CY1122218T1 - Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονης - Google Patents
Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονηςInfo
- Publication number
- CY1122218T1 CY1122218T1 CY20191101132T CY191101132T CY1122218T1 CY 1122218 T1 CY1122218 T1 CY 1122218T1 CY 20191101132 T CY20191101132 T CY 20191101132T CY 191101132 T CY191101132 T CY 191101132T CY 1122218 T1 CY1122218 T1 CY 1122218T1
- Authority
- CY
- Cyprus
- Prior art keywords
- azepino
- methylamino
- indole
- tetrahydro
- fluoro
- Prior art date
Links
- HMABYWSNWIZPAG-UHFFFAOYSA-N rucaparib Chemical compound C1=CC(CNC)=CC=C1C(N1)=C2CCNC(=O)C3=C2C1=CC(F)=C3 HMABYWSNWIZPAG-UHFFFAOYSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 abstract 1
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 abstract 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract
Η παρούσα εφεύρεση αναφέρεται σε νέες πολυμορφικές μορφές της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6Η-αζεπινο[5,4,3-cd]ινδολο-6-όνης•(Ι), και σε διαδικασίες παρασκευής τους. Τέτοιες πολυμορφικές μορφές μπορεί να είναι ένα συστατικό μίας φαρμακευτικής συνθέσεως και μπορεί να χρησιμοποιούνται για την αγωγή μίας νοσούσας καταστάσεως των θηλαστικών διαμεσολαβούμενης από δραστηριότητα της πολυμεράσης της πολυ(ΑDΡ-ριβόζης) που περιλαμβάνει μία νοσούσα κατάσταση όπως είναι ο καρκίνος.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US30427710P | 2010-02-12 | 2010-02-12 | |
EP11708094.5A EP2534153B1 (en) | 2010-02-12 | 2011-02-10 | Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one |
PCT/IB2011/050571 WO2011098971A1 (en) | 2010-02-12 | 2011-02-10 | Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one |
Publications (1)
Publication Number | Publication Date |
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CY1122218T1 true CY1122218T1 (el) | 2020-11-25 |
Family
ID=43859823
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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CY20161101288T CY1118319T1 (el) | 2010-02-12 | 2016-12-13 | Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονης |
CY2018031C CY2018031I1 (el) | 2010-02-12 | 2018-11-13 | Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονης |
CY20191101132T CY1122218T1 (el) | 2010-02-12 | 2019-10-31 | Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονης |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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CY20161101288T CY1118319T1 (el) | 2010-02-12 | 2016-12-13 | Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονης |
CY2018031C CY2018031I1 (el) | 2010-02-12 | 2018-11-13 | Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονης |
Country Status (30)
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US (5) | US8754072B2 (el) |
EP (4) | EP3150610B1 (el) |
JP (6) | JP5745283B2 (el) |
KR (2) | KR20120127495A (el) |
CN (2) | CN102884066B (el) |
AR (2) | AR080164A1 (el) |
AU (1) | AU2011213944B2 (el) |
CA (2) | CA3024216C (el) |
CY (3) | CY1118319T1 (el) |
DK (2) | DK3150610T3 (el) |
ES (2) | ES2607806T3 (el) |
HK (1) | HK1176617A1 (el) |
HR (2) | HRP20161742T1 (el) |
HU (3) | HUE047248T2 (el) |
IL (1) | IL220921B (el) |
LT (3) | LT3150610T (el) |
LU (1) | LUC00093I2 (el) |
MX (1) | MX343383B (el) |
NL (1) | NL300958I2 (el) |
NO (1) | NO2018039I1 (el) |
NZ (1) | NZ601445A (el) |
PL (2) | PL3150610T3 (el) |
PT (2) | PT3150610T (el) |
RS (2) | RS55487B1 (el) |
RU (1) | RU2570198C2 (el) |
SG (2) | SG10201406805RA (el) |
SI (2) | SI2534153T1 (el) |
SM (1) | SMT201600462B (el) |
TW (1) | TWI545123B (el) |
