CU20130142A7 - Preparación de gadobutrol de alta pureza - Google Patents

Preparación de gadobutrol de alta pureza

Info

Publication number
CU20130142A7
CU20130142A7 CU2013000142A CU20130142A CU20130142A7 CU 20130142 A7 CU20130142 A7 CU 20130142A7 CU 2013000142 A CU2013000142 A CU 2013000142A CU 20130142 A CU20130142 A CU 20130142A CU 20130142 A7 CU20130142 A7 CU 20130142A7
Authority
CU
Cuba
Prior art keywords
gadobutrol
high purity
gadovist
magnetic resonance
preparation
Prior art date
Application number
CU2013000142A
Other languages
English (en)
Inventor
Johannes Platzek
Wilhelm Trentmann
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46208435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20130142(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CU20130142A7 publication Critical patent/CU20130142A7/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Proceso para producir gadobutrol de alta pureza con una pureza (de acuerdo con HPLC) mayor de 99,7 ó 99,9 % y su uso para preparar una formulación farmacéutica para administración parenteral. El proceso se lleva a cabo usando condiciones de cristalización específicamente controladas. Los desarrollos más recientes en el campo de los agentes de contraste de resonancia magnética que contienen gadolinio ( EP 0448191 B1, CA Patente 1341176, EP 0643705 B1, EP 0986548 B1, EP 0596586 B1) incluyen el agente de contraste para tomografía de resonancia magnética gadobutrol ( Gadovist® 1.0) que ha estado aprobado durante un tiempo relativamente prolongado en Europa y más recientemente también en los EE.UU, con el nombre Gadovist®.
CU2013000142A 2011-04-21 2013-10-21 Preparación de gadobutrol de alta pureza CU20130142A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011100128 2011-04-21
PCT/EP2012/057013 WO2012143355A1 (en) 2011-04-21 2012-04-17 Preparation of high-purity gadobutrol

Publications (1)

Publication Number Publication Date
CU20130142A7 true CU20130142A7 (es) 2014-02-28

Family

ID=46208435

Family Applications (2)

Application Number Title Priority Date Filing Date
CU2016000163A CU24439B1 (es) 2011-04-21 2012-04-17 Preparación de gadobutrol de alta pureza
CU2013000142A CU20130142A7 (es) 2011-04-21 2013-10-21 Preparación de gadobutrol de alta pureza

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CU2016000163A CU24439B1 (es) 2011-04-21 2012-04-17 Preparación de gadobutrol de alta pureza

Country Status (34)

Country Link
US (2) US10072027B2 (es)
EP (2) EP2699556A1 (es)
JP (3) JP6096757B2 (es)
KR (3) KR102003570B1 (es)
CN (1) CN103547573B (es)
AR (1) AR086190A1 (es)
AU (2) AU2012244791B2 (es)
BR (1) BR112013027028B1 (es)
CA (1) CA2833659C (es)
CL (1) CL2013003045A1 (es)
CO (1) CO6801752A2 (es)
CU (2) CU24439B1 (es)
DK (1) DK2896405T3 (es)
DO (1) DOP2013000245A (es)
EA (2) EA026572B1 (es)
EC (1) ECSP13013010A (es)
ES (1) ES2780599T3 (es)
GT (1) GT201300253A (es)
HK (1) HK1193817A1 (es)
HR (1) HRP20200336T1 (es)
IL (1) IL228885A (es)
LT (1) LT2896405T (es)
MX (1) MX362133B (es)
MY (1) MY163709A (es)
NZ (1) NZ616637A (es)
PE (1) PE20141325A1 (es)
PL (1) PL2896405T3 (es)
PT (1) PT2896405T (es)
RS (1) RS60001B1 (es)
SG (1) SG194511A1 (es)
SI (1) SI2896405T1 (es)
TW (1) TW201249818A (es)
WO (1) WO2012143355A1 (es)
ZA (1) ZA201308706B (es)

