CO6801752A2 - Preparación de gadobutrol de alta pureza - Google Patents

Preparación de gadobutrol de alta pureza

Info

Publication number
CO6801752A2
CO6801752A2 CO13248770A CO13248770A CO6801752A2 CO 6801752 A2 CO6801752 A2 CO 6801752A2 CO 13248770 A CO13248770 A CO 13248770A CO 13248770 A CO13248770 A CO 13248770A CO 6801752 A2 CO6801752 A2 CO 6801752A2
Authority
CO
Colombia
Prior art keywords
preparation
high purity
purity gadobutrol
gadobutrol
purity
Prior art date
Application number
CO13248770A
Other languages
English (en)
Inventor
Johannes Platzek
Wilhelm Trentmann
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46208435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6801752(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CO6801752A2 publication Critical patent/CO6801752A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
CO13248770A 2011-04-21 2013-10-21 Preparación de gadobutrol de alta pureza CO6801752A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102011100128 2011-04-21

Publications (1)

Publication Number Publication Date
CO6801752A2 true CO6801752A2 (es) 2013-11-29

Family

ID=46208435

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13248770A CO6801752A2 (es) 2011-04-21 2013-10-21 Preparación de gadobutrol de alta pureza

Country Status (34)

Country Link
US (2) US10072027B2 (es)
EP (2) EP2896405B1 (es)
JP (3) JP6096757B2 (es)
KR (3) KR20190079682A (es)
CN (1) CN103547573B (es)
AR (1) AR086190A1 (es)
AU (2) AU2012244791B2 (es)
BR (1) BR112013027028B1 (es)
CA (1) CA2833659C (es)
CL (1) CL2013003045A1 (es)
CO (1) CO6801752A2 (es)
CU (2) CU24439B1 (es)
DK (1) DK2896405T3 (es)
DO (1) DOP2013000245A (es)
EA (2) EA026572B1 (es)
EC (1) ECSP13013010A (es)
ES (1) ES2780599T3 (es)
GT (1) GT201300253A (es)
HK (1) HK1193817A1 (es)
HR (1) HRP20200336T1 (es)
IL (1) IL228885A (es)
LT (1) LT2896405T (es)
MX (1) MX362133B (es)
MY (1) MY163709A (es)
NZ (1) NZ616637A (es)
PE (1) PE20141325A1 (es)
PL (1) PL2896405T3 (es)
PT (1) PT2896405T (es)
RS (1) RS60001B1 (es)
SG (1) SG194511A1 (es)
SI (1) SI2896405T1 (es)
TW (1) TW201249818A (es)
WO (1) WO2012143355A1 (es)
ZA (1) ZA201308706B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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AU2012244791B2 (en) * 2011-04-21 2017-04-27 Bayer Intellectual Property Gmbh Preparation of high-purity gadobutrol
WO2015117911A1 (en) * 2014-02-06 2015-08-13 Agfa Healthcare Process for purifying 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101646211B1 (ko) * 2014-11-12 2016-08-05 (주)디아이테크 자기공명영상용 조영제의 제조방법
KR101653064B1 (ko) 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
EP3519394B1 (en) 2016-09-27 2020-05-27 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
JP7034160B2 (ja) 2016-11-28 2022-03-11 バイエル・ファルマ・アクティエンゲゼルシャフト 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物
CN109293592A (zh) * 2017-07-24 2019-02-01 天津科伦药物研究有限公司 一种制备钆布醇的方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
CN108840832A (zh) * 2018-06-29 2018-11-20 广州康瑞泰药业有限公司 一种钆布醇中间体的制备方法
EP4083026A1 (en) 2018-07-10 2022-11-02 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
US11944690B2 (en) * 2018-11-23 2024-04-02 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
MX2021006957A (es) * 2018-12-12 2021-07-15 Medibeacon Inc Usos de la medicion de la velocidad de filtracion glomerular transdermica en terapia continua de reemplazo renal.
GB201919073D0 (en) * 2019-12-20 2020-02-05 Ge Healthcare As Novel manufacturing process
CN113087680A (zh) * 2020-01-08 2021-07-09 威智医药有限公司 Dota晶型及其制备方法
CN113105407A (zh) * 2020-01-13 2021-07-13 北京北陆药业股份有限公司 一种钆布醇新型晶型及其制备方法
KR20210114742A (ko) * 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법
CN114539178B (zh) * 2020-11-26 2024-03-15 江苏恒瑞医药股份有限公司 一种钆布醇的纯化方法
CN114573522A (zh) * 2020-11-30 2022-06-03 江苏恒瑞医药股份有限公司 一种考布曲钙的新晶型及其制备方法
CN112939806B (zh) * 2021-03-08 2023-05-16 山东新华制药股份有限公司 一种卡比多巴的精制方法
CN113527223B (zh) * 2021-06-22 2023-05-09 安徽普利药业有限公司 一种钆布醇的精制方法
CN114105897B (zh) * 2021-07-29 2023-04-04 安徽普利药业有限公司 一种钆特醇的制备方法

