HRP20130983T1 - Derivati arilciklopropilacetamida, korisni kao aktivatori glukokinaze - Google Patents
Derivati arilciklopropilacetamida, korisni kao aktivatori glukokinaze Download PDFInfo
- Publication number
- HRP20130983T1 HRP20130983T1 HRP20130983AT HRP20130983T HRP20130983T1 HR P20130983 T1 HRP20130983 T1 HR P20130983T1 HR P20130983A T HRP20130983A T HR P20130983AT HR P20130983 T HRP20130983 T HR P20130983T HR P20130983 T1 HRP20130983 T1 HR P20130983T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- derivatives useful
- glucokinase activators
- compound according
- Prior art date
Links
- 102000030595 Glucokinase Human genes 0.000 title 1
- 108010021582 Glucokinase Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Claims (6)
1. Spoj, naznačen time što je spoj formule:
[image]
,
ili njegova farmaceutski prihvatljiva sol.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što je spoj formule:
[image]
,
ili njegova farmaceutski prihvatljiva sol.
3. Farmaceutski pripravak, naznačen time što sadrži spoj u skladu s patentnim zahtjevom 1 ili 2, ili njegovu farmaceutski prihvatljivu sol, i farmaceutski prihvatljiv razrjeđivač ili podlogu.
4. Spoj u skladu s patentnim zahtjevom 1 ili 2, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u terapiji.
5. Spoj u skladu s patentnim zahtjevom 1 ili 2, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju dijabetesa.
6. Spoj u skladu s patentnim zahtjevom 5, ili njegova farmaceutski prihvatljiva sol, naznačen time što je namijenjen upotrebi u liječenju dijabetesa tip II.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08380341 | 2008-12-19 | ||
| US15378109P | 2009-02-19 | 2009-02-19 | |
| PCT/US2009/067603 WO2010080333A1 (en) | 2008-12-19 | 2009-12-11 | Arylcyclopropylacetamide derivatives useful as glucokinase activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130983T1 true HRP20130983T1 (hr) | 2013-11-22 |
Family
ID=40545955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130983AT HRP20130983T1 (hr) | 2008-12-19 | 2013-10-16 | Derivati arilciklopropilacetamida, korisni kao aktivatori glukokinaze |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8063079B2 (hr) |
| EP (1) | EP2379517B1 (hr) |
| JP (1) | JP5497064B2 (hr) |
| KR (1) | KR101290437B1 (hr) |
| CN (1) | CN102256952B (hr) |
| AR (1) | AR074470A1 (hr) |
| AU (1) | AU2009335931B2 (hr) |
| BR (1) | BRPI0923183B1 (hr) |
| CA (1) | CA2746746C (hr) |
| CO (1) | CO6382120A2 (hr) |
| CR (1) | CR20110342A (hr) |
| DK (1) | DK2379517T3 (hr) |
| DO (1) | DOP2011000197A (hr) |
| EA (1) | EA019055B1 (hr) |
| EC (1) | ECSP11011150A (hr) |
| ES (1) | ES2435242T3 (hr) |
| HR (1) | HRP20130983T1 (hr) |
| IL (1) | IL213210A (hr) |
| JO (1) | JO2979B1 (hr) |
| MA (1) | MA32902B1 (hr) |
| MX (1) | MX2011006434A (hr) |
| MY (1) | MY180567A (hr) |
| NZ (1) | NZ592930A (hr) |
| PA (1) | PA8851901A1 (hr) |
| PE (1) | PE20120339A1 (hr) |
| PL (1) | PL2379517T3 (hr) |
| PT (1) | PT2379517E (hr) |
| SG (1) | SG172256A1 (hr) |
| SI (1) | SI2379517T1 (hr) |
| TN (1) | TN2011000294A1 (hr) |
| TW (1) | TWI395748B (hr) |
| UA (1) | UA104742C2 (hr) |
| WO (1) | WO2010080333A1 (hr) |
| ZA (1) | ZA201103944B (hr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| EP3072506B1 (en) | 2013-11-22 | 2022-04-20 | The University of Tokyo | Carrier for drug delivery and conjugate, composition containing same, and method for administering same |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2407416C (en) | 2000-05-03 | 2006-07-18 | Paige Erin Mahaney | Alkynyl phenyl heteroaromatic glucokinase activators |
| ES2230309T3 (es) | 2000-05-08 | 2005-05-01 | F. Hoffmann-La Roche Ag | Fenilacetamidas sustituidas y su empleo con ativadores de qucokinasa. |
| AU6591401A (en) | 2000-05-08 | 2001-11-20 | Hoffmann La Roche | Para-amine substituted phenylamide glucokinase activators |
| MY141521A (en) * | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
