CU24340B1 - Derivados de acetamidas fluoradas para el tratamiento del vih - Google Patents
Derivados de acetamidas fluoradas para el tratamiento del vihInfo
- Publication number
- CU24340B1 CU24340B1 CUP2015000096A CU20150096A CU24340B1 CU 24340 B1 CU24340 B1 CU 24340B1 CU P2015000096 A CUP2015000096 A CU P2015000096A CU 20150096 A CU20150096 A CU 20150096A CU 24340 B1 CU24340 B1 CU 24340B1
- Authority
- CU
- Cuba
- Prior art keywords
- hiv
- derivatives
- acetamids
- fluorated
- treatment
- Prior art date
Links
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 241000712907 Retroviridae Species 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 150000003869 acetamides Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361771655P | 2013-03-01 | 2013-03-01 | |
US201361857636P | 2013-07-23 | 2013-07-23 | |
PCT/US2014/019663 WO2014134566A2 (en) | 2013-03-01 | 2014-02-28 | Therapeutic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20150096A7 CU20150096A7 (es) | 2016-07-29 |
CU24340B1 true CU24340B1 (es) | 2018-05-08 |
Family
ID=50382584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2015000096A CU24340B1 (es) | 2013-03-01 | 2014-02-28 | Derivados de acetamidas fluoradas para el tratamiento del vih |
Country Status (37)
Country | Link |
---|---|
US (4) | US9951043B2 (de) |
EP (3) | EP3954679A3 (de) |
JP (5) | JP6519486B2 (de) |
KR (1) | KR102229989B1 (de) |
CN (2) | CN108516974A (de) |
AP (1) | AP2015008717A0 (de) |
AU (3) | AU2014223973B2 (de) |
BR (1) | BR112015021027B1 (de) |
CA (2) | CA3007006A1 (de) |
CL (1) | CL2015002445A1 (de) |
CR (2) | CR20190504A (de) |
CU (1) | CU24340B1 (de) |
CY (1) | CY1121047T1 (de) |
DK (1) | DK2961742T3 (de) |
EA (1) | EA035127B1 (de) |
ES (2) | ES2688571T3 (de) |
HK (3) | HK1222169A1 (de) |
HR (1) | HRP20181679T1 (de) |
HU (1) | HUE039521T2 (de) |
IL (1) | IL240519B (de) |
LT (1) | LT2961742T (de) |
MD (1) | MD20150092A2 (de) |
MX (1) | MX2015011478A (de) |
MY (1) | MY195364A (de) |
NZ (3) | NZ728537A (de) |
PE (2) | PE20151749A1 (de) |
PH (1) | PH12015501881B1 (de) |
PL (2) | PL2961742T3 (de) |
PT (2) | PT3409667T (de) |
RS (1) | RS57718B1 (de) |
SG (2) | SG11201506929VA (de) |
SI (2) | SI3409667T1 (de) |
TW (2) | TWI694071B (de) |
UA (1) | UA120346C2 (de) |
UY (1) | UY35362A (de) |
WO (1) | WO2014134566A2 (de) |
ZA (1) | ZA201506098B (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9540343B2 (en) | 2011-07-06 | 2017-01-10 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
NZ631762A (en) | 2013-01-09 | 2017-02-24 | Gilead Sciences Inc | 5-membered heteroaryls and their use as antiviral agents |
TW201443037A (zh) * | 2013-01-09 | 2014-11-16 | Gilead Sciences Inc | 治療用化合物 |
TWI694071B (zh) * | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物 |
WO2014144545A2 (en) * | 2013-03-15 | 2014-09-18 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
US10202353B2 (en) | 2014-02-28 | 2019-02-12 | Gilead Sciences, Inc. | Therapeutic compounds |
NZ729150A (en) * | 2014-08-29 | 2018-02-23 | Gilead Sciences Inc | Antiretroviral agents |
US9855230B2 (en) | 2014-09-09 | 2018-01-02 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
US20160145344A1 (en) * | 2014-10-20 | 2016-05-26 | University Of Southern California | Murine and human innate lymphoid cells and lung inflammation |
HUE056470T2 (hu) | 2014-12-26 | 2022-02-28 | Univ Emory | Vírusellenes N4-Hidroxicitidin származékok |
WO2016123629A1 (en) * | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
