CS247076B2 - Production method of tetrazole derivatives - Google Patents

Production method of tetrazole derivatives Download PDF

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Publication number
CS247076B2
CS247076B2 CS838106A CS810683A CS247076B2 CS 247076 B2 CS247076 B2 CS 247076B2 CS 838106 A CS838106 A CS 838106A CS 810683 A CS810683 A CS 810683A CS 247076 B2 CS247076 B2 CS 247076B2
Authority
CS
Czechoslovakia
Prior art keywords
compounds
alkyl
hydrogen
formula
tetrazole
Prior art date
Application number
CS838106A
Other languages
Czech (cs)
English (en)
Other versions
CS810683A2 (en
Inventor
Vinston S Marshall
John P Verge
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS810683A2 publication Critical patent/CS810683A2/cs
Publication of CS247076B2 publication Critical patent/CS247076B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
CS838106A 1982-11-03 1983-11-03 Production method of tetrazole derivatives CS247076B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/439,239 US4661505A (en) 1982-11-03 1982-11-03 Leukotriene antagonists

Publications (2)

Publication Number Publication Date
CS810683A2 CS810683A2 (en) 1985-06-13
CS247076B2 true CS247076B2 (en) 1986-11-13

Family

ID=23743890

Family Applications (1)

Application Number Title Priority Date Filing Date
CS838106A CS247076B2 (en) 1982-11-03 1983-11-03 Production method of tetrazole derivatives

Country Status (28)

Country Link
US (1) US4661505A (ja)
EP (1) EP0108592B1 (ja)
JP (1) JPS59104344A (ja)
KR (1) KR860001570B1 (ja)
AR (1) AR240318A1 (ja)
AT (1) ATE30023T1 (ja)
AU (1) AU572806B2 (ja)
CA (1) CA1242194A (ja)
CS (1) CS247076B2 (ja)
DD (1) DD215083A5 (ja)
DE (1) DE3373899D1 (ja)
DK (1) DK499883D0 (ja)
EG (1) EG16819A (ja)
ES (1) ES526940A0 (ja)
FI (1) FI81343C (ja)
GB (1) GB2129797B (ja)
GR (1) GR78946B (ja)
HU (1) HU197871B (ja)
IE (1) IE56204B1 (ja)
IL (1) IL70093A (ja)
MY (1) MY102027A (ja)
NZ (1) NZ206111A (ja)
PH (1) PH21170A (ja)
PL (1) PL139647B1 (ja)
PT (1) PT77592B (ja)
RO (1) RO88317B (ja)
SU (1) SU1433412A3 (ja)
ZA (1) ZA838118B (ja)

