CY1114171T1 - Συζευγματα αλλεργιογονων γατας και χρησεις τους - Google Patents
Συζευγματα αλλεργιογονων γατας και χρησεις τουςInfo
- Publication number
- CY1114171T1 CY1114171T1 CY20131100638T CY131100638T CY1114171T1 CY 1114171 T1 CY1114171 T1 CY 1114171T1 CY 20131100638 T CY20131100638 T CY 20131100638T CY 131100638 T CY131100638 T CY 131100638T CY 1114171 T1 CY1114171 T1 CY 1114171T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cat
- antigen
- compositions
- vlp
- conjunctions
- Prior art date
Links
- 230000002009 allergenic effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 6
- 102000036639 antigens Human genes 0.000 abstract 6
- 108091007433 antigens Proteins 0.000 abstract 6
- 241000282326 Felis catus Species 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 239000013566 allergen Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 208000001840 Dandruff Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000005180 public health Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66291805P | 2005-03-18 | 2005-03-18 | |
| EP06725140.5A EP1868642B1 (en) | 2005-03-18 | 2006-03-17 | Cat allergen fusion proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114171T1 true CY1114171T1 (el) | 2016-08-31 |
Family
ID=36843236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100638T CY1114171T1 (el) | 2005-03-18 | 2013-07-26 | Συζευγματα αλλεργιογονων γατας και χρησεις τους |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7767212B2 (https=) |
| EP (1) | EP1868642B1 (https=) |
| JP (2) | JP5302671B2 (https=) |
| KR (1) | KR20070112225A (https=) |
| CN (2) | CN103203016A (https=) |
| AU (1) | AU2006224529B2 (https=) |
| BR (1) | BRPI0608455A2 (https=) |
| CA (1) | CA2599218C (https=) |
| CY (1) | CY1114171T1 (https=) |
| DK (1) | DK1868642T3 (https=) |
| ES (1) | ES2424229T3 (https=) |
| IL (1) | IL185103A0 (https=) |
| MX (1) | MX2007011160A (https=) |
| NZ (1) | NZ561040A (https=) |
| PL (1) | PL1868642T3 (https=) |
| PT (1) | PT1868642E (https=) |
| RU (1) | RU2414239C2 (https=) |
| WO (1) | WO2006097530A2 (https=) |
| ZA (1) | ZA200707413B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| US7138252B2 (en) * | 2002-07-17 | 2006-11-21 | Cytos Biotechnology Ag | Molecular antigen arrays |
| EP2338510A1 (en) * | 2002-07-19 | 2011-06-29 | Novartis Pharma AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| ZA200707413B (en) * | 2005-03-18 | 2009-01-28 | Cytos Biotechnology Ag | Cat allergen fusion proteins and uses thereof |
| CA2636139A1 (en) * | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| WO2007113633A2 (en) * | 2006-04-03 | 2007-10-11 | Pfizer Products Inc. | Immunogenic compositions comprising cat allergen fel dl |
| AT503690A1 (de) * | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| US8541559B2 (en) | 2006-06-12 | 2013-09-24 | Cytos Biotechnology Ag | Process for producing aggregated oligonucleotides |
| EP2066354B1 (en) | 2006-09-29 | 2013-04-17 | Ligocyte Pharmaceuticals, Inc. | Norovirus vaccine formulations |
| US9388236B2 (en) | 2007-07-09 | 2016-07-12 | Nestec Sa | Methods for reducing allergies caused by environmental allergens |
| ES2599639T3 (es) * | 2007-07-09 | 2017-02-02 | Nestec S.A. | Procedimientos para reducir las alergias causadas por alérgenos ambientales |