KR20180005673A (ko) | 2015-04-23 | 2018-01-16 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 인간 면역결핍 바이러스 복제 억제제 |
KR20180005195A (ko) | 2015-04-23 | 2018-01-15 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 인간 면역결핍 바이러스 복제의 억제제 |
US20170040479A1 (en) | 2015-08-07 | 2017-02-09 | Solaero Technologies Corp. | Reliable interconnection of solar cells |
US20170081324A1 (en) * | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Triazolones derivatives and their use in the treatment, amelioration or prevention of a viral disease |
US20190135857A1 (en) | 2016-06-30 | 2019-05-09 | Viiv Healthcare Uk (No. 5) Limited | Triterpenoid inhibitors of human immunodeficiency virus replication |
ES2836402T3 (es) | 2016-06-30 | 2021-06-25 | Viiv Healthcare Uk No 5 Ltd | Derivados de azadecalina como inhibidores de la replicación del virus de inmunodeficiencia humana |
WO2018002847A1 (en) | 2016-06-30 | 2018-01-04 | VIIV Healthcare UK (No.5) Limited | Aza-substituted inhibitors of human immunodeficiency virus replication |
EP3597646B1 (de) * | 2016-08-19 | 2023-06-21 | Gilead Sciences, Inc. | Therapeutische verbindungen zur prophylaktischen oder therapeutischen behandlung einer hiv-virusinfektion |
EA036921B1 (ru) * | 2017-02-10 | 2021-01-15 | Джилид Сайэнс, Инк. | Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич |
TW201906834A (zh) | 2017-05-02 | 2019-02-16 | 英商Viiv醫療保健英國(No.5)有限公司 | 人類免疫不全病毒複製之抑制劑 |
TWI687415B (zh) | 2017-08-17 | 2020-03-11 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
AR112412A1 (es) * | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
GB2590198B (en) | 2017-12-07 | 2022-02-23 | Univ Emory | N4-hydroxycytidine derivatives and anti-viral uses related thereto |
EP3752495B1 (de) | 2018-02-15 | 2023-07-19 | Gilead Sciences, Inc. | Pyridinderivate und ihre verwendung zur behandlung von hiv-infektionen |
CN112055712B (zh) * | 2018-02-16 | 2023-07-14 | 吉利德科学公司 | 用于制备可用于治疗逆转录病毒科病毒感染的治疗性化合物的方法和中间体 |
JP7307747B2 (ja) * | 2018-04-11 | 2023-07-12 | ヴィーブ ヘルスケア ユーケー(ナンバー5)リミテッド | ヒト免疫不全ウイルス複製の阻害剤としての4-オキソ-3,4-ジヒドロキナゾリン化合物 |
TWI814350B (zh) | 2018-07-16 | 2023-09-01 | 美商基利科學股份有限公司 | 用於治療hiv之蛋白殼抑制劑 |
EP3833436A1 (de) * | 2018-08-09 | 2021-06-16 | VIIV Healthcare UK (No.5) Limited | Inhibitoren der neubildung menschlicher immundefektviren |
EP3849982A1 (de) | 2018-09-14 | 2021-07-21 | VIIV Healthcare UK (No.5) Limited | Inhibitoren der neubildung menschlicher immundefektviren |
WO2020058844A1 (en) | 2018-09-20 | 2020-03-26 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
EP3870576B1 (de) | 2018-10-24 | 2024-01-24 | VIIV Healthcare UK (No.5) Limited | Benzopyrazole abkömmlinge als hemmstoffe der neubildung menschlicher immundefektviren |
CN113195475A (zh) | 2018-10-24 | 2021-07-30 | Viiv保健英国第五有限公司 | 人免疫缺陷病毒复制的抑制剂 |
WO2020084480A1 (en) | 2018-10-25 | 2020-04-30 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
EP3873607B1 (de) | 2018-10-29 | 2023-11-29 | VIIV Healthcare UK (No.5) Limited | Chinazolinylindazolderivate und ihre verwendung als inhibitoren der replikation des menschlichen immundefizienzvirus |
US20210379071A1 (en) | 2018-11-05 | 2021-12-09 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
US20210395248A1 (en) | 2018-11-05 | 2021-12-23 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
UY38559A (es) | 2019-02-01 | 2020-07-31 | Viiv Healthcare Uk No 5 Ltd | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
