AU2003233399B2 - Primitive and proximal hepatic stem cells - Google Patents

Primitive and proximal hepatic stem cells Download PDF

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Publication number
AU2003233399B2
AU2003233399B2 AU2003233399A AU2003233399A AU2003233399B2 AU 2003233399 B2 AU2003233399 B2 AU 2003233399B2 AU 2003233399 A AU2003233399 A AU 2003233399A AU 2003233399 A AU2003233399 A AU 2003233399A AU 2003233399 B2 AU2003233399 B2 AU 2003233399B2
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Prior art keywords
cells
cell
liver
hepatic
stem cells
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Ceased
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AU2003233399A
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AU2003233399A1 (en
Inventor
Andrew T. Bruce
Mark E. Furth
John W. Ludlow
Nicholas G. Moss
Lola Reid
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University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
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University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
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Priority to AU2008202656A priority Critical patent/AU2008202656B8/en
Assigned to UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, VESTA THERAPEUTICS, INC. reassignment UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Request for Assignment Assignors: INCARA CELL TECHNOLOGIES, INC., UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2003233399A 2002-03-15 2003-03-14 Primitive and proximal hepatic stem cells Ceased AU2003233399B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2008202656A AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15
US60/365,361 2002-03-15
PCT/US2003/007852 WO2003078588A2 (en) 2002-03-15 2003-03-14 Primitive and proximal hepatic stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2008202656A Division AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

Publications (2)

Publication Number Publication Date
AU2003233399A1 AU2003233399A1 (en) 2003-09-29
AU2003233399B2 true AU2003233399B2 (en) 2008-03-20

Family

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Application Number Title Priority Date Filing Date
AU2003233399A Ceased AU2003233399B2 (en) 2002-03-15 2003-03-14 Primitive and proximal hepatic stem cells
AU2008202656A Ceased AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

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AU2008202656A Ceased AU2008202656B8 (en) 2002-03-15 2008-06-16 Primitive and proximal hepatic stem cells

Country Status (18)

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US (4) US7413897B2 (enExample)
EP (2) EP1490480B1 (enExample)
JP (2) JP4723811B2 (enExample)
KR (1) KR101119878B1 (enExample)
CN (3) CN1742082A (enExample)
AU (2) AU2003233399B2 (enExample)
CA (1) CA2479510C (enExample)
CY (1) CY1118167T1 (enExample)
DK (1) DK1490480T3 (enExample)
ES (1) ES2569951T3 (enExample)
HK (1) HK1209783A1 (enExample)
HU (1) HUE032238T2 (enExample)
IL (1) IL164048A0 (enExample)
MX (1) MXPA04009031A (enExample)
PL (1) PL372619A1 (enExample)
RU (1) RU2327479C2 (enExample)
SI (1) SI1490480T1 (enExample)
WO (1) WO2003078588A2 (enExample)