| CN104740624B (zh) | 2007-09-18 | 2018-04-24 | 武田疫苗股份有限公司 | 赋予针对诺如病毒的保护性免疫应答的疫苗 |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| EP2042193A1 (en) * | 2007-09-28 | 2009-04-01 | Biomay AG | RNA Vaccines |
| NO2324113T3 (https=) | 2008-08-08 | 2018-07-28 | ||
| BR112013011069A2 (pt) * | 2009-11-05 | 2017-03-28 | Padgett Hal | geração de partículas antigênicas semelhantes a virus através de ligações de proteína-proteína |
| US8321012B2 (en) | 2009-12-22 | 2012-11-27 | The Invention Science Fund I, Llc | Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject |
| EP4112074A1 (en) | 2011-07-11 | 2023-01-04 | Takeda Vaccines, Inc. | Parenteral norovirus vaccine formulations |
| CN104011080B (zh) | 2011-12-22 | 2017-10-20 | 弗·哈夫曼-拉罗切有限公司 | 用于真核细胞的全长抗体展示系统及其用途 |
| JO3820B1 (ar) | 2012-05-03 | 2021-01-31 | Regeneron Pharma | أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها |
| EP3587455A1 (en) * | 2012-10-23 | 2020-01-01 | Emory University | Gm-csf and il-4 conjugates, compositions, and methods related thereto |
| US10935554B2 (en) | 2013-08-23 | 2021-03-02 | Regeneron Pharmaceuticals, Inc. | Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (SIT) |
| JP2017512213A (ja) * | 2013-12-19 | 2017-05-18 | ネステク ソシエテ アノニム | 環境中のネコアレルゲンを減少するための組成物及び方法 |
| MA40824A (fr) * | 2014-10-22 | 2017-08-29 | Saiba Gmbh | Particules de cmv de type virus modifié |
| WO2016112921A1 (en) | 2015-01-15 | 2016-07-21 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| WO2016192788A1 (en) * | 2015-06-03 | 2016-12-08 | Universität Zürich Prorektorat Mnw | Methods and compositions for preventing and treating cat or dog dander allergy |
| HK1255206A1 (zh) * | 2015-09-08 | 2019-08-09 | 苏黎世大学 | 抗猫过敏的组合物 |
| EP3368068B1 (en) | 2015-10-30 | 2020-11-18 | University of Copenhagen | Virus like particle with efficient epitope display |
| CN105219742A (zh) * | 2015-11-10 | 2016-01-06 | 海南大学 | 一种展示重组猫致敏原rFel d 1蛋白的免疫增强型病毒样颗粒、其表达载体及其制备与应用 |
| WO2017179025A1 (en) | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
| FR3054547B1 (fr) * | 2016-07-29 | 2020-06-05 | Angany Inc. | Particules pseudo-virales et leurs utilisations |
| RS67826B1 (sr) | 2016-12-22 | 2026-03-31 | Regeneron Pharma | Postupak za lečenje alergije sa monoklonskim antitelima specifičnim za alergen |
| JP7623282B2 (ja) | 2018-12-20 | 2025-01-28 | サイバ アクチェンゲゼルシャフト | 融合によって修飾されたｃｍｖのウイルス様粒子 |
| WO2023176206A1 (ja) * | 2022-03-18 | 2023-09-21 | デンカ株式会社 | リンカーにより連結されたカプシドタンパク質を含むウイルス様粒子 |
| CN114933639B (zh) * | 2022-05-05 | 2023-12-29 | 中国农业科学院兰州兽医研究所 | 非洲猪瘟病毒p72N抗原表位蛋白及其制备方法和用途 |
| CN117004650B (zh) * | 2023-06-25 | 2024-05-14 | 山东立菲生物产业有限公司 | 一种猫皮屑过敏原组分feld1双链二聚体重组蛋白、制备方法及应用 |
| WO2025139524A1 (zh) * | 2023-12-28 | 2025-07-03 | 江苏众红生物工程创药研究院有限公司 | 猫重组变应原及其药用组合物、制备方法和应用 |
| WO2025194374A1 (zh) * | 2024-03-20 | 2025-09-25 | 深圳赫兹生命科学技术有限公司 | 猫过敏原多肽片段及应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4163778A (en) * | 1978-05-04 | 1979-08-07 | The Foundation for the Study of Asthma and Related Diseases | Asthma immunotherapy |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| DE68924850T2 (de) * | 1988-06-14 | 1996-10-10 | Cell Med Inc | Heterofunktionelle zellular immunologische reagenzien, impfstoffe daraus und verwendungsverfahren. |