EP3962603A1 (de) | 2019-04-30 | 2022-03-09 | ViiV Healthcare UK (No.5) Limited | Inhibitoren der neubildung menschlicher immundefektviren |
PE20220510A1 (es) | 2019-06-19 | 2022-04-07 | Viiv Healthcare Uk No 5 Ltd | Inhibidores de la replicacion del virus de inmunodeficiencia humana |
WO2021064571A1 (en) | 2019-10-01 | 2021-04-08 | VIIV Healthcare UK (No.5) Limited | N-substituted-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl derivatives as inhibitors of the human immunodeficiency virus replication |
EP4038064B1 (de) | 2019-10-01 | 2024-02-21 | VIIV Healthcare UK (No.5) Limited | N-substituierte-6-oxo-1,6-dihydropyrimidin-2-yl-derivate als inhibitoren der replikation des menschlichen immunschwächevirus |
TW202128648A (zh) | 2019-10-04 | 2021-08-01 | 英商Viiv醫療保健英國(No 5)有限公司 | 人類免疫不全病毒複製之抑制劑 |
EP4041729B1 (de) | 2019-10-08 | 2023-09-27 | VIIV Healthcare UK (No.5) Limited | Inhibitoren der neubildung menschlicher immundefektviren |
CN114727999A (zh) | 2019-11-26 | 2022-07-08 | 吉利德科学公司 | 用于预防hiv的衣壳抑制剂 |
US20230059640A1 (en) | 2019-11-28 | 2023-02-23 | Shionogi & Co., Ltd. | Prophylactic and therapeutic pharmaceutical agent for hiv infectious diseases characterized by comprising combination of integrase inhibitor and anti-hiv agent |
AU2020390305A1 (en) | 2019-11-29 | 2022-07-07 | Jiangsu Hengrui Medicine Co., Ltd. | Fused pyridine ring derivative, preparation method therefor, and pharmaceutical use thereof |
JP2023513047A (ja) * | 2020-01-30 | 2023-03-30 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に有効な縮合二環式芳香族複素環式アミノ化合物 |
EP4114527A1 (de) | 2020-03-06 | 2023-01-11 | VIIV Healthcare UK (No.5) Limited | Inhibitoren der neubildung menschlicher immundefektviren |
CN115551858A (zh) * | 2020-03-06 | 2022-12-30 | Viiv保健英国第五有限公司 | 人类免疫缺陷病毒复制的抑制剂 |
EP4121437A1 (de) | 2020-03-20 | 2023-01-25 | Gilead Sciences, Inc. | Prodrugs von 4'-c-substituierten-2-halo-2'-deoxyadenosinnukleosiden und verfahren zur herstellung und verwendung davon |
MX2022012881A (es) | 2020-04-15 | 2022-11-08 | Viiv Healthcare Uk No 5 Ltd | Inhibidores de replicacion del virus de inmunodeficiencia humana. |
CN115996925A (zh) | 2020-06-25 | 2023-04-21 | 吉利德科学公司 | 用于治疗hiv的衣壳抑制剂 |
TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
US20220144923A1 (en) | 2020-11-11 | 2022-05-12 | Gilead Sciences, Inc. | METHODS OF IDENTIFYING HIV PATIENTS SENSITIVE TO THERAPY WITH gp120 CD4 BINDING SITE-DIRECTED ANTIBODIES |
CN118159529A (zh) * | 2021-05-28 | 2024-06-07 | 江苏恒瑞医药股份有限公司 | 一种稠合吡啶环衍生物的可药用盐、晶型及其制备方法 |
WO2023102529A1 (en) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
WO2023102523A1 (en) | 2021-12-03 | 2023-06-08 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
AU2022401696A1 (en) | 2021-12-03 | 2024-05-09 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
TW202400172A (zh) | 2022-04-06 | 2024-01-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
US20240034724A1 (en) | 2022-07-01 | 2024-02-01 | Gilead Sciences, Inc. | Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection |
US20240083984A1 (en) | 2022-08-26 | 2024-03-14 | Gilead Sciences, Inc. | Dosing and scheduling regimen for broadly neutralizing antibodies |
WO2024076915A1 (en) | 2022-10-04 | 2024-04-11 | Gilead Sciences, Inc. | 4'-thionucleoside analogues and their pharmaceutical use |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5269761B2 (ja) | 2006-04-12 | 2013-08-21 | メルク・シャープ・アンド・ドーム・コーポレーション | ピリジルアミドt型カルシウムチャンネルアンタゴニスト |