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KR102003570B1 (ko) * 2011-04-21 2019-07-24 바이엘 인텔렉쳐 프로퍼티 게엠베하 고순도 가도부트롤의 제조
EP3102566B1 (en) * 2014-02-06 2018-09-12 T2Pharma GmbH Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101646211B1 (ko) * 2014-11-12 2016-08-05 (주)디아이테크 자기공명영상용 조영제의 제조방법
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
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CN109293592A (zh) * 2017-07-24 2019-02-01 天津科伦药物研究有限公司 一种制备钆布醇的方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
CN108840832A (zh) * 2018-06-29 2018-11-20 广州康瑞泰药业有限公司 一种钆布醇中间体的制备方法
US20210284662A1 (en) * 2018-07-10 2021-09-16 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
JOP20210114A1 (ar) * 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها
MX2021006957A (es) * 2018-12-12 2021-07-15 Medibeacon Inc Usos de la medicion de la velocidad de filtracion glomerular transdermica en terapia continua de reemplazo renal.
GB201919073D0 (en) * 2019-12-20 2020-02-05 Ge Healthcare As Novel manufacturing process
CN113087680A (zh) * 2020-01-08 2021-07-09 威智医药有限公司 Dota晶型及其制备方法
CN113105407A (zh) * 2020-01-13 2021-07-13 北京北陆药业股份有限公司 一种钆布醇新型晶型及其制备方法
KR20210114742A (ko) * 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법
CN114539178B (zh) * 2020-11-26 2024-03-15 江苏恒瑞医药股份有限公司 一种钆布醇的纯化方法
CN114573522A (zh) * 2020-11-30 2022-06-03 江苏恒瑞医药股份有限公司 一种考布曲钙的新晶型及其制备方法
CN112939806B (zh) * 2021-03-08 2023-05-16 山东新华制药股份有限公司 一种卡比多巴的精制方法
CN113527223B (zh) * 2021-06-22 2023-05-09 安徽普利药业有限公司 一种钆布醇的精制方法
CN114105897B (zh) * 2021-07-29 2023-04-04 安徽普利药业有限公司 一种钆特醇的制备方法

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KR101653064B1 (ko) 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법

Also Published As

Publication number Publication date
EA201301182A1 (ru) 2014-08-29
CU24439B1 (es) 2019-09-04
CN103547573A (zh) 2014-01-29
SG194511A1 (en) 2013-12-30
AR086190A1 (es) 2013-11-27
PL2896405T3 (pl) 2020-06-15
CU20160163A7 (es) 2017-02-02
PE20141325A1 (es) 2014-10-08
DOP2013000245A (es) 2013-12-31
CL2013003045A1 (es) 2014-05-02
GT201300253A (es) 2015-01-16
KR20200059319A (ko) 2020-05-28
AU2012244791A1 (en) 2013-10-31
CO6801752A2 (es) 2013-11-29
JP2014522387A (ja) 2014-09-04
CA2833659C (en) 2019-12-03
IL228885A (en) 2016-11-30
EA026572B1 (ru) 2017-04-28
ES2780599T3 (es) 2020-08-26
LT2896405T (lt) 2020-03-25
MX362133B (es) 2019-01-07
ZA201308706B (en) 2015-08-26
EA201600272A1 (ru) 2016-12-30
BR112013027028A2 (pt) 2016-12-27
SI2896405T1 (sl) 2020-04-30
CN103547573B (zh) 2016-08-17
IL228885A0 (en) 2013-12-31
US20180105537A1 (en) 2018-04-19
US10435417B2 (en) 2019-10-08
HK1193817A1 (zh) 2014-10-03
ECSP13013010A (es) 2013-12-31
RS60001B1 (sr) 2020-04-30
KR20140035911A (ko) 2014-03-24
BR112013027028B1 (pt) 2020-08-11
KR20190079682A (ko) 2019-07-05
NZ616637A (en) 2016-01-29
EP2896405A1 (en) 2015-07-22
JP2018188477A (ja) 2018-11-29
US20140107325A1 (en) 2014-04-17
AU2012244791B2 (en) 2017-04-27
MY163709A (en) 2017-10-13
JP2017031220A (ja) 2017-02-09
CA2833659A1 (en) 2012-10-26
MX2013012290A (es) 2013-11-21
KR102003570B1 (ko) 2019-07-24
JP6096757B2 (ja) 2017-03-15
AU2017204495A1 (en) 2017-07-20
WO2012143355A1 (en) 2012-10-26
EP2699556A1 (en) 2014-02-26
DK2896405T3 (da) 2020-04-06
US10072027B2 (en) 2018-09-11
PT2896405T (pt) 2020-03-31
TW201249818A (en) 2012-12-16
HRP20200336T1 (hr) 2020-06-12
EP2896405B1 (en) 2020-02-19

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