CU24439B1 - Preparación de gadobutrol de alta pureza - Google Patents
Preparación de gadobutrol de alta purezaInfo
- Publication number
- CU24439B1 CU24439B1 CU2016000163A CU20160163A CU24439B1 CU 24439 B1 CU24439 B1 CU 24439B1 CU 2016000163 A CU2016000163 A CU 2016000163A CU 20160163 A CU20160163 A CU 20160163A CU 24439 B1 CU24439 B1 CU 24439B1
- Authority
- CU
- Cuba
- Prior art keywords
- gadobutrol
- high purity
- preparation
- gadovist
- purity gadobutrol
- Prior art date
Links
- ZPDFIIGFYAHNSK-CTHHTMFSSA-K 2-[4,10-bis(carboxylatomethyl)-7-[(2r,3s)-1,3,4-trihydroxybutan-2-yl]-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+) Chemical compound [Gd+3].OC[C@@H](O)[C@@H](CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-CTHHTMFSSA-K 0.000 title abstract 3
- 229960003411 gadobutrol Drugs 0.000 title abstract 3
- ZPDFIIGFYAHNSK-UHFFFAOYSA-K gadobutrol Chemical compound [Gd+3].OCC(O)C(CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-UHFFFAOYSA-K 0.000 abstract 2
- 229910052688 Gadolinium Inorganic materials 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000011161 development Methods 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002405 nuclear magnetic resonance imaging agent Substances 0.000 abstract 1
- 238000003325 tomography Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<p>Proceso para producir gadobutrol de alta pureza con una pureza (de acuerdo con HPLC) mayor de 99,7 ó 99,8 ó 99,9%, el cual se lleva a cabo usando condiciones de cristalización específicamente controladas.</p> <p>Los desarrollos más recientes en el campo de los agentes de contraste de resonancia magnética que contienen gadolinio (EP 0448191 B1, CA Patente 1341176, EP 0643705 B1, EP 0986548 B1, EP 0596586 B1) incluyen el agente de contraste para tomografía de resonancia magnética gadobutrol (Gadovist® 1.0) que ha estado aprobado durante un tiempo relativamente prolongado en Europa y más recientemente también en los EE.UU., con el nombre Gadovist®.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011100128 | 2011-04-21 | ||
PCT/EP2012/057013 WO2012143355A1 (en) | 2011-04-21 | 2012-04-17 | Preparation of high-purity gadobutrol |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20160163A7 CU20160163A7 (es) | 2017-02-02 |
CU24439B1 true CU24439B1 (es) | 2019-09-04 |
Family
ID=46208435
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2016000163A CU24439B1 (es) | 2011-04-21 | 2012-04-17 | Preparación de gadobutrol de alta pureza |
CU2013000142A CU20130142A7 (es) | 2011-04-21 | 2013-10-21 | Preparación de gadobutrol de alta pureza |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2013000142A CU20130142A7 (es) | 2011-04-21 | 2013-10-21 | Preparación de gadobutrol de alta pureza |
Country Status (34)
Country | Link |
---|---|
US (2) | US10072027B2 (es) |
EP (2) | EP2699556A1 (es) |
JP (3) | JP6096757B2 (es) |
KR (3) | KR20190079682A (es) |
CN (1) | CN103547573B (es) |
AR (1) | AR086190A1 (es) |
AU (2) | AU2012244791B2 (es) |
BR (1) | BR112013027028B1 (es) |
CA (1) | CA2833659C (es) |
CL (1) | CL2013003045A1 (es) |
CO (1) | CO6801752A2 (es) |
CU (2) | CU24439B1 (es) |
DK (1) | DK2896405T3 (es) |
DO (1) | DOP2013000245A (es) |
EA (2) | EA201600272A1 (es) |
EC (1) | ECSP13013010A (es) |
ES (1) | ES2780599T3 (es) |
GT (1) | GT201300253A (es) |
HK (1) | HK1193817A1 (es) |
HR (1) | HRP20200336T1 (es) |
IL (1) | IL228885A (es) |
LT (1) | LT2896405T (es) |