KR20100072266A (ko) * | 2007-10-24 | 2010-06-30 | 머크 샤프 앤드 돔 코포레이션 | 헤테로사이클 페닐 아미드 t-형 칼슘 채널 길항제 |
AU2008317352A1 (en) | 2007-10-24 | 2009-04-30 | Merck Sharp & Dohme Corp. | Heterocycle amide T-type calcium channel antagonists |
WO2009062285A1 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
CN102414217A (zh) | 2009-02-25 | 2012-04-11 | 彼格泰格私人有限公司 | 用于检测基孔肯雅病毒的探针和引物 |
US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
US20110035387A1 (en) * | 2009-08-10 | 2011-02-10 | Telcordia Technologies, Inc. | System and method for the controlled introduction of noise to information filtering |
WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
US20130165489A1 (en) | 2010-05-03 | 2013-06-27 | The Trustees Of The University Of Pennsylvania | Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof |
WO2011143772A1 (en) | 2010-05-21 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Inhibitors of hiv replication |
PT2588450T (pt) | 2010-07-02 | 2017-08-03 | Gilead Sciences Inc | Derivados do ácido naft-2-ilacético para tratamento da sida |
PE20130525A1 (es) | 2010-07-02 | 2013-05-05 | Gilead Sciences Inc | Derivados de acido 2 quinolinil acetico como compuestos antivirales frente a vih |
CN102464654B (zh) | 2010-11-12 | 2016-01-13 | 上海泓博智源医药技术有限公司 | 抗病毒化合物 |
LT2688403T (lt) | 2011-03-23 | 2017-07-25 | Trevena, Inc. | Opioidų receptorių ligandai ir jų panaudojimo bei gamybos būdai |
EP2699558B1 (de) | 2011-04-21 | 2016-11-23 | Gilead Sciences, Inc. | Benzothiazol-verbindungen und ihre pharmazeutische verwendung |
US9540343B2 (en) | 2011-07-06 | 2017-01-10 | Gilead Sciences, Inc. | Compounds for the treatment of HIV |
CN102863512B (zh) | 2011-07-07 | 2016-04-20 | 上海泓博智源医药技术有限公司 | 抗病毒化合物 |
US20140155381A1 (en) * | 2011-07-29 | 2014-06-05 | Erkan Baloglu | Compounds and methods |
WO2013159064A1 (en) | 2012-04-20 | 2013-10-24 | Gilead Sciences, Inc. | Benzothiazol- 6 -yl acetic acid derivatives and their use for treating an hiv infection |
GB201213087D0 (en) | 2012-07-24 | 2012-09-05 | Medical Res Council | Inhibition of HIV-1 infection |
WO2014028931A2 (en) | 2012-08-17 | 2014-02-20 | Brandeis University | Compounds and methods for treating mammalian gastrointestinal microbial infections |
PL2943493T3 (pl) | 2013-01-09 | 2017-12-29 | Gilead Sciences, Inc. | Związki terapeutyczne do leczenia zakażeń wirusowych |
TW201443037A (zh) | 2013-01-09 | 2014-11-16 | Gilead Sciences Inc | 治療用化合物 |
NZ631762A (en) | 2013-01-09 | 2017-02-24 | Gilead Sciences Inc | 5-membered heteroaryls and their use as antiviral agents |
US20140296266A1 (en) | 2013-03-01 | 2014-10-02 | Gilead Sciences, Inc. | Therapeutic compounds |
TWI694071B (zh) | 2013-03-01 | 2020-05-21 | 美商基利科學股份有限公司 | 治療反轉錄病毒科(Retroviridae)病毒感染之治療性化合物 |
GB201312991D0 (en) | 2013-07-19 | 2013-09-04 | Isis Innovation | Process |
EP3060554A1 (de) | 2013-10-24 | 2016-08-31 | Bristol-Myers Squibb Company | Hemmer der neubildung menschlicher immundefektviren |
WO2015130966A1 (en) | 2014-02-28 | 2015-09-03 | Gilead Sciences, Inc. | Antiviral agents |
US10202353B2 (en) | 2014-02-28 | 2019-02-12 | Gilead Sciences, Inc. | Therapeutic compounds |
NZ729150A (en) | 2014-08-29 | 2018-02-23 | Gilead Sciences Inc | Antiretroviral agents |
US9855230B2 (en) | 2014-09-09 | 2018-01-02 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
KR20180005673A (ko) | 2015-04-23 | 2018-01-16 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 인간 면역결핍 바이러스 복제 억제제 |
