FI841989A - Foerfarande foer framstaellning av terapeutiskt anvaendbara aryloxi- och aryltiohydroxipropylenpiperazinylacetanilider. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara aryloxi- och aryltiohydroxipropylenpiperazinylacetanilider. Download PDF

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Publication number
FI841989A
FI841989A FI841989A FI841989A FI841989A FI 841989 A FI841989 A FI 841989A FI 841989 A FI841989 A FI 841989A FI 841989 A FI841989 A FI 841989A FI 841989 A FI841989 A FI 841989A
Authority
FI
Finland
Prior art keywords
lower alkyl
independently hydrogen
together form
och2o
halo
Prior art date
Application number
FI841989A
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English (en)
Other versions
FI841989A0 (fi
FI78479C (fi
FI78479B (fi
Inventor
Arthur Frederick Kluge
Robin Douglas Clark
Arthur Martin Strosberg
Jean Claude Pascal
Roger Lewis Whiting
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI841989A0 publication Critical patent/FI841989A0/fi
Publication of FI841989A publication Critical patent/FI841989A/fi
Application granted granted Critical
Publication of FI78479B publication Critical patent/FI78479B/fi
Publication of FI78479C publication Critical patent/FI78479C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Cosmetics (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyesters Or Polycarbonates (AREA)
FI841989A 1983-05-18 1984-05-17 Foerfarande foer framstaellning av terapeutiskt anvaendbara aryloxi-hydroxipropylenpiperazinylacetanilider. FI78479C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49590483 1983-05-18
US06/495,904 US4567264A (en) 1983-05-18 1983-05-18 Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry

Publications (4)

Publication Number Publication Date
FI841989A0 FI841989A0 (fi) 1984-05-17
FI841989A true FI841989A (fi) 1984-11-19
FI78479B FI78479B (fi) 1989-04-28
FI78479C FI78479C (fi) 1989-08-10

Family

ID=23970461

Family Applications (1)

Application Number Title Priority Date Filing Date
FI841989A FI78479C (fi) 1983-05-18 1984-05-17 Foerfarande foer framstaellning av terapeutiskt anvaendbara aryloxi-hydroxipropylenpiperazinylacetanilider.

Country Status (26)

