DK1668031T3 - Homogene præparater af IL-29 - Google Patents
Homogene præparater af IL-29Info
- Publication number
- DK1668031T3 DK1668031T3 DK04809553T DK04809553T DK1668031T3 DK 1668031 T3 DK1668031 T3 DK 1668031T3 DK 04809553 T DK04809553 T DK 04809553T DK 04809553 T DK04809553 T DK 04809553T DK 1668031 T3 DK1668031 T3 DK 1668031T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- seq
- cysteine
- acid residues
- correspond
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49319403P | 2003-08-07 | 2003-08-07 | |
US55184104P | 2004-03-10 | 2004-03-10 | |
US55914204P | 2004-04-02 | 2004-04-02 | |
PCT/US2004/025864 WO2005023862A2 (en) | 2003-08-07 | 2004-08-09 | Homogeneous preparations of il-28 and il-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1668031T3 true DK1668031T3 (da) | 2008-06-30 |
Family
ID=34279787
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10173335.0T DK2251353T3 (da) | 2003-08-07 | 2004-08-09 | Homogene fremstillinger af IL-29 |
DK04809553T DK1668031T3 (da) | 2003-08-07 | 2004-08-09 | Homogene præparater af IL-29 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10173335.0T DK2251353T3 (da) | 2003-08-07 | 2004-08-09 | Homogene fremstillinger af IL-29 |
Country Status (16)
Country | Link |
---|---|
US (38) | US7157559B2 (el) |
EP (4) | EP2251352A1 (el) |
JP (2) | JP4808157B2 (el) |
CN (1) | CN1910200A (el) |
AT (1) | ATE388963T1 (el) |
AU (1) | AU2004270652B2 (el) |
CA (1) | CA2534907C (el) |
CY (1) | CY1114030T1 (el) |
DE (1) | DE602004012424T2 (el) |
DK (2) | DK2251353T3 (el) |
ES (2) | ES2303132T3 (el) |
HK (1) | HK1150618A1 (el) |
IL (1) | IL210381A0 (el) |
PL (1) | PL2251353T3 (el) |
PT (1) | PT2251353E (el) |
WO (1) | WO2005023862A2 (el) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
EP1294888B1 (en) * | 2000-06-30 | 2007-04-25 | ZymoGenetics, Inc. | Interferon-like protein zcyto21 |
US7910313B2 (en) | 2001-04-20 | 2011-03-22 | Zymogenetics, Inc. | Cytokine protein family |
US7038032B2 (en) | 2001-04-20 | 2006-05-02 | Zymogenetics, Inc. | Cytokine protein family |
WO2004037995A2 (en) * | 2002-10-23 | 2004-05-06 | Zymogenetics, Inc. | Methods for treating viral infection using il-28 and il-29 |
DK2351844T3 (da) | 2003-04-29 | 2014-09-22 | Sarepta Therapeutics Inc | Præparater til forøgelse af transport- og antisense-effektivitet af nukleinsyreanalog i celler |
ATE388963T1 (de) | 2003-08-07 | 2008-03-15 | Zymogenetics Inc | Homogene herstellungen von il-29 |
GB0405634D0 (en) | 2004-03-12 | 2004-04-21 | Univ Southampton | Anti-virus therapy for respiratory diseases |
WO2005097165A2 (en) | 2004-04-02 | 2005-10-20 | Zymogenetics, Inc. | Il-28 and il-29 cysteine mutants for treating viral infection |
WO2006012644A2 (en) * | 2004-07-29 | 2006-02-02 | Zymogenetics, Inc. | Use of il-28 and il-29 to treat cancer |
US20060228329A1 (en) * | 2005-01-28 | 2006-10-12 | Brady Lowell J | Homogeneous preparations of IL-31 |
US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
JP4987001B2 (ja) * | 2005-07-20 | 2012-07-25 | ザイモジェネティクス リミテッド ライアビリティ カンパニー | 癌および自己免疫障害を処置するためのil28およびil29の短縮型システイン変異体の使用法 |
CA2616122A1 (en) * | 2005-07-20 | 2007-01-25 | Zymogenetics, Inc. | Il28 and il29 truncated cysteine mutants and antiviral methods of using same |
CA2625208A1 (en) * | 2005-10-04 | 2007-04-12 | Zymogenetics, Inc. | Production and purification of il-29 |
US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
