CS270577B2 - Method of quinoline carboxylic acids production - Google Patents

Method of quinoline carboxylic acids production Download PDF

Info

Publication number
CS270577B2
CS270577B2 CS878688A CS868887A CS270577B2 CS 270577 B2 CS270577 B2 CS 270577B2 CS 878688 A CS878688 A CS 878688A CS 868887 A CS868887 A CS 868887A CS 270577 B2 CS270577 B2 CS 270577B2
Authority
CS
Czechoslovakia
Prior art keywords
group
oxo
cyclopropyl
dihydro
fluoro
Prior art date
Application number
CS878688A
Other languages
Czech (cs)
English (en)
Other versions
CS868887A2 (en
Inventor
Michael Dr Preiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CS868887A2 publication Critical patent/CS868887A2/cs
Publication of CS270577B2 publication Critical patent/CS270577B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CS878688A 1986-12-03 1987-11-30 Method of quinoline carboxylic acids production CS270577B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863641312 DE3641312A1 (de) 1986-12-03 1986-12-03 Verfahren zur herstellung von chinolincarbonsaeuren

Publications (2)

Publication Number Publication Date
CS868887A2 CS868887A2 (en) 1989-11-14
CS270577B2 true CS270577B2 (en) 1990-07-12

Family

ID=6315377

Family Applications (1)

Application Number Title Priority Date Filing Date
CS878688A CS270577B2 (en) 1986-12-03 1987-11-30 Method of quinoline carboxylic acids production

Country Status (25)

Country Link
EP (1) EP0274033B1 (no)
JP (1) JPS63145268A (no)
KR (1) KR970005191B1 (no)
CN (1) CN87107230A (no)
AT (1) ATE73446T1 (no)
AU (1) AU593961B2 (no)
CS (1) CS270577B2 (no)
DD (1) DD270904A5 (no)
DE (2) DE3641312A1 (no)
DK (1) DK174929B1 (no)
ES (1) ES2038156T3 (no)
FI (1) FI875289A (no)
GR (1) GR3004301T3 (no)
HU (1) HU199823B (no)
IE (1) IE64261B1 (no)
IL (1) IL84627A (no)
NO (1) NO174199C (no)
NZ (1) NZ222736A (no)
PH (1) PH24489A (no)
PL (1) PL158614B1 (no)
PT (1) PT86252B (no)
SU (1) SU1482526A3 (no)
UA (1) UA8017A1 (no)
YU (1) YU45049B (no)
ZA (1) ZA879040B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (no) * 1985-09-18 1990-05-05 Pfizer
EP0470252A4 (en) * 1989-04-28 1992-12-02 Daiichi Pharmaceutical Co., Ltd. Anti-hiv drug
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
WO1991004972A1 (en) * 1989-10-06 1991-04-18 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
ES2050613B1 (es) * 1992-10-16 1996-03-16 Iteve S A Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico.
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
AU6421898A (en) * 1997-03-25 1998-10-20 Sankyo Company Limited Anti-fiv agent
KR100454750B1 (ko) * 2002-06-20 2004-11-03 삼성에스디아이 주식회사 유기 전계 발광 소자용 청색 발광 화합물 및 이를 사용한유기 전계 발광 소자
BRPI0413964B8 (pt) 2003-09-10 2021-05-25 Kyorin Seiyaku Kk ácido derivado do ácido carboxílico quinolona, sua composição e agente antibacterial
JP5322927B2 (ja) 2007-05-24 2013-10-23 杏林製薬株式会社 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
CN101671302B (zh) * 2008-12-30 2011-03-30 广东海康兽药有限公司 禽畜用抗菌药恩诺沙星的生产工艺
CN101899044B (zh) * 2010-08-16 2012-07-18 常州市勇毅生物药业有限公司 吉米沙星主环化合物的合成方法
CN113912540A (zh) * 2021-12-15 2022-01-11 山东国邦药业有限公司 一种1-环丙基-6,7-二氟-1,4-二氢-4-氧代-3-喹啉甲酸的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5365887A (en) * 1976-11-22 1978-06-12 Kyorin Seiyaku Kk Substituted quinoline*arboxylate and process for preparing same
DE2656574A1 (de) * 1976-12-10 1978-06-15 Schering Ag Neue 1,6-naphthyridincarbonsaeurederivate und verfahren zu ihrer herstellung
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法