KR20180005195A (ko) | 2015-04-23 | 2018-01-15 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 인간 면역결핍 바이러스 복제의 억제제 |
JP6620763B2 (ja) * | 2017-01-16 | 2019-12-18 | マツダ株式会社 | 電動車両 |
-
2014
- 2014-02-27 TW TW103106785A patent/TWI694071B/zh active
- 2014-02-27 TW TW108101371A patent/TWI706945B/zh active
- 2014-02-28 EP EP21184874.2A patent/EP3954679A3/de active Pending
- 2014-02-28 HU HUE14712844A patent/HUE039521T2/hu unknown
- 2014-02-28 NZ NZ728537A patent/NZ728537A/en unknown
- 2014-02-28 PE PE2015001811A patent/PE20151749A1/es unknown
- 2014-02-28 US US14/771,779 patent/US9951043B2/en active Active
- 2014-02-28 CN CN201810393664.7A patent/CN108516974A/zh active Pending
- 2014-02-28 EP EP18181536.6A patent/EP3409667B1/de active Active
- 2014-02-28 DK DK14712844.1T patent/DK2961742T3/en active
- 2014-02-28 SI SI201431878T patent/SI3409667T1/sl unknown
- 2014-02-28 PT PT181815366T patent/PT3409667T/pt unknown
- 2014-02-28 PE PE2019001438A patent/PE20191461A1/es unknown
- 2014-02-28 NZ NZ631754A patent/NZ631754A/en unknown
- 2014-02-28 CA CA3007006A patent/CA3007006A1/en not_active Abandoned
- 2014-02-28 CU CUP2015000096A patent/CU24340B1/xx unknown
- 2014-02-28 PL PL14712844T patent/PL2961742T3/pl unknown
- 2014-02-28 MY MYPI2015002119A patent/MY195364A/en unknown
- 2014-02-28 PT PT14712844T patent/PT2961742T/pt unknown
- 2014-02-28 SG SG11201506929VA patent/SG11201506929VA/en unknown
- 2014-02-28 CA CA2901502A patent/CA2901502C/en active Active
- 2014-02-28 BR BR112015021027-9A patent/BR112015021027B1/pt active IP Right Grant
- 2014-02-28 MX MX2015011478A patent/MX2015011478A/es active IP Right Grant
- 2014-02-28 AU AU2014223973A patent/AU2014223973B2/en active Active
- 2014-02-28 MD MDA20150092A patent/MD20150092A2/ro not_active Application Discontinuation
- 2014-02-28 PL PL18181536T patent/PL3409667T3/pl unknown
- 2014-02-28 WO PCT/US2014/019663 patent/WO2014134566A2/en active Application Filing
- 2014-02-28 ES ES14712844.1T patent/ES2688571T3/es active Active
- 2014-02-28 RS RS20181186A patent/RS57718B1/sr unknown
- 2014-02-28 UA UAA201508564A patent/UA120346C2/uk unknown
- 2014-02-28 ES ES18181536T patent/ES2887578T3/es active Active
- 2014-02-28 EP EP14712844.1A patent/EP2961742B1/de active Active
- 2014-02-28 SG SG10201710764YA patent/SG10201710764YA/en unknown
- 2014-02-28 LT LTEP14712844.1T patent/LT2961742T/lt unknown
- 2014-02-28 US US14/194,623 patent/US20140303164A1/en not_active Abandoned
- 2014-02-28 AP AP2015008717A patent/AP2015008717A0/xx unknown
- 2014-02-28 JP JP2015560381A patent/JP6519486B2/ja active Active
- 2014-02-28 NZ NZ742681A patent/NZ742681A/en not_active IP Right Cessation
- 2014-02-28 EA EA201591457A patent/EA035127B1/ru unknown
- 2014-02-28 CN CN201480020587.0A patent/CN105705500B/zh active Active
- 2014-02-28 CR CR20190504A patent/CR20190504A/es unknown
- 2014-02-28 KR KR1020157026837A patent/KR102229989B1/ko active IP Right Grant
- 2014-02-28 SI SI201430847T patent/SI2961742T1/sl unknown
- 2014-03-05 UY UY0001035362A patent/UY35362A/es not_active Application Discontinuation
-
2015
- 2015-08-12 IL IL240519A patent/IL240519B/en active IP Right Grant
- 2015-08-21 ZA ZA2015/06098A patent/ZA201506098B/en unknown
- 2015-08-26 PH PH12015501881A patent/PH12015501881B1/en unknown
- 2015-08-31 CL CL2015002445A patent/CL2015002445A1/es unknown
- 2015-09-01 CR CR20150454A patent/CR20150454A/es unknown
-
2016