BRPI0817026A2 (pt) | 2007-09-20 | 2017-05-16 | Australian Poultry Crc Pty Ltd | molécula de ácido nucleico, polipeptídeo isolado, polipeptídeo de fusão, construção genética, métodos para produzir uma molécula de interferon-lambda recombinante aviário em uma célula, para identificar uma sequência genética de interferon-lambda aviário, para induzir ou regular de modo positivo uma resposta imune em aves e para o tratamento ou profilaxia de aves, molécula de interferon-lambda recombinante aviário, célula isolada, molécula de anticorpo, meio legível por computador, ensaio para mdir o nível de um polipeptídeo de interferon-lambda aviário em aves, uso do polipeptídeo de interferon-lambda aviário ou de uma molécula de ácido nucleico, gênero alimentício medicinal ou terapêutico, adjuvante, e, composição farmacêutica veterinária. |
US8354125B2 (en) | 2007-10-27 | 2013-01-15 | Grant Gallagher | Ex-vivo treatment of peripheral blood leukocytes with IFN-λ |
EP2796466B1 (en) | 2007-12-07 | 2017-11-22 | ZymoGenetics, Inc. | Humanized antibody molecules specific for IL-31 |
WO2009124309A2 (en) | 2008-04-04 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same |
CA2727026A1 (en) * | 2008-06-05 | 2009-12-10 | Zymogenetics, Llc | Use of pegylated type iii interferons for the treatment of hepatitis c |
KR20110074850A (ko) * | 2008-08-25 | 2011-07-04 | 앰플리뮨, 인크. | Pd-1 길항제 및 그의 사용 방법 |
WO2010027423A2 (en) | 2008-08-25 | 2010-03-11 | Amplimmune, Inc. | Compositions of pd-1 antagonists and methods of use |
US8363580B2 (en) * | 2009-03-31 | 2013-01-29 | Rosemount Inc. | Disparate radios in a wireless mesh network |
EP2362332A1 (en) | 2010-02-26 | 2011-08-31 | Seremfor, S.L.U. | Method and system of auto checking personal protective equipment, systems and technical work instructions as regards labour risk prevention |
ES2816898T3 (es) * | 2010-05-13 | 2021-04-06 | Sarepta Therapeutics Inc | Compuestos que modulan la actividad de señalización de las interleucinas 17 y 23 |
WO2012065755A1 (en) * | 2010-11-19 | 2012-05-24 | Bavarian Nordic A/S | Production of ifn-lambda by b cells |
CN102584979B (zh) * | 2011-01-18 | 2015-10-14 | 北京凯因科技股份有限公司 | PEG化干扰素λ |
US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
FR2975185A1 (fr) * | 2011-05-12 | 2012-11-16 | Univ Claude Bernard Lyon | Procede de determination in vitro de la presence d'une sclerose en plaques |
WO2013024158A1 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection |
WO2013024156A2 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection |
WO2013029062A1 (en) * | 2011-08-25 | 2013-02-28 | Nanogen Pharmaceutical Biotechnology Co., Ltd | Peginterferon lambda 1 conjugates, processes for their preparation, pharmaceutical compositions containing these conjugates and processes for making the same |
CN102559737A (zh) * | 2011-12-13 | 2012-07-11 | 江南大学 | 一种人白细胞介素29的变异体及其制备方法 |
WO2014033266A1 (en) | 2012-08-31 | 2014-03-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection |
EP2922870B1 (en) * | 2012-11-21 | 2019-08-07 | The Governors of the University of Alberta | Immunomodulatory peptides and methods of use thereof |
US9464321B2 (en) * | 2013-03-15 | 2016-10-11 | Medical Diagnostic Laboratories, Llc | Methods and reagents that specifically detect, distinguish and quantify IFN-λ2 mRNA from IFN-λ3 mRNA in humans |
EP3954714A1 (en) * | 2014-01-08 | 2022-02-16 | Prosit Sole Biotechnology (Beijing) Co. Ltd | Fusion polypeptides and methods of use |
US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