MX (1) | MX362133B (es) |
MY (1) | MY163709A (es) |
NZ (1) | NZ616637A (es) |
PE (1) | PE20141325A1 (es) |
PL (1) | PL2896405T3 (es) |
PT (1) | PT2896405T (es) |
RS (1) | RS60001B1 (es) |
SG (1) | SG194511A1 (es) |
SI (1) | SI2896405T1 (es) |
TW (1) | TW201249818A (es) |
WO (1) | WO2012143355A1 (es) |
ZA (1) | ZA201308706B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2780599T3 (es) * | 2011-04-21 | 2020-08-26 | Bayer Ip Gmbh | Preparación de gadobutrol de alta pureza |
WO2015117911A1 (en) * | 2014-02-06 | 2015-08-13 | Agfa Healthcare | Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid |
KR101693400B1 (ko) * | 2014-09-17 | 2017-01-05 | 에스티팜 주식회사 | 칼코부트롤의 제조방법 |
KR101646211B1 (ko) * | 2014-11-12 | 2016-08-05 | (주)디아이테크 | 자기공명영상용 조영제의 제조방법 |
KR101653064B1 (ko) * | 2014-12-26 | 2016-09-09 | 에스티팜 주식회사 | 가도부트롤의 제조방법 |
HUE050553T2 (hu) * | 2016-09-27 | 2020-12-28 | Bayer Pharma AG | Eljárás A módosulatú kalkobutrol kristályos alakjának elõállítására |
CN106543094A (zh) * | 2016-11-04 | 2017-03-29 | 嘉实(湖南)医药科技有限公司 | 高纯度钆布醇的制备方法 |
US10975060B2 (en) | 2016-11-28 | 2021-04-13 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
CN109293592A (zh) * | 2017-07-24 | 2019-02-01 | 天津科伦药物研究有限公司 | 一种制备钆布醇的方法 |
KR101971435B1 (ko) * | 2017-08-29 | 2019-04-24 | 주식회사 엔지켐생명과학 | 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법 |
CN108840832A (zh) * | 2018-06-29 | 2018-11-20 | 广州康瑞泰药业有限公司 | 一种钆布醇中间体的制备方法 |
EP4083026A1 (en) | 2018-07-10 | 2022-11-02 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes |
KR102167614B1 (ko) * | 2018-08-23 | 2020-10-19 | 에스티팜 주식회사 | 가도부트롤의 제조방법 |
CN113164628A (zh) * | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | 造影介质制剂及其制备方法 |
MX2021006957A (es) * | 2018-12-12 | 2021-07-15 | Medibeacon Inc | Usos de la medicion de la velocidad de filtracion glomerular transdermica en terapia continua de reemplazo renal. |
GB201919073D0 (en) * | 2019-12-20 | 2020-02-05 | Ge Healthcare As | Novel manufacturing process |
CN113087680A (zh) * | 2020-01-08 | 2021-07-09 | 威智医药有限公司 | Dota晶型及其制备方法 |
CN113105407A (zh) * | 2020-01-13 | 2021-07-13 | 北京北陆药业股份有限公司 | 一种钆布醇新型晶型及其制备方法 |
KR20210114742A (ko) * | 2020-03-11 | 2021-09-24 | 주식회사 엔지켐생명과학 | 칼테리돌의 제조방법 |
CN114539178B (zh) * | 2020-11-26 | 2024-03-15 | 江苏恒瑞医药股份有限公司 | 一种钆布醇的纯化方法 |
CN114573522A (zh) * | 2020-11-30 | 2022-06-03 | 江苏恒瑞医药股份有限公司 | 一种考布曲钙的新晶型及其制备方法 |
CN112939806B (zh) * | 2021-03-08 | 2023-05-16 | 山东新华制药股份有限公司 | 一种卡比多巴的精制方法 |
CN113527223B (zh) * | 2021-06-22 | 2023-05-09 | 安徽普利药业有限公司 | 一种钆布醇的精制方法 |
CN114105897B (zh) * | 2021-07-29 | 2023-04-04 | 安徽普利药业有限公司 | 一种钆特醇的制备方法 |
CN116023345A (zh) * | 2023-02-16 | 2023-04-28 | 渭南瑞联制药有限责任公司 | 一种钆布醇中间体杂质的制备方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
NL194579C (nl) | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
DE3625417C2 (de) | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
DE4009119A1 (de) | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US7385041B2 (en) | 1990-04-25 | 2008-06-10 | Bracco International B.V. | Dual functioning excipient for metal chelate contrast agents |
DE4035760A1 (de) | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5410043A (en) | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
DE4140779A1 (de) | 1991-12-06 | 1993-06-09 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen |
DE4237943C2 (de) | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
