CS246080B2 - Method of piperazine derivatives production - Google Patents

Method of piperazine derivatives production Download PDF

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Publication number
CS246080B2
CS246080B2 CS843680A CS368084A CS246080B2 CS 246080 B2 CS246080 B2 CS 246080B2 CS 843680 A CS843680 A CS 843680A CS 368084 A CS368084 A CS 368084A CS 246080 B2 CS246080 B2 CS 246080B2
Authority
CS
Czechoslovakia
Prior art keywords
piperazine
formula
aminocarbonylmethyl
hydroxypropyl
methoxyphenoxy
Prior art date
Application number
CS843680A
Other languages
Czech (cs)
English (en)
Inventor
Arthur F Kluge
Robin D Clark
Arthur M Strosberg
Jean C Pascal
Roger L Whiting
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Priority to CS853492A priority Critical patent/CS246099B2/cs
Publication of CS246080B2 publication Critical patent/CS246080B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Cosmetics (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyesters Or Polycarbonates (AREA)
CS843680A 1983-05-18 1984-05-17 Method of piperazine derivatives production CS246080B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS853492A CS246099B2 (cs) 1983-05-18 1985-05-15 Způsob výroby derivátů piperazinu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/495,904 US4567264A (en) 1983-05-18 1983-05-18 Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry

Publications (1)

Publication Number Publication Date
CS246080B2 true CS246080B2 (en) 1986-10-16

Family

ID=23970461

Family Applications (1)

Application Number Title Priority Date Filing Date
CS843680A CS246080B2 (en) 1983-05-18 1984-05-17 Method of piperazine derivatives production

Country Status (26)