CN104672318A (zh) * | 2014-12-17 | 2015-06-03 | 江南大学 | 一种肽链第43位赖氨酸定点突变为亮氨酸的人白介素-29变异体 |
KR102514971B1 (ko) | 2015-04-21 | 2023-03-27 | 아이거 바이오파마슈티컬스 인코포레이티드 | 로나파르닙 및 리토나버를 포함하는 약제 조성물 |
EP3302489A4 (en) | 2015-06-04 | 2019-02-06 | Sarepta Therapeutics, Inc. | METHOD AND COMPOUNDS FOR THE TREATMENT OF DISEASES AND SUFFERING IN CONNECTION WITH LYMPHOCYTES |
CN105037523B (zh) * | 2015-06-25 | 2019-02-19 | 北京三元基因药业股份有限公司 | 干扰素突变体及其聚乙二醇衍生物 |
DK3370723T3 (da) | 2015-11-04 | 2021-01-25 | Eiger Biopharmaceuticals Inc | Behandling af hepatitis delta-virusinfektion |
US11123405B2 (en) | 2015-12-23 | 2021-09-21 | The Johns Hopkins University | Long-acting GLP-1R agonist as a therapy of neurological and neurodegenerative conditions |
PL3416675T3 (pl) | 2016-02-19 | 2021-10-11 | Eiger Biopharmaceuticals, Inc. | Leczenie zakażenia wirusem zapalenia wątroby typu delta za pomocą interferonu lambda |
CN106047806B (zh) * | 2016-08-19 | 2019-07-16 | 上海逍鹏生物科技有限公司 | 一种适用于高密度细胞培养体系的外周血细胞培养基 |
MX2019003744A (es) * | 2016-09-30 | 2019-10-30 | Univ Leland Stanford Junior | Interferones de variante tipo iii y sintecinas. |
CN107043740A (zh) * | 2017-05-10 | 2017-08-15 | 浙江美保龙生物技术有限公司 | 一种mdbk细胞培养液及其制备方法、使用方法 |
CN107630086B (zh) * | 2017-11-13 | 2020-11-03 | 吉林大学 | 一种与hbv感染相关的snp分子标记及其应用 |
CN108070647B (zh) * | 2017-12-25 | 2021-06-01 | 吉林大学 | 与hbv感染相关的基因单体型及其应用 |
CN108570459B (zh) * | 2018-04-10 | 2022-10-04 | 南京农业大学 | 一种高效发酵生产重组细菌漆酶的方法 |
BR112022015502A2 (pt) * | 2020-02-06 | 2022-09-27 | Eiger Biopharmaceuticals Inc | Tratamento da infecção por coronavírus com interferon lambda |
TW202146011A (zh) | 2020-03-05 | 2021-12-16 | 美商詹森藥物公司 | 治療b型肝炎病毒感染之組合療法 |
JP2023531682A (ja) | 2020-06-22 | 2023-07-25 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | D型肝炎ウイルス感染の処置のための組成物および方法 |
CN116219078B (zh) * | 2023-05-08 | 2023-07-11 | 上海惠盾因泰生物科技有限公司 | 一种il-29生物学活性测定方法 |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US485332A (en) * | 1892-11-01 | Wagon-brake | ||
ES498343A0 (es) | 1980-01-08 | 1983-09-01 | Biogen Nv | Un metodo de producir un polipeptido que exhibe actividad inmunologica o biologica del interferon de leucocitos humanos. |
US4615974A (en) | 1981-08-25 | 1986-10-07 | Celltech Limited | Yeast expression vectors |
US4579821A (en) | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
US4977092A (en) | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
US4853332A (en) * | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
US4661454A (en) | 1983-02-28 | 1987-04-28 | Collaborative Research, Inc. | GAL1 yeast promoter linked to non galactokinase gene |
US5139936A (en) | 1983-02-28 | 1992-08-18 | Collaborative Research, Inc. | Use of the GAL1 yeast promoter |
US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
ATE54167T1 (de) | 1984-12-06 | 1990-07-15 | Fina Research | Promotoren fuer die expression von fremden genen in hefe, plasmide, die diese promotoren enthalten, sowie deren verwendung zur herstellung von polypeptiden. |
GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
EP0229108B1 (en) * | 1985-06-26 | 1990-12-27 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
US5063154A (en) | 1987-06-24 | 1991-11-05 | Whitehead Institute For Biomedical Research | Pheromone - inducible yeast promoter |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5750375A (en) | 1988-01-22 | 1998-05-12 | Zymogenetics, Inc. | Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions |
US6018026A (en) | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
