CY1118167T1 - Πρωτογενη και εγγυς ηπατικα βλαστοκυτταρα - Google Patents
Πρωτογενη και εγγυς ηπατικα βλαστοκυτταραInfo
- Publication number
- CY1118167T1 CY1118167T1 CY20161100363T CY161100363T CY1118167T1 CY 1118167 T1 CY1118167 T1 CY 1118167T1 CY 20161100363 T CY20161100363 T CY 20161100363T CY 161100363 T CY161100363 T CY 161100363T CY 1118167 T1 CY1118167 T1 CY 1118167T1
- Authority
- CY
- Cyprus
- Prior art keywords
- liver
- stem cells
- human
- primary
- cells
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 11
- 210000004185 liver Anatomy 0.000 abstract 9
- 210000003897 hepatic stem cell Anatomy 0.000 abstract 5
- 210000005229 liver cell Anatomy 0.000 abstract 3
- 210000000941 bile Anatomy 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 2
- 210000003494 hepatocyte Anatomy 0.000 abstract 2
- 238000001114 immunoprecipitation Methods 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36536102P | 2002-03-15 | 2002-03-15 | |
| PCT/US2003/007852 WO2003078588A2 (en) | 2002-03-15 | 2003-03-14 | Primitive and proximal hepatic stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118167T1 true CY1118167T1 (el) | 2017-06-28 |
Family
ID=28042021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100363T CY1118167T1 (el) | 2002-03-15 | 2016-04-28 | Πρωτογενη και εγγυς ηπατικα βλαστοκυτταρα |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7413897B2 (enExample) |
| EP (2) | EP1490480B1 (enExample) |
| JP (2) | JP4723811B2 (enExample) |
| KR (1) | KR101119878B1 (enExample) |
| CN (3) | CN1742082A (enExample) |
| AU (2) | AU2003233399B2 (enExample) |
| CA (1) | CA2479510C (enExample) |
| CY (1) | CY1118167T1 (enExample) |
| DK (1) | DK1490480T3 (enExample) |
| ES (1) | ES2569951T3 (enExample) |
| HK (1) | HK1209783A1 (enExample) |
| HU (1) | HUE032238T2 (enExample) |
| IL (1) | IL164048A0 (enExample) |
| MX (1) | MXPA04009031A (enExample) |
| PL (1) | PL372619A1 (enExample) |
| RU (1) | RU2327479C2 (enExample) |
| SI (1) | SI1490480T1 (enExample) |
| WO (1) | WO2003078588A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1490480T3 (en) * | 2002-03-15 | 2016-04-11 | Univ North Carolina | PRIMITIVE AND PROXIMAL Liver Stem Cells |
| WO2007083504A1 (ja) * | 2003-08-01 | 2007-07-26 | Norimasa Nakamura | スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ－ｆｒｅｅ Ｓｅｌｆ－Ｏｒｇａｎｉｚｅｄ ３Ｄ ｓｙｎｔｈｅｔｉｃ ｔｉｓｓｕｅ） |
| CA2534356A1 (en) | 2003-08-01 | 2005-02-10 | Norimasa Nakamura | Scaffold-free self-organized 3d synthetic tissue |
| US7622108B2 (en) * | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
| CN101080486B (zh) * | 2004-04-23 | 2012-05-16 | 佰欧益股份有限公司 | 多谱系祖细胞 |
| WO2006126219A1 (en) * | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| BRPI0618724A2 (pt) | 2005-11-16 | 2011-09-06 | Univ North Carolina | componentes da matriz extracelular para expansão ou diferenciação de progenitores hepáticos |
| WO2007075812A2 (en) | 2005-12-22 | 2007-07-05 | Vesta Therapeutics, Inc. | Method of using hepatic progenitors in treating liver dysfunction |
| CA2646491A1 (en) * | 2006-04-17 | 2007-10-25 | Bioe, Inc. | Differentiation of multi-lineage progenitor cells to respiratory epithelial cells |
| WO2007127698A2 (en) * | 2006-04-25 | 2007-11-08 | Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College | Adipose derived adult stem cells in hepatic regeneration |