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US4939279A (en) * 1985-04-19 1990-07-03 Smithkline Beecham Corporation Leukotriene antagonists
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US4801616A (en) * 1986-03-25 1989-01-31 Eli Lilly And Company Diphenylmethanone compounds and anti-inflammatory use thereof
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FR2598146B1 (fr) * 1986-04-30 1989-01-20 Rech Ind Nouveau procede de preparation de fibrates.
US5098613A (en) * 1987-01-12 1992-03-24 Eli Lilly And Company Anti-inflammatory agents
US5294613A (en) * 1987-01-12 1994-03-15 Eli Lilly And Company Method of treating endotoxic shock in mammals
CA1315279C (en) * 1987-01-12 1993-03-30 Nancy Grace Bollinger Anti-inflammatory agents
US4992576A (en) * 1987-01-12 1991-02-12 Eli Lilly And Company Intermediates for leukotriene antagonists
US5171882A (en) * 1987-01-12 1992-12-15 Eli Lilly And Company Leukotriene antagonists
US4945099A (en) * 1987-01-12 1990-07-31 Eli Lilly And Company Anti-inflammatory agents
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US4874777A (en) * 1987-04-10 1989-10-17 Eli Lilly And Company Leukotriene antagonists
US4853398A (en) * 1987-04-13 1989-08-01 Eli Lilly And Company Leukotriene antagonists and use thereas
US4942245A (en) * 1987-04-20 1990-07-17 Kyorin Pharmaceutical Co., Ltd. Benzimidazole Derivatives
US4777298A (en) * 1987-06-19 1988-10-11 Eli Lilly And Company Process for intermediates to leukotriene antagonists
US4777299A (en) * 1987-06-19 1988-10-11 Eli Lilly And Company Process for leukotriene antagonists
EP0295882B1 (en) * 1987-06-19 1991-08-21 Eli Lilly And Company Process for intermediates to leukotriene antagonists
PT87616B (pt) * 1987-06-24 1992-09-30 Smithkline Beecham Corp Processo de preparacao de antagonistas do leucotrieno e de composicoes farmaceuticas
US4820722A (en) * 1987-08-14 1989-04-11 Eli Lilly And Company Disubstituted tetrazoles and their use as leukotriene antagonists
US4820723A (en) * 1987-08-14 1989-04-11 Eli Lilly And Company Disubstituted tetrazole leukotriene antagonists and methods for their use thereas
US5008439A (en) * 1988-03-21 1991-04-16 Hoechst Celanese Corporation Synthesis of 2-(4-hydroxyphenoxy) alkanoic acid esters
US4908476A (en) * 1988-03-21 1990-03-13 Hoechst Celanese Corporation Synthesis of 2-(4-hydroxyphenoxy)alkanoic acids
US4935522A (en) * 1988-03-21 1990-06-19 Hoechst Celanese Corporation Process for producing ethyl 2-[4'-(6"-chloro-2"-benzoxazolyloxy)phenoxy]propionate
EP0357545A3 (de) * 1988-07-21 1990-03-21 Ciba-Geigy Ag Kationische Verbindungen, deren Herstellung und deren Anwendung zur fotochemischen Stabilisierung basisch anfärbbarer Polyamid-, Polyacrylnitril-und Polyesterfasermaterialien
US4954513A (en) * 1988-12-23 1990-09-04 Smithkline Beecham Corporation Leukotriene antagonists
JPH04297466A (ja) * 1990-06-22 1992-10-21 Nippon Shinyaku Co Ltd テトラゾール誘導体及び医薬
DE4028866A1 (de) * 1990-09-07 1992-03-12 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-antagonisten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CN1037681C (zh) * 1991-01-31 1998-03-11 日本新药株式会社 四唑衍生物与医药
IT1250436B (it) * 1991-07-01 1995-04-07 Mini Ricerca Scient Tecnolog Benzofenoni ad azione antifungina
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
US5455274A (en) * 1992-12-09 1995-10-03 Ciba-Geigy Corporation Hydroxyamidine derivatives
WO1995022323A1 (en) * 1994-02-16 1995-08-24 Idun Pharmaceuticals Methods for controlling free radical generation by inflammatory cells
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
WO2002026728A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
AU2001296402A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
US6756399B2 (en) * 2001-06-29 2004-06-29 The United States Of America As Represented By The Department Of Health And Human Services Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents
AU2003214226A1 (en) * 2002-03-18 2003-10-08 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use

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Also Published As

Publication number Publication date
ES8601829A1 (es) 1985-11-01
EP0108592A1 (en) 1984-05-16
IL70093A (en) 1988-03-31
GB8329099D0 (en) 1983-12-07
GR78946B (ja) 1984-10-02
RO88317B (ro) 1985-12-31
DE3373899D1 (en) 1987-11-05
AU572806B2 (en) 1988-05-19
FI81343B (fi) 1990-06-29
PT77592B (en) 1986-05-05
EP0108592B1 (en) 1987-09-30
US4661505A (en) 1987-04-28
PL139647B1 (en) 1987-02-28
IE832551L (en) 1984-05-03
KR840006805A (ko) 1984-12-03
CS810683A2 (en) 1985-06-13
PT77592A (en) 1983-12-01
JPS59104344A (ja) 1984-06-16
AR240318A1 (es) 1990-03-30
FI834002A0 (fi) 1983-11-01
GB2129797B (en) 1986-07-02
GB2129797A (en) 1984-05-23
KR860001570B1 (ko) 1986-10-08
ZA838118B (en) 1985-06-26
AU2087583A (en) 1984-05-10
ES526940A0 (es) 1985-11-01
RO88317A (ro) 1985-12-30
NZ206111A (en) 1986-03-14
DD215083A5 (de) 1984-10-31
FI834002A (fi) 1984-05-04
IE56204B1 (en) 1991-05-22
PL244401A1 (en) 1985-03-12
HUT35234A (en) 1985-06-28
FI81343C (fi) 1990-10-10
CA1242194A (en) 1988-09-20
MY102027A (en) 1992-02-29
SU1433412A3 (ru) 1988-10-23
ATE30023T1 (de) 1987-10-15
EG16819A (en) 1992-06-30
JPH0347256B2 (ja) 1991-07-18
PH21170A (en) 1987-08-07
DK499883D0 (da) 1983-11-01
HU197871B (en) 1989-06-28

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