| US6120769A (en) * | 1989-11-03 | 2000-09-19 | Immulogic Pharmaceutical Corporation | Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor |
| EP0563091A1 (en) | 1990-12-20 | 1993-10-06 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccines based on hepatitis b surface antigen |
| GB9114003D0 (en) * | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| EP0783322A1 (en) | 1994-09-02 | 1997-07-16 | Immunologic Pharmaceutical Corporation | Peptide compositions capable of down regulating an antigen specific immune response |
| US6759234B1 (en) * | 1994-09-02 | 2004-07-06 | Immulogic Pharmaceutical Corporation | Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response |
| CN1185811A (zh) | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| US6054312A (en) * | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| EP1037663A2 (en) * | 1997-12-16 | 2000-09-27 | Regents Of The University Of Minnesota | Methods to treat undesirable immune responses |
| AR020102A1 (es) | 1998-07-30 | 2002-04-10 | Ucb Sa | Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento |
| WO2000020032A1 (en) | 1998-10-06 | 2000-04-13 | Trustees Of Dartmouth College | RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY |
| DE69929232T2 (de) * | 1998-10-21 | 2006-08-31 | The United States Government As Represented By The Department Of Health And Human Services | Virusähnliche partikel zur induktion von autoantikörpern |
| MXPA01005389A (es) * | 1998-11-30 | 2003-03-27 | Cytos Biotechnology Ag | Presentacion molecular ordenada de antigenos, metodos de preparacion y uso. |
| NZ517929A (en) | 1999-09-25 | 2004-02-27 | Univ Iowa Res Found | Immunostimulatory nucleic acids |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| ATE414773T1 (de) | 2000-11-16 | 2008-12-15 | Alk Abello As | Mutante allergene |
| EP1221317A1 (en) * | 2000-12-28 | 2002-07-10 | SHAN-Beteiligungsgesellschaft m.b.H. | Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins |
| DE60032250T2 (de) * | 2000-12-28 | 2007-03-15 | Biomay Produktions- Und Handels-Aktiengesellschaft | Behandlung von Allergien |
| US7264810B2 (en) | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| WO2002070665A2 (en) | 2001-03-02 | 2002-09-12 | The Rockefeller University | Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen |
| CA2492823A1 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| AU2002363382B2 (en) * | 2001-11-07 | 2007-07-19 | Cytos Biotechnology Ag | Antigen arrays presenting IL-5, IL-3 or eotaxin for treatment of allergic eosinophilic diseases |
| ES2316628T3 (es) * | 2001-11-07 | 2009-04-16 | Cytos Biotechnology Ag | Disposicion ordenada de antigenos que comprende rankl para el tratamiento de enfermedades oseas. |
| US7138252B2 (en) | 2002-07-17 | 2006-11-21 | Cytos Biotechnology Ag | Molecular antigen arrays |
| ATE441429T1 (de) | 2002-07-19 | 2009-09-15 | Cytos Biotechnology Ag | Ghrelin-träger-konjugate |
| WO2004018506A2 (en) * | 2002-08-22 | 2004-03-04 | Cytos Biotechnology Ag | Inducible alphaviral/orip based gene expression system |
| CA2503886A1 (en) | 2002-11-01 | 2004-05-13 | Alk-Abello A/S | Recombinant protein variants |
| WO2004047793A1 (en) | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
| AU2004224761A1 (en) * | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
