CY1114893T1 - Παραγωγη ανθρωπινης γλυκοσερεμπροσιδασης υψηλης μαννοζης σε φυτικη καλλιεργεια - Google Patents

Παραγωγη ανθρωπινης γλυκοσερεμπροσιδασης υψηλης μαννοζης σε φυτικη καλλιεργεια

Info

Publication number
CY1114893T1
CY1114893T1 CY20141100067T CY141100067T CY1114893T1 CY 1114893 T1 CY1114893 T1 CY 1114893T1 CY 20141100067 T CY20141100067 T CY 20141100067T CY 141100067 T CY141100067 T CY 141100067T CY 1114893 T1 CY1114893 T1 CY 1114893T1
Authority
CY
Cyprus
Prior art keywords
human
glucoseremoproduction
manufacture
plant cultivation
protein
Prior art date
Application number
CY20141100067T
Other languages
English (en)
Inventor
Yoseph Shaaltiel
Gideon Baum
Sharon Hashmueli
Ayala Lewkowicz
Daniel Bartfeld
Original Assignee
Protalix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protalix Ltd filed Critical Protalix Ltd
Publication of CY1114893T1 publication Critical patent/CY1114893T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε ανασυνδυασμένη πρωτεΐνη που περιλαμβάνει πρωτεΐνη ανθρώπινης γλυκοσερεμπροσιδάσης (GCD) που συνδέεται στο C άκρο αυτής προς κενοτοπιακό στοχοθετικό σηματοδοτικό πεπτίδιο όπως εκτίθεται στην SEQ ID NO: 2.
CY20141100067T 2003-04-27 2014-01-24 Παραγωγη ανθρωπινης γλυκοσερεμπροσιδασης υψηλης μαννοζης σε φυτικη καλλιεργεια CY1114893T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL15558803A IL155588A0 (en) 2003-04-27 2003-04-27 Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
EP10012376.9A EP2333083B1 (en) 2003-04-27 2004-02-24 Production of high mannose human glucocerebrosidease in plant culture

Publications (1)

Publication Number Publication Date
CY1114893T1 true CY1114893T1 (el) 2016-12-14

Family

ID=32697072

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100067T CY1114893T1 (el) 2003-04-27 2014-01-24 Παραγωγη ανθρωπινης γλυκοσερεμπροσιδασης υψηλης μαννοζης σε φυτικη καλλιεργεια

Country Status (21)