- 2016-06-07 HK HK16106521.7A patent/HK1222169A1/zh unknown
- 2016-11-22 AU AU2016262671A patent/AU2016262671B2/en active Active
- 2016-12-22 HK HK16114621A patent/HK1226078B/zh unknown
- 2016-12-22 HK HK18114165.0A patent/HK1260892A1/zh unknown
-
2018
- 2018-03-02 US US15/910,083 patent/US20180273508A1/en not_active Abandoned
- 2018-06-15 JP JP2018114786A patent/JP6893899B2/ja active Active
- 2018-09-12 CY CY181100946T patent/CY1121047T1/el unknown
- 2018-10-15 HR HRP20181679TT patent/HRP20181679T1/hr unknown
- 2018-10-15 AU AU2018247348A patent/AU2018247348A1/en not_active Abandoned
-
2019
- 2019-08-16 JP JP2019149366A patent/JP2019214599A/ja not_active Withdrawn
-
2020
- 2020-05-26 US US16/882,804 patent/US20210009555A1/en active Pending
-
2021
- 2021-10-29 JP JP2021177617A patent/JP2022009742A/ja not_active Withdrawn
-
2023
- 2023-05-31 JP JP2023090106A patent/JP2023101723A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU24340B1 (es) | Derivados de acetamidas fluoradas para el tratamiento del vih | |
CO2019001379A2 (es) | Compuestos terapéuticos útiles para el tratamiento profiláctico o terapéutico de una infección por el virus del vih . | |
UY37710A (es) | Inhibidores de la replicación del virus de la inmunodeficiencia humana | |
UY35263A (es) | Compuestos terapéuticos | |
CL2020000501A1 (es) | Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp1) y usos de los mismos. | |
CO2018000660A2 (es) | Compuestos derivados del (3β)-cholest-5-en-3-alquil-3-ol y (3β)-cholest-3-alquil-3-ol | |
CO2017007355A2 (es) | Compuestos derivados de pirazincarbozamida y de pirazincarboxilato para el tratamiento de la infección por el virus de hepatitis b | |
CR20150313A (es) | Composiciones farmacéuticas | |
CO2018000589A2 (es) | Oxiesteroles y composiciones farmacéuticas que los contienen | |
UY36648A (es) | Inhibidores de la replicación del virus de inmunodeficiencia humana | |
CU20170089A7 (es) | Derivados de quinazolina utilizados para tratar el vih | |
NZ732391A (en) | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use | |
CR20140231A (es) | Derivados de ácido benzotiazol-6-il acético y su uso para tratar una infección por vih | |
CR20180232A (es) | Macrociclos peptídicos contra acinetobacter baumannii | |
CL2020000487A1 (es) | Agentes antivirales contra la hepatitis b. | |
BR112017020837A2 (pt) | compostos de carbamoilpiridona policíclicos e seu uso farmacêutico | |
UY35213A (es) | Compuestos del tipo de las carbamilpiridonas policíclicas y su uso farmaceutico | |
EA201690687A1 (ru) | Ингибиторы репликации вируса иммунодефицита | |
ECSP11011310A (es) | Análogos carba - nucleósido para tratamiento antiviral | |
CL2017000714A1 (es) | Composiciones farmacéuticas de acción prolongada | |
CU24525B1 (es) | Derivado de quinoleína para tratar y prevenir infecciones virales | |
CU24519B1 (es) | Derivados de aminotiazol útiles como agentes antivíricos | |
CL2014000393A1 (es) | Compuestos derivados de benzofurano y sus sales, como inhibidores del virus de hepatitis c; composicion farmaceutica que los comprende; y su uso para el tratamiento o la prevencion de una infeccion por el virus de hepatitis c o de una enfermedad asociada con dicha infeccion. | |
CO2021012579A2 (es) | Compuestos útiles en la terapia del vih | |
DOP2018000035A (es) | Derivados del ácido 5-(n-bencil-tetrahidroisoquinolin-6-il)-piridin-3-il acético como inhibidores de la replicación del virus de la inmunodeficiencia humana |