devices
CN107456608A (zh) * 2017-07-27 2017-12-12 中山大学附属第医院 一种三维多孔结构的人工皮肤及制备方法
WO2019042261A1 (zh) * 2017-08-28 2019-03-07 武汉杨森生物技术有限公司 复合肝素抗凝涂层液、涂层用微球及制备方法与应用
JP2021500160A (ja) 2017-10-24 2021-01-07 エムボディ インコーポレイテッド 生体高分子足場移植片およびその生成のための方法
CN107596448B (zh) * 2017-11-14 2020-06-05 四川大学 可梯度降解的生物膜支架材料及其制备方法
CN107899080A (zh) * 2017-11-30 2018-04-13 振德医疗用品股份有限公司 一种真皮修复支架制备方法
CN108014371A (zh) * 2017-12-29 2018-05-11 上海纽脉医疗科技有限公司 一种可再生心脏瓣膜及其制备装置、方法
US20210162095A1 (en) * 2018-02-15 2021-06-03 Biom'up France SAS Multi-dimensional hemostatic product and method for producing the same
US11944723B2 (en) 2018-03-13 2024-04-02 Institut Quimic De Sarria Cets Fundacio Privada Vascular repair patch
SG11202102910VA (en) * 2018-09-24 2021-04-29 Procyon Tech Llc Methods and systems for implantable medical devices and vascularization membranes
CN109276755B (zh) * 2018-10-11 2021-04-20 山东大学齐鲁医院(青岛) 基于自组装纳米多肽和干细胞的3d打印组织工程血管及其制备方法
CN110859997B (zh) * 2018-12-20 2020-06-23 四川大学 具有成骨-抗炎-血糖三维响应结构的牙种植体及其制备方法
JP2022524714A (ja) 2019-02-01 2022-05-10 エンボディ，インコーポレイテッド マイクロフルイディック押出
CN109735819B (zh) * 2019-03-14 2020-01-31 西南交通大学 具有NO催化释放与EPCs捕获功能的生物材料及其制备方法
WO2020198246A1 (en) * 2019-03-26 2020-10-01 The General Hospital Corporation Anti-microbial methods and materials
CN110115645A (zh) * 2019-04-18 2019-08-13 新疆医科大学第一附属医院 多通道人工神经导管及其制备方法
CN110124107B (zh) * 2019-04-23 2021-07-09 哈尔滨医科大学 一种用于关节软骨修复的plga细胞支架及其制备方法和应用
CN110105730B (zh) * 2019-04-30 2021-07-13 大川(清新)塑料制品有限公司 一种复合高强型聚乳酸梯度膜材料的制备方法
US20220241204A1 (en) * 2019-06-07 2022-08-04 Diomics Corporation Topical time release delivery using layered biopolymer
WO2021006426A1 (ko) * 2019-07-09 2021-01-14 연세대학교 산학협력단 생체모사 조직 접착성 하이드로젤 패치 및 이의 용도
WO2021030621A1 (en) * 2019-08-14 2021-02-18 The Regents Of The University Of Colorado, A Body Corporate Polyurethane-reinforced hydrogel cardiac patch
CN110433335B (zh) * 2019-08-19 2021-12-03 江苏地韵医疗科技有限公司 梯度密度型软骨修复用水凝胶及其制备方法
US20220389355A1 (en) * 2019-11-21 2022-12-08 The Japan Wool Textile Co., Ltd. Cell aggregate, producing method for manufacturing cell aggregate, producing kit for cell aggregate, and chemical compound evaluating method using cell aggregate
JP7267172B2 (ja) * 2019-11-21 2023-05-01 日本毛織株式会社 細胞培養用立体足場、その製造方法、それを用いた細胞播種方法及び細胞培養方法
CN111110922B (zh) * 2019-12-25 2020-10-27 四川大学 一种用于3d生物打印的牙周生物模块及构建方法及应用
WO2021162529A1 (ko) * 2020-02-14 2021-08-19 연세대학교 산학협력단 페놀 유도체가 수식된 콘드로이틴 설페이트 하이드로젤 및 이의 용도
US20210252185A1 (en) * 2020-02-18 2021-08-19 Ethicon, Inc. Melt Blown Dressing with Gradient Density
CN111298192B (zh) * 2020-03-06 2021-11-16 华中科技大学同济医学院附属协和医院 一种用于皮肤和黏膜破损部位的防护性修复水凝胶及其制备方法
CN111481733B (zh) * 2020-04-22 2022-04-26 欣乐加生物科技温州有限公司 一种生物医药创面敷料
CN111803709A (zh) * 2020-06-24 2020-10-23 湖北中部医疗科技有限公司 一种人工皮肤及其制备方法
JP7433692B2 (ja) * 2020-10-06 2024-02-20 テンシブ ソシエタ・ア・レスポンサビリタ・リミタータ 異物反応が低減された三次元埋入型マトリックス
CN116802289A (zh) * 2020-10-15 2023-09-22 东北大学 用于增加胶原蛋白产量的工程化细胞
CN112406095B (zh) * 2020-11-05 2021-09-28 三阳纺织有限公司 一种具有抗菌功能的织物及其快速成形方法
CN113041396B (zh) * 2021-03-08 2021-11-30 四川大学 一种空隙梯度结构支架材料的制备方法
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE
CZ35836U1 (cs) 2021-09-10 2022-03-08 Contipro A.S. Kompozitní kryt obsahující nanovlákennou aktivní vrstvu
CN113999630B (zh) * 2021-09-24 2023-11-28 广东省科学院健康医学研究所 一种粘合剂及其制备方法与应用
CN114191615B (zh) * 2021-12-21 2022-07-08 浙江大学 促进关节软骨-钙化层-软骨下骨修复的多层复合材料及其制备方法
TWI801069B (zh) * 2021-12-28 2023-05-01 國立成功大學 電紡纖維基質及其製備方法與用途
CN114569799B (zh) * 2022-03-24 2023-01-06 卢霄 承载模块化陶瓷的金属假体及其制备方法
CN114732948A (zh) * 2022-03-25 2022-07-12 上海工程技术大学 肩袖补片及其制备方法
CN114870090B (zh) * 2022-05-13 2023-05-19 中国人民解放军陆军军医大学 功能化nHA/明胶–壳聚糖梯度纳米复合仿生骨膜、制备方法及其应用
CN115058383B (zh) * 2022-06-20 2023-06-27 广东赛尔生物科技有限公司 三维重编USCs、其培养方法及其在抗糖尿病和降血压中的应用
FR3138298A1 (fr) * 2022-07-26 2024-02-02 Universite De Lorraine Membrane d’Assistance Musculaire
CN115282339B (zh) * 2022-07-28 2023-02-28 四川大学 一种交联透明质酸/羟基磷灰石可注射材料、制备方法及应用
CN115624646B (zh) * 2022-10-25 2023-09-05 维达纸业(浙江)有限公司 一种用于卫生用品的抗菌吸液非织造材料
CN115737902A (zh) * 2022-11-07 2023-03-07 重庆正仁医疗器械有限公司 一种医用重组iii型人源化胶原蛋白凝胶