| EP2029725B1 (en) | 2006-05-26 | 2018-01-03 | The University of North Carolina at Chapel Hill | Hepatic stellate cell precursors and methods of isolating same |
| TW200916581A (en) * | 2007-06-15 | 2009-04-16 | Univ North Carolina | Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same |
| EP2192908A4 (en) * | 2007-07-25 | 2010-09-01 | Bioe Inc | DIFFERENTIATION OF PRECURSOR CELLS OF MULTIPLE ABSTRACTS AGAINST CHONDROCYTES |
| WO2009134773A1 (en) * | 2008-05-02 | 2009-11-05 | Vesta Therapeutics, Inc. | Hepatic progenitor cell and method of isolating same |
| WO2009139419A1 (ja) * | 2008-05-14 | 2009-11-19 | 公立大学法人横浜市立大学 | ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法 |
| US20090291494A1 (en) * | 2008-05-21 | 2009-11-26 | Bioe, Inc. | Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells |
| EP2291514B1 (en) * | 2008-05-22 | 2020-12-23 | Vesta Therapeutics, Inc. | Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells |
| US20100227393A1 (en) * | 2009-03-06 | 2010-09-09 | Eric Lagasse | Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder |
| US20110135610A1 (en) * | 2009-10-30 | 2011-06-09 | The University Of North Carolina At Chapel Hill | Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same |
| JP5943521B2 (ja) * | 2010-11-19 | 2016-07-05 | 株式会社オンチップ・バイオテクノロジーズ | 高濃度夾雑細胞群から低濃度の特定細胞を検出する方法と検出した細胞を回収し解析する方法 |
| MX2013013877A (es) * | 2011-05-27 | 2014-05-28 | Depuy Synthes Products Llc | Sistemas de tubulos proximales bioartificiales y metodos de uso. |
| EP3034087B1 (en) | 2011-12-08 | 2018-03-14 | Yeda Research and Development Co. Ltd. | Mammalian fetal pulmonary cells and therapeutic use of same |
| CN104508122A (zh) * | 2012-06-20 | 2015-04-08 | 赛璐拉有限公司 | 用于处理细胞群体的材料和方法 |
| JP6510162B2 (ja) * | 2013-01-21 | 2019-05-08 | テルモ株式会社 | シート状細胞培養物の製造方法 |
| US9533013B2 (en) * | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| CA2959117C (en) * | 2013-09-19 | 2023-08-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for producing hepatocyte-like cells |
| EP3083941B1 (en) | 2013-12-16 | 2023-02-22 | Fresenius Medical Care Deutschland GmbH | Pancreatic islet-like cell structures and a method of preparing thereof |
| JP6595157B2 (ja) * | 2014-03-04 | 2019-10-23 | 富士フイルム株式会社 | 細胞撮像制御装置および方法並びにプログラム |
| US10179896B2 (en) | 2015-05-12 | 2019-01-15 | Baker Group, LLP | Method and system for a bioartificial organ |
| WO2016200340A1 (en) | 2015-06-12 | 2016-12-15 | Agency For Science, Technology And Research | Derivation of hepatic stem cells and mature liver cell types and uses thereof |
| US10668109B2 (en) | 2015-06-18 | 2020-06-02 | Yeda Research And Development Co. Ltd. | Conditioning protocols and use of same for tissue regeneration |
| CN105483077A (zh) * | 2015-12-24 | 2016-04-13 | 福州市传染病医院 | 一种提高肝细胞增殖活性的细胞培养方法 |
| JP2019134682A (ja) * | 2016-06-01 | 2019-08-15 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 肝幹細胞様細胞の調製方法 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| EP3743080A4 (en) * | 2018-01-26 | 2021-10-27 | Polarityte, Inc. | SELF-ASSEMBLY MATERIALS COORDINATED WITH A COMPLEX LIVING INTERFACE (CLICSAM) |
| EP4293109A1 (en) | 2022-06-14 | 2023-12-20 | Upside Foods, Inc. | Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665589A (en) * | 1988-12-14 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Human liver epithelial cell lines |