IT1275426B (it) | 1995-05-16 | 1997-08-07 | Bracco Spa | Recupero del gadolinio e dei suoi agenti complessanti da soluzioni acquose contenenti i loro complessi |
DE19608307C1 (de) * | 1996-02-26 | 1997-08-28 | Schering Ag | Verfahren zur Herstellung von 1,4,7,10-Tetraazacyclododecan und dessen Derivaten |
US5744616A (en) | 1996-02-26 | 1998-04-28 | Schering Aktiengesellschaft | Process for the production of 1,4,7,10-tetraazacyclododecane and its derivatives |
DE19724186C2 (de) | 1997-06-02 | 2002-07-18 | Schering Ag | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
IT1292128B1 (it) | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
IT1292127B1 (it) | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la dissalazione di sostanze instabili a ph acidi |
EP0985548B1 (fr) | 1998-09-08 | 2002-10-23 | Kba-Giori S.A. | Machine d'impression de sécurité sur des papiers-valeur |
DE10064467C2 (de) | 2000-12-15 | 2002-10-31 | Schering Ag | Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung |
DE102009053171B4 (de) | 2009-11-04 | 2011-07-21 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol) |
WO2011054480A1 (de) | 2009-11-09 | 2011-05-12 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer membran |
DE102010013833A1 (de) | 2010-03-29 | 2011-09-29 | Bayer Schering Pharma Aktiengesellschaft | Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal |
DE102010023105A1 (de) | 2010-06-04 | 2011-12-08 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol |
ES2780599T3 (es) * | 2011-04-21 | 2020-08-26 | Bayer Ip Gmbh | Preparación de gadobutrol de alta pureza |
KR101653064B1 (ko) | 2014-12-26 | 2016-09-09 | 에스티팜 주식회사 | 가도부트롤의 제조방법 |
-
2012
- 2012-04-17 ES ES14172784T patent/ES2780599T3/es active Active
- 2012-04-17 WO PCT/EP2012/057013 patent/WO2012143355A1/en active Application Filing
- 2012-04-17 AU AU2012244791A patent/AU2012244791B2/en active Active
- 2012-04-17 EP EP12725635.2A patent/EP2699556A1/en not_active Ceased
- 2012-04-17 EA EA201600272A patent/EA201600272A1/ru unknown
- 2012-04-17 SG SG2013077094A patent/SG194511A1/en unknown
- 2012-04-17 DK DK14172784.2T patent/DK2896405T3/da active
- 2012-04-17 PT PT141727842T patent/PT2896405T/pt unknown
- 2012-04-17 PE PE2013002379A patent/PE20141325A1/es active IP Right Grant
- 2012-04-17 SI SI201231741T patent/SI2896405T1/sl unknown
- 2012-04-17 NZ NZ616637A patent/NZ616637A/en unknown
- 2012-04-17 US US14/112,994 patent/US10072027B2/en active Active
- 2012-04-17 CN CN201280024781.7A patent/CN103547573B/zh active Active
- 2012-04-17 CA CA2833659A patent/CA2833659C/en active Active
- 2012-04-17 EA EA201301182A patent/EA026572B1/ru not_active IP Right Cessation
- 2012-04-17 EP EP14172784.2A patent/EP2896405B1/en active Active
- 2012-04-17 RS RS20200238A patent/RS60001B1/sr unknown
- 2012-04-17 KR KR1020197017528A patent/KR20190079682A/ko active Application Filing
- 2012-04-17 MY MYPI2013701962A patent/MY163709A/en unknown
- 2012-04-17 KR KR1020207014352A patent/KR20200059319A/ko not_active IP Right Cessation
- 2012-04-17 LT LTEP14172784.2T patent/LT2896405T/lt unknown
- 2012-04-17 CU CU2016000163A patent/CU24439B1/es unknown
- 2012-04-17 KR KR1020137030655A patent/KR102003570B1/ko active IP Right Grant
- 2012-04-17 MX MX2013012290A patent/MX362133B/es active IP Right Grant
- 2012-04-17 PL PL14172784T patent/PL2896405T3/pl unknown
- 2012-04-17 JP JP2014505591A patent/JP6096757B2/ja active Active
