ATE518960T1 - Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression - Google Patents

Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression

Info

Publication number
ATE518960T1
ATE518960T1 AT04784464T AT04784464T ATE518960T1 AT E518960 T1 ATE518960 T1 AT E518960T1 AT 04784464 T AT04784464 T AT 04784464T AT 04784464 T AT04784464 T AT 04784464T AT E518960 T1 ATE518960 T1 AT E518960T1
Authority
AT
Austria
Prior art keywords
gene expression
zinc finger
finger proteins
regulate gene
produced zinc
Prior art date
Application number
AT04784464T
Other languages
English (en)
Inventor
Michael Moore
Yen Choo
Aaron Klug
Original Assignee
Sangamo Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sangamo Biosciences Inc filed Critical Sangamo Biosciences Inc
Application granted granted Critical
Publication of ATE518960T1 publication Critical patent/ATE518960T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04784464T 2003-09-19 2004-09-17 Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression ATE518960T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50450203P 2003-09-19 2003-09-19
PCT/US2004/030606 WO2005028630A2 (en) 2003-09-19 2004-09-17 Engineered zinc finger proteins for regulation of gene expression

Publications (1)

Publication Number Publication Date
ATE518960T1 true ATE518960T1 (de) 2011-08-15

Family

ID=34375508

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04784464T ATE518960T1 (de) 2003-09-19 2004-09-17 Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression

Country Status (6)

Country Link
US (1) US7407776B2 (de)
EP (1) EP1678315B1 (de)
AT (1) ATE518960T1 (de)
AU (1) AU2004274957B2 (de)
CA (1) CA2539439C (de)
WO (1) WO2005028630A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7429374B2 (en) * 2001-12-04 2008-09-30 Teva Pharmaceutical Industries, Ltd. Process for the measurement of the potency of glatiramer acetate
WO2007006808A1 (en) * 2005-07-13 2007-01-18 Novo Nordisk Health Care Ag Host cell protein knock-out cells for production of therapeutic proteins
CA2667414C (en) 2006-11-13 2015-12-29 Sangamo Biosciences, Inc. Methods and compositions for modification of the human glucocorticoid receptor locus
KR101723350B1 (ko) 2006-12-14 2017-04-05 다우 아그로사이언시즈 엘엘씨 최적화된 비-정규 아연 손가락 단백질
CA2687688C (en) 2007-05-23 2017-03-28 Sangamo Biosciences, Inc. Methods and compositions for increased transgene expression in t cells
ES2657067T3 (es) 2009-10-22 2018-03-01 Dow Agrosciences Llc Proteínas con dedos de zinc modificadas genéticamente que se dirigen a genes vegetales implicados en la biosíntesis de ácidos grasos
US8772453B2 (en) * 2010-05-03 2014-07-08 Sangamo Biosciences, Inc. Compositions for linking zinc finger modules
JP6309461B2 (ja) 2012-02-28 2018-04-11 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーSigma−Aldrich Co., LLC ヒストンアセチル化の標的化
EP2841572B1 (de) 2012-04-27 2019-06-19 Duke University Genetische korrektur mutierter gene
UA118090C2 (uk) * 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
WO2014130770A1 (en) 2013-02-22 2014-08-28 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US20170107486A1 (en) 2014-04-21 2017-04-20 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
GB201418965D0 (de) 2014-10-24 2014-12-10 Ospedale San Raffaele And Fond Telethon
US11970710B2 (en) 2015-10-13 2024-04-30 Duke University Genome engineering with Type I CRISPR systems in eukaryotic cells
CA3133899A1 (en) 2018-03-30 2019-10-03 University Of Geneva Micro rna expression constructs and uses thereof
CN110791523B (zh) * 2019-12-13 2022-05-10 南京农业大学 一种棉花抗旱相关基因GhRCHY1及其应用
US20230242643A1 (en) 2020-05-27 2023-08-03 Antion Biosciences Sa Adapter molecules to re-direct car t cells to an antigen of interest
GB202010075D0 (en) * 2020-07-01 2020-08-12 Imp College Innovations Ltd Therapeutic nucleic acids, peptides and uses
IL313565A (en) * 2021-12-15 2024-08-01 Univ Indiana Trustees Cell Targeting Compounds and Methods

