CN1742082A - 原肝干细胞和近肝干细胞 - Google Patents

原肝干细胞和近肝干细胞 Download PDF

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Publication number
CN1742082A
CN1742082A CNA038099896A CN03809989A CN1742082A CN 1742082 A CN1742082 A CN 1742082A CN A038099896 A CNA038099896 A CN A038099896A CN 03809989 A CN03809989 A CN 03809989A CN 1742082 A CN1742082 A CN 1742082A
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stem cells
cells
cell
liver stem
human
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Chinese (zh)
Inventor
洛拉·里德
尼古拉斯·G·莫斯
马克·E·福斯
约翰·W·拉德洛
安德鲁·T·布鲁斯
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University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
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University of North Carolina at Chapel Hill
Vesta Therapeutics Inc
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CNA038099896A 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞 Granted CN1742082A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36536102P 2002-03-15 2002-03-15
US60/365,361 2002-03-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410815377.2A Division CN104630129A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞

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CN1742082A true CN1742082A (zh) 2006-03-01

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CNA038099896A Granted CN1742082A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞
CN201410815377.2A Pending CN104630129A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞
CN03809989.6A Expired - Fee Related CN1742082B (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞

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CN201410815377.2A Pending CN104630129A (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞
CN03809989.6A Expired - Fee Related CN1742082B (zh) 2002-03-15 2003-03-14 原肝干细胞和近肝干细胞

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US (4) US7413897B2 (enExample)
EP (2) EP1490480B1 (enExample)
JP (2) JP4723811B2 (enExample)
KR (1) KR101119878B1 (enExample)
CN (3) CN1742082A (enExample)
AU (2) AU2003233399B2 (enExample)
CA (1) CA2479510C (enExample)
CY (1) CY1118167T1 (enExample)
DK (1) DK1490480T3 (enExample)
ES (1) ES2569951T3 (enExample)
HK (1) HK1209783A1 (enExample)
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IL (1) IL164048A0 (enExample)
MX (1) MXPA04009031A (enExample)
PL (1) PL372619A1 (enExample)
RU (1) RU2327479C2 (enExample)
SI (1) SI1490480T1 (enExample)
WO (1) WO2003078588A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105264065A (zh) * 2013-03-13 2016-01-20 北卡罗来纳大学教堂山分校 通过将干细胞移植到胆管壁来治疗胰腺和肝脏病症的方法
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
TWI641688B (zh) * 2009-10-30 2018-11-21 北卡羅來納大學教堂山 來自肝外樹狀膽管的多潛能幹細胞及其分離方法

