BR112012019050A8 - sais e polimorfos de 8-fluoro-2-{metilamino)metil]fenil}-1,3,4,5-tetra-hidro-6h-azepino[5,4,3cd]indol-6-ona. - Google Patents
sais e polimorfos de 8-fluoro-2-{metilamino)metil]fenil}-1,3,4,5-tetra-hidro-6h-azepino[5,4,3cd]indol-6-ona.Info
- Publication number
- BR112012019050A8 BR112012019050A8 BR112012019050A BR112012019050A BR112012019050A8 BR 112012019050 A8 BR112012019050 A8 BR 112012019050A8 BR 112012019050 A BR112012019050 A BR 112012019050A BR 112012019050 A BR112012019050 A BR 112012019050A BR 112012019050 A8 BR112012019050 A8 BR 112012019050A8
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- azepino
- tetrahydro
- fluoro
- polymorphs
- Prior art date
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 title abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 abstract 1
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 abstract 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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Abstract
sais e polimorfos de 8-fluoro-2{metil-amino)metil]fenil}-1,3,4,5-tetra-hidro-6h-azepino[5,4,3cd]in-dol-6-ona. a presente invenção refere-se a novas formas polimórficas de 8-fluoro-2-{4-[metilamino)metil}-1,3,4,5-tetra-hidro-6h-azepino[5,4,3-cd]indo-6-ona, e aos processos para sua preparação. tais formas polimórficas podem ser um componente de uma composição farmacêutica e podem ser usadas para tratar uma condição de doença mamífera mediada por atividade de poli(adp-ribose) polimerase incluindo a condição de doença tal como câncer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30427710P | 2010-02-12 | 2010-02-12 | |
| US61/304,277 | 2010-02-12 | ||
| PCT/IB2011/050571 WO2011098971A1 (en) | 2010-02-12 | 2011-02-10 | Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012019050A2 BR112012019050A2 (pt) | 2016-09-13 |
| BR112012019050A8 true BR112012019050A8 (pt) | 2017-12-26 |
| BR112012019050B1 BR112012019050B1 (pt) | 2021-12-21 |
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