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217344A (en) 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4186183A (en) 1978-03-29 1980-01-29 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in chemotherapy of leishmaniasis
US4261975A (en) 1979-09-19 1981-04-14 Merck & Co., Inc. Viral liposome particle
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4603044A (en) 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5049386A (en) 1985-01-07 1991-09-17 Syntex (U.S.A.) Inc. N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4774085A (en) 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators
US5422251A (en) 1986-11-26 1995-06-06 Princeton University Triple-stranded nucleic acids
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US4957773A (en) 1989-02-13 1990-09-18 Syracuse University Deposition of boron-containing films from decaborane
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1991017424A1 (en) 1990-05-03 1991-11-14 Vical, Inc. Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
US5916794A (en) 1992-04-03 1999-06-29 Johns Hopkins University Methods for inactivating target DNA and for detecting conformational change in a nucleic acid
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US5792640A (en) 1992-04-03 1998-08-11 The Johns Hopkins University General method to clone hybrid restriction endonucleases using lig gene
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
CA2135644C (en) 1992-05-14 2009-01-27 Elisabetta Vegeto Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy
US5364791A (en) 1992-05-14 1994-11-15 Elisabetta Vegeto Progesterone receptor having C. terminal hormone binding domain truncations
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
US5503022A (en) 1993-01-25 1996-04-02 Barone; Larry A. Marine impeller tester
US5834266A (en) 1993-02-12 1998-11-10 President & Fellows Of Harvard College Regulated apoptosis
AU6234594A (en) 1993-02-12 1994-08-29 Johns Hopkins University, The Functional domains in (flavobacterium okeanokoites) (foki) restriction endonuclease
KR960702518A (ko) 1993-05-17 1996-04-27 린다 에스, 스티븐슨 Hiv 감염 및 aids에 대한 리보자임 유전자 치료(ribozyme gene therapy for hiv infection and aids)
CA2181548C (en) 1994-01-18 2009-11-03 Carlos F. Barbas, Iii Zinc finger protein derivatives and methods therefor
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5585245A (en) 1994-04-22 1996-12-17 California Institute Of Technology Ubiquitin-based split protein sensor
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
USRE45721E1 (en) 1994-08-20 2015-10-06 Gendaq, Ltd. Relating to binding proteins for recognition of DNA
US5789538A (en) 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
US5935811A (en) 1995-03-03 1999-08-10 California Institute Of Technology Neuron-restrictive silencer factor nucleic acids
US6265196B1 (en) 1996-05-07 2001-07-24 Johns Hopkins University Methods for inactivating target DNA and for detecting conformational change in a nucleic acid
US5925523A (en) 1996-08-23 1999-07-20 President & Fellows Of Harvard College Intraction trap assay, reagents and uses thereof
US6342345B1 (en) 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
AU752129B2 (en) 1997-08-27 2002-09-05 Ariad Gene Therapeutics, Inc. Chimeric transcriptional activators and compositions and uses related thereto
GB9724829D0 (en) 1997-11-21 1998-01-21 Muller Rolf Transcription factor
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
AU5994599A (en) 1999-07-12 2001-01-30 Mcgill University Rbp1 polypeptides and uses thereof
EP1250424B1 (de) 2000-01-24 2007-02-28 Gendaq, Ltd. Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne
US20020061512A1 (en) 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same
US7001768B2 (en) 2000-04-28 2006-02-21 Sangamo Biosciences, Inc. Targeted modification of chromatin structure
US20030044787A1 (en) 2000-05-16 2003-03-06 Joung J. Keith Methods and compositions for interaction trap assays
CA2423620A1 (en) 2000-09-28 2002-04-04 Sangamo Biosciences, Inc. Nuclear reprogramming using iwsi and related chromatin remodeling atpases
AU2002213431A1 (en) 2000-09-29 2002-04-08 Sangamo Biosciences, Inc. Modulation of gene expression using localization domains
WO2002044376A2 (en) 2000-11-28 2002-06-06 Sangamo Biosciences, Inc. Modulation of gene expression using insulator binding proteins
AU2002219992A1 (en) * 2000-12-01 2002-06-11 Sangamo Biosciences, Inc. Targeted regulation of gene expression
GB0108491D0 (en) 2001-04-04 2001-05-23 Gendaq Ltd Engineering zinc fingers
US20040224385A1 (en) 2001-08-20 2004-11-11 Barbas Carlos F Zinc finger binding domains for cnn
CA2474486C (en) 2002-01-23 2013-05-14 The University Of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
EP2927318B1 (de) 2003-08-08 2020-05-20 Sangamo Therapeutics, Inc. Verfahren und Zusammensetzungen für gezielte Spaltung und Rekombination
KR100857125B1 (ko) 2004-05-25 2008-09-11 주식회사 툴젠 단일클론 항체 생산을 증가시키는 폴리펩타이드, 이를코드하는 핵산 및 이의 용도