Country Link
US (1) US4567264A (fr)
EP (1) EP0126449B1 (fr)
JP (1) JPS59219271A (fr)
KR (1) KR890000020B1 (fr)
AT (1) ATE31533T1 (fr)
AU (1) AU566489B2 (fr)
BR (1) BR1100474A (fr)
CA (1) CA1256874A (fr)
CS (1) CS246080B2 (fr)
DE (1) DE3468215D1 (fr)
DK (1) DK168535B1 (fr)
ES (1) ES8601947A1 (fr)
FI (1) FI78479C (fr)
HK (1) HK91989A (fr)
HU (1) HU192404B (fr)
IE (1) IE57487B1 (fr)
IL (1) IL71863A (fr)
MX (1) MX9203001A (fr)
NO (1) NO163618C (fr)
NZ (1) NZ208188A (fr)
PH (1) PH20016A (fr)
PL (2) PL142760B1 (fr)
PT (1) PT78604B (fr)
RU (2) RU2071471C1 (fr)
SG (1) SG25086G (fr)
ZA (1) ZA843746B (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
ES2050425T3 (es) * 1988-12-26 1994-05-16 Kowa Co Produccion de un eter glicidilico.
ATE218344T1 (de) * 1989-06-23 2002-06-15 Syntex Llc Ranolazin und verwandte piperazine zur behandlung von schockzuständen
HU209723B (en) * 1990-10-31 1994-10-28 Richter Gedeon Vegyeszet Process for producing of piperazine derivatives
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
JPH10504324A (ja) * 1995-06-07 1998-04-28 デイド、ケミストリー、システムズ、インコーポレイテッド 薬物の免疫原その他の接合体の製造
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
CA2398691A1 (fr) 2000-02-18 2001-08-23 Cv Therapeutics, Inc. Inhibiteurs partiels de l'oxydation d'acides gras pour le traitement de l'insuffisance cardiaque globale
WO2001062711A2 (fr) * 2000-02-22 2001-08-30 Cv Therapeutics, Inc. Composes alkylene diamine substitues
US6677336B2 (en) * 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
US6451798B2 (en) * 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
US6677343B2 (en) 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
US6552023B2 (en) * 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
CA2400176C (fr) * 2000-02-22 2009-04-28 Cv Therapeutics, Inc. Composes de piperazine substitues
US20020052377A1 (en) * 2000-07-21 2002-05-02 Wolff Andrew A. Method for treating angina
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6573264B1 (en) 2000-10-23 2003-06-03 Cv Therapeutics, Inc. Heteroaryl alkyl piperazine derivatives
CA2454059A1 (fr) * 2001-07-19 2003-01-30 Cv Therapeutics, Inc. Composes de piperazine substitues et leur utilisation en tant qu'inhibiteurs de l'oxydation d'acides gras
US7001909B2 (en) * 2001-07-19 2006-02-21 Cv Therapeutics, Inc. Substituted heterocyclic compounds
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US20080109040A1 (en) * 2002-04-04 2008-05-08 Luiz Belardinelli Method of treating arrhythmias
US20030220344A1 (en) * 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias
US8822473B2 (en) * 2002-05-21 2014-09-02 Gilead Sciences, Inc. Method of treating diabetes
WO2003099281A2 (fr) * 2002-05-21 2003-12-04 Cv Therapeutics, Inc. Procede de traitement du diabete
ATE432267T1 (de) 2002-06-24 2009-06-15 Janssen Pharmaceutica Nv Verfahren zur herstellung von n-(2,6- dimethylphenyl)-2-piperazin-1-ylacetamid
US7056924B2 (en) * 2002-07-18 2006-06-06 Cv Therapeutics, Inc. Substituted heterocyclic compounds
AU2003300827B2 (en) * 2002-12-05 2009-08-13 Gilead Palo Alto, Inc. Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
EP1806346B1 (fr) * 2002-12-05 2009-07-22 Cv Therapeutics, Inc. Dérivés de Pipérazine substitués et leur utilisation comme inhibiteurs de l'oxydation d'acids gras
ES2329997T3 (es) * 2003-01-03 2009-12-03 Cv Therapeutics, Inc. Compuestos heterociclicos sustituidos.
WO2004069818A1 (fr) * 2003-01-17 2004-08-19 Cv Therapeutics Inc. Composes heterocycliques substitues utiles pour le traitement de maladies cardio-vasculaires
WO2005000826A1 (fr) * 2003-06-23 2005-01-06 Cv Therapeutics, Inc. Derives d'uree de piperazines et de piperidines comme inhibiteurs de l'oxydation d'acides gras
JP2007514769A (ja) 2003-12-18 2007-06-07 シーブイ・セラピューティクス・インコーポレイテッド １−アルカン−２−オール置換ピペラジンおよびピペリジン化合物
WO2006008753A1 (fr) * 2004-07-19 2006-01-26 Unichem Laboratories Limited Forme cristalline et amorphe de ranolazine et son processus de fabrication
WO2006029179A2 (fr) * 2004-09-08 2006-03-16 Cv Therapeutics, Inc. Composes heterocycliques substitues
CA2593593A1 (fr) * 2005-01-06 2006-07-13 Cv Therapeutics, Inc. Formulations pharmaceutiques a liberation prolongee
WO2008047388A2 (fr) * 2006-10-20 2008-04-24 Ind-Swift Laboratories Limited Procédé amélioré de préparation de ranolazine
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
JP2010518171A (ja) * 2007-02-13 2010-05-27 ギリアード・パロ・アルト・インコーポレイテッド 非冠微小血管疾患の処置のためのラノラジンの使用
JP2010518170A (ja) * 2007-02-13 2010-05-27 ギリアード・パロ・アルト・インコーポレイテッド 冠微小血管疾患の処置のためのラノラジンの使用
CA2678515A1 (fr) * 2007-02-13 2008-08-21 Cv Therapeutics, Inc. Utilisation de la ranolazine dans le traitement des maladies cardiovasculaires
EP2139877B1 (fr) * 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Dérivés de pipérazine deutérés utilisés en tant que composés antiangoreux
WO2008116083A1 (fr) * 2007-03-22 2008-09-25 Cv Therapeutics, Inc. Utilisation de ranolazine contre un taux élevé de peptide natriurétique de type b
WO2008139492A2 (fr) * 2007-05-15 2008-11-20 Natco Pharma Limited Procédé de préparation de base de ranolazine de haute pureté
EP2170333B1 (fr) * 2007-05-31 2013-02-20 Gilead Sciences, Inc. Utilisation de ranolazine pour peptide cérébral natriurétique élevé
AU2008266124A1 (en) * 2007-06-13 2008-12-24 Auspex Pharmaceuticals, Inc. Substituted piperazines
US20090247535A1 (en) * 2008-03-26 2009-10-01 Duke University Use of ranolazine for non-cardiovascular disorders
WO2009153651A1 (fr) * 2008-06-19 2009-12-23 Medichem, S.A. Procédé de préparation d’un dérivé de pipérazine
WO2010023687A2 (fr) * 2008-08-28 2010-03-04 Shodhana Laboratories Limited Préparation de la ranolazine, ses sels et des intermédiaires de ceux-ci
WO2010025370A2 (fr) * 2008-08-28 2010-03-04 Dr. Reddy's Laboratories Ltd. Préparation de ranolazine
US20110300218A1 (en) * 2008-09-09 2011-12-08 Actavis Group Ptc Ehf Novel solid state forms of ranolazine salts
EP2356097A2 (fr) * 2008-10-15 2011-08-17 Actavis Group PTC ehf. Ranolazine très pure ou sel de celle-ci de qualité pharmaceutique acceptable
WO2010097805A1 (fr) 2009-02-24 2010-09-02 Lupin Limited Procédé pour la préparation de ranolazine
WO2010137040A2 (fr) 2009-05-28 2010-12-02 Lupin Limited Nouvelles compositions pharmaceutiques de ranolazine
MX2012003362A (es) 2009-09-25 2012-06-27 Lupin Ltd Composicion de liberación sostenida de ranolazina.
TWI508726B (zh) 2009-12-21 2015-11-21 Gilead Sciences Inc 治療心房纖維性顫動之方法
TW201215392A (en) 2010-06-16 2012-04-16 Gilead Sciences Inc Use of ranolazine for treating pulmonary hypertension
NO3175985T3 (fr) 2011-07-01 2018-04-28
EP2758053A1 (fr) 2011-09-21 2014-07-30 Gilead Sciences, Inc. Bloqueurs des canaux sodiques réduisant la sécrétion de glucagon
CN103570645A (zh) * 2012-08-01 2014-02-12 上海迪赛诺化学制药有限公司 一种制备n-(2,6-二甲基苯基)-2-(1-哌嗪基)乙酰胺的方法
EP3233814A4 (fr) 2015-03-10 2018-07-18 Unichem Laboratories Limited Nouveau procédé de préparation de ranolazine
TW201717919A (zh) 2015-07-02 2017-06-01 國際藥品股份公司 雷諾多重壓縮錠劑
WO2018001582A1 (fr) 2016-06-30 2018-01-04 Interquim, S.A. Comprimés multiples à base de ranolazine