US5162228A (en) | 1988-12-28 | 1992-11-10 | Takeda Chemical Industries, Ltd. | Gylceraldehyde-3-phosphate dehydrogenase gene and promoter |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5162222A (en) | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
US5298418A (en) | 1991-09-16 | 1994-03-29 | Boyce Thompson Institute For Plant Research, Inc. | Cell line isolated from larval midgut tissue of Trichoplusia ni |
US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
CA2144651A1 (en) | 1992-09-14 | 1994-03-31 | Timothy J. Miller | Immortalized cells and uses therefor |
CA2183266A1 (en) | 1994-02-14 | 1995-08-17 | Richard D. Holly | Hematopoietic protein and materials and methods for making it |
US5738846A (en) | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
US5641655A (en) | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
EP0862640A2 (en) | 1995-11-09 | 1998-09-09 | ZymoGenetics, Inc. | Production of gad65 in methylotrophic yeast |
US6001597A (en) | 1995-11-09 | 1999-12-14 | Zymogenetics, Inc. | Compositions and methods for producing heterologous polypeptides in Pichia methanolica |
US5955349A (en) | 1996-08-26 | 1999-09-21 | Zymogenetics, Inc. | Compositions and methods for producing heterologous polypeptides in Pichia methanolica |
CN1230997A (zh) | 1996-07-17 | 1999-10-06 | 津莫吉尼蒂克斯公司 | 甲醇毕赤酵母的转化 |
US5736383A (en) | 1996-08-26 | 1998-04-07 | Zymogenetics, Inc. | Preparation of Pichia methanolica auxotrophic mutants |
US5985614A (en) | 1996-08-30 | 1999-11-16 | Human Genome Sciences, Inc. | Polynucleotides encoding interleukin-19 |
US5945511A (en) | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
US5965704A (en) | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
AU2871899A (en) | 1998-03-09 | 1999-09-27 | Schering Corporation | Human receptor proteins; related reagents and methods |
AU3891600A (en) | 1999-03-18 | 2000-10-04 | Zymogenetics Inc. | Murine interferon-alpha named also zcyto13 |
AU2001255495A1 (en) | 2000-04-20 | 2001-11-07 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rnain patients having chronic hepatitis c infection |
US6376585B1 (en) | 2000-06-26 | 2002-04-23 | Apex Advanced Technologies, Llc | Binder system and method for particulate material with debind rate control additive |
EP1294888B1 (en) | 2000-06-30 | 2007-04-25 | ZymoGenetics, Inc. | Interferon-like protein zcyto21 |
WO2002002621A2 (en) * | 2000-06-30 | 2002-01-10 | Zymogenetics, Inc. | Mammalian secreted proteins |
EP2298789B1 (en) | 2000-09-08 | 2012-03-14 | Schering Corporation | Mammalian genes; related reagents and methods |
ES2334888T3 (es) | 2000-11-28 | 2010-03-17 | Zymogenetics, L.L.C. | Receptor de citocina zcytor19. |
JP2002308030A (ja) * | 2001-04-16 | 2002-10-23 | Yazaki Corp | 車両用周辺監視装置 |
US7038032B2 (en) | 2001-04-20 | 2006-05-02 | Zymogenetics, Inc. | Cytokine protein family |
CA2441958C (en) * | 2001-04-20 | 2012-01-17 | Zymogenetics, Inc. | Il-28 polypeptides and polynucleotids |
CA2446180A1 (en) | 2001-05-10 | 2002-11-21 | Immunex Corporation | Cytokine polypeptides |
TW200300170A (en) | 2001-11-09 | 2003-05-16 | Wyeth Corp | Type 2 cytokine receptor and nucleic acids encoding same |
AU2003215136A1 (en) | 2002-02-08 | 2003-09-02 | University Of Medicine And Dentistry Of New Jersey | Ifn-a/b-independent mechanism of antiviral protection |
EP1497415B1 (en) | 2002-04-19 | 2010-12-29 | ZymoGenetics, L.L.C. | Methods for detection or modulation of the interaction of a cytokine receptor with its ligand |