WO (1) | WO2011098971A1 (el) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3150610T (lt) | 2010-02-12 | 2019-11-11 | Pfizer | 8-fluor-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ono druskos ir polimorfai |
TW201516636A (zh) * | 2013-10-22 | 2015-05-01 | Hon Hai Prec Ind Co Ltd | 電子裝置及其供電方法 |
EP3182975A4 (en) | 2014-08-22 | 2018-04-18 | Clovis Oncology, Inc. | High dosage strength tablets of rucaparib |
AU2017267768A1 (en) * | 2016-05-16 | 2019-01-03 | Gb001, Inc. | Crystal of quinoline derivative |
DE102016218772A1 (de) * | 2016-09-28 | 2018-03-29 | Bruker Biospin Gmbh | Verbesserte Temperierung eines NMR-MAS-Rotors |
US10875870B2 (en) | 2017-01-24 | 2020-12-29 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib and of rucaparib salts |
CN109651377B (zh) * | 2017-10-12 | 2020-10-20 | 成都海创药业有限公司 | 一种治疗癌症的化合物及其用途 |
EP3704124A1 (en) | 2017-11-03 | 2020-09-09 | Sandoz AG | Crystalline salt of a tricyclic poly(adp-ribose) polymerase inhibitor |
US11220507B2 (en) | 2017-12-15 | 2022-01-11 | Advitech Advisory And Technologies Sa | Process for the preparation of rucaparib and novel synthesis intermediates |
WO2019130229A1 (en) | 2017-12-28 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing rucaparib |
BR112020013672A2 (pt) | 2018-01-05 | 2020-12-01 | Cybrexa 1, Inc. | compostos, composições, e métodos para tratamento de doenças que envolvem tecidos afetados por ácidos ou hipoxia |
US10442813B2 (en) | 2018-01-30 | 2019-10-15 | RK Pharma Solutions LLC | Polymorphs of rucaparib camsylate and methods of making same |
WO2019207498A1 (en) * | 2018-04-25 | 2019-10-31 | Biophore India Pharmaceuticals Pvt. Ltd | Solid forms of 8-fluoro-2-{4-[(methylamino)methyl] phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd] indol-6-one ((1s,4r)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt (rucaparib camsylate) and the prerparation thereof |
WO2019207596A1 (en) | 2018-04-25 | 2019-10-31 | Mylan Laboratories Limited | Novel crystalline forms of rucaparib (s)-camsylate salt and rucaparib free base |
CN108743557A (zh) * | 2018-06-27 | 2018-11-06 | 李莉 | 一种磷酸瑞卡帕布软胶囊及其制备方法 |
CN109111454A (zh) * | 2018-08-01 | 2019-01-01 | 宁波金未生物科技有限公司 | 一种瑞卡帕布s-樟脑磺酸盐 |
CN111217818A (zh) * | 2018-11-27 | 2020-06-02 | 台耀化学股份有限公司 | 芦卡帕尼樟脑磺酸盐的结晶、及制备三环化合物、芦卡帕尼及其樟脑磺酸盐结晶的方法 |
CN111542527A (zh) * | 2018-12-06 | 2020-08-14 | 上海诚妙医药科技有限公司 | 芦卡帕利樟脑磺酸盐的新晶型和制备方法及其用途 |
PE20220485A1 (es) | 2019-07-10 | 2022-04-04 | Cybrexa 3 Inc | Conjugados peptidicos de agentes dirigidos a microtubulos como terapeuticos |
TW202116778A (zh) | 2019-07-10 | 2021-05-01 | 美商斯布雷克薩二號公司 | 作為治療劑之細胞毒素之肽結合物 |
CN111004244A (zh) * | 2019-12-27 | 2020-04-14 | 重庆市碚圣医药科技股份有限公司 | 一种瑞卡帕布樟脑磺酸盐的合成方法 |
WO2021156140A1 (en) | 2020-02-03 | 2021-08-12 | Sandoz Ag | Polymorph of rucaparib mesylate |
IL297218A (en) * | 2020-04-24 | 2022-12-01 | Astrazeneca Ab | Pharmaceutical formulations |
MX2022013378A (es) | 2020-04-28 | 2023-02-15 | Rhizen Pharmaceuticals Ag | Compuestos novedosos útiles como inhibidores de poli(adp-ribosa) polimerasa (parp). |
EP4178571A1 (en) | 2020-07-10 | 2023-05-17 | The Regents Of The University Of Michigan | Gas41 inhibitors and methods of use thereof |
WO2022015557A1 (en) | 2020-07-14 | 2022-01-20 | Assia Chemical Industries Ltd | Solid state forms of rucaparib salts |
WO2022090938A1 (en) | 2020-10-31 | 2022-05-05 | Rhizen Pharmaceuticals Ag | Phthalazinone derivatives useful as parp inhibitors |
JP2024515338A (ja) | 2021-04-08 | 2024-04-09 | ライゼン ファーマシューティカルズ アーゲー | ポリ(adp-リボース)ポリメラーゼの阻害剤 |
WO2023137060A1 (en) | 2022-01-11 | 2023-07-20 | Assia Chemical Industries Ltd. | Solid state forms of rucaparib tosylate |
