SMT201300112B - Sale citrato di 9E-15-(2-pirrolidin-1-il-etossi)-7,12,25-triossa-19,21,24-triaza-tetracicloÄ18.3.1.1(2,5).1(14,18)Üesacos a-1(24),2,4,9,14,16,18(26),20,22-nonaene - Google Patents
Sale citrato di 9E-15-(2-pirrolidin-1-il-etossi)-7,12,25-triossa-19,21,24-triaza-tetracicloÄ18.3.1.1(2,5).1(14,18)Üesacos a-1(24),2,4,9,14,16,18(26),20,22-nonaeneInfo
- Publication number
- SMT201300112B SMT201300112B SM201300112T SM201300112T SMT201300112B SM T201300112 B SMT201300112 B SM T201300112B SM 201300112 T SM201300112 T SM 201300112T SM 201300112 T SM201300112 T SM 201300112T SM T201300112 B SMT201300112 B SM T201300112B
- Authority
- SM
- San Marino
- Prior art keywords
- citrate salt
- nonaene
- triaza
- pyrrolidin
- ethoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22560909P | 2009-07-15 | 2009-07-15 | |
| PCT/SG2010/000265 WO2011008172A1 (en) | 2009-07-15 | 2010-07-14 | 9e-15-(2-pyrrolidin-1-yl-ethoxy)-7,12,25-trioxa-19,21,24-triaza- tetracyclo[18.3.1.1(2,5).1(14)18)]hexacosa-1(24),2,4,9,14,16,18(26),20,22-nonaene citrate salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201300112B true SMT201300112B (it) | 2013-11-08 |
Family
ID=42790728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201300112T SMT201300112B (it) | 2009-07-15 | 2013-10-04 | Sale citrato di 9E-15-(2-pirrolidin-1-il-etossi)-7,12,25-triossa-19,21,24-triaza-tetracicloÄ18.3.1.1(2,5).1(14,18)Üesacos a-1(24),2,4,9,14,16,18(26),20,22-nonaene |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9062074B2 (it) |
| EP (1) | EP2454266B1 (it) |
| JP (2) | JP6013911B2 (it) |
| CN (1) | CN102762577B (it) |
| AR (2) | AR077483A1 (it) |
| BR (1) | BR112012000750B1 (it) |
| CA (1) | CA2768210C (it) |
| DK (1) | DK2454266T3 (it) |
| ES (1) | ES2429525T3 (it) |
| HK (1) | HK1178159A1 (it) |
| HR (1) | HRP20130941T1 (it) |
| MX (1) | MX2012000680A (it) |
| PL (1) | PL2454266T3 (it) |
| PT (1) | PT2454266E (it) |
| RU (1) | RU2543721C2 (it) |
| SI (1) | SI2454266T1 (it) |
| SM (1) | SMT201300112B (it) |
| TW (1) | TWI537276B (it) |
| WO (1) | WO2011008172A1 (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2017005163A (es) | 2014-11-17 | 2018-01-18 | Arno Therapeutics Inc | Composiciones de liberación prolongada de onapristona y métodos. |
| BR112018005999A2 (pt) | 2015-09-25 | 2019-01-08 | Context Biopharma Inc | métodos para a produção de intermediários de onapristona |
| CN108883067B (zh) | 2015-12-15 | 2021-03-09 | 康特斯生物制药公司 | 非晶奥那司酮组合物及其制备方法 |
| US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY110603A (en) * | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
| US7151096B2 (en) * | 2003-03-05 | 2006-12-19 | Irm Llc | Cyclic compounds and compositions as protein kinase inhibitors |
| WO2007058628A1 (en) * | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Heteroalkyl linked pyrimidine derivatives |
-
2010
- 2010-07-14 US US13/384,139 patent/US9062074B2/en active Active
- 2010-07-14 DK DK10737645.1T patent/DK2454266T3/da active
- 2010-07-14 MX MX2012000680A patent/MX2012000680A/es active IP Right Grant
- 2010-07-14 CN CN201080032627.5A patent/CN102762577B/zh active Active
- 2010-07-14 ES ES10737645T patent/ES2429525T3/es active Active
- 2010-07-14 PT PT107376451T patent/PT2454266E/pt unknown
- 2010-07-14 EP EP10737645.1A patent/EP2454266B1/en active Active
- 2010-07-14 CA CA2768210A patent/CA2768210C/en active Active
- 2010-07-14 BR BR112012000750-5A patent/BR112012000750B1/pt active IP Right Grant
- 2010-07-14 RU RU2012105044/04A patent/RU2543721C2/ru active
- 2010-07-14 JP JP2012520571A patent/JP6013911B2/ja active Active
- 2010-07-14 PL PL10737645T patent/PL2454266T3/pl unknown
- 2010-07-14 SI SI201030347T patent/SI2454266T1/sl unknown
- 2010-07-14 WO PCT/SG2010/000265 patent/WO2011008172A1/en active Application Filing
- 2010-07-15 AR ARP100102594A patent/AR077483A1/es not_active Application Discontinuation
- 2010-07-15 TW TW099123331A patent/TWI537276B/zh active
-
2013
- 2013-04-29 HK HK13105191.1A patent/HK1178159A1/xx unknown
- 2013-10-04 SM SM201300112T patent/SMT201300112B/it unknown
- 2013-10-07 HR HRP20130941AT patent/HRP20130941T1/hr unknown
-
2015
- 2015-05-07 JP JP2015094972A patent/JP2015164941A/ja active Pending
-
2019
- 2019-08-05 AR ARP190102219A patent/AR114987A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2454266T3 (pl) | 2014-01-31 |
| US20120196876A1 (en) | 2012-08-02 |
| EP2454266B1 (en) | 2013-07-10 |
| HRP20130941T1 (hr) | 2013-11-08 |
| BR112012000750B1 (pt) | 2021-05-25 |
| TW201107336A (en) | 2011-03-01 |
| EP2454266A1 (en) | 2012-05-23 |
| RU2012105044A (ru) | 2013-08-20 |
| ES2429525T3 (es) | 2013-11-15 |
| HK1178159A1 (en) | 2013-09-06 |
| CA2768210A1 (en) | 2011-01-20 |
| JP6013911B2 (ja) | 2016-10-25 |
| JP2012533539A (ja) | 2012-12-27 |
| CN102762577B (zh) | 2015-01-07 |
| BR112012000750A2 (pt) | 2016-08-09 |
| SI2454266T1 (sl) | 2013-10-30 |
| CA2768210C (en) | 2017-08-15 |
| BR112012000750A8 (pt) | 2018-02-06 |
| DK2454266T3 (da) | 2013-09-08 |
| AR077483A1 (es) | 2011-08-31 |
| TWI537276B (zh) | 2016-06-11 |
| US9062074B2 (en) | 2015-06-23 |
| JP2015164941A (ja) | 2015-09-17 |
| MX2012000680A (es) | 2012-02-28 |
| WO2011008172A1 (en) | 2011-01-20 |
| RU2543721C2 (ru) | 2015-03-10 |
| CN102762577A (zh) | 2012-10-31 |
| AR114987A2 (es) | 2020-11-11 |
| PT2454266E (pt) | 2013-10-10 |
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