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1490480T3 (en) * 2002-03-15 2016-04-11 Univ North Carolina PRIMITIVE AND PROXIMAL Liver Stem Cells
WO2007083504A1 (ja) * 2003-08-01 2007-07-26 Norimasa Nakamura スキャフォールドフリー自己組織性三次元人工組織(Scaffold-free Self-Organized 3D synthetic tissue)
CA2534356A1 (en) 2003-08-01 2005-02-10 Norimasa Nakamura Scaffold-free self-organized 3d synthetic tissue
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
CN101080486B (zh) * 2004-04-23 2012-05-16 佰欧益股份有限公司 多谱系祖细胞
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
BRPI0618724A2 (pt) 2005-11-16 2011-09-06 Univ North Carolina componentes da matriz extracelular para expansão ou diferenciação de progenitores hepáticos
WO2007075812A2 (en) 2005-12-22 2007-07-05 Vesta Therapeutics, Inc. Method of using hepatic progenitors in treating liver dysfunction
CA2646491A1 (en) * 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
WO2007127698A2 (en) * 2006-04-25 2007-11-08 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Adipose derived adult stem cells in hepatic regeneration
EP2029725B1 (en) 2006-05-26 2018-01-03 The University of North Carolina at Chapel Hill Hepatic stellate cell precursors and methods of isolating same
TW200916581A (en) * 2007-06-15 2009-04-16 Univ North Carolina Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
EP2192908A4 (en) * 2007-07-25 2010-09-01 Bioe Inc DIFFERENTIATION OF PRECURSOR CELLS OF MULTIPLE ABSTRACTS AGAINST CHONDROCYTES
WO2009134773A1 (en) * 2008-05-02 2009-11-05 Vesta Therapeutics, Inc. Hepatic progenitor cell and method of isolating same
WO2009139419A1 (ja) * 2008-05-14 2009-11-19 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
US20090291494A1 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of Multi-Lineage Progenitor Cells to Pancreatic Cells
EP2291514B1 (en) * 2008-05-22 2020-12-23 Vesta Therapeutics, Inc. Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
JP5943521B2 (ja) * 2010-11-19 2016-07-05 株式会社オンチップ・バイオテクノロジーズ 高濃度夾雑細胞群から低濃度の特定細胞を検出する方法と検出した細胞を回収し解析する方法
MX2013013877A (es) * 2011-05-27 2014-05-28 Depuy Synthes Products Llc Sistemas de tubulos proximales bioartificiales y metodos de uso.
EP3034087B1 (en) 2011-12-08 2018-03-14 Yeda Research and Development Co. Ltd. Mammalian fetal pulmonary cells and therapeutic use of same
CN104508122A (zh) * 2012-06-20 2015-04-08 赛璐拉有限公司 用于处理细胞群体的材料和方法
JP6510162B2 (ja) * 2013-01-21 2019-05-08 テルモ株式会社 シート状細胞培養物の製造方法
CA2959117C (en) * 2013-09-19 2023-08-22 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for producing hepatocyte-like cells
EP3083941B1 (en) 2013-12-16 2023-02-22 Fresenius Medical Care Deutschland GmbH Pancreatic islet-like cell structures and a method of preparing thereof
JP6595157B2 (ja) * 2014-03-04 2019-10-23 富士フイルム株式会社 細胞撮像制御装置および方法並びにプログラム
US10179896B2 (en) 2015-05-12 2019-01-15 Baker Group, LLP Method and system for a bioartificial organ
US10668109B2 (en) 2015-06-18 2020-06-02 Yeda Research And Development Co. Ltd. Conditioning protocols and use of same for tissue regeneration
CN105483077A (zh) * 2015-12-24 2016-04-13 福州市传染病医院 一种提高肝细胞增殖活性的细胞培养方法
JP2019134682A (ja) * 2016-06-01 2019-08-15 国立研究開発法人医薬基盤・健康・栄養研究所 肝幹細胞様細胞の調製方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
EP3743080A4 (en) * 2018-01-26 2021-10-27 Polarityte, Inc. SELF-ASSEMBLY MATERIALS COORDINATED WITH A COMPLEX LIVING INTERFACE (CLICSAM)
EP4293109A1 (en) 2022-06-14 2023-12-20 Upside Foods, Inc. Non-skeletal muscle-derived cells as a source of suspension capable myogenic cells for cultured foods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665589A (en) * 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
AU667680B2 (en) * 1991-08-07 1996-04-04 Albert Einstein College Of Medicine Of Yeshiva University Proliferation of hepatocyte precursors
ATE318075T1 (de) * 1993-11-19 2006-03-15 Einstein Coll Med Hepatoblasten und verfahren zu ihrer isolierung
YU8395A (sh) * 1994-02-14 1998-07-10 Kirin Brewery Company Protein sa tpo aktivnošću
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
RU2217168C2 (ru) * 1998-04-17 2003-11-27 Лексиген Фармасьютикэлс Корпорейшн Усиление иммунных ответов, опосредованных белками, слитыми из антитела и цитокина, посредством совместного введения ингибитора простагландина
US6129911A (en) * 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
PE20001250A1 (es) * 1998-11-16 2000-11-21 Detroit Diesel Corp Metodo y sistema para el control de material devuelto
JP2000287680A (ja) * 1999-04-09 2000-10-17 Sentan Kagaku Gijutsu Incubation Center:Kk 未成熟肝細胞を成熟肝細胞へ分化させる方法
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
CN1461341A (zh) * 2000-10-03 2003-12-10 北卡罗来纳大学 肝祖先细胞克隆生长的方法
DK1490480T3 (en) * 2002-03-15 2016-04-11 Univ North Carolina PRIMITIVE AND PROXIMAL Liver Stem Cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ERIC R. LEMMER等: "Isolation from human fetal liver of cells co-expressing CD34 haematopoietic stem cell and CAM 5.2 pancytokeratin markers", 《JOURNAL OF HEPATOLOGY》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI641688B (zh) * 2009-10-30 2018-11-21 北卡羅來納大學教堂山 來自肝外樹狀膽管的多潛能幹細胞及其分離方法
CN105264065A (zh) * 2013-03-13 2016-01-20 北卡罗来纳大学教堂山分校 通过将干细胞移植到胆管壁来治疗胰腺和肝脏病症的方法
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
CN108431209B (zh) * 2015-06-12 2023-02-10 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
US11795436B2 (en) 2015-06-12 2023-10-24 Agency For Science, Technology And Research Derivation of hepatic stem cells and mature liver cell types and uses thereof

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CA2479510A1 (en) 2003-09-25
JP5463271B2 (ja) 2014-04-09
MXPA04009031A (es) 2005-12-12
US20070099297A1 (en) 2007-05-03
EP1490480B1 (en) 2016-02-03
WO2003078588A3 (en) 2004-04-01
AU2008202656B8 (en) 2011-12-15
EP1490480A4 (en) 2006-06-14
JP2005520513A (ja) 2005-07-14
HUE032238T2 (en) 2017-09-28
KR20060010693A (ko) 2006-02-02
US20040018621A1 (en) 2004-01-29
WO2003078588A9 (en) 2003-12-11
WO2003078588A2 (en) 2003-09-25
RU2005125598A (ru) 2006-01-27
EP3023491A1 (en) 2016-05-25
SI1490480T1 (sl) 2016-06-30
US20140302601A1 (en) 2014-10-09
HK1209783A1 (en) 2016-04-08
JP2011087591A (ja) 2011-05-06
CY1118167T1 (el) 2017-06-28
US20170096641A1 (en) 2017-04-06
DK1490480T3 (en) 2016-04-11
KR101119878B1 (ko) 2012-03-09
AU2003233399A1 (en) 2003-09-29
CN104630129A (zh) 2015-05-20
RU2327479C2 (ru) 2008-06-27
AU2008202656B2 (en) 2011-03-17
AU2008202656A8 (en) 2011-12-15
ES2569951T3 (es) 2016-05-13
PL372619A1 (en) 2005-07-25
AU2008202656A1 (en) 2008-07-10
EP1490480A2 (en) 2004-12-29
US7413897B2 (en) 2008-08-19
US8691523B2 (en) 2014-04-08
JP4723811B2 (ja) 2011-07-13
CN1742082B (zh) 2015-01-21
IL164048A0 (en) 2005-12-18
AU2003233399B2 (en) 2008-03-20
CA2479510C (en) 2019-10-29

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