Country Link
US (1) US20060204487A1 (el)
EP (6) EP1618177B1 (el)
JP (2) JP4993693B2 (el)
KR (3) KR101332372B1 (el)
CN (2) CN1875111B (el)
AU (1) AU2004234635B2 (el)
BR (1) BRPI0410520B8 (el)
CA (1) CA2523539C (el)
CY (1) CY1114893T1 (el)
DK (1) DK2333083T3 (el)
ES (2) ES2391057T3 (el)
HK (1) HK1088041A1 (el)
IL (3) IL155588A0 (el)
MX (1) MXPA05011507A (el)
PT (1) PT2333083E (el)
RU (2) RU2385928C3 (el)
SG (2) SG2013021217A (el)
SI (1) SI2333083T1 (el)
UA (1) UA89944C2 (el)
WO (1) WO2004096978A2 (el)
ZA (1) ZA200508680B (el)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
US7951557B2 (en) * 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
WO2006094267A2 (en) * 2005-03-03 2006-09-08 Indiana University Research And Technology Corporation Permethylation of oligosaccharides
EP1904638A2 (en) * 2005-07-18 2008-04-02 Metabogal Ltd. Mucosal or enteral administration of biologically active macromolecules
ATE543508T1 (de) 2006-10-31 2012-02-15 Yildiz Dr Med Yildiz Therapeutische verwendung von gba2
ES2660667T3 (es) 2007-05-07 2018-03-23 Protalix Ltd. Biorreactor desechable a gran escala
US9080180B2 (en) 2007-07-03 2015-07-14 Idemitsu Kosan Co., Ltd. Transgenic plants expressing STX2EB protein for use as a pig edema disease vaccine
US8742079B2 (en) 2007-08-20 2014-06-03 Protalix Ltd. Saccharide-containing protein conjugates and uses thereof
ITUD20080055A1 (it) * 2008-03-13 2009-09-14 Transactiva S R L Procedimento per la produzione di una proteina umana in pianta, in particolare un enzima lisosomiale umano ricombinante in endosperma di cereali
JP5305284B2 (ja) * 2008-03-26 2013-10-02 独立行政法人産業技術総合研究所 糖化合物の質量分析法
EP2413962A1 (en) 2009-03-30 2012-02-08 Mount Sinai School of Medicine Influenza virus vaccines and uses thereof
ES2668079T3 (es) 2009-07-28 2018-05-16 Shire Human Genetic Therapies Composiciones y métodos para tratar la enfermedad de Gaucher
EP3482767B1 (en) 2009-08-28 2021-10-06 Icahn School of Medicine at Mount Sinai Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
US20120230974A1 (en) 2009-11-17 2012-09-13 Protalix Ltd Alkaline alpha galactosidase for the treatment of fabry disease
WO2011107992A2 (en) 2010-03-02 2011-09-09 Protalix Ltd. Multimeric forms of therapeutic proteins and uses thereof
CA2792537A1 (en) 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
WO2012001641A1 (en) * 2010-06-30 2012-01-05 Actelion Pharmaceuticals Ltd Stable pharmaceutical compositions
US20130224797A1 (en) 2010-10-15 2013-08-29 Jcr Pharmaceuticals Co., Ltd. Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
DK2665814T3 (en) * 2011-01-20 2017-09-11 Protalix Ltd NUCLEIC ACID CONSTRUCTION FOR EXPRESSION OF ALPHA-GALACTOSIDASE IN PLANTS AND PLANT CELLS
KR101158673B1 (ko) 2011-06-24 2012-07-03 주식회사 지씨바이오 재조합 인간 이듀로네이트-2-설파타아제를 포함하는 조성물, 제제 및 이의 제조방법
US20160145589A1 (en) 2011-06-24 2016-05-26 Green Cross Corporation Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
EP2758075B1 (en) 2011-09-20 2023-05-03 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
AU2013220005A1 (en) 2012-02-19 2014-09-04 Protalix Ltd. Oral unit dosage forms and uses of same for the treatment of Gaucher disease
CA2865614A1 (en) 2012-03-02 2013-09-06 Shire Human Genetic Therapies, Inc. Compositions and methods for treating type iii gaucher disease
JP2016508133A (ja) 2012-12-18 2016-03-17 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン及びその使用
WO2014133365A1 (ko) * 2013-02-28 2014-09-04 주식회사 운화 재조합 식물세포, 이의 제조방법 및 이를 이용한 목적 단백질의 생산방법
CA2902298A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
EP2789686A1 (en) 2013-04-11 2014-10-15 Greenovation Biotech GmbH Expression of phosphorylated glycoproteins in plants
WO2015118547A1 (en) 2014-02-10 2015-08-13 Protalix Ltd. Method of maintaining disease stability in a subject having gaucher's disease
EP3166626B1 (en) * 2014-07-11 2021-04-28 Biostrategies LC Materials and methods for treating disorders associated with sulfatase enzymes
US10000551B2 (en) 2014-09-11 2018-06-19 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
EP3221455B1 (en) 2014-11-20 2020-08-12 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells
JP2018504412A (ja) 2015-01-23 2018-02-15 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン接種レジメン
KR20170124549A (ko) * 2015-03-17 2017-11-10 그리노파티온 바이오테크 게엠베하 글리코실화된 리소좀 단백질, 생산 방법 및 용도
CN109475795B (zh) * 2016-05-13 2021-06-01 安捷伦科技有限公司 用于自动对准、校准和标准化电泳数据的系统和方法
EP3471767A4 (en) 2016-06-15 2020-01-15 Icahn School of Medicine at Mount Sinai INFLUENZA VIRUS HEMAGGLUTININS AND USES THEREOF
EP3606555A4 (en) 2017-04-07 2021-08-04 Icahn School of Medicine at Mount Sinai INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES
RU2668158C1 (ru) * 2017-06-28 2018-09-26 Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" Способ очистки имиглюцеразы