| DK1585739T3 (da) | 2003-01-06 | 2011-06-20 | Lilly Co Eli | Substituerede arylcyclopropylacetamider som glucokinaseaktivatorer |
| JP4621198B2 (ja) | 2003-02-11 | 2011-01-26 | プロシディオン・リミテッド | トリ（シクロ）置換アミドグルコキナーゼ活性化化合物 |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| EP1600442B1 (en) * | 2003-02-26 | 2018-01-17 | Msd K.K. | Heteroarylcarbamoylbenzene derivative |
| MXPA06012008A (es) | 2004-04-21 | 2007-01-25 | Prosidion Ltd | Compuestos de amida tri(ciclo) sustituidos. |
| JP2008509898A (ja) | 2004-08-12 | 2008-04-03 | プロシディオン・リミテッド | 置換されたフェニルアセトアミドおよびグルコキナーゼ活性化剤としてのこれらの使用 |
| JP2008521864A (ja) * | 2004-12-03 | 2008-06-26 | トランステック・ファーマ、インコーポレイテッド | ヘテロ芳香族グルコキナーゼ活性化剤 |
| EP1907004A2 (en) | 2005-07-01 | 2008-04-09 | Novartis AG | Combination of a renin inhibitor and an insulin secretion enhancer or an insulin sensitizer |
| KR100965040B1 (ko) | 2005-07-11 | 2010-06-21 | 미쓰비시 타나베 파마 코퍼레이션 | 옥심 유도체 및 그의 제조 방법 |
| WO2007017649A1 (en) * | 2005-08-09 | 2007-02-15 | Astrazeneca Ab | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
| US20080293741A1 (en) | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
| BRPI0618067A2 (pt) | 2005-11-03 | 2011-08-16 | Prosidion Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso e processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo |
| US20090005391A1 (en) | 2005-11-03 | 2009-01-01 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides |
| AU2007278261A1 (en) * | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
| EP2105435A4 (en) * | 2007-01-10 | 2011-06-15 | Mitsubishi Tanabe Pharma Corp | Hydrazone derivatives |
| NZ588462A (en) | 2008-04-28 | 2012-07-27 | Kyorin Seiyaku Kk | Cyclopentylacrylic acid amide derivative |
-
2009
- 2009-11-12 UA UAA201107562A patent/UA104742C2/uk unknown
- 2009-12-03 AR ARP090104672A patent/AR074470A1/es active IP Right Grant
- 2009-12-03 PA PA20098851901A patent/PA8851901A1/es unknown
- 2009-12-04 TW TW098141556A patent/TWI395748B/zh active
- 2009-12-06 JO JO2009467A patent/JO2979B1/en active
- 2009-12-11 KR KR1020117014073A patent/KR101290437B1/ko active IP Right Grant
- 2009-12-11 US US12/635,758 patent/US8063079B2/en active Active
- 2009-12-11 SG SG2011044823A patent/SG172256A1/en unknown
- 2009-12-11 EA EA201170845A patent/EA019055B1/ru not_active IP Right Cessation
- 2009-12-11 JP JP2011542276A patent/JP5497064B2/ja active Active
- 2009-12-11 PL PL09768316T patent/PL2379517T3/pl unknown
- 2009-12-11 AU AU2009335931A patent/AU2009335931B2/en not_active Ceased
- 2009-12-11 WO PCT/US2009/067603 patent/WO2010080333A1/en active Application Filing
- 2009-12-11 NZ NZ592930A patent/NZ592930A/xx not_active IP Right Cessation
- 2009-12-11 PT PT97683163T patent/PT2379517E/pt unknown
- 2009-12-11 MY MYPI2011002765A patent/MY180567A/en unknown
- 2009-12-11 MX MX2011006434A patent/MX2011006434A/es active IP Right Grant
- 2009-12-11 SI SI200930713T patent/SI2379517T1/sl unknown
- 2009-12-11 CA CA2746746A patent/CA2746746C/en active Active
- 2009-12-11 CN CN200980150686XA patent/CN102256952B/zh active Active
- 2009-12-11 DK DK09768316.3T patent/DK2379517T3/da active
- 2009-12-11 EP EP09768316.3A patent/EP2379517B1/en active Active
- 2009-12-11 BR BRPI0923183-8A patent/BRPI0923183B1/pt not_active IP Right Cessation
- 2009-12-11 PE PE2011001220A patent/PE20120339A1/es active IP Right Grant
- 2009-12-11 ES ES09768316T patent/ES2435242T3/es active Active
-
2011
- 2011-05-27 ZA ZA2011/03944A patent/ZA201103944B/en unknown
- 2011-05-30 IL IL213210A patent/IL213210A/en active IP Right Grant
- 2011-06-09 TN TN2011000294A patent/TN2011000294A1/fr unknown
- 2011-06-14 MA MA33945A patent/MA32902B1/fr unknown
- 2011-06-17 EC EC2011011150A patent/ECSP11011150A/es unknown
- 2011-06-17 CR CR20110342A patent/CR20110342A/es unknown
- 2011-06-17 DO DO2011000197A patent/DOP2011000197A/es unknown
- 2011-06-23 CO CO11079303A patent/CO6382120A2/es active IP Right Grant
-
2013
- 2013-10-16 HR HRP20130983AT patent/HRP20130983T1/hr unknown
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