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DK1490480T3 (en) * 2002-03-15 2016-04-11 Univ North Carolina PRIMITIVE AND PROXIMAL Liver Stem Cells
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ－ｆｒｅｅ Ｓｅｌｆ－Ｏｒｇａｎｉｚｅｄ ３Ｄ ｓｙｎｔｈｅｔｉｃ ｔｉｓｓｕｅ）
CA2534356A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3d synthetic tissue
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
CN101080486B (zh) * 2004-04-23 2012-05-16 佰欧益股份有限公司 多谱系祖细胞
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
BRPI0618724A2 (pt) 2005-11-16 2011-09-06 Univ North Carolina componentes da matriz extracelular para expansão ou diferenciação de progenitores hepáticos
WO2007075812A2 (en) 2005-12-22 2007-07-05 Vesta Therapeutics, Inc. Method of using hepatic progenitors in treating liver dysfunction
CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
WO2007127698A2 (en) * 2006-04-25 2007-11-08 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Adipose derived adult stem cells in hepatic regeneration
EP2029725B1 (en) 2006-05-26 2018-01-03 The University of North Carolina at Chapel Hill Hepatic stellate cell precursors and methods of isolating same
TW200916581A (en) * 2007-06-15 2009-04-16 Univ North Carolina Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
EP2192908A4 (en) * 2007-07-25 2010-09-01 Bioe Inc DIFFERENTIATION OF PRECURSOR CELLS OF MULTIPLE ABSTRACTS AGAINST CHONDROCYTES
WO2009134773A1 (en) * 2008-05-02 2009-11-05 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
WO2009139419A1 (ja) * 2008-05-14 2009-11-19 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
US20090291494A1 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells
EP2291514B1 (en) * 2008-05-22 2020-12-23 Vesta Therapeutics, Inc. Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
US20110135610A1 (en) * 2009-10-30 2011-06-09 The University Of North Carolina At Chapel Hill Multipotent stem cells from the extrahepatic biliary tree and methods of isolating same
JP5943521B2 (ja) * 2010-11-19 2016-07-05 株式会社オンチップ・バイオテクノロジーズ 高濃度夾雑細胞群から低濃度の特定細胞を検出する方法と検出した細胞を回収し解析する方法
MX2013013877A (es) * 2011-05-27 2014-05-28 Depuy Synthes Products Llc Sistemas de tubulos proximales bioartificiales y metodos de uso.
EP3034087B1 (en) 2011-12-08 2018-03-14 Yeda Research and Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
CN104508122A (zh) * 2012-06-20 2015-04-08 赛璐拉有限公司 用于处理细胞群体的材料和方法
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
CA2959117C (en) * 2013-09-19 2023-08-22 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for producing hepatocyte-like cells
EP3083941B1 (en) 2013-12-16 2023-02-22 Fresenius Medical Care Deutschland GmbH Pancreatic islet-like cell structures and a method of preparing thereof
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
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US10668109B2 (en) 2015-06-18 2020-06-02 Yeda Research And Development Co. Ltd. Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
EP3743080A4 (en) * 2018-01-26 2021-10-27 Polarityte, Inc. SELF-ASSEMBLY MATERIALS COORDINATED WITH A COMPLEX LIVING INTERFACE (CLICSAM)
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US5576207A (en) * 1991-08-07 1996-11-19 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of expanding hepatic precursor cells
WO2000030011A1 (en) * 1998-11-16 2000-05-25 Detroit Diesel Corporation Method and system for returned-material control
AU2000277535B2 (en) * 2000-10-03 2007-03-29 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells

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WO2000030011A1 (en) * 1998-11-16 2000-05-25 Detroit Diesel Corporation Method and system for returned-material control
AU2000277535B2 (en) * 2000-10-03 2007-03-29 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells

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Also Published As

Publication number Publication date
CA2479510A1 (en) 2003-09-25
JP5463271B2 (ja) 2014-04-09
MXPA04009031A (es) 2005-12-12
US20070099297A1 (en) 2007-05-03
EP1490480B1 (en) 2016-02-03
WO2003078588A3 (en) 2004-04-01
AU2008202656B8 (en) 2011-12-15
EP1490480A4 (en) 2006-06-14
JP2005520513A (ja) 2005-07-14
HUE032238T2 (en) 2017-09-28
KR20060010693A (ko) 2006-02-02
US20040018621A1 (en) 2004-01-29
WO2003078588A9 (en) 2003-12-11
WO2003078588A2 (en) 2003-09-25
RU2005125598A (ru) 2006-01-27
EP3023491A1 (en) 2016-05-25
SI1490480T1 (sl) 2016-06-30
US20140302601A1 (en) 2014-10-09
HK1209783A1 (en) 2016-04-08
JP2011087591A (ja) 2011-05-06
CY1118167T1 (el) 2017-06-28
US20170096641A1 (en) 2017-04-06
DK1490480T3 (en) 2016-04-11
KR101119878B1 (ko) 2012-03-09
AU2003233399A1 (en) 2003-09-29
CN104630129A (zh) 2015-05-20
RU2327479C2 (ru) 2008-06-27
CN1742082A (zh) 2006-03-01
AU2008202656B2 (en) 2011-03-17
AU2008202656A8 (en) 2011-12-15
ES2569951T3 (es) 2016-05-13
PL372619A1 (en) 2005-07-25
AU2008202656A1 (en) 2008-07-10
EP1490480A2 (en) 2004-12-29
US7413897B2 (en) 2008-08-19
US8691523B2 (en) 2014-04-08
JP4723811B2 (ja) 2011-07-13
CN1742082B (zh) 2015-01-21
IL164048A0 (en) 2005-12-18
CA2479510C (en) 2019-10-29

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