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US467993A (en) * 1892-02-02 Alfred jorgensen
US2147271A (en) * 1937-07-16 1939-02-14 Schwarz Lab Inc Pure yeast culture apparatus
US2341259A (en) * 1941-01-22 1944-02-08 Lummus Co Inoculating method and apparatus
US2836434A (en) * 1952-08-21 1958-05-27 Separator Ab Arrangement for sterile interconnection and sealing of apparatuses in a plant for instance for cultivation of bacteria
US3201327A (en) * 1962-08-21 1965-08-17 Sun Oil Co Fermentation apparatus and process
SE347015B (el) * 1966-10-06 1972-07-24 Sanraku Ocean Co
US3468520A (en) * 1967-05-12 1969-09-23 American Cyanamid Co Combination agitation and transfer unit for suspended cells
US3504185A (en) * 1968-05-09 1970-03-31 Univ Syracuse Res Corp Apparatus for measuring and controlling cell population density in a liquid medium
GB1284077A (en) * 1968-10-18 1972-08-02 British Petroleum Co Process and apparatus for the cultivation of micro-organisms
US3540700A (en) * 1969-01-24 1970-11-17 New Brunswick Scientific Co Rotary processing apparatus
DE2059931C3 (de) * 1970-12-05 1973-10-18 Knapsack Ag, 5033 Huerth-Knapsack Verfahren zum Verhindern von Schaumausbrüchen aus geschlossenen Reaktionsräumen
US3950227A (en) * 1970-12-21 1976-04-13 St. John's University Batch method of establishing and maintaining a controlled aerobic environment for a microbial culture
US3793154A (en) * 1970-12-21 1974-02-19 Univ St Johns Apparatus for gaseous environmental control of batch cultures of micro-organisms
US4179339A (en) * 1977-03-02 1979-12-18 Olympus Optical Company, Ltd. Liquid feeder for automatic culture apparatus
US4228243A (en) * 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
US4328317A (en) * 1980-03-31 1982-05-04 Solargizer International, Inc. Continuous chemical conversion or fermentation apparatus
DE3133314A1 (de) * 1981-08-22 1983-03-10 Hoechst Ag, 6000 Frankfurt "vorrichtung zum dispergieren einer zweiten phase in einer ersten phase"
US4519984A (en) * 1982-01-18 1985-05-28 Phillips Petroleum Company Apparatus for carrying out sparged reaction
CH663422A5 (de) * 1982-05-27 1987-12-15 Chemap Ag Verfahren und fermenter zur zuechtung von gewebezellen.
US4708938A (en) * 1984-04-30 1987-11-24 Hickinbotham Winemakers Pty. Ltd. Alcoholic fermentation
US4668632A (en) * 1985-02-06 1987-05-26 Vxr, Inc. Sparger and apparatus for and method of growing cells
US5372945A (en) * 1985-06-06 1994-12-13 Alchas; Paul G. Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product
CN85100412B (zh) * 1985-06-25 1988-02-10 山东省食品发酵工业研究所 用嗜热放线菌生产固定化葡萄糖异构酶的方法及其用于高果糖糖浆的生产方法
US4713345A (en) * 1985-07-29 1987-12-15 Grain Processing Corporation Fermentation methods and apparatus
EP0224962A1 (en) * 1985-11-25 1987-06-10 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Apparatus for the continuous cultivation of microorganisms in a culture liquid
US5166072A (en) * 1986-06-26 1992-11-24 Bayer Aktiengesellschaft Apparatus for the cultivation of immobilized micro-organisms
US4717668A (en) * 1986-12-12 1988-01-05 Baxter Travenol Laboratories, Inc. Plastic roller bottle for suspension cultures
US5081036A (en) * 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
US4908315A (en) * 1987-03-04 1990-03-13 Agristar, Inc. Integument and method for micropropagation and tissue culturing
CN1033394A (zh) * 1987-11-28 1989-06-14 日本新药株式会社 氨基脱氧甘露糖醇的制法
US6846968B1 (en) * 1988-02-26 2005-01-25 Large Scale Biology Corporation Production of lysosomal enzymes in plants by transient expression
US4931401A (en) * 1988-09-01 1990-06-05 La Societe De Recherche Snc Inc. Bioreactor
US5549892A (en) 1988-12-23 1996-08-27 Genzyme Corporation Enhanced in vivo uptake of glucocerebrosidase
US5073491A (en) * 1988-12-23 1991-12-17 Hoffman-La Roche Inc. Immobilization of cells in alginate beads containing cavities for growth of cells in airlift bioreactors
US5188946A (en) * 1989-01-26 1993-02-23 Biocontrol Systems Incorporated Process and device for sequential microbial enrichment in a single apparatus
US5100801A (en) * 1989-01-26 1992-03-31 Biocontrol Systems, Inc. Device for sequential microbial enrichment in a single apparatus
JP2514102B2 (ja) * 1990-06-13 1996-07-10 ユリカ株式会社 ユリ科アロエ属に属する植物の真空凍結乾燥体を利用した錠剤製品及びその製造方法