Country Link
US (1) US4567264A (fi)
EP (1) EP0126449B1 (fi)
JP (1) JPS59219271A (fi)
KR (1) KR890000020B1 (fi)
AT (1) ATE31533T1 (fi)
AU (1) AU566489B2 (fi)
BR (1) BR1100474A (fi)
CA (1) CA1256874A (fi)
CS (1) CS246080B2 (fi)
DE (1) DE3468215D1 (fi)
DK (1) DK168535B1 (fi)
ES (1) ES532565A0 (fi)
FI (1) FI78479C (fi)
HK (1) HK91989A (fi)
HU (1) HU192404B (fi)
IE (1) IE57487B1 (fi)
IL (1) IL71863A (fi)
MX (1) MX9203001A (fi)
NO (1) NO163618C (fi)
NZ (1) NZ208188A (fi)
PH (1) PH20016A (fi)
PL (2) PL143558B1 (fi)
PT (1) PT78604B (fi)
RU (2) RU2071471C1 (fi)
SG (1) SG25086G (fi)
ZA (1) ZA843746B (fi)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028610A (en) * 1987-03-18 1991-07-02 Sankyo Company Limited N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use
WO1990007506A1 (en) * 1988-12-26 1990-07-12 Kowa Company, Ltd. Production of glycidyl ether
EP0714660B1 (en) * 1989-06-23 2002-09-04 Syntex (U.S.A.) LLC Ranolazine and related piperazines for protecting skeletal muscles
HU209723B (en) * 1990-10-31 1994-10-28 Richter Gedeon Vegyeszet Process for producing of piperazine derivatives
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
EP0775128A1 (en) * 1995-06-07 1997-05-28 Dade Chemistry Systems Inc. Preparation of immunogens and other conjugates of drugs
US6479496B1 (en) * 1998-09-10 2002-11-12 Cv Therapeutics, Inc. Methods for treating angina with ranolazine
US6303607B1 (en) * 1998-09-10 2001-10-16 Cv Therapeutics, Inc. Method for administering a sustained release ranolanolazine formulation
BR0108452A (pt) 2000-02-18 2003-04-01 Cv Therapeutics Inc Inibidores da oxidação parcial de ácido graxo no tratamento de insuficiência cardìaca congestiva
US6677336B2 (en) * 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
US6451798B2 (en) * 2000-02-22 2002-09-17 Cv Therapeutics, Inc. Substituted alkyl piperazine derivatives
US6638970B2 (en) 2000-02-22 2003-10-28 Cv Therapeutics, Inc. Substituted alkylene diamine compounds
EP1259493A2 (en) * 2000-02-22 2002-11-27 Cv Therapeutics, Inc. Substituted piperazine compounds
US6677343B2 (en) 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
US6552023B2 (en) * 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
AU2001277938A1 (en) * 2000-07-21 2002-02-05 Cv Therapeutics, Inc. Method for treating angina
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6573264B1 (en) 2000-10-23 2003-06-03 Cv Therapeutics, Inc. Heteroaryl alkyl piperazine derivatives
PT1406898E (pt) * 2001-07-19 2005-08-31 Cv Therapeutics Inc Compostos de piperazina substituida e sua utilizacao como inibidores de oxidacao de acidos gordos
US7001909B2 (en) * 2001-07-19 2006-02-21 Cv Therapeutics, Inc. Substituted heterocyclic compounds
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US20080109040A1 (en) * 2002-04-04 2008-05-08 Luiz Belardinelli Method of treating arrhythmias
US20030220344A1 (en) * 2002-04-04 2003-11-27 Luiz Belardinelli Method of treating arrhythmias
EP1505977B1 (en) 2002-05-21 2014-09-10 Gilead Sciences, Inc. Administration of a partial fatty acid oxidation inhibitor such as ranolazine for the treatment of diabetes
US8822473B2 (en) * 2002-05-21 2014-09-02 Gilead Sciences, Inc. Method of treating diabetes
AU2003255511B2 (en) 2002-06-24 2009-02-05 Janssen Pharmaceutica N.V. Process for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide
US7056924B2 (en) * 2002-07-18 2006-06-06 Cv Therapeutics, Inc. Substituted heterocyclic compounds
EP1806346B1 (en) * 2002-12-05 2009-07-22 Cv Therapeutics, Inc. Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
EP1567525B1 (en) * 2002-12-05 2007-06-27 Cv Therapeutics, Inc. Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
WO2004063180A1 (en) * 2003-01-03 2004-07-29 Cv Therapeutics, Inc. Substituted heterocyclic compounds
JP2006515891A (ja) * 2003-01-17 2006-06-08 シーブイ・セラピューティクス・インコーポレイテッド 循環器疾患の処置に有効な置換ヘテロ環化合物
WO2005000826A1 (en) * 2003-06-23 2005-01-06 Cv Therapeutics, Inc. Urea derivatives of piperazines and piperidines as fatty acid oxidation inhibitors
AU2004303882A1 (en) 2003-12-18 2005-07-07 Gilead Palo Alto, Inc. 1-akan-2-ol substituted piperazine and piperidine compounds
WO2006008753A1 (en) * 2004-07-19 2006-01-26 Unichem Laboratories Limited Crystalline and amorphous form of ranolazine and the process for manufacturing them
JP2008512465A (ja) * 2004-09-08 2008-04-24 シーブイ・セラピューティクス・インコーポレイテッド 脂肪酸酸化阻害剤としての置換ピペラジン化合物およびその使用
EP1841411A2 (en) * 2005-01-06 2007-10-10 Cv Therapeutics, Inc. Sustained release pharmaceutical formulations comprising ranolazine
WO2008047388A2 (en) * 2006-10-20 2008-04-24 Ind-Swift Laboratories Limited Improved process for the preparation of ranolazine
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
US20080248112A1 (en) * 2007-02-13 2008-10-09 Brent Blackburn Use of ranolazine for the treatment of coronary microvascular diseases
JP2010518171A (ja) * 2007-02-13 2010-05-27 ギリアード・パロ・アルト・インコーポレイテッド 非冠微小血管疾患の処置のためのラノラジンの使用
JP2010518169A (ja) * 2007-02-13 2010-05-27 ギリアード・パロ・アルト・インコーポレイテッド 心血管疾患の処置のためのラノラジンの使用
EP2139877B1 (en) * 2007-03-07 2011-05-11 Concert Pharmaceuticals Inc. Deuterated piperazine derivatives as anti-anginal compounds
US20080233191A1 (en) * 2007-03-22 2008-09-25 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
WO2008139492A2 (en) * 2007-05-15 2008-11-20 Natco Pharma Limited A process for the preparation of highly pure ranolazine base
KR20100033490A (ko) * 2007-05-31 2010-03-30 질레드 팔로 알토 인코포레이티드 상승된 뇌-형 나트륨이뇨 펩티드에 대한 라놀라진
AU2008266124A1 (en) * 2007-06-13 2008-12-24 Auspex Pharmaceuticals, Inc. Substituted piperazines
US20090247535A1 (en) * 2008-03-26 2009-10-01 Duke University Use of ranolazine for non-cardiovascular disorders
WO2009153651A1 (en) * 2008-06-19 2009-12-23 Medichem, S.A. Process for preparing a piperazine derivative
WO2010023687A2 (en) * 2008-08-28 2010-03-04 Shodhana Laboratories Limited Preparation of ranolazine, its salts and intermediates thereof
EP2328873A4 (en) * 2008-08-28 2011-09-07 Reddys Lab Ltd Dr PREPARATION OF RANOLAZINE
WO2010029436A2 (en) * 2008-09-09 2010-03-18 Actavis Group Ptc Ehf Novel solid state forms of ranolazine salts
WO2010043976A2 (en) * 2008-10-15 2010-04-22 Actavis Group Ptc Ehf Highly pure ranolazine or a pharmaceutically acceptable salt thereof
WO2010097805A1 (en) 2009-02-24 2010-09-02 Lupin Limited A process for the preparation of ranolazine
US8901128B2 (en) 2009-05-28 2014-12-02 Lupin Limited Pharmaceutical compositions of ranolazine
WO2011036677A2 (en) 2009-09-25 2011-03-31 Lupin Limited Sustained release composition of ranolazine
TWI508726B (zh) 2009-12-21 2015-11-21 Gilead Sciences Inc 治療心房纖維性顫動之方法
TW201215392A (en) 2010-06-16 2012-04-16 Gilead Sciences Inc Use of ranolazine for treating pulmonary hypertension
NO3175985T3 (fi) 2011-07-01 2018-04-28
CA2849505A1 (en) 2011-09-21 2013-03-28 Gilead Sciences, Inc. Sodium channel blockers reduce glucagon secretion
CN103570645A (zh) * 2012-08-01 2014-02-12 上海迪赛诺化学制药有限公司 一种制备n-(2,6-二甲基苯基)-2-(1-哌嗪基)乙酰胺的方法
EP3233814A4 (en) 2015-03-10 2018-07-18 Unichem Laboratories Limited Novel process for the preparation of ranolazine
TW201717919A (zh) 2015-07-02 2017-06-01 國際藥品股份公司 雷諾多重壓縮錠劑
WO2018001582A1 (en) 2016-06-30 2018-01-04 Interquim, S.A. Ranolazine multiple compressed tablets