- 2012-04-17 BR BR112013027028-4A patent/BR112013027028B1/pt active IP Right Grant
- 2012-04-20 AR ARP120101354A patent/AR086190A1/es active Pending
- 2012-04-23 TW TW101114466A patent/TW201249818A/zh unknown
-
2013
- 2013-10-15 IL IL228885A patent/IL228885A/en active IP Right Grant
- 2013-10-18 GT GT201300253A patent/GT201300253A/es unknown
- 2013-10-21 CO CO13248770A patent/CO6801752A2/es not_active Application Discontinuation
- 2013-10-21 CU CU2013000142A patent/CU20130142A7/es unknown
- 2013-10-21 DO DO2013000245A patent/DOP2013000245A/es unknown
- 2013-10-21 CL CL2013003045A patent/CL2013003045A1/es unknown
- 2013-11-05 EC ECSP13013010 patent/ECSP13013010A/es unknown
- 2013-11-20 ZA ZA2013/08706A patent/ZA201308706B/en unknown
-
2014
- 2014-07-15 HK HK14107203.2A patent/HK1193817A1/zh unknown
-
2016
- 2016-11-08 JP JP2016217880A patent/JP2017031220A/ja active Pending
-
2017
- 2017-06-30 AU AU2017204495A patent/AU2017204495A1/en not_active Abandoned
- 2017-07-31 US US15/664,060 patent/US10435417B2/en active Active
-
2018
- 2018-09-05 JP JP2018165787A patent/JP2018188477A/ja active Pending
-
2020
- 2020-02-27 HR HRP20200336TT patent/HRP20200336T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU24439B1 (es) | Preparación de gadobutrol de alta pureza | |
MX2013000001A (es) | Composición farmaceutica de liberacion prolongada y acción retardada que comprende dapoxetina para administaracion oral. | |
HK1166788A1 (es) | ||
WO2010005480A3 (en) | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor | |
UY32731A (es) | Nuevos derivados de piperidin-ilidenaminooxi-piperidin, composiciones farmacéuticas y métodos relacionados con ellos | |
MX2014002171A (es) | Tratamientos de combinacion para hepatitis c. | |
GEP201706656B (en) | 2-thiopyrimidinones | |
CY1122596T1 (el) | Νεες φαρμακοτεχνικες μορφες (τριμεθοξυφαινυλαμινο)πυριμιδινυλιου | |
WO2012071369A3 (en) | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease | |
NZ606366A (en) | Stabilization of fsh | |
MY165902A (en) | Substituted pyridine derivatives as fabi inhibitors | |
MX2010006650A (es) | Materiales y metodos para el tratamiento de proliferacion vascular ocular patologica. | |
MX2013008340A (es) | Novedosas 4-amino-n-hidroxi-benzamidas para el tratamiento de cancer. | |
MX2012007896A (es) | Derivados de piridino-piridinonas arilsulfonamidas, su preparacion y su uso en terapeutica. | |
MX2012001691A (es) | Composiciones de linaclotida que se desintegran oralmente. | |
IN2014DN03197A (es) | ||
MX343234B (es) | Formas cristalinas de 6-(1h-imidazol-1-il)-2-fenilquinazolina. | |
WO2009102808A3 (en) | Doxorubicin adjuvants to reduce toxicity and methods for using the same | |
SMT201300112B (it) | Sale citrato di 9E-15-(2-pirrolidin-1-il-etossi)-7,12,25-triossa-19,21,24-triaza-tetracicloÄ18.3.1.1(2,5).1(14,18)Üesacos a-1(24),2,4,9,14,16,18(26),20,22-nonaene | |
NZ621994A (en) | Transdermal venous access locking solutions | |
MY163058A (en) | Fluorinated derivatives of 3-hydroxypyridin-4-ones | |
NZ609804A (en) | Crystalline forms of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid | |
IL222642A0 (en) | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives for the treatment of males | |
EP1846037A4 (en) | METHODS OF TREATING VARIOUS CONDITIONS BY ADMINISTERING L-ARGININE WITH PROLONGED RELEASE | |
EP2119700A4 (en) | BENZYLAMINE DERIVATIVE OR PHARMACEUTICALLY SUBSTANTIAL ACIDIC ACID SALT AND THE USE THEREOF FOR MEDICAL PURPOSES |