CU24097B1 - Compuestos piridiloxi-indoles sustituidos como inhibidores del vegf-r2 útiles para el tratamiento de enfermedades proliferativas - Google Patents

Compuestos piridiloxi-indoles sustituidos como inhibidores del vegf-r2 útiles para el tratamiento de enfermedades proliferativas

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Publication number
CU24097B1
CU24097B1 CU2011000129A CU20110129A CU24097B1 CU 24097 B1 CU24097 B1 CU 24097B1 CU 2011000129 A CU2011000129 A CU 2011000129A CU 20110129 A CU20110129 A CU 20110129A CU 24097 B1 CU24097 B1 CU 24097B1
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CU
Cuba
Prior art keywords
treatment
vegf
piridiloxi
proliferative diseases
inhibitors useful
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CU2011000129A
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English (en)
Other versions
CU20110129A7 (es
Inventor
Gerald David Artman Iii
Jason Mathew Elliot
Nan Ji
Donglei Liu
Fupeng Ma
Nello Mainolfi
Erik Meredith
Karl Miranda
James J Powers
Chang Rao
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42034535&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24097(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20110129A7 publication Critical patent/CU20110129A7/es
Publication of CU24097B1 publication Critical patent/CU24097B1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
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  • Dermatology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos orgánicos novedosos de la fórmula (I): ESPACIO PARA LA FÓRMULA como inhibidores del VEGF-R2, útiles en el tratamiento de enfermedades dependientes de la cinasa de proteína, en especial de enfermedades proliferativas, tal como en el tratamiento de enfermedades tumorales y enfermedades neovasculares oculares.
CU2011000129A 2008-12-09 2009-12-07 Compuestos piridiloxi-indoles sustituidos como inhibidores del vegf-r2 útiles para el tratamiento de enfermedades proliferativas CU24097B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20124308P 2008-12-09 2008-12-09
US23334109P 2009-08-12 2009-08-12
PCT/EP2009/066540 WO2010066684A2 (en) 2008-12-09 2009-12-07 Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease

Publications (2)

Publication Number Publication Date
CU20110129A7 CU20110129A7 (es) 2012-01-31
CU24097B1 true CU24097B1 (es) 2015-06-30

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ID=42034535

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CU2011000129A CU24097B1 (es) 2008-12-09 2009-12-07 Compuestos piridiloxi-indoles sustituidos como inhibidores del vegf-r2 útiles para el tratamiento de enfermedades proliferativas

Country Status (39)

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US (6) US8242125B2 (es)
EP (1) EP2376478B1 (es)
JP (1) JP5580330B2 (es)
KR (1) KR101345956B1 (es)
CN (2) CN102307870B (es)
AR (1) AR074499A1 (es)
AU (1) AU2009326110B9 (es)
BR (1) BRPI0922552A2 (es)
CA (1) CA2745922C (es)
CL (1) CL2011001378A1 (es)
CO (1) CO6382119A2 (es)
CR (1) CR20110270A (es)
CU (1) CU24097B1 (es)
CY (1) CY1119091T1 (es)
DK (1) DK2376478T3 (es)
EA (1) EA019681B1 (es)
EC (1) ECSP11011113A (es)
ES (1) ES2633959T3 (es)
HN (1) HN2011001593A (es)
HR (1) HRP20171075T1 (es)
HU (1) HUE035292T2 (es)
IL (1) IL213068A (es)
JO (1) JO3265B1 (es)
LT (1) LT2376478T (es)
MX (1) MX2011006093A (es)
MY (1) MY155649A (es)
NZ (2) NZ593030A (es)
PE (1) PE20110835A1 (es)
PL (1) PL2376478T3 (es)
PT (1) PT2376478T (es)
RS (1) RS56076B1 (es)
SG (1) SG171784A1 (es)
SI (1) SI2376478T1 (es)
SV (1) SV2011003939A (es)
TN (1) TN2011000263A1 (es)
TW (1) TWI429640B (es)
UY (1) UY32302A (es)
WO (1) WO2010066684A2 (es)
ZA (1) ZA201103759B (es)

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