WO2023152754A1 (en) * | 2022-02-08 | 2023-08-17 | Sawant, Mohit Manikrao | Crystalline form of rosuvastatin allyl ester |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4489011A (en) | 1983-05-16 | 1984-12-18 | Merrell Dow Pharmaceuticals Inc. | Hypoglycemic N-(2-substituted-3-dialkylamino-2-propenylidene)-N-alkylalkanaminium camsylate salts |
GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
DE4125292A1 (de) * | 1991-07-31 | 1993-02-04 | Kali Chemie Pharma Gmbh | 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
MX9708026A (es) | 1995-04-20 | 1997-11-29 | Pfizer | Derivados del acido arislfulfonil hidroxamico, composiciones que los contienen y uso de los mismos. |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
EP0780386B1 (en) | 1995-12-20 | 2002-10-02 | F. Hoffmann-La Roche Ag | Matrix metalloprotease inhibitors |
PT885198E (pt) | 1996-03-05 | 2002-06-28 | Astrazeneca Ab | Derivados de 4-anilinoquinazolina |
JP3195756B2 (ja) | 1996-07-04 | 2001-08-06 | 公子 吉水 | 潤滑補助体 |
EP0818442A3 (en) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor |
EA199900021A1 (ru) | 1996-07-13 | 1999-08-26 | Глаксо, Груп Лимитед | Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы |
EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
EP0923585B1 (en) | 1996-07-18 | 2002-05-08 | Pfizer Inc. | Phosphinate based inhibitors of matrix metalloproteases |
EA199900139A1 (ru) | 1996-08-23 | 1999-08-26 | Пфайзер, Инк. | Производные арилсульфониламиногидроксамовой кислоты |
ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
ATE272640T1 (de) | 1997-01-06 | 2004-08-15 | Pfizer | Cyclische sulfonderivate |
JP3765584B2 (ja) | 1997-02-03 | 2006-04-12 | ファイザー・プロダクツ・インク | アリールスルホニルアミノヒドロキサム酸誘導体 |
BR9807824A (pt) | 1997-02-07 | 2000-03-08 | Pfizer | Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz |
IL131123A0 (en) | 1997-02-11 | 2001-01-28 | Pfizer | Arylsulfonyl hydroxamic acid derivatives |
CA2289102A1 (en) | 1997-05-07 | 1998-11-12 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
JP2002501532A (ja) | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
US5835420A (en) | 1997-06-27 | 1998-11-10 | Aplus Flash Technology, Inc. | Node-precise voltage regulation for a MOS memory system |
ATE263147T1 (de) | 1997-08-08 | 2004-04-15 | Pfizer Prod Inc | Derivate von aryloxyarylsulfonylamino hydroxyaminsäuren |
DE69838172T2 (de) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | Oxindolylchinazolinderivate als angiogenesehemmer |
AU744939B2 (en) | 1997-09-26 | 2002-03-07 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
WO1999024440A1 (en) | 1997-11-11 | 1999-05-20 | Pfizer Products Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
JP4462654B2 (ja) | 1998-03-26 | 2010-05-12 | ソニー株式会社 | 映像素材選択装置及び映像素材選択方法 |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
CA2314156C (en) | 1998-05-29 | 2010-05-25 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
DE69915004T2 (de) | 1998-11-05 | 2004-09-09 | Pfizer Products Inc., Groton | 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate |
US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
EP1140179A2 (en) | 1998-12-23 | 2001-10-10 | G.D. SEARLE & CO. | Use of a cyclooxygenase 2 inhibitor and an integrin antagonist as a combination therapy in the treatment of neoplasia |
JP4093448B2 (ja) | 1999-01-11 | 2008-06-04 | アグロン・ファーマシューティカルズ・インコーポレーテッド | ポリ(adp−リボース)ポリメラーゼの三環系阻害剤 |
KR100452491B1 (ko) | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법 |
KR20040011751A (ko) | 2002-07-30 | 2004-02-11 | 씨제이 주식회사 | 암로디핀의 유기산염 |