EP0462065B1 (de) * 1990-06-15 2005-03-02 Syngenta Participations AG Neue Signalsequenzen
EP0471947A1 (en) * 1990-06-29 1992-02-26 Sekisui Chemical Co., Ltd. Culture bag
US5240598A (en) * 1990-09-18 1993-08-31 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Microbubble generator for the transfer of oxygen to microbial inocula and microbubble generator immobilized cell reactor
US5401650A (en) * 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
EP0485970A3 (en) * 1990-11-13 1992-07-01 Yeda Research And Development Company Limited Transgenic plants overproducing threonine and lysine
AT394576B (de) * 1991-01-16 1992-05-11 Vogelbusch Gmbh Reaktor zur durchfuehrung biologischer reaktionen mittels biokatalysatoren
US5612188A (en) * 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
US5267791A (en) * 1991-12-13 1993-12-07 Corning Incorporated Suspended cell culture stirring vessel closure and apparatus
JPH05219834A (ja) * 1992-02-14 1993-08-31 Fumiko Kobayashi ディスポーサブル培養袋及び培養方法
IL102189A (en) * 1992-06-12 1995-07-31 Univ Ben Gurion Device for growing microorganisms
US5409833A (en) * 1993-07-01 1995-04-25 Baxter International Inc. Microvessel cell isolation apparatus
US5342781A (en) * 1993-07-15 1994-08-30 Su Wei Wen W External-loop perfusion air-lift bioreactor
EP0793717B1 (en) * 1994-10-24 2005-01-26 The Texas A & M University System Oral immunization with transgenic plants
EP0865499B1 (en) * 1995-09-14 2009-03-18 Virginia Tech Intellectual Properties, Inc. Production of lysosomal enzymes in plant-based expression systems
WO1997029200A1 (de) * 1996-02-08 1997-08-14 Institut für Pflanzengenetik und Kulturpflanzenforschung Kassetten zur expression von lagerstabilen proteinen in pflanzen
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US6083725A (en) * 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL119310A (en) 1996-09-26 1999-07-14 Metabogal Ltd Cell/tissue culturing device and method
US6190913B1 (en) * 1997-08-12 2001-02-20 Vijay Singh Method for culturing cells using wave-induced agitation
US6096546A (en) * 1998-01-30 2000-08-01 Board Of Trustees, Rutgers, The State University Of New Jersey Methods for recovering polypeptides from plants and portions thereof
WO2000011953A1 (en) * 1998-09-01 2000-03-09 Penn State Research Foundation Method and apparatus for aseptic growth or processing of biomass
IL142041A0 (en) * 1998-10-07 2002-03-10 Syngenta Participations Ag Therapeutically active proteins in plants
US6432698B1 (en) * 1999-01-06 2002-08-13 Rutgers, The State University Disposable bioreactor for culturing microorganisms and cells
JP2002000248A (ja) * 2000-06-23 2002-01-08 Daiichi Kagaku Kk 凍結法及び凍結乾燥法
AU8822601A (en) * 2000-07-31 2002-02-13 Biolex Inc Expression of biologically active polypeptides in duckweed
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
AU2002232803A1 (en) * 2000-11-15 2002-05-27 Genzyme Corporation Expression system for recombinant proteins
WO2002081695A2 (en) * 2001-04-06 2002-10-17 Syngenta Participations Ag Genes that are modulated by posttranscriptional gene silencing
DE60233395D1 (de) * 2001-04-18 2009-10-01 Valtion Teknillinen Die verwendung von abc transporter kodierenden genen zur stimulierung der herstellung von sekundärmetaboliten in biologischen zellen
US7629309B2 (en) * 2002-05-29 2009-12-08 Zystor Therapeutics, Inc. Targeted therapeutic proteins
ES2224792B1 (es) * 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
US7951557B2 (en) * 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
EP1682576A1 (en) * 2003-11-06 2006-07-26 Compugen Ltd. Variants of human glycoprotein hormone alpha chain: compositions and uses thereof
DE602005007423D1 (de) * 2004-06-02 2008-07-24 Millipore Corp Einwegreaktor
DK1773976T4 (da) * 2004-06-04 2020-02-10 Global Life Sciences Solutions Usa Llc Engangsbioreaktorsystemer og -fremgangsmåder
DE602005021379D1 (de) * 2004-10-13 2010-07-01 Protalix Ltd System und verfahren zur produktion von antikörpern in der pflanzenzellkultur
US20080132743A1 (en) * 2006-12-01 2008-06-05 Albemarle Corporation Production of high purity decabromodiphenylalkanes
ES2660667T3 (es) * 2007-05-07 2018-03-23 Protalix Ltd. Biorreactor desechable a gran escala