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DE3625417C2 (de) 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
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US7385041B2 (en) 1990-04-25 2008-06-10 Bracco International B.V. Dual functioning excipient for metal chelate contrast agents
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DE4140779A1 (de) 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
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IT1275426B (it) 1995-05-16 1997-08-07 Bracco Spa Recupero del gadolinio e dei suoi agenti complessanti da soluzioni acquose contenenti i loro complessi
US5744616A (en) 1996-02-26 1998-04-28 Schering Aktiengesellschaft Process for the production of 1,4,7,10-tetraazacyclododecane and its derivatives
DE19608307C1 (de) 1996-02-26 1997-08-28 Schering Ag Verfahren zur Herstellung von 1,4,7,10-Tetraazacyclododecan und dessen Derivaten
DE19724186C2 (de) 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292127B1 (it) 1997-06-11 1999-01-25 Bracco Spa Processo per la dissalazione di sostanze instabili a ph acidi
DE69903603T2 (de) 1998-09-08 2003-08-14 Kba Giori Sa Sicherheitsdruckmaschine für Wertpapiere
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DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
AU2012244791B2 (en) * 2011-04-21 2017-04-27 Bayer Intellectual Property Gmbh Preparation of high-purity gadobutrol
KR101653064B1 (ko) 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법

Also Published As

Publication number Publication date
MX2013012290A (es) 2013-11-21
JP2018188477A (ja) 2018-11-29
EA201301182A1 (ru) 2014-08-29
EP2896405B1 (en) 2020-02-19
RS60001B1 (sr) 2020-04-30
CL2013003045A1 (es) 2014-05-02
SI2896405T1 (sl) 2020-04-30
DK2896405T3 (da) 2020-04-06
IL228885A (en) 2016-11-30
ZA201308706B (en) 2015-08-26
AR086190A1 (es) 2013-11-27
KR102003570B1 (ko) 2019-07-24
US10072027B2 (en) 2018-09-11
BR112013027028B1 (pt) 2020-08-11
CA2833659A1 (en) 2012-10-26
PL2896405T3 (pl) 2020-06-15
SG194511A1 (en) 2013-12-30
DOP2013000245A (es) 2013-12-31
GT201300253A (es) 2015-01-16
IL228885A0 (en) 2013-12-31
JP2017031220A (ja) 2017-02-09
CN103547573B (zh) 2016-08-17
CA2833659C (en) 2019-12-03
AU2012244791B2 (en) 2017-04-27
PE20141325A1 (es) 2014-10-08
EP2699556A1 (en) 2014-02-26
JP2014522387A (ja) 2014-09-04
JP6096757B2 (ja) 2017-03-15
MX362133B (es) 2019-01-07
TW201249818A (en) 2012-12-16
US10435417B2 (en) 2019-10-08
AU2017204495A1 (en) 2017-07-20
CU20160163A7 (es) 2017-02-02
PT2896405T (pt) 2020-03-31
LT2896405T (lt) 2020-03-25
ES2780599T3 (es) 2020-08-26
ECSP13013010A (es) 2013-12-31
CU24439B1 (es) 2019-09-04
MY163709A (en) 2017-10-13
KR20200059319A (ko) 2020-05-28
HK1193817A1 (zh) 2014-10-03
EA026572B1 (ru) 2017-04-28
WO2012143355A1 (en) 2012-10-26
CN103547573A (zh) 2014-01-29
KR20140035911A (ko) 2014-03-24
KR20190079682A (ko) 2019-07-05
NZ616637A (en) 2016-01-29
AU2012244791A1 (en) 2013-10-31
EA201600272A1 (ru) 2016-12-30
US20180105537A1 (en) 2018-04-19
CU20130142A7 (es) 2014-02-28
BR112013027028A2 (pt) 2016-12-27
HRP20200336T1 (hr) 2020-06-12
US20140107325A1 (en) 2014-04-17
EP2896405A1 (en) 2015-07-22

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