CY1115354T1 - Ενωσεις πεγκυλιωμενης ινσουλινης lispro - Google Patents

Ενωσεις πεγκυλιωμενης ινσουλινης lispro

Info

Publication number
CY1115354T1
CY1115354T1 CY20141100472T CY141100472T CY1115354T1 CY 1115354 T1 CY1115354 T1 CY 1115354T1 CY 20141100472 T CY20141100472 T CY 20141100472T CY 141100472 T CY141100472 T CY 141100472T CY 1115354 T1 CY1115354 T1 CY 1115354T1
Authority
CY
Cyprus
Prior art keywords
lispro
consulated
relates
insulation units
pegylated
Prior art date
Application number
CY20141100472T
Other languages
English (en)
Inventor
John Michael Beals
Gordon Butler Cutler
Brandon Doyle
Ryan John Hansen
Shun Li
Shahriar Shirani
Lianshan Zhang
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41110836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1115354(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1115354T1 publication Critical patent/CY1115354T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Abstract

Η παρούσα εφεύρεση αναφέρεται στο πεδίο του διαβήτη. Ειδικότερα, η εφεύρεση αφορά σε ενώσεις πεγκυλιωμένης ινσουλίνης lispro που πεγκυλιώνονται με υψηλού μοριακού βάρους πολύ(αιθυλενογλυκόλη), είναι ιδιαίτερα διαλυτές σε φυσιολογικό pΗ, έχουν μια εκτεταμένη διάρκεια δράσης και χαρακτηρίζονται από φαρμακοκινητικούς, φαρμακοδυναμικούς, ή/και αιχμής-κοιλιάς λόγους μικρότερους από 2. Η εφεύρεση αφορά επίσης σε μεθόδους παροχής αυτών των μορίων, σε φαρμακευτικές συνθέσεις που τα περιέχουν και στις θεραπευτικές χρήσεις τους.
CY20141100472T 2008-06-13 2014-06-26 Ενωσεις πεγκυλιωμενης ινσουλινης lispro CY1115354T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6128108P 2008-06-13 2008-06-13
US12139408P 2008-12-10 2008-12-10
EP12158390.0A EP2476430B1 (en) 2008-06-13 2009-06-09 Pegylated insulin lispro compounds

Publications (1)

Publication Number Publication Date
CY1115354T1 true CY1115354T1 (el) 2017-01-04

Family

ID=41110836

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20121100478T CY1112977T1 (el) 2008-06-13 2012-05-25 Ενωσεις πεγκυλιωμενης ινσουλινης lispro
CY20141100472T CY1115354T1 (el) 2008-06-13 2014-06-26 Ενωσεις πεγκυλιωμενης ινσουλινης lispro

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20121100478T CY1112977T1 (el) 2008-06-13 2012-05-25 Ενωσεις πεγκυλιωμενης ινσουλινης lispro

Country Status (34)

Country Link
US (3) US9050371B2 (el)
EP (2) EP2476430B1 (el)
JP (2) JP4890662B2 (el)
KR (1) KR101238979B1 (el)
CN (1) CN102065884B (el)
AR (1) AR071990A1 (el)
AT (1) ATE554786T1 (el)
AU (1) AU2009257597B2 (el)
BR (1) BRPI0915838A2 (el)
CA (1) CA2727825C (el)
CL (1) CL2009001340A1 (el)
CO (1) CO6331292A2 (el)
CY (2) CY1112977T1 (el)
DK (2) DK2288375T3 (el)
DO (1) DOP2010000379A (el)
EA (1) EA028657B1 (el)
EC (1) ECSP10010677A (el)
ES (2) ES2473580T3 (el)
HK (2) HK1170659A1 (el)
HR (2) HRP20120397T1 (el)
IL (1) IL209265A (el)
JO (1) JO2932B1 (el)
MA (1) MA32394B1 (el)
MX (1) MX2010013837A (el)
MY (1) MY158890A (el)
NZ (1) NZ588997A (el)
PE (2) PE20091960A1 (el)
PL (2) PL2288375T3 (el)
PT (2) PT2288375E (el)
RS (1) RS52361B (el)
SI (2) SI2288375T1 (el)
TW (1) TWI451876B (el)
WO (1) WO2009152128A1 (el)
ZA (1) ZA201008174B (el)

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