MX2013013877A - Sistemas de tubulos proximales bioartificiales y metodos de uso. - Google Patents

Sistemas de tubulos proximales bioartificiales y metodos de uso.

Info

Publication number
MX2013013877A
MX2013013877A MX2013013877A MX2013013877A MX2013013877A MX 2013013877 A MX2013013877 A MX 2013013877A MX 2013013877 A MX2013013877 A MX 2013013877A MX 2013013877 A MX2013013877 A MX 2013013877A MX 2013013877 A MX2013013877 A MX 2013013877A
Authority
MX
Mexico
Prior art keywords
proximal tubule
cells
methods
application
bioartificial
Prior art date
Application number
MX2013013877A
Other languages
English (en)
Inventor
Christian Kazanecki
David C Colter
Johanna Schanz
Anke Hoppensack
Jan Hansmann
Heike Walles
Original Assignee
Depuy Synthes Products Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Synthes Products Llc filed Critical Depuy Synthes Products Llc
Publication of MX2013013877A publication Critical patent/MX2013013877A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C12N2533/92—Amnion; Decellularised dermis or mucosa

Abstract

La presente solicitud describe un dispositivo de túbulo proximal bioartificial construido por medio de la preparación de una matriz biológica descelularizada, la siembra de la matriz biológica con células derivadas del riñón de un mamífero y, opcionalmente, células endoteliales de un mamífero; después, el dispositivo se puede cultivar estáticamente o madurarse con el uso de un cultivo en biorreactor para permitir la diferenciación de las células del riñón en células del túbulo proximal en funcionamiento; el dispositivo puede realizar funciones del túbulo proximal; la solicitud describe, además, varios métodos para preparar los dispositivos de túbulo proximal; la solicitud describe, además, métodos de uso de los dispositivos de túbulo proximal bioartificial, por ejemplo, para estudios in vitro del transporte de células del túbulo, efectos de toxicidad de varios compuestos o análisis de compuestos farmacéuticos.
MX2013013877A 2011-05-27 2012-05-25 Sistemas de tubulos proximales bioartificiales y metodos de uso. MX2013013877A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161490890P 2011-05-27 2011-05-27
PCT/US2012/039732 WO2012166668A1 (en) 2011-05-27 2012-05-25 Bioartificial proximal tubule systems and methods of use

Publications (1)

Publication Number Publication Date
MX2013013877A true MX2013013877A (es) 2014-05-28

Family

ID=46229935

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013877A MX2013013877A (es) 2011-05-27 2012-05-25 Sistemas de tubulos proximales bioartificiales y metodos de uso.

Country Status (15)

Country Link
US (1) US20120301958A1 (es)
EP (1) EP2714894B1 (es)
JP (2) JP6158175B2 (es)
KR (1) KR102034496B1 (es)
CN (2) CN103842497A (es)
AU (1) AU2012262382B2 (es)
BR (1) BR112013030567B1 (es)
CA (1) CA2837462C (es)
ES (1) ES2764850T3 (es)
MX (1) MX2013013877A (es)
PL (1) PL2714894T3 (es)
RU (1) RU2620947C2 (es)
SG (1) SG195125A1 (es)
WO (1) WO2012166668A1 (es)
ZA (1) ZA201309678B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6490669B2 (ja) * 2013-05-08 2019-03-27 インリージェン 単離腎細胞を含有するオルガノイド及びその使用
WO2015152025A1 (ja) * 2014-03-31 2015-10-08 テルモ株式会社 シート状細胞培養物の品質評価方法
JP6755085B2 (ja) * 2015-11-10 2020-09-16 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
JP6995112B2 (ja) * 2017-04-06 2022-02-04 日機装株式会社 細胞の培養方法及び細胞支持複合体の製造方法
CN108588006A (zh) * 2018-05-10 2018-09-28 华东理工大学 一种用于肝细胞三维培养的生物支架及其制备方法和应用
JP7141688B2 (ja) * 2018-05-15 2022-09-26 学校法人北里研究所 近位尿細管上皮細胞株及びその使用

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US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
AU2002340463A1 (en) * 2001-11-16 2003-06-10 Children's Medical Center Corporation Augmentation of organ function
AU2002353078A1 (en) * 2001-12-07 2003-07-09 Earl Y. Cheng Tissue graft compositions and methods for producing same
CN1742082A (zh) * 2002-03-15 2006-03-01 北卡罗来纳大学查伯山分校 原肝干细胞和近肝干细胞
US8568761B2 (en) * 2005-07-15 2013-10-29 Cormatrix Cardiovascular, Inc. Compositions for regenerating defective or absent myocardium
PL1928519T3 (pl) * 2005-08-26 2012-08-31 Univ Minnesota Decelularyzacja i recelularyzacja narządów i tkanek
SI2078073T1 (sl) * 2006-10-12 2013-11-29 Ethicon, Inc. Celice, pridobljene iz ledvice, in postopki uporabe pri popravljanju tkiv in regeneraciji
JP5166275B2 (ja) * 2006-10-17 2013-03-21 学校法人東海大学 バイオ人工尿細管
US8460929B2 (en) * 2007-06-04 2013-06-11 The Regents Of The University Of California Methods of tissue generation and tissue engineered compositions
EP2229435B1 (en) * 2007-12-06 2016-03-02 Agency for Science, Technology And Research Method for extracellular matrix mediated differentiation and proliferation of stem cells
EP2177603A1 (en) * 2008-09-25 2010-04-21 Gambro Lundia AB Device for renal cell expansion
DE102008056037B4 (de) 2008-11-05 2012-10-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidischer Bioreaktor
WO2010057015A1 (en) * 2008-11-14 2010-05-20 Wake Forest University Health Sciences Kidney structures and methods of forming the same
US20110236874A1 (en) * 2008-12-02 2011-09-29 Daniele Zink Method for formation of renal tubules
KR20120023626A (ko) * 2009-03-31 2012-03-13 리전츠 오브 더 유니버스티 오브 미네소타 기관 및 조직의 탈세포화 및 재세포화

Also Published As

Publication number Publication date
BR112013030567A2 (pt) 2017-07-04
PL2714894T3 (pl) 2020-04-30
SG195125A1 (en) 2013-12-30
RU2013158327A (ru) 2015-07-10
BR112013030567B1 (pt) 2021-02-17
CN103842497A (zh) 2014-06-04
US20120301958A1 (en) 2012-11-29
KR102034496B1 (ko) 2019-10-22
EP2714894B1 (en) 2019-10-30
JP2014515270A (ja) 2014-06-30
JP6158175B2 (ja) 2017-07-05
CN110511901A (zh) 2019-11-29
RU2620947C2 (ru) 2017-05-30
ZA201309678B (en) 2015-08-26
AU2012262382A8 (en) 2014-01-16
JP2017099417A (ja) 2017-06-08
AU2012262382A1 (en) 2013-12-12
ES2764850T3 (es) 2020-06-04
EP2714894A1 (en) 2014-04-09
AU2012262382B2 (en) 2016-10-13
WO2012166668A1 (en) 2012-12-06
CA2837462C (en) 2021-06-01
CA2837462A1 (en) 2012-12-06
JP6523358B2 (ja) 2019-05-29
KR20140042824A (ko) 2014-04-07

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Owner name: H. LUNDBECK A/S