JO3229B1 - العمل على استقرار الهرمون المنبه للجريب - Google Patents

العمل على استقرار الهرمون المنبه للجريب

Info

Publication number
JO3229B1
JO3229B1 JOP/2011/0231A JOP20110231A JO3229B1 JO 3229 B1 JO3229 B1 JO 3229B1 JO P20110231 A JOP20110231 A JO P20110231A JO 3229 B1 JO3229 B1 JO 3229B1
Authority
JO
Jordan
Prior art keywords
stabilization
salts
fsh
pharmaceutically acceptable
addition
Prior art date
Application number
JOP/2011/0231A
Other languages
English (en)
Inventor
Louise Bagger Heidi
SJOGREN Helen
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Application granted granted Critical
Publication of JO3229B1 publication Critical patent/JO3229B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Fats And Perfumes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

يتعلق الاختراع الحالي بصفة عامة بمجال تثبيت صيغ الهرمونات المنشطة للحويصلات (FSH)، وبصفة خاصة صيغ FSH السائلة. يتحقق التثبيت بواسطة إضافة أملاح تشتمل على كاتيونات معدنية قلوية مقبولة صيدلانياً، وفي النماذج المفضلة يتحقق التثبيت بإضافة أملاح تشتمل على كاتيونات معدنية قلوية مقبولة صيدلانياً، وفي النماذج المفضلة يتم ذلك من خلال إضافة أملاح مقبولة صيدلانياً، مثل أملاح الصوديوم أو أملاح البوتاسيوم.
JOP/2011/0231A 2010-07-30 2011-07-21 العمل على استقرار الهرمون المنبه للجريب JO3229B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10171428A EP2417982A1 (en) 2010-07-30 2010-07-30 Stabilization of gonadotropins

Publications (1)

Publication Number Publication Date
JO3229B1 true JO3229B1 (ar) 2018-03-08

Family

ID=43216624

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2011/0231A JO3229B1 (ar) 2010-07-30 2011-07-21 العمل على استقرار الهرمون المنبه للجريب

Country Status (27)

Country Link
US (3) US8993732B2 (ar)
EP (3) EP2417982A1 (ar)
JP (3) JP5860047B2 (ar)
KR (2) KR101820115B1 (ar)
CN (2) CN105106939A (ar)
AR (1) AR082776A1 (ar)
AU (1) AU2011284702C1 (ar)
BR (1) BR112013002312B1 (ar)
CA (1) CA2805864A1 (ar)
DK (1) DK2598160T3 (ar)
ES (1) ES2623634T3 (ar)
HR (1) HRP20170386T1 (ar)
HU (1) HUE033592T2 (ar)
IL (2) IL223821A (ar)
JO (1) JO3229B1 (ar)
LT (1) LT2598160T (ar)
MX (2) MX356951B (ar)
NZ (2) NZ606366A (ar)
PL (1) PL2598160T3 (ar)
PT (1) PT2598160T (ar)
RS (1) RS55772B1 (ar)
RU (1) RU2574012C2 (ar)
SA (1) SA114350786B1 (ar)
SI (1) SI2598160T1 (ar)
TW (1) TWI439283B (ar)
WO (1) WO2012013742A2 (ar)
ZA (1) ZA201209497B (ar)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
EP2417982A1 (en) * 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
SG11201603142YA (en) * 2013-11-12 2016-05-30 Cadila Healthcare Ltd Formulation for gonadotropins
CN105727260A (zh) * 2016-02-03 2016-07-06 华侨大学 一种卵泡刺激素的长效制剂
GB201603280D0 (en) * 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
FR3083089A1 (fr) * 2018-06-29 2020-01-03 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
CN111727049A (zh) 2017-12-07 2020-09-29 阿道恰公司 Ph 7的包含至少一种pi在5.8与8.5之间的基础胰岛素和带有羧酸根电荷及疏水基的共聚氨基酸的可注射溶液
TW201938190A (zh) 2017-12-07 2019-10-01 法商阿道洽公司 包含至少一具有pi從5.8至8.5之基礎胰島素以及一帶有羧酸鹽電荷及疏水基之共聚胺基酸的ph 7之可注射溶液
FR3084586B1 (fr) * 2018-08-03 2020-11-06 Adocia Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un compose amphiphile porteur de radicaux hydrophobes
FR3084584B1 (fr) * 2018-08-03 2020-11-06 Adocia Solution injectable a ph 7 comprenant du glucagon humain et un compose amphiphile porteur de radicaux hydrophobes
JP7425459B2 (ja) * 2019-10-11 2024-01-31 株式会社シノテスト 安定化されたｈｍｇｂ１含有溶液