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3360529A (en) * 1962-01-29 1967-12-26 Smith Kline French Lab Guanidinoalkylbenzodioxan derivatives
US3829441A (en) * 1962-01-29 1974-08-13 Smith Kline French Lab Guanidinoalkylbenzodioxan derivatives
US3496183A (en) * 1964-11-19 1970-02-17 Egyt Gyogyszervegyeszeti Gyar Beta-guanidino-ethyl-piperazine derivatives
DE1795362A1 (de) * 1968-09-19 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
DE1795375A1 (de) * 1968-09-21 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
FR2154493B1 (fi) * 1971-09-13 1975-10-31 Kali Chemie Ag
GB1332008A (en) * 1971-09-28 1973-10-03 Pfizer Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
GB1374366A (en) * 1972-07-21 1974-11-20 Science Union & Cie Propanol derivatives and a process for their preparation
GB1425559A (en) * 1972-09-01 1976-02-18 Wyeth John & Brother Ltd Pyridine tetrahydropyridine and piperidine derivatives
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
US3953448A (en) * 1972-12-07 1976-04-27 Delmar Chemicals Limited Piperazino-anilido compounds
FR2267104A1 (en) * 1974-04-12 1975-11-07 Ferlux Labo Sa Hypotensive and antiarrhythmic piperazines - 1-(3-phenoxy-2-hydroxy propyl)-4-substd. piperazines
FR2310763A1 (fr) * 1975-05-13 1976-12-10 Buzas Andre Derives 1,4-disubstitues de la piperazine, leur procede de preparation et leurs applications
US4335126A (en) * 1977-03-10 1982-06-15 Degussa Aktiengesellschaft 1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
FR2462432A2 (fr) * 1979-08-03 1981-02-13 Delalande Sa Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique
FR2456738A2 (fr) * 1978-04-10 1980-12-12 Delalande Sa Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique
JPS6042795B2 (ja) * 1978-10-23 1985-09-25 日本新薬株式会社 カルバモイルピペラジン誘導体
DE3068678D1 (en) * 1979-08-10 1984-08-30 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DE2941597A1 (de) * 1979-10-13 1981-04-23 Basf Ag, 6700 Ludwigshafen Piperidinderivate von 4,5-dialkyl-3-hydroxy-pyrrol-2-carbonsaeureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4368199A (en) * 1980-01-21 1983-01-11 Delalande S.A. Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, their salts, the process for preparing the same and their application in therapeutics
DE3005287A1 (de) * 1980-02-13 1981-08-20 Basf Ag, 6700 Ludwigshafen Phenylpiperazinderivate von 1,3,4-oxadiazolylphenolen, ihre herstellung und diese enthaltende therapeutische mittel
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4684651A (en) * 1981-03-17 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene and acid addition salts thereof useful as hypotensives
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4374837A (en) * 1981-07-31 1983-02-22 Laroche Navarron, S.A. Piperazine derivatives of theobromine
US4353901A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones

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KR890000020B1 (ko) 1989-03-06
DK248384D0 (da) 1984-05-17
PL143558B1 (en) 1988-02-29
DK168535B1 (da) 1994-04-18
EP0126449A1 (en) 1984-11-28
MX9203001A (es) 1992-07-01
IE57487B1 (en) 1993-02-10
FI841989A0 (fi) 1984-05-17
IE841224L (en) 1984-11-18
IL71863A (en) 1987-10-30
HU192404B (en) 1987-06-29
JPS59219271A (ja) 1984-12-10
FI78479C (fi) 1989-08-10
JPH0469151B2 (fi) 1992-11-05
CS246080B2 (en) 1986-10-16
ES8601947A1 (es) 1985-12-01
HUT34177A (en) 1985-02-28
NO163618C (no) 1990-06-27
IL71863A0 (en) 1984-09-30
AU566489B2 (en) 1987-10-22
CA1256874A (en) 1989-07-04
HK91989A (en) 1989-11-24
US4567264A (en) 1986-01-28
BR1100474A (pt) 2000-03-14
ZA843746B (en) 1986-01-29
KR850002475A (ko) 1985-05-13
PL247722A1 (en) 1985-08-13
FI78479B (fi) 1989-04-28
DK248384A (da) 1984-11-19
DE3468215D1 (en) 1988-02-04
ATE31533T1 (de) 1988-01-15
PH20016A (en) 1986-09-01
SG25086G (en) 1989-12-29
EP0126449B1 (en) 1987-12-23
NO163618B (no) 1990-03-19
NO841968L (no) 1984-11-19
RU2071471C1 (ru) 1997-01-10
NZ208188A (en) 1987-10-30
ES532565A0 (es) 1985-12-01
AU2834684A (en) 1984-11-22
PT78604A (en) 1984-06-01
PL142760B1 (en) 1987-11-30
PL252856A1 (en) 1985-11-19
PT78604B (en) 1986-07-15
RU2083570C1 (ru) 1997-07-10

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