CY1114030T1 - Ομοιογενη παρασκευασματα toy il-29 - Google Patents

Ομοιογενη παρασκευασματα toy il-29

Info

Publication number
CY1114030T1
CY1114030T1 CY20131100436T CY131100436T CY1114030T1 CY 1114030 T1 CY1114030 T1 CY 1114030T1 CY 20131100436 T CY20131100436 T CY 20131100436T CY 131100436 T CY131100436 T CY 131100436T CY 1114030 T1 CY1114030 T1 CY 1114030T1
Authority
CY
Cyprus
Prior art keywords
amino acid
seq
cysteine
toy
acid residues
Prior art date
Application number
CY20131100436T
Other languages
English (en)
Inventor
Lowell J Brady
Kevin M Klucher
Chung Chan
Dennis L Dong
Hong Y Liu
Paul O Sheppard
Thomas R Bukowski
Original Assignee
Zymogenetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics, Inc. filed Critical Zymogenetics, Inc.
Publication of CY1114030T1 publication Critical patent/CY1114030T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Abstract

Παρέχεται απομονωμένο πολυπεπτίδιο το οποίο αποτελείται από μια αλληλουχία αμινοξέων που έχει τουλάχιστον 90% ταυτότητα αλληλουχίας προς τα υπολείμματα αμινοξέων 1-181 της SEQ ID ΝΟ:4, όπου το υπόλειμμα αμινοξέος που αντιστοιχεί στην κυστεΐνη στη θέση 171 της SEQ ID ΝΟ:4 υποκαθίσταται με ένα άλλο αμινοξύ, όπου τα υπολείμματα αμινοξέων που αντιστοιχούν στην κυστεΐνη στη θέση 15 και στη θέση 112 της SEQ ID ΝΟ:4 σχηματίζουν πρώτο δισουλφιδικό δεσμό, και όπου τα υπολείμματα αμινοξέων που αντιστοιχούν στην κυστεΐνη στη θέση 49 και στη θέση 145 της SEQ ID ΝΟ:4 σχηματίζουν δεύτερο δισουλφιδικό δεσμό, και όπου το πολυπεπτίδιο επάγει την έκφραση Διεγειρόμενων από Ιντερφερόνη Γονιδίων στα ανθρώπινα ηπατοκύτταρα.
CY20131100436T 2003-08-07 2013-05-31 Ομοιογενη παρασκευασματα toy il-29 CY1114030T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49319403P 2003-08-07 2003-08-07
US55184104P 2004-03-10 2004-03-10
US55914204P 2004-04-02 2004-04-02
EP10173335A EP2251353B1 (en) 2003-08-07 2004-08-09 Homogeneous preparations of IL-29

Publications (1)

Publication Number Publication Date
CY1114030T1 true CY1114030T1 (el) 2016-07-27

Family

ID=34279787

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100436T CY1114030T1 (el) 2003-08-07 2013-05-31 Ομοιογενη παρασκευασματα toy il-29

Country Status (16)

Country Link
US (38) US7157559B2 (el)
EP (4) EP2251353B1 (el)
JP (2) JP4808157B2 (el)
CN (1) CN1910200A (el)
AT (1) ATE388963T1 (el)
AU (1) AU2004270652B2 (el)
CA (1) CA2534907C (el)
CY (1) CY1114030T1 (el)
DE (1) DE602004012424T2 (el)
DK (2) DK1668031T3 (el)
ES (2) ES2303132T3 (el)
HK (1) HK1150618A1 (el)
IL (1) IL210381A0 (el)
PL (1) PL2251353T3 (el)
PT (1) PT2251353E (el)
WO (1) WO2005023862A2 (el)

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