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2129210A1 (en) 1994-03-31 1995-10-01 Debra Jean Mcdowall Liquid distribution layer for absorbent articles
US20040116032A1 (en) * 1999-02-25 2004-06-17 Bowlin Gary L. Electroprocessed collagen
US20020090725A1 (en) 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
ATE410198T1 (de) 2002-02-21 2008-10-15 Encelle Inc Immobilisierte bioaktive hydrogel matrizen für oberflächenbeschichtungen
US7252837B2 (en) * 2002-06-28 2007-08-07 Ethicon, Inc. Hemostatic wound dressing and method of making same
US20060204539A1 (en) 2005-03-11 2006-09-14 Anthony Atala Electrospun cell matrices
EP1868660B1 (en) * 2005-04-04 2016-08-03 Technion Research & Development Foundation Limited Medical scaffold, methods of fabrication and using thereof
US8048446B2 (en) 2005-05-10 2011-11-01 Drexel University Electrospun blends of natural and synthetic polymer fibers as tissue engineering scaffolds
KR100875189B1 (ko) 2005-08-26 2008-12-19 이화여자대학교 산학협력단 전기방사를 이용한 조직 재생용 섬유형 삼차원 다공성 지지체 및 그의 제조방법
WO2009120248A1 (en) * 2008-03-28 2009-10-01 Osteotech, Inc. Delivery system attachment
NL1036038C (en) * 2008-10-09 2010-04-14 Univ Eindhoven Tech Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof.
US8613943B2 (en) * 2009-01-23 2013-12-24 Royal College Of Surgeons In Ireland Process for producing a multi-layered scaffold suitable for osteochondral repair
CN101716375B (zh) * 2009-11-20 2014-10-22 深圳齐康医疗器械有限公司 由纯天然原料制备的具有梯度孔结构和性能的人工皮肤