Also Published As

Publication number Publication date
JPS63145268A (ja) 1988-06-17
PH24489A (en) 1990-07-18
KR880007472A (ko) 1988-08-27
UA8017A1 (uk) 1995-12-26
NO174199B (no) 1993-12-20
FI875289A0 (fi) 1987-12-01
ATE73446T1 (de) 1992-03-15
DK633187D0 (da) 1987-12-02
DK174929B1 (da) 2004-03-01
DE3777370D1 (de) 1992-04-16
DK633187A (da) 1988-06-04
CN87107230A (zh) 1988-07-06
NZ222736A (en) 1990-08-28
PT86252B (pt) 1990-11-07
DD270904A5 (de) 1989-08-16
IE873279L (en) 1988-06-03
NO874788D0 (no) 1987-11-17
PL269185A1 (en) 1989-01-05
IL84627A (en) 1992-01-15
CS868887A2 (en) 1989-11-14
NO174199C (no) 1994-04-06
PL158614B1 (pl) 1992-09-30
ZA879040B (en) 1988-05-26
IE64261B1 (en) 1995-07-26
EP0274033B1 (de) 1992-03-11
NO874788L (no) 1988-06-06
YU45049B (en) 1991-06-30
SU1482526A3 (ru) 1989-05-23
AU8217787A (en) 1988-06-09
EP0274033A1 (de) 1988-07-13
ES2038156T3 (es) 1993-07-16
HU199823B (en) 1990-03-28
HUT45521A (en) 1988-07-28
KR970005191B1 (ko) 1997-04-14
YU215687A (en) 1988-10-31
IL84627A0 (en) 1988-04-29
FI875289A (fi) 1988-06-04
PT86252A (en) 1988-01-01
DE3641312A1 (de) 1988-06-09
AU593961B2 (en) 1990-02-22
GR3004301T3 (no) 1993-03-31

Similar Documents

Publication Publication Date Title
KR0130931B1 (ko) 항균제
KR920005112B1 (ko) 7-아미노-1-시클로프로필-6,8-디할로게노-1,4-디히드로-4-옥소-3-퀴놀린카르복실산의 제조방법
JP4111431B2 (ja) キノロン−およびナフチリドン−カルボン酸誘導体類
KR900004995B1 (ko) 항균성 카복실산류
KR920000759B1 (ko) 7-(3-아릴-1-피페라지닐)- 및 7-(3-시클로헥실-1-피페라지닐)-3-퀴놀론 카르복실산의 제조방법
CS270577B2 (en) Method of quinoline carboxylic acids production
JPH10114779A (ja) 抗細菌剤
JPH05213836A (ja) シクロプロピルアミン類
JPH05239051A (ja) ７−イソインドリニル−キノロン−および−ナフチリドンカルボン酸誘導体
FI90239B (fi) Menetelmä terapeuttisesti aktiivisten 7-tetrahydronaftyridiini-6-fluori-1,4-dihydro-4-oksokinoliini-3-karboksyylihappojen valmistamiseksi
JPH06247962A (ja) キノロン−及びナフチリドンカルボン酸誘導体
US4954507A (en) 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents
JPS61238779A (ja) キノリン‐３‐カルボン酸抗菌剤の製法
HU195954B (en) Process for producing 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid ester derivatives and pharmaceutics comprising the same
DE3811341A1 (de) In 7-stellung c-verknuepfte chinolon- und 1,8-naphthyridin-4-on-carbonsaeure und ein verfahren zu ihrer herstellung
AU8158187A (en) 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
US4965273A (en) Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents
US5585491A (en) Antibacterial agents
FI100798B (fi) Menetelmä antibakteeristen aineiden valmistuksessa käyttökelpoisten yh disteiden valmistamiseksi
KR960011391B1 (ko) 항균작용을 갖는 퀴놀론계 유도체와 그의 제조방법
JPS61282362A (ja) キノロンカルボン酸エステル
JPH01254666A (ja) キノロンカルボン酸及び１，８−ナフチリジン‐４−オンカルボン酸、その製造方法及び中間体としてのそれらの使用
NZ239718A (en) 2-(substituted phenyl)-4,4-dimethyl-2-oxazoline derivatives and their preparation

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20071130