WO2004037995A2 (en) | 2002-10-23 | 2004-05-06 | Zymogenetics, Inc. | Methods for treating viral infection using il-28 and il-29 |
WO2004077898A2 (en) * | 2003-02-26 | 2004-09-10 | Wavezero Inc. | Methods and devices for connecting and grounding an emi shield to a printed circuit board |
ATE388963T1 (de) | 2003-08-07 | 2008-03-15 | Zymogenetics Inc | Homogene herstellungen von il-29 |
US7208541B2 (en) * | 2003-08-22 | 2007-04-24 | National Starch And Chemical Investment Holding Corporation | Hot melt adhesive |
WO2005097165A2 (en) | 2004-04-02 | 2005-10-20 | Zymogenetics, Inc. | Il-28 and il-29 cysteine mutants for treating viral infection |
JP4468734B2 (ja) * | 2004-04-27 | 2010-05-26 | オリンパス株式会社 | 映像信号処理装置と映像信号処理プログラム |
WO2006012644A2 (en) | 2004-07-29 | 2006-02-02 | Zymogenetics, Inc. | Use of il-28 and il-29 to treat cancer |
CN1305902C (zh) | 2004-11-25 | 2007-03-21 | 汕头大学医学院 | 一种人白细胞介素29的生产方法及重组il-29工程菌 |
CA2616122A1 (en) | 2005-07-20 | 2007-01-25 | Zymogenetics, Inc. | Il28 and il29 truncated cysteine mutants and antiviral methods of using same |
JP4987001B2 (ja) * | 2005-07-20 | 2012-07-25 | ザイモジェネティクス リミテッド ライアビリティ カンパニー | 癌および自己免疫障害を処置するためのil28およびil29の短縮型システイン変異体の使用法 |
DE102005000107B4 (de) * | 2005-08-25 | 2014-03-13 | Hilti Aktiengesellschaft | Pneumatisch betriebenes Setzgerät |
CA2625208A1 (en) | 2005-10-04 | 2007-04-12 | Zymogenetics, Inc. | Production and purification of il-29 |
CA2727026A1 (en) | 2008-06-05 | 2009-12-10 | Zymogenetics, Llc | Use of pegylated type iii interferons for the treatment of hepatitis c |
-
2004
- 2004-08-09 AT AT04809553T patent/ATE388963T1/de active
- 2004-08-09 EP EP10173331A patent/EP2251352A1/en not_active Withdrawn
- 2004-08-09 EP EP08150287A patent/EP1927600A1/en not_active Withdrawn
- 2004-08-09 DK DK10173335.0T patent/DK2251353T3/da active
- 2004-08-09 EP EP10173335A patent/EP2251353B1/en active Active
- 2004-08-09 JP JP2006522809A patent/JP4808157B2/ja active Active
- 2004-08-09 AU AU2004270652A patent/AU2004270652B2/en active Active
- 2004-08-09 DE DE602004012424T patent/DE602004012424T2/de active Active
- 2004-08-09 WO PCT/US2004/025864 patent/WO2005023862A2/en active Application Filing
- 2004-08-09 DK DK04809553T patent/DK1668031T3/da active
- 2004-08-09 ES ES04809553T patent/ES2303132T3/es active Active
- 2004-08-09 ES ES10173335T patent/ES2405209T3/es active Active
- 2004-08-09 PL PL10173335T patent/PL2251353T3/pl unknown
- 2004-08-09 PT PT101733350T patent/PT2251353E/pt unknown
- 2004-08-09 US US10/914,772 patent/US7157559B2/en active Active
- 2004-08-09 EP EP04809553A patent/EP1668031B1/en active Active
- 2004-08-09 CA CA2534907A patent/CA2534907C/en active Active
- 2004-08-09 CN CNA2004800291707A patent/CN1910200A/zh active Pending
-
2006
- 2006-10-13 US US11/549,519 patent/US7485701B2/en active Active
- 2006-10-13 US US11/549,479 patent/US7517961B2/en active Active
- 2006-10-13 US US11/549,469 patent/US7468423B2/en active Active
- 2006-10-13 US US11/549,531 patent/US7544779B2/en active Active
- 2006-10-13 US US11/549,490 patent/US7495077B2/en active Active
- 2006-10-16 US US11/549,707 patent/US7485702B2/en active Active
- 2006-10-16 US US11/549,760 patent/US7479542B2/en active Active
- 2006-10-16 US US11/549,729 patent/US7495079B2/en active Active
- 2006-10-16 US US11/549,705 patent/US7495078B2/en active Active
- 2006-10-17 US US11/550,230 patent/US7588918B2/en active Active
- 2006-10-17 US US11/550,208 patent/US7582450B2/en active Active