Also Published As

Publication number Publication date
US20140112973A1 (en) 2014-04-24
ES2621414T3 (es) 2017-07-04
LT2694124T (lt) 2017-05-10
SI2694124T1 (sl) 2017-07-31
EP2694124B1 (en) 2017-01-04
DK2694124T3 (en) 2017-04-24
PL2694124T3 (pl) 2017-08-31
JP2014514942A (ja) 2014-06-26
PT2694124T (pt) 2017-04-07
EP2508212A1 (en) 2012-10-10
WO2012136701A1 (en) 2012-10-11
CN103648536A (zh) 2014-03-19
CN103648536B9 (zh) 2017-05-24
HRP20170550T1 (hr) 2017-06-16
US9937278B2 (en) 2018-04-10
CN103648536B (zh) 2017-03-22
WO2012136701A4 (en) 2012-12-20
EP2694124A1 (en) 2014-02-12

Similar Documents

Publication Publication Date Title
CY1118954T1 (el) Βιοσυμβατο και βιοδιασπωμενο συστημα στιβαδων βαθμιδωσης για την αναγεννητικη ιατρικη και την υποστηριξη των ιστων
CY1121785T1 (el) Μεθοδος για αποκατασταση συνδεσμου ή τενοντα
CO2019003130A2 (es) Polímeros absorbentes, métodos para su producción y usos de los mismos.
AR110022A1 (es) Polímeros absorbentes y métodos para su producción y uso
BR112015017629A2 (pt) filme e laminado biodegradáveis
BR112012009287A2 (pt) dispositivo de embolização feito de polímero expansível
BR112013031188A8 (pt) Curativo para aplicação em um ferimento e seu método de produção
BR112012007597A2 (pt) material de suporte para cuidado de ferimentos e/ou outras aplicações curativas de tecido
CY1116785T1 (el) Χαμηλης αποτομης αποδεσμευσης πολυ-(γαλακτιδιο/γλυκολιδιο) και μεθοδοι παραγωγης πολυμερων
BRPI0812418B8 (pt) artigo absorvente descartável com material polimérico absorvente distribuído de modo substancialmente contínuo e método
BR112015019440A2 (pt) métodos e dispositivos para fortalecimento da pele
CO6690781A2 (es) Inmunoglobulinas con dominio variable dual y usos de las mismas
ECSP13012648A (es) Inmunoglobulinas con dominio variable dual y usos de las mismas
BR112015019546A2 (pt) implante de distribuição de drogas prolongado
UY33707A (es) Inmunoglobulinas con dominio variable dual y usos de las mismas
MX345643B (es) Cubierta médica.
CY1116940T1 (el) Φλυκταινες εμπλουτισμενες σε φωσφολιπιδιο που φερουν παραγοντα ιστου εχουσες αιμοστατικες δραστικοτητες και χρησεις αυτων
CY1117654T1 (el) Πολυαιθυλενογλυκολιωμενη απελινη και χρησεις αυτης
NZ729417A (en) Compositions and methods for enhancing healing and regeneration of bone and soft tissue
BR112018015603A2 (pt) ?conjugado de enzimas terapêuticas, seu método de preparação, composição farmacêutica, composição para aumentar a transcitose e seu método, composição para aumentar a distribuição de tecido de uma enzima e seu método?
UY31645A1 (es) Nuevas imidazolidinas fenil-sustituidas, procedimiento para su preparación, medicamentos que conprenden dichos compuestos y su uso.
BR112017010395A2 (pt) adesão de tecido a um aparelho
PH12016501469B1 (en) Ketoprofen-containing poultice
BR112014029149A2 (pt) biomateriais adequados para uso como implantes eluíveis por fármacos e detectáveis por ressonância magnética para oclusão vascular
ES2497240B1 (es) Membrana reabsorbible para regeneración ósea guiada