WO2004056802A1 (en) | 2002-12-19 | 2004-07-08 | Pfizer Products Inc. | Complexes of e-2-methoxy-n-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide, their method of production, and use |
MXPA05010563A (es) | 2003-03-31 | 2005-11-23 | Pfizer | Sales de los inhibidores triciclicos de las poli(adp-ribosa) polimerasas. |
NZ544989A (en) | 2003-07-25 | 2009-10-30 | Cancer Rec Tech Ltd | Tricyclic PARP inhibitors |
CN101384264B (zh) * | 2004-09-22 | 2012-03-14 | 辉瑞大药厂 | 含有聚(adp-核糖)聚合酶抑制剂的治疗组合物 |
ATE551345T1 (de) * | 2004-09-22 | 2012-04-15 | Pfizer | Polymorphe formen des phosphatsalzes von 8-fluor- 2-ä4-ä(methylamino)methylüphenylü-1,3,4,5- tetrahydro-6h-azepinoä5,4,3-cdüindol-6-on |
DE602005018506D1 (de) | 2004-09-22 | 2010-02-04 | Pfizer | Verfahren zur herstellung von poly(adp-ribose)polymeraseinhibitoren |
EP1793830A2 (en) | 2004-09-22 | 2007-06-13 | Pfizer, Inc. | Therapeutic combinations comprising poly(adp-ribose) polymerases inhibitor |
GB0502509D0 (en) | 2005-02-07 | 2005-03-16 | Pfizer Ltd | Novel salt form of a dopamine agonist |
EP1848402B2 (en) * | 2005-02-23 | 2019-02-20 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
JP2009542647A (ja) * | 2006-07-05 | 2009-12-03 | テバ ファーマシューティカル インダストリーズ リミティド | メマンチン医薬組成物 |
KR100843401B1 (ko) | 2006-12-04 | 2008-07-04 | 씨제이제일제당 (주) | 결정성 s-(-)-암로디핀 캠실레이트 무수물 및 이의제조방법 |
PL2091910T3 (pl) * | 2006-12-06 | 2015-02-27 | Conatus Pharmaceuticals Inc | Postacie krystaliczne kwasu (3S)-3-[N-(N’-(2-tert-butylofenylo)oksamylo)alaninylo]amino-5-(2’,3’,5’,6’-tetrafluorofenoksy)-4-oksopentanowego |
WO2008114114A2 (en) * | 2007-03-16 | 2008-09-25 | Pfizer Products Inc. | Poly(adp-ribose) polymerases inhibitor for treating ophthalmic condition |
EP2065385A1 (en) | 2007-11-28 | 2009-06-03 | Laboratorios SALVAT, S.A. | Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester |
US20110053997A1 (en) * | 2007-12-05 | 2011-03-03 | Alexander Beliaev | Salts and Crystal Forms |
KR20090060674A (ko) | 2007-12-10 | 2009-06-15 | 씨제이제일제당 (주) | 결정형의 지프라시돈 술폰산염, 그 제조방법, 및 그것를포함하는 약제학적 조성물 |
CA2711491C (en) | 2008-01-08 | 2016-03-08 | Jennifer R. Foley | Pharmaceutically acceptable salts of 2-{4-[(3s)-piperidin-3-yl]phenyl}-2h-indazole-7-carboxamide |
BRPI1006813A2 (pt) | 2009-01-17 | 2016-04-12 | Boomerang Systems Inc | sistema de armazenamento automático e veículo de transporte |
LT3150610T (lt) * | 2010-02-12 | 2019-11-11 | Pfizer | 8-fluor-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ono druskos ir polimorfai |
WO2013044077A1 (en) | 2011-09-23 | 2013-03-28 | Johnson Controls Technology Company | Systems and methods for rear view mirror displays |
CN104053696B (zh) | 2011-12-26 | 2015-07-08 | 胜技高分子株式会社 | 聚对苯二甲酸丁二醇酯树脂颗粒、以及该聚对苯二甲酸丁二醇酯树脂颗粒的制造方法 |
US9384339B2 (en) | 2012-01-13 | 2016-07-05 | Telecommunication Systems, Inc. | Authenticating cloud computing enabling secure services |
US9672526B2 (en) | 2012-03-13 | 2017-06-06 | American Express Travel Related Services Company, Inc. | Systems and methods for tailoring marketing |
KR101984831B1 (ko) | 2013-01-31 | 2019-05-31 | 삼성전자 주식회사 | 반도체 패키지 및 그 제조 방법 |
CN103309115B (zh) | 2013-05-30 | 2016-03-23 | 京东方科技集团股份有限公司 | 彩色电泳显示面板及其制造方法、显示装置 |
US9501163B2 (en) | 2014-05-06 | 2016-11-22 | Symbol Technologies, Llc | Apparatus and method for activating a trigger mechanism |
US10884952B2 (en) | 2016-09-30 | 2021-01-05 | Intel Corporation | Enforcing memory operand types using protection keys |
JP6943759B2 (ja) | 2017-12-28 | 2021-10-06 | 株式会社東海理化電機製作所 | シフト装置 |
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