- 2006-10-17 US US11/550,194 patent/US7595174B2/en active Active
- 2006-10-17 US US11/550,284 patent/US7608427B2/en active Active
- 2006-10-17 US US11/550,186 patent/US7514536B2/en active Active
- 2006-10-17 US US11/550,278 patent/US7588919B2/en active Active
- 2006-10-18 US US11/550,596 patent/US7629148B2/en active Active
- 2006-10-18 US US11/550,613 patent/US7629149B2/en active Active
- 2006-10-18 US US11/550,585 patent/US7608428B2/en active Active
- 2006-10-18 US US11/550,661 patent/US7662589B2/en active Active
- 2006-10-18 US US11/550,652 patent/US7638305B2/en active Active
- 2006-10-19 US US11/550,879 patent/US20070055053A1/en not_active Abandoned
- 2006-10-19 US US11/550,909 patent/US20070059313A1/en not_active Abandoned
- 2006-10-19 US US11/550,904 patent/US20070055054A1/en not_active Abandoned
- 2006-10-19 US US11/550,877 patent/US20070055052A1/en not_active Abandoned
- 2006-10-19 US US11/550,887 patent/US20070043210A1/en not_active Abandoned
- 2006-10-19 US US11/550,892 patent/US20070049737A1/en not_active Abandoned
- 2006-10-19 US US11/550,903 patent/US20070073044A1/en not_active Abandoned
- 2006-10-19 US US11/550,899 patent/US20070041975A1/en not_active Abandoned
- 2006-10-19 US US11/551,129 patent/US20070117967A1/en not_active Abandoned
- 2006-10-19 US US11/550,911 patent/US20070066810A1/en not_active Abandoned
- 2006-10-19 US US11/550,873 patent/US7662590B2/en active Active
-
2008
- 2008-03-06 US US12/043,885 patent/US7727518B2/en active Active
-
2009
- 2009-10-01 US US12/572,167 patent/US20100104531A1/en not_active Abandoned
-
2010
- 2010-12-30 IL IL210381A patent/IL210381A0/en unknown
-
2011
- 2011-05-13 HK HK11104722.4A patent/HK1150618A1/xx unknown
- 2011-06-09 JP JP2011128827A patent/JP2011200252A/ja active Pending
- 2011-06-16 US US13/161,720 patent/US8343476B2/en active Active
-
2012
- 2012-11-28 US US13/687,851 patent/US8734776B2/en active Active
-
2013
- 2013-05-31 CY CY20131100436T patent/CY1114030T1/el unknown
-
2014
- 2014-01-28 US US14/165,915 patent/US9499598B2/en active Active
-
2016
- 2016-10-14 US US15/294,153 patent/US20170209542A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1668031T3 (da) | Homogene præparater af IL-29 | |
DE69839812D1 (de) | Analoge des menschlichen interferon-alpha mit niedriger toxizität | |
IL179617A0 (en) | Method of stabilizing proteins | |
DE60135393D1 (de) | Allelische Variante des Interferon-ähnlichen Proteins Zcyto21 | |
LU92060I2 (fr) | Interféron beta-1a | |
DK1844150T3 (da) | Rekombinant ekspression af proteiner i en to-kædet form med disulfidbroer | |
MX9200709A (es) | Activacion mejorada de proteinas recombinadas. activacion mejorada de proteinas recombinadas. | |
DK1383874T3 (da) | Varianter af lipogygenase og deres anvendelse | |
DK1501936T3 (da) | Familie af cytokin-proteiner | |
DE59108947D1 (de) | Neues menschliches, rekombinantes interferon gamma | |
TW200722104A (en) | Low-toxicity, long-circulating human interferon-α analogs | |
ATE271054T1 (de) | Herstellung von metallkomplexen von aminosäuren, hergestellt durch hydrolyse von sojaprotein | |
DE60329115D1 (de) | Tumorantigenprotein und dessen verwendung | |
ATE432985T1 (de) | Polypeptide mit aktivität der stimulierung von neutrophilen | |
DE60041075D1 (de) | Antigene modifikation von polypeptiden | |
ATE347899T1 (de) | Interferon nachahmende peptide und rekombinante proteine | |
MX9702475A (es) | Analogos del factor de crecimiento acido de fibroblasto que tienen estabilidad y acticidad biologica mejoradas. |