DK2379517T3 - Arylcyclopropylacetamidderivater, der er anvendelige som glucokinaseaktivatorer - Google Patents

Arylcyclopropylacetamidderivater, der er anvendelige som glucokinaseaktivatorer

Info

Publication number
DK2379517T3
DK2379517T3 DK09768316.3T DK09768316T DK2379517T3 DK 2379517 T3 DK2379517 T3 DK 2379517T3 DK 09768316 T DK09768316 T DK 09768316T DK 2379517 T3 DK2379517 T3 DK 2379517T3
Authority
DK
Denmark
Prior art keywords
derivatives useful
glucokinase activators
arylcyclopropylacetamide
arylcyclopropylacetamide derivatives
glucokinase
Prior art date
Application number
DK09768316.3T
Other languages
English (en)
Inventor
Melendo Ana Belen Bueno
Francisco Javier Agejas-Chicharro
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK2379517T3 publication Critical patent/DK2379517T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK09768316.3T 2008-12-19 2009-12-11 Arylcyclopropylacetamidderivater, der er anvendelige som glucokinaseaktivatorer DK2379517T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08380341 2008-12-19
US15378109P 2009-02-19 2009-02-19
PCT/US2009/067603 WO2010080333A1 (en) 2008-12-19 2009-12-11 Arylcyclopropylacetamide derivatives useful as glucokinase activators

Publications (1)

Publication Number Publication Date
DK2379517T3 true DK2379517T3 (da) 2013-09-30

Family

ID=40545955

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09768316.3T DK2379517T3 (da) 2008-12-19 2009-12-11 Arylcyclopropylacetamidderivater, der er anvendelige som glucokinaseaktivatorer

Country Status (34)

Country Link
US (1) US8063079B2 (da)
EP (1) EP2379517B1 (da)
JP (1) JP5497064B2 (da)
KR (1) KR101290437B1 (da)
CN (1) CN102256952B (da)
AR (1) AR074470A1 (da)
AU (1) AU2009335931B2 (da)
BR (1) BRPI0923183B1 (da)
CA (1) CA2746746C (da)
CO (1) CO6382120A2 (da)
CR (1) CR20110342A (da)
DK (1) DK2379517T3 (da)
DO (1) DOP2011000197A (da)
EA (1) EA019055B1 (da)
EC (1) ECSP11011150A (da)
ES (1) ES2435242T3 (da)
HR (1) HRP20130983T1 (da)
IL (1) IL213210A (da)
JO (1) JO2979B1 (da)
MA (1) MA32902B1 (da)
MX (1) MX2011006434A (da)
MY (1) MY180567A (da)
NZ (1) NZ592930A (da)
PA (1) PA8851901A1 (da)
PE (1) PE20120339A1 (da)
PL (1) PL2379517T3 (da)
PT (1) PT2379517E (da)
SG (1) SG172256A1 (da)
SI (1) SI2379517T1 (da)
TN (1) TN2011000294A1 (da)
TW (1) TWI395748B (da)
UA (1) UA104742C2 (da)
WO (1) WO2010080333A1 (da)
ZA (1) ZA201103944B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3936608A1 (en) 2010-03-31 2022-01-12 The Scripps Research Institute Reprogramming cells
CN105899192B (zh) * 2013-11-22 2019-08-13 国立大学法人东京大学 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7049401A (en) 2000-05-03 2001-11-12 Hoffmann La Roche Alkynyl phenyl heteroaromatic glucokinase activators
DE60106599T2 (de) 2000-05-08 2006-02-09 F. Hoffmann-La Roche Ag Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren
WO2001085707A1 (en) 2000-05-08 2001-11-15 F. Hoffmann-La Roche Ag Para-amine substituted phenylamide glucokinase activators
MY141521A (en) * 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
ES2362656T3 (es) 2003-01-06 2011-07-11 Eli Lilly And Company Arilciclopropilacetamidas sustituidas como activadores de glucoquinasa.
PL378117A1 (pl) 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
WO2004072066A1 (en) 2003-02-11 2004-08-26 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
MXPA05009059A (es) * 2003-02-26 2005-10-19 Banyu Pharma Co Ltd Derivados de heteroarilcarbamoilbenceno.
JP2007533722A (ja) 2004-04-21 2007-11-22 プロシディオン・リミテッド トリ（シクロ）置換アミド化合物
MX2007001650A (es) 2004-08-12 2007-07-13 Prosidion Ltd Fenilacetamidas substituidas y su uso como activadores de glucocinasa.
CA2590720A1 (en) * 2004-12-03 2006-06-08 Lone Jeppesen Heteroaromatic glucokinase activators
WO2007005763A2 (en) 2005-07-01 2007-01-11 Novartis Ag Combination of a renin inhibitor and an insulin secretion enhancer or an insulin sensitizer
EP1907387A1 (en) 2005-07-11 2008-04-09 Mitsubishi Tanabe Pharma Corporation An oxime derivative and preparations thereof
JP2009504621A (ja) * 2005-08-09 2009-02-05 アストラゼネカ アクチボラグ 糖尿病の処置のためのヘテロアリールカルバモイルベンゼン誘導体
US20080293741A1 (en) * 2005-11-03 2008-11-27 Matthew Colin Thor Fyfe Tricyclo Substituted Amides as Glucokinase Modulators
EP1948645A1 (en) 2005-11-03 2008-07-30 Prosidion Limited Tricyclo substituted amides
US20090005391A1 (en) 2005-11-03 2009-01-01 Matthew Colin Thor Fyfe Tricyclo Substituted Amides
EP2046755A2 (en) * 2006-07-24 2009-04-15 F. Hoffmann-Roche AG Pyrazoles as glucokinase activators
WO2008084872A1 (ja) * 2007-01-10 2008-07-17 Mitsubishi Tanabe Pharma Corporation ヒドラゾン誘導体
CA2722733C (en) 2008-04-28 2016-02-23 Kyorin Pharmaceutical Co., Ltd. Cyclopentylacrylamide derivative