| AU667680B2 (en) * | 1991-08-07 | 1996-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Proliferation of hepatocyte precursors |
| ATE318075T1 (de) * | 1993-11-19 | 2006-03-15 | Einstein Coll Med | Hepatoblasten und verfahren zu ihrer isolierung |
| YU8395A (sh) * | 1994-02-14 | 1998-07-10 | Kirin Brewery Company | Protein sa tpo aktivnošću |
| US5843633A (en) * | 1996-04-26 | 1998-12-01 | Amcell Corporation | Characterization of a human hematopoietic progenitor cell antigen |
| RU2217168C2 (ru) * | 1998-04-17 | 2003-11-27 | Лексиген Фармасьютикэлс Корпорейшн | Усиление иммунных ответов, опосредованных белками, слитыми из антитела и цитокина, посредством совместного введения ингибитора простагландина |
| US6129911A (en) * | 1998-07-10 | 2000-10-10 | Rhode Island Hospital, A Lifespan Partner | Liver stem cell |
| PE20001250A1 (es) * | 1998-11-16 | 2000-11-21 | Detroit Diesel Corp | Metodo y sistema para el control de material devuelto |
| JP2000287680A (ja) * | 1999-04-09 | 2000-10-17 | Sentan Kagaku Gijutsu Incubation Center:Kk | 未成熟肝細胞を成熟肝細胞へ分化させる方法 |
| JP3553858B2 (ja) * | 1999-08-25 | 2004-08-11 | 東洋紡績株式会社 | 血管網類似構造体を有する細胞培養用モジュール |
| CN1461341A (zh) * | 2000-10-03 | 2003-12-10 | 北卡罗来纳大学 | 肝祖先细胞克隆生长的方法 |
| DK1490480T3 (en) * | 2002-03-15 | 2016-04-11 | Univ North Carolina | PRIMITIVE AND PROXIMAL Liver Stem Cells |
-
2003
- 2003-03-14 DK DK03728245.6T patent/DK1490480T3/en active
- 2003-03-14 EP EP03728245.6A patent/EP1490480B1/en not_active Expired - Lifetime
- 2003-03-14 JP JP2003576582A patent/JP4723811B2/ja not_active Expired - Lifetime
- 2003-03-14 CA CA2479510A patent/CA2479510C/en not_active Expired - Lifetime
- 2003-03-14 MX MXPA04009031A patent/MXPA04009031A/es active IP Right Grant
- 2003-03-14 AU AU2003233399A patent/AU2003233399B2/en not_active Ceased
- 2003-03-14 CN CNA038099896A patent/CN1742082A/zh active Granted
- 2003-03-14 ES ES03728245.6T patent/ES2569951T3/es not_active Expired - Lifetime
- 2003-03-14 HU HUE03728245A patent/HUE032238T2/en unknown
- 2003-03-14 EP EP15003527.7A patent/EP3023491A1/en not_active Withdrawn
- 2003-03-14 US US10/387,547 patent/US7413897B2/en not_active Expired - Lifetime
- 2003-03-14 CN CN201410815377.2A patent/CN104630129A/zh active Pending
- 2003-03-14 RU RU2005125598/15A patent/RU2327479C2/ru not_active IP Right Cessation
- 2003-03-14 WO PCT/US2003/007852 patent/WO2003078588A2/en not_active Ceased
- 2003-03-14 IL IL16404803A patent/IL164048A0/xx not_active IP Right Cessation
- 2003-03-14 KR KR1020047014503A patent/KR101119878B1/ko not_active Expired - Fee Related
- 2003-03-14 PL PL03372619A patent/PL372619A1/xx not_active Application Discontinuation
- 2003-03-14 SI SI200332477A patent/SI1490480T1/sl unknown
- 2003-03-14 CN CN03809989.6A patent/CN1742082B/zh not_active Expired - Fee Related
-
2006
- 2006-12-12 US US11/609,729 patent/US8691523B2/en not_active Expired - Fee Related
-
2008
- 2008-06-16 AU AU2008202656A patent/AU2008202656B8/en not_active Ceased
-
2010
- 2010-12-03 JP JP2010270893A patent/JP5463271B2/ja not_active Expired - Fee Related
-
2014
- 2014-04-03 US US14/244,761 patent/US20140302601A1/en not_active Abandoned
-
2015
- 2015-10-22 HK HK15110414.0A patent/HK1209783A1/xx unknown
-
2016
- 2016-04-28 CY CY20161100363T patent/CY1118167T1/el unknown
- 2016-10-12 US US15/291,785 patent/US20170096641A1/en not_active Abandoned
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