| DE602004011502T2 (de) * | 2003-04-24 | 2009-01-22 | Imvision Gmbh | Rekombinantes fel d 1 allergen |
| RU2375076C2 (ru) * | 2003-07-10 | 2009-12-10 | Цитос Биотехнологи Аг | Укомплектованные вирусоподобные частицы |
| ZA200707413B (en) * | 2005-03-18 | 2009-01-28 | Cytos Biotechnology Ag | Cat allergen fusion proteins and uses thereof |
-
2006
- 2006-03-17 ZA ZA200707413A patent/ZA200707413B/xx unknown
- 2006-03-17 CN CN2013101152149A patent/CN103203016A/zh active Pending
- 2006-03-17 US US11/886,577 patent/US7767212B2/en not_active Expired - Fee Related
- 2006-03-17 CN CN2006800088726A patent/CN101141979B/zh not_active Expired - Fee Related
- 2006-03-17 JP JP2008501331A patent/JP5302671B2/ja not_active Expired - Fee Related
- 2006-03-17 WO PCT/EP2006/060845 patent/WO2006097530A2/en not_active Ceased
- 2006-03-17 DK DK06725140.5T patent/DK1868642T3/da active
- 2006-03-17 AU AU2006224529A patent/AU2006224529B2/en not_active Ceased
- 2006-03-17 ES ES06725140T patent/ES2424229T3/es not_active Expired - Lifetime
- 2006-03-17 RU RU2007138265/15A patent/RU2414239C2/ru not_active IP Right Cessation
- 2006-03-17 EP EP06725140.5A patent/EP1868642B1/en not_active Expired - Lifetime
- 2006-03-17 PL PL06725140T patent/PL1868642T3/pl unknown
- 2006-03-17 NZ NZ561040A patent/NZ561040A/en not_active IP Right Cessation
- 2006-03-17 PT PT67251405T patent/PT1868642E/pt unknown
- 2006-03-17 BR BRPI0608455-9A patent/BRPI0608455A2/pt active Search and Examination
- 2006-03-17 MX MX2007011160A patent/MX2007011160A/es active IP Right Grant
- 2006-03-17 CA CA2599218A patent/CA2599218C/en not_active Expired - Fee Related
- 2006-03-17 KR KR1020077022225A patent/KR20070112225A/ko not_active Withdrawn
-
2007
- 2007-08-07 IL IL185103A patent/IL185103A0/en not_active IP Right Cessation
-
2010
- 2010-05-21 US US12/785,174 patent/US20110045013A1/en not_active Abandoned
-
2012
- 2012-12-21 US US13/724,331 patent/US20130344098A1/en not_active Abandoned
-
2013
- 2013-03-12 JP JP2013048847A patent/JP2013155176A/ja active Pending
- 2013-07-26 CY CY20131100638T patent/CY1114171T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2599218C (en) | 2015-08-11 |
| US20090175896A1 (en) | 2009-07-09 |
| CN101141979A (zh) | 2008-03-12 |
| RU2414239C2 (ru) | 2011-03-20 |
| EP1868642B1 (en) | 2013-05-08 |
| US20110045013A1 (en) | 2011-02-24 |
| ZA200707413B (en) | 2009-01-28 |
| KR20070112225A (ko) | 2007-11-22 |
| CA2599218A1 (en) | 2006-09-21 |
| CN103203016A (zh) | 2013-07-17 |
| BRPI0608455A2 (pt) | 2010-01-05 |
| US20130344098A1 (en) | 2013-12-26 |
| AU2006224529A1 (en) | 2006-09-21 |
| MX2007011160A (es) | 2007-11-13 |
| JP2008535800A (ja) | 2008-09-04 |
| JP5302671B2 (ja) | 2013-10-02 |
| IL185103A0 (en) | 2007-12-03 |
| PT1868642E (pt) | 2013-07-10 |
| WO2006097530A2 (en) | 2006-09-21 |
| NZ561040A (en) | 2009-04-30 |
| PL1868642T3 (pl) | 2013-10-31 |
| DK1868642T3 (da) | 2013-06-24 |
| WO2006097530A3 (en) | 2007-06-21 |
| US7767212B2 (en) | 2010-08-03 |
| JP2013155176A (ja) | 2013-08-15 |
| AU2006224529B2 (en) | 2012-05-24 |
| EP1868642A2 (en) | 2007-12-26 |
| RU2007138265A (ru) | 2009-04-27 |
| ES2424229T3 (es) | 2013-09-30 |
| CN101141979B (zh) | 2013-05-08 |
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