Also Published As

Publication number Publication date
JP5497064B2 (ja) 2014-05-21
AR074470A1 (es) 2011-01-19
EA201170845A1 (ru) 2011-12-30
SG172256A1 (en) 2011-07-28
AU2009335931A1 (en) 2011-07-07
ZA201103944B (en) 2012-11-28
DOP2011000197A (es) 2011-09-15
EP2379517A1 (en) 2011-10-26
TWI395748B (zh) 2013-05-11
KR20110086751A (ko) 2011-07-29
ECSP11011150A (es) 2011-07-29
BRPI0923183A2 (pt) 2016-02-16
ES2435242T3 (es) 2013-12-17
PE20120339A1 (es) 2012-04-16
HRP20130983T1 (hr) 2013-11-22
US8063079B2 (en) 2011-11-22
JP2012512874A (ja) 2012-06-07
EP2379517B1 (en) 2013-08-28
UA104742C2 (uk) 2014-03-11
CA2746746C (en) 2013-09-24
EA019055B1 (ru) 2013-12-30
TN2011000294A1 (en) 2012-12-17
CO6382120A2 (es) 2012-02-15
TW201029999A (en) 2010-08-16
JO2979B1 (en) 2016-03-15
US20100160395A1 (en) 2010-06-24
BRPI0923183A8 (pt) 2017-09-12
BRPI0923183B1 (pt) 2019-03-19
MX2011006434A (es) 2011-07-19
CR20110342A (es) 2011-09-14
CN102256952A (zh) 2011-11-23
PL2379517T3 (pl) 2014-01-31
PT2379517E (pt) 2013-11-21
SI2379517T1 (sl) 2013-10-30
AU2009335931B2 (en) 2012-05-31
KR101290437B1 (ko) 2013-07-29
IL213210A0 (en) 2011-07-31
PA8851901A1 (es) 2010-07-27
CA2746746A1 (en) 2010-07-15
CN102256952B (zh) 2013-12-11
NZ592930A (en) 2013-01-25
IL213210A (en) 2015-03-31
MA32902B1 (fr) 2011-12-01
MY180567A (en) 2020-12-02
WO2010080333A1 (en) 2010-07-15

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