CS259536B2 - Method of insulin's new derivatives production - Google Patents
Method of insulin's new derivatives production Download PDFInfo
- Publication number
- CS259536B2 CS259536B2 CS861666A CS166686A CS259536B2 CS 259536 B2 CS259536 B2 CS 259536B2 CS 861666 A CS861666 A CS 861666A CS 166686 A CS166686 A CS 166686A CS 259536 B2 CS259536 B2 CS 259536B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- formula
- amino
- iii
- threonine
- defined above
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- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 1
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- 125000000962 organic group Chemical group 0.000 description 1
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- 239000013612 plasmid Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
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- 229940048914 protamine Drugs 0.000 description 1
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- 125000006413 ring segment Chemical group 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK113585A DK113585D0 (da) | 1985-03-12 | 1985-03-12 | Nye peptider |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS166686A2 CS166686A2 (en) | 1987-12-17 |
| CS259536B2 true CS259536B2 (en) | 1988-10-14 |
Family
ID=8101410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS861666A CS259536B2 (en) | 1985-03-12 | 1986-03-11 | Method of insulin's new derivatives production |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0194864B1 (fi) |
| JP (1) | JPS61212598A (fi) |
| KR (1) | KR930007433B1 (fi) |
| CN (1) | CN86101489A (fi) |
| AT (1) | ATE77391T1 (fi) |
| AU (1) | AU612964B2 (fi) |
| CS (1) | CS259536B2 (fi) |
| DD (1) | DD244345A5 (fi) |
| DE (1) | DE3685668T2 (fi) |
| DK (2) | DK113585D0 (fi) |
| ES (1) | ES8800276A1 (fi) |
| FI (1) | FI861007L (fi) |
| GR (1) | GR860687B (fi) |
| HU (1) | HU201097B (fi) |
| IL (1) | IL78103A0 (fi) |
| MY (1) | MY102102A (fi) |
| NO (1) | NO172441C (fi) |
| NZ (1) | NZ215445A (fi) |
| PH (1) | PH24260A (fi) |
| PT (1) | PT82173B (fi) |
| YU (1) | YU46001B (fi) |
| ZA (1) | ZA861432B (fi) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
| DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
| US5149777A (en) * | 1988-07-20 | 1992-09-22 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
| DE3827533A1 (de) * | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
| DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| US5130298A (en) * | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
| DE3936876A1 (de) * | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| AUPP609198A0 (en) * | 1998-09-22 | 1998-10-15 | Curtin University Of Technology | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| AU2005205867A1 (en) | 2004-01-21 | 2005-08-04 | Novo Nordisk Health Care Ag | Transglutaminase mediated conjugation of peptides |
| JP4808785B2 (ja) | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー／エス | インスリン組成物および組成物の製造方法 |
| DE102006031962A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| DE102006031955A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102008003566A1 (de) * | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
| KR20100111683A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
| HUE030537T2 (en) * | 2008-01-09 | 2017-05-29 | Sanofi Aventis Deutschland | New insulin analogues with a particularly prolonged effect profile |
| EP3677275B1 (de) | 2008-10-17 | 2024-06-12 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
| EP2451472A1 (de) * | 2009-07-06 | 2012-05-16 | Sanofi-Aventis Deutschland GmbH | Hitze- und schüttelstabile insulinzubereitungen |
| PL2498802T3 (pl) | 2009-11-13 | 2015-06-30 | Sanofi Aventis Deutschland | Kompozycja farmaceutyczna zawierająca agonistę GLP-1, insulinę i metioninę |
| ES2965209T3 (es) | 2009-11-13 | 2024-04-11 | Sanofi Aventis Deutschland | Composición farmacéutica que comprende desPro36exendina-4(1-39)-Lys6-NH2 y metionina |
| AU2011252127B2 (en) * | 2010-05-10 | 2014-02-20 | Novo Nordisk A/S | Process for the preparation of insulin-zinc complexes |
| JP6199186B2 (ja) | 2010-08-30 | 2017-09-20 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用 |
| CN102174495A (zh) * | 2011-01-20 | 2011-09-07 | 马忠仁 | 一种提取糜胰蛋白酶的方法 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| TWI608847B (zh) | 2011-08-29 | 2017-12-21 | 賽諾菲阿凡提斯德意志有限公司 | 用於控制糖尿病二型病患血糖的醫藥組合物 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| ES2949095T3 (es) | 2014-12-12 | 2023-09-25 | Sanofi Aventis Deutschland | Formulación de relación fija de insulina glargina/lixisenatida |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| WO2021009027A1 (en) | 2019-07-12 | 2021-01-21 | Novo Nordisk A/S | High concentration insulin formulation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK319780A (da) * | 1980-07-24 | 1982-01-25 | Forenede Bryggerier As | Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
-
1985
- 1985-03-12 DK DK113585A patent/DK113585D0/da unknown
-
1986
- 1986-02-26 ZA ZA861432A patent/ZA861432B/xx unknown
- 1986-02-27 PH PH33459A patent/PH24260A/en unknown
- 1986-03-10 DK DK107086A patent/DK158677C/da active
- 1986-03-10 DD DD86287734A patent/DD244345A5/de not_active IP Right Cessation
- 1986-03-10 YU YU34586A patent/YU46001B/sh unknown
- 1986-03-11 IL IL78103A patent/IL78103A0/xx not_active IP Right Cessation
- 1986-03-11 JP JP61051586A patent/JPS61212598A/ja active Pending
- 1986-03-11 NO NO860920A patent/NO172441C/no unknown
- 1986-03-11 AT AT86301755T patent/ATE77391T1/de not_active IP Right Cessation
- 1986-03-11 PT PT82173A patent/PT82173B/pt not_active IP Right Cessation
- 1986-03-11 CS CS861666A patent/CS259536B2/cs unknown
- 1986-03-11 AU AU54495/86A patent/AU612964B2/en not_active Ceased
- 1986-03-11 CN CN198686101489A patent/CN86101489A/zh active Pending
- 1986-03-11 HU HU861024A patent/HU201097B/hu not_active IP Right Cessation
- 1986-03-11 NZ NZ215445A patent/NZ215445A/xx unknown
- 1986-03-11 FI FI861007A patent/FI861007L/fi not_active Application Discontinuation
- 1986-03-11 DE DE8686301755T patent/DE3685668T2/de not_active Expired - Fee Related
- 1986-03-11 KR KR1019860001737A patent/KR930007433B1/ko not_active Expired - Lifetime
- 1986-03-11 EP EP86301755A patent/EP0194864B1/en not_active Expired - Lifetime
- 1986-03-11 ES ES552879A patent/ES8800276A1/es not_active Expired
- 1986-03-12 GR GR860687A patent/GR860687B/el unknown
-
1987
- 1987-09-30 MY MYPI87002520A patent/MY102102A/en unknown
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