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4165718B2 (ja) 1995-03-21 2008-10-15 ラボラトワール セローノ ソシエテ アノニム ｈＣＧ液体製剤
RU2208582C2 (ru) * 1996-05-29 2003-07-20 Биоксид Ой Средство для доставки, обеспечивающее непрерывное и/или регулируемое высвобождение биологически активных агентов
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US20030166525A1 (en) * 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
JP4719357B2 (ja) * 1998-07-23 2011-07-06 アレス トレイディング ソシエテ アノニム Ｆｓｈ及びｆｓｈ変異体の製剤、製品及び方法
JP4991522B2 (ja) * 2004-04-07 2012-08-01 アレス トレーディング ソシエテ アノニム 成長ホルモン液剤
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
DE202009009905U1 (de) * 2008-02-08 2009-10-29 Biogenerix Ag Flüssig-Formulierung von FSH
TWI488640B (zh) 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
CN101614748A (zh) * 2008-06-25 2009-12-30 上海新波生物技术有限公司 促卵泡激素时间分辨免疫荧光分析法及试剂盒
EA020621B1 (ru) * 2009-06-22 2014-12-30 Амген Инк. Рефолдинг белков с использованием химически контролируемого окислительно-восстановительного состояния
CN102821782B (zh) * 2010-02-12 2015-07-15 印塔斯生物制药有限公司 促卵泡激素的液体配制品
EP2417982A1 (en) * 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins

Also Published As

Publication number Publication date
RU2012157154A (ru) 2014-09-10
BR112013002312B1 (pt) 2021-09-21
WO2012013742A3 (en) 2012-04-19
LT2598160T (lt) 2017-04-10
CN103052398B (zh) 2015-09-16
MX2013000681A (es) 2013-02-27
TW201208694A (en) 2012-03-01
EP2598160B1 (en) 2017-02-22
ES2623634T3 (es) 2017-07-11
JP2013532677A (ja) 2013-08-19
DK2598160T3 (en) 2017-03-27
TWI439283B (zh) 2014-06-01
WO2012013742A2 (en) 2012-02-02
KR101991756B1 (ko) 2019-06-21
HRP20170386T1 (hr) 2017-05-05
JP2016102127A (ja) 2016-06-02
SA114350786B1 (ar) 2015-07-09
AU2011284702B2 (en) 2015-05-14
CA2805864A1 (en) 2012-02-02
CN105106939A (zh) 2015-12-02
EP2598160A2 (en) 2013-06-05
PT2598160T (pt) 2017-03-30
BR112013002312A2 (pt) 2018-03-20
AU2011284702C1 (en) 2015-09-03
EP2417982A1 (en) 2012-02-15
MX356951B (es) 2018-06-21
AR082776A1 (es) 2013-01-09
JP6522711B2 (ja) 2019-05-29
US9463221B2 (en) 2016-10-11
ZA201209497B (en) 2013-08-28
KR20130143692A (ko) 2013-12-31
NZ606366A (en) 2014-08-29
HUE033592T2 (hu) 2017-12-28
JP5860047B2 (ja) 2016-02-16
KR101820115B1 (ko) 2018-01-18
US20170216405A1 (en) 2017-08-03
RS55772B1 (sr) 2017-07-31
US20130210727A1 (en) 2013-08-15
KR20180008916A (ko) 2018-01-24
CN103052398A (zh) 2013-04-17
PL2598160T3 (pl) 2017-06-30
AU2011284702A1 (en) 2013-02-07
SI2598160T1 (sl) 2017-07-31
IL249920A0 (en) 2017-03-30
US20150265681A1 (en) 2015-09-24
IL223821A (en) 2017-01-31
MX341464B (es) 2016-08-22
US8993732B2 (en) 2015-03-31
EP3144010A1 (en) 2017-03-22
JP2018048188A (ja) 2018-03-29
NZ628962A (en) 2016-01-29
RU2574012C2 (ru) 2016-01-27

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