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3829441A (en) * 1962-01-29 1974-08-13 Smith Kline French Lab Guanidinoalkylbenzodioxan derivatives
US3360529A (en) * 1962-01-29 1967-12-26 Smith Kline French Lab Guanidinoalkylbenzodioxan derivatives
US3496183A (en) * 1964-11-19 1970-02-17 Egyt Gyogyszervegyeszeti Gyar Beta-guanidino-ethyl-piperazine derivatives
DE1795362A1 (de) * 1968-09-19 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
FR2154493B1 (fr) * 1971-09-13 1975-10-31 Kali Chemie Ag
GB1332008A (en) * 1971-09-28 1973-10-03 Pfizer Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
GB1374366A (en) * 1972-07-21 1974-11-20 Science Union & Cie Propanol derivatives and a process for their preparation
GB1425559A (en) * 1972-09-01 1976-02-18 Wyeth John & Brother Ltd Pyridine tetrahydropyridine and piperidine derivatives
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
US3953448A (en) * 1972-12-07 1976-04-27 Delmar Chemicals Limited Piperazino-anilido compounds
FR2267104A1 (en) * 1974-04-12 1975-11-07 Ferlux Labo Sa Hypotensive and antiarrhythmic piperazines - 1-(3-phenoxy-2-hydroxy propyl)-4-substd. piperazines
FR2310763A1 (fr) * 1975-05-13 1976-12-10 Buzas Andre Derives 1,4-disubstitues de la piperazine, leur procede de preparation et leurs applications
US4335126A (en) * 1977-03-10 1982-06-15 Degussa Aktiengesellschaft 1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity
FR2462432A2 (fr) * 1979-08-03 1981-02-13 Delalande Sa Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
FR2456738A2 (fr) * 1978-04-10 1980-12-12 Delalande Sa Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique
JPS6042795B2 (ja) * 1978-10-23 1985-09-25 日本新薬株式会社 カルバモイルピペラジン誘導体
EP0025111B1 (fr) * 1979-08-10 1984-07-25 Sandoz Ag Dérivés 3-aminopropoxyaryliques, leur préparation et compositions pharmaceutiques les contenant
DE2941597A1 (de) * 1979-10-13 1981-04-23 Basf Ag, 6700 Ludwigshafen Piperidinderivate von 4,5-dialkyl-3-hydroxy-pyrrol-2-carbonsaeureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4368199A (en) * 1980-01-21 1983-01-11 Delalande S.A. Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, their salts, the process for preparing the same and their application in therapeutics
DE3005287A1 (de) * 1980-02-13 1981-08-20 Basf Ag, 6700 Ludwigshafen Phenylpiperazinderivate von 1,3,4-oxadiazolylphenolen, ihre herstellung und diese enthaltende therapeutische mittel
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4684651A (en) * 1981-03-17 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene and acid addition salts thereof useful as hypotensives
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4374837A (en) * 1981-07-31 1983-02-22 Laroche Navarron, S.A. Piperazine derivatives of theobromine
US4353901A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones

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IE841224L (en) 1984-11-18
JPS59219271A (ja) 1984-12-10
ATE31533T1 (de) 1988-01-15
NZ208188A (en) 1987-10-30
RU2083570C1 (ru) 1997-07-10
PL247722A1 (en) 1985-08-13
PL142760B1 (en) 1987-11-30
NO163618C (no) 1990-06-27
HU192404B (en) 1987-06-29
DE3468215D1 (en) 1988-02-04
ZA843746B (en) 1986-01-29
RU2071471C1 (ru) 1997-01-10
PT78604B (en) 1986-07-15
KR890000020B1 (ko) 1989-03-06
IL71863A (en) 1987-10-30
FI841989A0 (fi) 1984-05-17
EP0126449A1 (fr) 1984-11-28
PL143558B1 (en) 1988-02-29
JPH0469151B2 (fr) 1992-11-05
NO841968L (no) 1984-11-19
DK168535B1 (da) 1994-04-18
IL71863A0 (en) 1984-09-30
EP0126449B1 (fr) 1987-12-23
ES532565A0 (es) 1985-12-01
US4567264A (en) 1986-01-28
NO163618B (no) 1990-03-19
DK248384A (da) 1984-11-19
PH20016A (en) 1986-09-01
ES8601947A1 (es) 1985-12-01
SG25086G (en) 1989-12-29
PT78604A (en) 1984-06-01
HK91989A (en) 1989-11-24
AU566489B2 (en) 1987-10-22
CA1256874A (fr) 1989-07-04
KR850002475A (ko) 1985-05-13
AU2834684A (en) 1984-11-22
PL252856A1 (en) 1985-11-19
BR1100474A (pt) 2000-03-14
MX9203001A (es) 1992-07-01
HUT34177A (en) 1985-02-28
DK248384D0 (da) 1984-05-17
FI78479C (fi) 1989-08-10
FI78479B (fi) 1989-04-28
FI841989A (fi) 1984-11-19
IE57487B1 (en) 1993-02-10

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