Also Published As

Publication number Publication date
EP2343378B1 (en) 2014-09-10
EP1618177A4 (en) 2007-07-04
RU2009148012A (ru) 2011-06-27
CN1875111A (zh) 2006-12-06
JP4993693B2 (ja) 2012-08-08
RU2535342C2 (ru) 2014-12-10
IL182888A (en) 2014-08-31
EP2343378A1 (en) 2011-07-13
RU2385928C9 (ru) 2021-07-19
KR20060018826A (ko) 2006-03-02
PT2333083E (pt) 2014-02-26
RU2385928C3 (ru) 2021-12-27
JP2011184445A (ja) 2011-09-22
SI2333083T1 (sl) 2014-03-31
IL171561A (en) 2014-09-30
KR20120093964A (ko) 2012-08-23
RU2385928C2 (ru) 2010-04-10
EP2330205B1 (en) 2015-01-21
RU2005136874A (ru) 2006-06-10
US20060204487A1 (en) 2006-09-14
WO2004096978A2 (en) 2004-11-11
EP2330205A1 (en) 2011-06-08
BRPI0410520A (pt) 2006-06-20
IL182888A0 (en) 2007-08-19
CA2523539A1 (en) 2004-11-11
EP2333083B1 (en) 2014-01-01
KR20110089193A (ko) 2011-08-04
UA89944C2 (ru) 2010-03-25
EP1618177A2 (en) 2006-01-25
EP2333083A1 (en) 2011-06-15
AU2004234635A1 (en) 2004-11-11
CN102240397A (zh) 2011-11-16
BRPI0410520B8 (pt) 2021-05-25
EP1618177B1 (en) 2012-06-06
ZA200508680B (en) 2008-10-29
SG2013021217A (en) 2015-08-28
EP2330204A1 (en) 2011-06-08
DK2333083T3 (da) 2014-01-27
KR101332372B1 (ko) 2013-11-27
SG2007172737A (en) 2014-09-26
ES2391057T3 (es) 2012-11-21
IL155588A0 (en) 2003-11-23
EP2322636A1 (en) 2011-05-18
ES2446965T3 (es) 2014-03-11
CN1875111B (zh) 2011-06-29
AU2004234635B2 (en) 2010-05-13
EP2322636B1 (en) 2015-04-08
HK1088041A1 (en) 2006-10-27
CA2523539C (en) 2017-06-06
BRPI0410520B1 (pt) 2021-02-23
JP2006524506A (ja) 2006-11-02
WO2004096978A3 (en) 2006-03-30
MXPA05011507A (es) 2006-07-03

Similar Documents

Publication Publication Date Title
CY1114893T1 (el) Παραγωγη ανθρωπινης γλυκοσερεμπροσιδασης υψηλης μαννοζης σε φυτικη καλλιεργεια
IN2014CN02050A (el)
CY1121353T1 (el) Anti-tnf αντισωματα, συνθεσεις, μεθοδοi και χρησεις
DK2327719T3 (da) Hybrid- og tandemekspression af neisseria-proteiner
ATE417595T1 (de) Keratin-bindende polypeptide
HK1088840A1 (en) Stable analogs of glp-1 glp-1
EP1200124A4 (en) IMMUNOGLOBIN FUSION PROTEINS
RS53505B1 (en) OXYTOMODULIN PEPTIDE ANALOG
NO20063026L (no) Antistoffer
DE602005008996D1 (de) Radiofluorierte peptide
MX2008009493A (es) Peptido novedoso y uso del mismo.
RS52747B (en) THERAPEUTIC ACTIVE ANALYSIS OF ALFA-MSH
DE602006020032D1 (de) Il-21-varianten
DK1904529T3 (da) Anvendelse af Stefin A som et scaffoldprotein
CY1114724T1 (el) Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων
EA201100459A1 (ru) Композиции, включающие интерлейкин-1 и пептиды
ATE521626T1 (de) Fusionsprotein zur inhibierung von gebärmutterhalskrebs
DK1417222T3 (da) Isolerede polypeptider baseret på den neutraliserende epitop af p17-proteinet fra HIV egnet til vacciner samt neutraliserende anti-p17-antistoffer, der specifikt genkender nævnte neutraliserende epitop
DK1778271T3 (da) Peptid til behandling af herpesvirusinfektioner
TR200102655T2 (tr) Dört L. infantum proteininin antijen belirleyicilerini kodlayan kimerik gen.
DK1519951T3 (da) Kationiske ligekædede peptider med antifungale egenskaber
TW200505943A (en) Polypeptide
ATE414156T1 (de) Lipase-varianten
ATE370964T1 (de) Isoliertes fluoreszierendes protein aus clytia gregaria cgfp, sowie dessen verwendung
DK2076532T3 (da) Cytokinderivater