Also Published As

Publication number Publication date
EP1678315A2 (de) 2006-07-12
CA2539439C (en) 2012-10-23
CA2539439A1 (en) 2005-03-31
WO2005028630A2 (en) 2005-03-31
US20070059795A1 (en) 2007-03-15
WO2005028630A3 (en) 2005-06-09
EP1678315B1 (de) 2011-08-03
EP1678315A4 (de) 2006-11-08
AU2004274957B2 (en) 2009-02-05
AU2004274957A1 (en) 2005-03-31
US7407776B2 (en) 2008-08-05

Similar Documents

Publication Publication Date Title
ATE518960T1 (de) Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression
CY1118167T1 (el) Πρωτογενη και εγγυς ηπατικα βλαστοκυτταρα
NZ592726A (en) Amnion derived adherent cells
ATE439440T1 (de) Sirna-vermitteltes gen-silencing von alpha- synuklein
DE502006007198D1 (de) Verfahren zur herstellung von permanenten humanen zelllinien
MX2009010492A (es) Elementos de vector de expresion recombinante (reves) para mejorar la expresion de proteinas recombinantes en celulas huesped.
WO2003105725A3 (en) ARTIFICIAL CORNEA
DE602005020303D1 (de) Hemmung von biofilmbildung
TW200621253A (en) 2-amido-thiazole-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
DK1210411T3 (da) Sammensætninger og fremgangsmåder til forbedret celledyrkning
WO2004073641A3 (en) Induced activation in dendritic cells
TW200519202A (en) Modulation of eIF4E expression
ATE472604T1 (de) Verfahren zur herstellung von proteinen
ATE412761T1 (de) Methode um rekombinante proteine in cho zellen zu exprimieren
ATE500330T1 (de) Pflanzenpromotoren und verwendung davon
MY149621A (en) Serum-free culture medium for the production of recombinant gonadotropins
ATE527378T1 (de) Antisense-modulation von p38-mitogen-aktivierter proteinkinase-expression
SE0301233D0 (sv) Tissue specific promoters
DE602005015823D1 (de) Veränderung der wurzelstruktur während der pflanzenentwicklung
WO2003105755A3 (en) ANTISENSE MODULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) EXPRESSION
DE602005015868D1 (de) Modulation der anzahl von pflanzenzellen
UA95266C2 (uk) Композиції корму для тварин із ферментами, що знижують імунний стрес
NO20044901L (no) Anvendelse av modifiserte novirhabdoviruser i vaksiner
ATE426672T1 (de) Pflanzentransformation mit in-vivo-zusammenbau einer eigenschaft
ATE425256T1 (de) Neuer endospermspezifischer pflanzenpromotor für kulturpflanzen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties